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Journal Articles

Warfarin Exposure Leads to Loss of Binding of Emicizumab to Factor IX

Kerry W Lannert, Ben Samelson-Jones, Katarina Berk, Nicholas A Popp, John P. Sheehan, Doug M Fowler, Jill M Johnsen

Blood (2024) 144 (Supplement 1): 3955.

https://doi.org/10.1182/blood-2024-211847

Published: 2024

Journal Articles

Interaction between Collagen IV and Heparin-Binding Sites in the Activity, Distribution and Clearance of Factor IX(a)

Douglas S. Annis, Pamela R. Westmark, Christina E. Amend, Brianna Torres, John P. Sheehan

Blood (2024) 144 (Supplement 1): 2574.

https://doi.org/10.1182/blood-2024-211131

Published: 2024

Journal Articles

First-in-Human Dose-Finding Study of AAVhu37 Vector-Based Gene Therapy: BAY 2599023 Has Stable and Sustained Expression of FVIII over 2 Years

Steven W Pipe, John P Sheehan, Michiel Coppens, Hermann Eichler, Camila Linardi, Sara Wiegmann, Charles RM Hay, Toshko Lissitchkov

Blood (2021) 138 (Supplement 1): 3971.

https://doi.org/10.1182/blood-2021-148661

Published: 2021

Journal Articles

Protease Domain Exosites Regulate Plasma Recovery and Extravascular Distribution of Factor IX(a) Variants in Hemophilic Mice

Pamela Westmark, John P Sheehan

Blood (2021) 138 (Supplement 1): 2093.

https://doi.org/10.1182/blood-2021-154532

Published: 2021

Journal Articles

Antithrombin- and Heparin-Binding Exosites Regulate Extravascular Binding and Clearance of Factor IXa

Pamela Westmark, PhD, John P. Sheehan, MD

Blood (2019) 134 (Supplement_1): 2392.

https://doi.org/10.1182/blood-2019-131580

Published: 2019

Journal Articles

Zebrafish factor 10 and the life aquatic

John P. Sheehan

Blood (2017) 130 (5): 563–565.

https://doi.org/10.1182/blood-2017-06-789149

Published: 2017

Journal Articles

Identification of the Protein S Binding Site in the Factor IXa Serine Protease Domain Presents Therapeutic Possibilities

William E. Plautz, Satish Sekhar, Rinku Majumder, PhD, John P. Sheehan, MD

Blood (2015) 126 (23): 2274.

https://doi.org/10.1182/blood.V126.23.2274.2274

Published: 2015

Journal Articles

Detection of Factor IXa Activity By the Enhanced Thrombin Generation Assay

Pansakorn Tanratana, MD, John P. Sheehan, MD

Blood (2014) 124 (21): 4242.

https://doi.org/10.1182/blood.V124.21.4242.4242

Published: 2014

Journal Articles

Effect Of Combined Heparin- and Antithrombin-Binding Exosite Mutations On Human Factor IX(a) Coagulant Activity, Thrombin Generation, and Protease Half-Life In Human Plasma

Pamela R. Westmark, Ph.D., Pansakorn Tanratana, M.D., John P. Sheehan, MD

Blood (2013) 122 (21): 2333.

https://doi.org/10.1182/blood.V122.21.2333.2333

Published: 2013

Journal Articles

Low Molecular Weight Heparin Inhibits Plasma Thrombin Generation Via Direct Targeting of Factor IXa: Contribution of the Serpin-Independent Mechanism

Yang Buyue, PhD, John P. Sheehan, MD

Blood (2011) 118 (21): 2242.

https://doi.org/10.1182/blood.V118.21.2242.2242

Published: 2011

Journal Articles

Activation of factor XI by products of prothrombin activation

Anton Matafonov, Suryakala Sarilla, Mao-fu Sun, John P. Sheehan, Vladimir Serebrov, Ingrid M. Verhamme, David Gailani

Blood (2011) 118 (2): 437–445.

https://doi.org/10.1182/blood-2010-10-312983

Published: 2011

Journal Articles

Activation of Factor XI and the Contact Proteases by Products of Prothrombin Activation.

Anton Matafonov, MD, Suryakala Sarilla, PhD, Mao-fu Sun, John P. Sheehan, MD, Vladimir Serebrov, MD, PhD, DMSci, Ingrid Verhamme, PhD, David Gailani, MD

Blood (2010) 116 (21): 1150.

https://doi.org/10.1182/blood.V116.21.1150.1150

Published: 2010

Journal Articles

Fucosylated chondroitin sulfate inhibits plasma thrombin generation via targeting of the factor IXa heparin-binding exosite

Yang Buyue, John P. Sheehan

Blood (2009) 114 (14): 3092–3100.

https://doi.org/10.1182/blood-2009-02-203661

Published: 2009

Journal Articles

Depolymerized Holothurian Glycosaminoglycan Inhibits Plasma Thrombin Generation Via Interaction with the Factor IXa Heparin-Binding Exosite

