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John W. Semple, PhD
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Journal Articles

Osteopontin Mediates Murine Transfusion-Related Acute Lung Injury through Stimulation of Pulmonary Neutrophil Accumulation

Rick Kapur, MDPhDMSc, Gopinath Kasetty, PhD, Johan Rebetz, PhD, Arne Egesten, MD PhD, John W Semple, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 739.
https://doi.org/10.1182/blood-2018-99-115770
Published: 2018
Journal Articles

Fcγ Receptors I and III on Splenic Macrophages Mediate GPIIb/IIIa Autoantibody-Dependent Phagocytosis of Platelets in Human Immune Thrombocytopenia

Peter A. A. Norris, BSc, George B. Segel, MD, Ulrich J Sachs, MD PhD, Behnaz Bayat, PhD, Gestur Vidarsson, PhD, Rick Kapur, MDPhDMSc, Christine M. Cserti-Gazdewich, BSc, MD FRCPC, Jeannie Callum, MD, Yulia Lin, MD FRCPC, Richard Burack, MD PhD, John W Semple, PhD, Alan H Lazarus, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 129.
https://doi.org/10.1182/blood-2018-99-117650
Published: 2018
Journal Articles

Erythrocyte-Specific Antibodies As a Potential New Therapeutic Modality in Autoimmune and Inflammatory Disorders Beyond Immune Thrombocytopenia (ITP)

Andrew R Crow, BRT, Rick Kapur, MDPhDMSc, Mark Jen, MSc, Patrick J Mott, MSc, Danielle Marjoram, MSc, Alaa Amash, PhD, Simrat S Kahlon, BSc, Issaka Yougbare, PhD, Heyu Ni, MD MSc, PhD, Michael Kim, BSc, John W Semple, PhD, Alan H Lazarus, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 231.
https://doi.org/10.1182/blood.V130.Suppl_1.231.231
Published: 2017
Journal Articles

Gastrointestinal Flora Dictates the Biological Response in Murine Transfusion Related Acute Lung Injury (TRALI)

Rick Kapur, MDPhDMSc, Michael Kim, BSc, Johan Rebetz, PhD, Alisa Takabe-French, Noel Kim, Shanjeevan Shanmugabhavananthan, BSc, Edwin R. Speck, BRT, John W Semple, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 766.
https://doi.org/10.1182/blood.V130.Suppl_1.766.766
Published: 2017
Journal Articles

Splenic Mechanisms of Thrombocytopenia

John W. Semple, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): SCI-33.
https://doi.org/10.1182/blood.V130.Suppl_1.SCI-33.SCI-33
Published: 2017
Journal Articles

Interleukin (IL)-10 Is an Effective Therapeutic for Murine Transfusion Related Acute Lung Injury (TRALI)

Rick Kapur, MD PhD M.Sc., Michael Kim, BSc, Shanjee Shanmugabhavananthan, Jonathan Liu, Noel Kim, Stefan Milosevic, Edwin R. Speck, BRT, John W. Semple, PhD
Journal: Blood
Blood (2016) 128 (22): 92.
https://doi.org/10.1182/blood.V128.22.92.92
Published: 2016
Journal Articles

CD4+CD25+Foxp3+ T Regulatory Cells Protect Against Murine Antibody-Mediated Transfusion-Related Acute Lung Injury (TRALI)

Rick Kapur, MD PhD, Michael Kim, BSc, Shanjee Shanmugabhavananthan, Edwin R. Speck, BRT, Rukhsana Aslam, PhD, Li Guo, MD, Anne Zufferey, PhD, John W. Semple, PhD
Journal: Blood
Blood (2015) 126 (23): 2342.
https://doi.org/10.1182/blood.V126.23.2342.2342
Published: 2015
Journal Articles

Successful Treatment of Thrombocytopenia with Staphylococcal Protein A (PRTX-100) in a Murine Model of Immune Thrombocytopenia (ITP)

John W. Semple, PhD, Edwin R. Speck, BRT, Rukhsana Aslam, PhD, Michael Kim, BSc, Anne Zufferey, PhD, Heyu Ni, MD PhD, Michelle Catalina, PhD, Richard Francovitch, PhD
Journal: Blood
Blood (2015) 126 (23): 1045.
https://doi.org/10.1182/blood.V126.23.1045.1045
Published: 2015
Journal Articles

Thymic-Derived Tolerizing Dendritic Cells Are up-Regulated upon Treatment with Intravenous Immunoglobulin or Splenectomy in a Murine Model of Immune Thrombocytopenia

Rick Kapur, MD PhD, Rukhsana Aslam, PhD, Edwin R. Speck, BRT, Michael Kim, BSc, Anne Zufferey, PhD, Li Guo, MD, George B. Segel, MD, Heyu Ni, MD PhD, John W. Semple, PhD
Journal: Blood
Blood (2015) 126 (23): 2251.
https://doi.org/10.1182/blood.V126.23.2251.2251
Published: 2015
Journal Articles

Murine Bone Marrow-Derived Megakaryocytes Are Capable of Antigen Cross-Presentation on Major Histocompatibility Class (MHC) I Molecules

Anne Zufferey, PhD, Edwin R. Speck, BRT, Li Guo, MD, Rukhsana Aslam, PhD, Rick Kapur, MD PhD, John W. Semple, PhD
Journal: Blood
Blood (2015) 126 (23): 3465.
https://doi.org/10.1182/blood.V126.23.3465.3465
Published: 2015
Journal Articles

