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Journal Articles

Single Cell RNA-Seq Reveals Deranged Developmental Hierarchy with Coexisting Oncogenic States and Immune Evasion Programs in ETP T-ALL

Blood (2019) 134 (Supplement_1): 3953.

https://doi.org/10.1182/blood-2019-130482

Published: 2019

Journal Articles

Enhancer Rewiring Dependent Switch from BCL2 to MCL1 Dependency Predicts NOTCH1 Inhibition Response in T-ALL

Valeriya Dimitrova, Huiyoung Yun, PhD, Sayalee Potdar, Alexandria Nicole Van Scoyk, BS, Shruti Bhatt, PhD, Praveen Anand, PhD, Monica S. Nair, Jake A. Kloeber, Antonis Kokkalis, PhD MSc, Julia Frede, PhD MPhil, Johannes M. Waldschmidt, MD, Anthony G. Letai, MD PhD, David M. Weinstock, MD, Jon C. Aster, MD PhD, Jens G. Lohr, MD PhD, Birgit Knoechel, MD PhD

Blood (2019) 134 (Supplement_1): 3948.

https://doi.org/10.1182/blood-2019-131148

Published: 2019

Journal Articles

Single-Cell RNA-Seq Reveals AML Cellular Hierarchies Relevant to Clinical Outcomes and Immunity

Peter Van Galen, PhD, Volker Hovestadt, PhD, Marc Wadsworth II, Travis Hughes, Gabriel Kenneth Griffin, MD, Julia A. Verga, Jason Stephansky, Timothy J. Pastika, Jennifer Lombardi Story, Geraldine S. Pinkus, MD, Olga Pozdnyakova, MD PhD, Ilene Galinsky, Richard M. Stone, MD, Timothy A. Graubert, MD, Alex K. Shalek, PhD, Jon C. Aster, MD PhD, Andrew A. Lane, MD PhD, Bradley E. Bernstein, MD PhD

Blood (2018) 132 (Supplement 1): 542.

https://doi.org/10.1182/blood-2018-99-113502

Published: 2018

Journal Articles

Systematic KIT Sequencing Identifies Unsuspected Systemic Mastocytosis with Associated Hematological Neoplasm

Elizabeth A Morgan, MD, Jeffrey W. Craig, MD PhD, Annette S. Kim, MDPhD, Geraldine S. Pinkus, Jon C. Aster, MD PhD, Frank C Kuo, MBBS, PhD, David P. Steensma, MD, R. Coleman Lindsley, MD PhD, Daniel J. DeAngelo, MD

Blood (2017) 130 (Supplement 1): 2923.

https://doi.org/10.1182/blood.V130.Suppl_1.2923.2923

Published: 2017

Journal Articles

Lymphoma Microenvironment Signature Predicts Clinical Outcomes in Diffuse Large B-Cell Lymphoma Patients

Kohta Miyawaki, MD, Takeshi Sugio, MD, Koji Kato, MD PhD, Kensuke Sasaki, MD, Hiroaki Miyoshi, MDPhD, Jon C. Aster, MD PhD, Frank C Kuo, MBBS, PhD, Koichi Ohshima, MDPhD, Takahiro Maeda, MDPhD, Koichi Akashi, MD PhD

Blood (2017) 130 (Supplement 1): 1474.

https://doi.org/10.1182/blood.V130.Suppl_1.1474.1474

Published: 2017

Journal Articles

Microenvironment-Specific Activation of Notch2 in Splenic Marginal Zone Lymphoma

Vignesh Shanmugam, MD, Scott B Lovitch, MD, PhD, Karim A. Benhadji, Gerald J. Oakley, MD, Jon C. Aster, MD PhD

Blood (2017) 130 (Supplement 1): 1485.

https://doi.org/10.1182/blood.V130.Suppl_1.1485.1485

Published: 2017

Journal Articles

Resistance to SL-401 in AML and BPDCN Is Associated with Loss of the Diphthamide Synthesis Pathway Enzyme DPH1 and Is Reversible By Azacitidine

Jason Stephansky, Katsuhiro Togami, MDPhD, Mahmoud Ghandi, PhD, Joan Montero, PhD, Nick vonEgypt, Ross Lindsay, PhD, Christopher Brooks, PhD, Jon C. Aster, MD PhD, Cory Johannessen, PhD, Andrew A. Lane, MD PhD

Blood (2017) 130 (Supplement 1): 797.

https://doi.org/10.1182/blood.V130.Suppl_1.797.797

Published: 2017

Journal Articles

Generation and Application of T-Cell Lymphoma Patient Derived Tumor Xenograft Models

Blood (2017) 130 (Supplement 1): 109.

https://doi.org/10.1182/blood.V130.Suppl_1.109.109

Published: 2017

Journal Articles

Resistant T-Cell Acute Lymphoblastic Leukemias That Emerge after In Vivo Treatment with Dexamethasone Frequently Down-Regulate Glucocorticoid Receptor Protein Expression