Buyue Yang, John P. Sheehan, MD

Blood (2008) 112 (11): 3081.

https://doi.org/10.1182/blood.V112.11.3081.3081

Published: 2008

Journal Articles

Factor XI Contributes to Thrombin Generation in the Absence of Factor XIIa

Anton Matafonov, Dmitri Kravtsov, Erik I. Tucker, Mao-fu Sun, John P. Sheehan, MD, Andras Gruber, MD, David Gailani

Blood (2008) 112 (11): 3082.

https://doi.org/10.1182/blood.V112.11.3082.3082

Published: 2008

Journal Articles

The heparin-binding exosite of factor IXa is a critical regulator of plasma thrombin generation and venous thrombosis

Yang Buyue, Herbert C. Whinna, John P. Sheehan

Blood (2008) 112 (8): 3234–3241.

https://doi.org/10.1182/blood-2008-01-136820

Published: 2008

Journal Articles

Depolymerized holothurian glycosaminoglycan and heparin inhibit the intrinsic tenase complex by a common antithrombin-independent mechanism

John P. Sheehan, Erik N. Walke

Blood (2006) 107 (10): 3876–3882.

https://doi.org/10.1182/blood-2005-07-3043

Published: 2006

Journal Articles

Depolymerized Holothurian Glycosaminoglycan and Heparin Inhibit the Intrinsic Tenase Complex by a Common Antithrombin-Independent Mechanism.

John P. Sheehan, MD, Erik N. Walke

Blood (2005) 106 (11): 1011.

https://doi.org/10.1182/blood.V106.11.1011.1011

Published: 2005

Journal Articles

The Factor IXA Heparin-Binding Exosite Is a Critical Cofactor Interactive Site: Mechanism for Antithrombin-Independent Inhibition of Intrinsic Tenase by Heparin.

John P. Sheehan, M.D., Qiu-Ping Yuan, Ph.D., Erik N. Walke, B.S.

Blood (2004) 104 (11): 1716.

https://doi.org/10.1182/blood.V104.11.1716.1716

Published: 2004

Journal Articles

Phosphorothioate Oligonucleotides Inhibit the Intrinsic Tenase Complex

John P. Sheehan, Hao-Chang Lan

Blood (1998) 92 (5): 1617–1625.

https://doi.org/10.1182/blood.V92.5.1617

Published: 1998

NARROW

Warfarin Exposure Leads to Loss of Binding of Emicizumab to Factor IX

Interaction between Collagen IV and Heparin-Binding Sites in the Activity, Distribution and Clearance of Factor IX(a)

First-in-Human Dose-Finding Study of AAVhu37 Vector-Based Gene Therapy: BAY 2599023 Has Stable and Sustained Expression of FVIII over 2 Years

Protease Domain Exosites Regulate Plasma Recovery and Extravascular Distribution of Factor IX(a) Variants in Hemophilic Mice

Antithrombin- and Heparin-Binding Exosites Regulate Extravascular Binding and Clearance of Factor IXa

Zebrafish factor 10 and the life aquatic

Identification of the Protein S Binding Site in the Factor IXa Serine Protease Domain Presents Therapeutic Possibilities

Detection of Factor IXa Activity By the Enhanced Thrombin Generation Assay

Effect Of Combined Heparin- and Antithrombin-Binding Exosite Mutations On Human Factor IX(a) Coagulant Activity, Thrombin Generation, and Protease Half-Life In Human Plasma

Low Molecular Weight Heparin Inhibits Plasma Thrombin Generation Via Direct Targeting of Factor IXa: Contribution of the Serpin-Independent Mechanism

Activation of factor XI by products of prothrombin activation

Activation of Factor XI and the Contact Proteases by Products of Prothrombin Activation.

Fucosylated chondroitin sulfate inhibits plasma thrombin generation via targeting of the factor IXa heparin-binding exosite

Depolymerized Holothurian Glycosaminoglycan Inhibits Plasma Thrombin Generation Via Interaction with the Factor IXa Heparin-Binding Exosite

Factor XI Contributes to Thrombin Generation in the Absence of Factor XIIa

The heparin-binding exosite of factor IXa is a critical regulator of plasma thrombin generation and venous thrombosis

Depolymerized holothurian glycosaminoglycan and heparin inhibit the intrinsic tenase complex by a common antithrombin-independent mechanism

Depolymerized Holothurian Glycosaminoglycan and Heparin Inhibit the Intrinsic Tenase Complex by a Common Antithrombin-Independent Mechanism.

The Factor IXA Heparin-Binding Exosite Is a Critical Cofactor Interactive Site: Mechanism for Antithrombin-Independent Inhibition of Intrinsic Tenase by Heparin.

Phosphorothioate Oligonucleotides Inhibit the Intrinsic Tenase Complex

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American Society of Hematology

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American Society of Hematology

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