C-Reactive Protein (CRP) Enhances Murine Antibody-Mediated Transfusion Related Acute Lung Injury (TRALI)

Rick Kapur, MD PhD, Michael Kim, BSc, Shanjee Shanmugabhavananthan, Edwin R. Speck, BRT, Rukhsana Aslam, PhD, Li Guo, MD, Anne Zufferey, PhD, John W. Semple, PhD
Journal: Blood
Blood (2015) 126 (23): 3561.
https://doi.org/10.1182/blood.V126.23.3561.3561
Published: 2015
Journal Articles

CD20 B Cell Depleting Therapy Is Associated with up-Regulation of CD8 + CD25 high Foxp3 + T Regulatory Cells in a Murine Model of Immune Thrombocytopenia (ITP)

Li Guo, MD, Rukhsana Aslam, PhD, Yajing Zhao, Edwin R. Speck, BRT, Heyu Ni, MD PhD, John W. Semple, PhD
Journal: Blood
Blood (2014) 124 (21): 2785.
https://doi.org/10.1182/blood.V124.21.2785.2785
Published: 2014
Journal Articles

Megakaryocyte Abnormalities Occur In The Absence Of Cell-Mediated Immunity In a Murine Model Of Passive Immune Thrombocytopenia (ITP)

John W. Semple, PhD, Kristin Hunt, Yu Hou, Rukhsana Aslam, PhD, Edwin R. Speck, Heyu Ni, MD, PhD, Alan H Lazarus, PhD
Journal: Blood
Blood (2013) 122 (21): 3537.
https://doi.org/10.1182/blood.V122.21.3537.3537
Published: 2013
Journal Articles

A Murine Model Of Hemorrhagic Shock/Resuscitation Demonstrates Transfusion Related Acute Lung Injury (TRALI) Induced By Stored Platelet Transfusions

Christopher G.J. McKenzie, PhD, Michael Kim, BSc, Dana Safavian, BSc, Ori D Rotstein, MD, John W. Semple, PhD
Journal: Blood
Blood (2013) 122 (21): 789.
https://doi.org/10.1182/blood.V122.21.789.789
Published: 2013
Journal Articles

CD8+ T Cells Are Predominantly Protective In a Murine Model Of ITP and Is Required For Effective Steroid Therapy

Li Ma, Elisa K. Simpson, H.B.Sc., June Li, BSc, Guangheng Zhu, MD, Pingguo Chen, PhD, John W. Semple, PhD, John Freedman, MD, Heyu Ni, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 1076.
https://doi.org/10.1182/blood.V122.21.1076.1076
Published: 2013
Journal Articles

Human and Murine Immune Thrombocytopenia (ITP) Is Associated with a Peripheral Deficiency of CD4- T Regulatory Cells (Tc-regs)

John W. Semple, PhD, Daoxin Ma, PhD, Rukhsana Aslam, PhD, Ming Hou, Heyu Ni, MD, PhD, Yu Hu
Journal: Blood
Blood (2012) 120 (21): 3333.
https://doi.org/10.1182/blood.V120.21.3333.3333
Published: 2012
Journal Articles

Identification of a Two-Step Mechanism Responsible for Antibody-Mediated Transfusion Related Acute Lung Injury (TRALI)

Christopher G.J. McKenzie, PhD, Michael Kim, BSc, Tarandeep Singh, John W. Semple, PhD
Journal: Blood
Blood (2012) 120 (21): 846.
https://doi.org/10.1182/blood.V120.21.846.846
Published: 2012
Journal Articles

Thrombopoietin Can Induce Tolerogenic Responses Via the Modulation of Thymic and Splenic T Lymphocyte Populations in a Murine Model of Immune Thrombocytopenia (ITP)

John W. Semple, PhD, Xu Zhang, Yu Hu, Li Guo, Edwin R. Speck, Heyu Ni, MD, PhD, Rukhsana Aslam, PhD
Journal: Blood
Blood (2012) 120 (21): 1088.
https://doi.org/10.1182/blood.V120.21.1088.1088
Published: 2012
Journal Articles

The Functional Role of TLR9 in Human Platelets

Jonathan Noah Thon, Ph.D., Christian G. Peters, Ph.D., Rukhsana Aslam, Ph.D., Jesse Rowley, Ph.D., Andrew S. Weyrich, Ph.D., John W. Semple, PhD, Robert C. Flaumenhaft, MD, PhD, Joseph E. Italiano, Jr., PhD
Journal: Blood
Blood (2011) 118 (21): 366.
https://doi.org/10.1182/blood.V118.21.366.366
Published: 2011
Journal Articles

Intravenous Gammaglobulin (IVIg) Therapy Prevents Antibody-Mediated Transfusion Related Acute Lung Injury (TRALI) by Directly Inhibiting Recipient Neutrophil Activation in a Murine Model

John W. Semple, PhD, Michael Kim, BSc, Jing Hou, Young Jin Lee, Arata Tabuchi, Wolfgang M. Kuebler, MD, PhD, Alan H Lazarus, PhD
Journal: Blood
Blood (2011) 118 (21): 42.
https://doi.org/10.1182/blood.V118.21.42.42
Published: 2011