Blood (2016) 128 (22): 753.

https://doi.org/10.1182/blood.V128.22.753.753

Published: 2016

Journal Articles

Two-Year Experience of Performing a Next-Generation-Sequencing Based Panel Test in an Academic Medical Center and Its Clinical Impact

Kuo Frank, MD PhD, Jon C. Aster, MD PhD, Coleman Lindsley, MD PhD

Blood (2016) 128 (22): 1707.

https://doi.org/10.1182/blood.V128.22.1707.1707

Published: 2016

Journal Articles

Systematic STAT3 Mutation Testing Identifies Patients with Unsuspected T-Cell Large Granular Lymphocytic Leukemia

Elizabeth A. Morgan, MD, Mark N. Lee, MD PhD, Daniel J. DeAngelo, MD PhD, David P. Steensma, MD, Richard M. Stone, MD, Frank C. Kuo, MD PhD, Jon C. Aster, MD PhD, Christopher J. Gibson, MD, R. Coleman Lindsley, MDPhD

Blood (2016) 128 (22): 919.

https://doi.org/10.1182/blood.V128.22.919.919

Published: 2016

Journal Articles

Generation of Models of Human Hematologic Malignancies Using CRISPR Genome Engineering

Zuzana Tothova, MD PhD, John M Krill-Burger, MCS, Katerina D Popova, BA, Quinlan Sievers, BA, David Yudovich, BSc, Roger Belizaire, MD PhD, Jon C. Aster, MD PhD, Elizabeth A. Morgan, MD, Aviad Tsherniak, MSc, Benjamin L Ebert, MD PhD

Blood (2016) 128 (22): 741.

https://doi.org/10.1182/blood.V128.22.741.741

Published: 2016

Journal Articles

Notch-Regulated Enhancers in B-Cell Lymphoma Activate MYC and Potentiate B-Cell Receptor Signaling

Russell J.H. Ryan, MD, Jelena Petrovic, PhD, Dylan Rausch, BS, Caleb Lareau, BS, Winston Lee, MD PhD, Laura Donohue, BS, Amanda L. Christie, BS, Shawn Gillespie, BS, Michael J. Kluk, MD PhD, Valentina Nardi, MD, Robert B. Faryabi, PhD, Ephraim P. Hochberg, MD, David M. Weinstock, MD, Bradley E. Bernstein, MD PhD, Jon C. Aster, MD PhD, Warren S. Pear, MD PhD

Blood (2016) 128 (22): 457.

https://doi.org/10.1182/blood.V128.22.457.457

Published: 2016

Journal Articles

T-Cell Lymphoma Patient-Derived Xenografts and Newly Developed Cell Lines Recapitulate Aspects of Disease Biology and Represent Novel Tools for Preclinical Drug Development

Blood (2016) 128 (22): 3015.

https://doi.org/10.1182/blood.V128.22.3015.3015

Published: 2016

Journal Articles

Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) Is Highly BCL-2 Dependent and Sensitive to Venetoclax

Joan Montero, PhD, Jason Stephansky, BS, Tianyu Cai, PhD, Gabriel K. Griffin, MD, Katsuhiro Togami, MD PhD, Lucia Cabal-Hierro, PhD, Nicole R. LeBoeuf, MD, Leah Hogdal, PhD, Ilene Galinsky, MSN, ANPc, Jon C. Aster, MD PhD, Matthew S. Davids, Naveen Pemmaraju, MD, Richard M. Stone, MD, Marina Konopleva, MD PhD, Anthony Letai, MD PhD, Andrew A. Lane, MD PhD

Blood (2016) 128 (22): 4045.

https://doi.org/10.1182/blood.V128.22.4045.4045

Published: 2016

Journal Articles

Therapeutic Targeting of PIM Protein Kinases in a Subset of T-Cell Acute Lymphoblastic Leukemia

Sathish Kumar Reddy Padi, PhD, Libia A Luevano, ND, Ningfei An, PhD, Ritu Pandey, PhD, Neha Singh, PhD, Jin H Song, PhD, Jon C. Aster, MD PhD, Xue-Zhong Yu, PhD, Shikhar Mehrotra, PhD, Andrew S Kraft, MD

Blood (2016) 128 (22): 2742.

https://doi.org/10.1182/blood.V128.22.2742.2742

Published: 2016

Journal Articles

Apurinic/Apyrimidinic Endonuclease 1 Induced Genomic Instability Causes T-Cell Acute Lymphoblastic Leukemia in Zebrafish

Jianhong Lin, MD M.Sc, Chun Yang, MD PhD, Ariel Kwart, B.S., Jianjun Zhao, MD PhD, Mehmet K Samur, PhD, Weihong Zhang, MD, Purushothama Nanjappa, M.S., Teresa Calimeri, MD PhD, Xiubao Ren, MD, Dongdong Ma, MD PhD, Xiaofeng Jiang, MD PhD, Yi Zhou, PhD, Masood Shammas, PhD, Kenneth C. Anderson, MD, Jon C. Aster, MD PhD, Leonard I. Zon, MD, Robert I. Handin, MD, Nikhil C. Munshi, MD

Blood (2015) 126 (23): 1431.

https://doi.org/10.1182/blood.V126.23.1431.1431

Published: 2015

Journal Articles

Selectively Targeting Mutated NOTCH1 with a Folate-Thapsigargin Derivative

Giovanni Roti, MD, Jun Qi, PhD, Angela Su, B.S., Antony Varca, B.S., Jon C Aster, MD PhD, James E. Bradner, Kimberly Stegmaier, MD

Blood (2014) 124 (21): 2158.

https://doi.org/10.1182/blood.V124.21.2158.2158

Published: 2014

Journal Articles

Alternative Super-Enhancer States Determine MYC Sensitivity to Notch and Brd4 Inhibitors in T Lymphoblastic Leukemia/Lymphoma

Hongfang Wang, PhD, Yumi Yashiro-Ohtani, PhD, Chongzhi Zang, PhD, Yinling Joey Wong, MS, Will Bailis, PhD, Birgit Knoechel, MD PhD, Bradley Bernstein, MD PhD, Steve Blacklow, MD PhD, X. Shirley Liu, PhD, Warren S. Pear, MD PhD, Jon C Aster, MD PhD

Blood (2014) 124 (21): 863.

https://doi.org/10.1182/blood.V124.21.863.863

Published: 2014

Journal Articles

RUNX1 Is Required For Maintenance Of Established T-ALL Blasts

Christopher R Jenkins, Olena O Shevchuk, Hongfang Wang, Ph.D., Vincenzo Giambra, PhD, Samuel D Gusscott, Jon C. Aster, MD, PhD, Andrew P Weng, MD, PhD

Blood (2013) 122 (21): 3742.

https://doi.org/10.1182/blood.V122.21.3742.3742

Published: 2013

NARROW

Single Cell RNA-Seq Reveals Deranged Developmental Hierarchy with Coexisting Oncogenic States and Immune Evasion Programs in ETP T-ALL

Enhancer Rewiring Dependent Switch from BCL2 to MCL1 Dependency Predicts NOTCH1 Inhibition Response in T-ALL

Single-Cell RNA-Seq Reveals AML Cellular Hierarchies Relevant to Clinical Outcomes and Immunity

Systematic KIT Sequencing Identifies Unsuspected Systemic Mastocytosis with Associated Hematological Neoplasm

Lymphoma Microenvironment Signature Predicts Clinical Outcomes in Diffuse Large B-Cell Lymphoma Patients

Microenvironment-Specific Activation of Notch2 in Splenic Marginal Zone Lymphoma

Resistance to SL-401 in AML and BPDCN Is Associated with Loss of the Diphthamide Synthesis Pathway Enzyme DPH1 and Is Reversible By Azacitidine

Generation and Application of T-Cell Lymphoma Patient Derived Tumor Xenograft Models

Resistant T-Cell Acute Lymphoblastic Leukemias That Emerge after In Vivo Treatment with Dexamethasone Frequently Down-Regulate Glucocorticoid Receptor Protein Expression

Two-Year Experience of Performing a Next-Generation-Sequencing Based Panel Test in an Academic Medical Center and Its Clinical Impact

Systematic STAT3 Mutation Testing Identifies Patients with Unsuspected T-Cell Large Granular Lymphocytic Leukemia

Generation of Models of Human Hematologic Malignancies Using CRISPR Genome Engineering

Notch-Regulated Enhancers in B-Cell Lymphoma Activate MYC and Potentiate B-Cell Receptor Signaling

T-Cell Lymphoma Patient-Derived Xenografts and Newly Developed Cell Lines Recapitulate Aspects of Disease Biology and Represent Novel Tools for Preclinical Drug Development

Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) Is Highly BCL-2 Dependent and Sensitive to Venetoclax

Therapeutic Targeting of PIM Protein Kinases in a Subset of T-Cell Acute Lymphoblastic Leukemia

Apurinic/Apyrimidinic Endonuclease 1 Induced Genomic Instability Causes T-Cell Acute Lymphoblastic Leukemia in Zebrafish

Selectively Targeting Mutated NOTCH1 with a Folate-Thapsigargin Derivative

Alternative Super-Enhancer States Determine MYC Sensitivity to Notch and Brd4 Inhibitors in T Lymphoblastic Leukemia/Lymphoma

RUNX1 Is Required For Maintenance Of Established T-ALL Blasts

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American Society of Hematology

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American Society of Hematology

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