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John G. Gribben, MD DSC
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Journal Articles

Multiplatform Profiling Characterizes Functional Networks in Genomically Stable and Instable Chronic Lymphocytic Leukemia

Johannes Bloehdorn, MD, Andrejs Braun, PhD, Billy Michael Chelliah Jebaraj, PhD, Amaro Taylor-Weiner, PhD, Sandra Robrecht, PhD, Julia Krzykalla, PhD, Karlheinz Holzmann, PhD, Harvey Johnston, PhD, Tetyana Klymenko, PhD, Barbara Eichhorst, MD, Ru-Fang Yeh, PhD, Martin Weisser, MD, Jennifer Edelmann, MDPhD, Kirsten Fischer, MD, John G. Gribben, MD DSc, FRCP, FRCPath, FMedSci, Dan A. Landau, MD PhD, Donna S. Neuberg, ScD, Mark S Cragg, PhD, Axel Benner, Michael Hallek, MD, Catherine J. Wu, MD, Hartmut Döhner, Stephan Stilgenbauer, MD, Daniel Mertens, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 12–13.
https://doi.org/10.1182/blood-2020-141552
Published: 2020
Journal Articles

Transplantation for Congenital Sideroblastic Anaemia Is Feasible and Offers Outcomes Comparable to Other Transfusion Dependent Anaemias. a Joint Retrospective Study of the Paediatric Diseases and Severe Aplastic Anaemia Working Parties (PDWP/SAAWP) of EBMT

Josu de la Fuente, Dirk-Jan Eikema, Paul Bosman, Robert F Wynn, MRCP,MDFRCPath, Miguel Díaz, Peter J Shaw, MD, Amal Al-Seraihy, MD, Muhlis Cem Ar, MD PhD, Mohamed Salaheldin Mohamed, Dominique Bron, MDPhD, Cristina Díaz de Heredia, MD PhD, Tobias Gedde-Dahl, Brenda Gibson, MD PhD, Rupert Handgretinger, MD, Professor John G. Gribben, MD DSc, Tessa Kerre, MD, Vassiliki Kitra-Roussou, MD, Stig Lenhoff, Jose Maria Moraleda, MD PhD, Antonio Perez Martinez, MD PhD, John Moppett, FRCPath, Henrik Sengeloev, Abdelghani Tbakhi, MD, Hendrik Veelken, MD PhD, Estelle Verburgh, MBChB, M MDInt, FCPSA, PhD, Giuseppe Visani, Antonio Risitano, Carlo Dufour, Selim Corbacioglu, MD, Regis Peffault De Latour, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 45–47.
https://doi.org/10.1182/blood-2020-142397
Published: 2020
Journal Articles

Assessment of Tumor Lysis Syndrome in Patients with Chronic Lymphocytic Leukemia Treated with Venetoclax in the Clinical Trial and Post-Marketing Settings

John F. Seymour, John G. Gribben, MD DSc, FRCP, FRCPath, FMedSci, Matthew S. Davids, MD, Anthony Mato, MD, Jeff P Sharman, MD, Aimee Cyr, Cynthia Bartkus, German Pena, MD, Michelle Boyer, Simon Sharmokh, MPH, PharmD, Tanya S Rosenberg, MD, William G. Wierda, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 37–38.
https://doi.org/10.1182/blood-2020-134938
Published: 2020
Journal Articles

Immune System Deregulation Predicts Outcome in Diffuse Large B Cell Lymphoma (DLBCL)

Edward Truelove, MBBS, BSc, MRCP, FRCPath, Joseph G Taylor, MBBS, BSc, Andrew James Clear, BSc, Mariarita Calaminici, Professor John G. Gribben, MD DSc
Journal: Blood
Blood (2020) 136 (Supplement 1): 33–34.
https://doi.org/10.1182/blood-2020-143104
Published: 2020
Journal Articles

Continued Long Term Responses to Ibrutinib + Venetoclax Treatment for Relapsed/Refractory CLL in the Blood Cancer UK TAP Clarity Trial

Peter Hillmen, MBChB, FRCP, FRCPath, PhD, Rebecca H. Boucher, BSc, MSc, PhD, Nichola Webster, Surita Dalal, PhD, Kristian Brock, PhD, Francesca Yates, PhD, Chhaya Sankhalpara, Donald Macdonald, MBChB, MD FRCP, PhD FCRPath, Christopher Fegan, Alison McCaig, MBChB, FRCPath, PhD MRCP, Anna Schuh, MD MRCP, PhD, Andrew Pettitt, MA, MB BChir, PhD MRCP, MRCPath, John G. Gribben, MD DSc, FRCP, FRCPath, FMedSci, Piers Patten, MD PhD, Stephen Devereux, PhD FRCP, FRCPath, MRCPath, MB BS, Adrian Bloor, PhD FRCP, FRCPath, Christopher P Fox, PhD FRCPath, MRCP, MBChB, Francesco Forconi, MD PhD FRCPath, Andrew Rawstron, PhD, Peter Hillmen, MBChB, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 17–18.
https://doi.org/10.1182/blood-2020-136960
Published: 2020
Journal Articles

Umbralisib Plus Ublituximab (U2) Is Superior to Obinutuzumab Plus Chlorambucil (O+Chl) in Patients with Treatment Naïve (TN) and Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia (CLL): Results from the Phase 3 Unity-CLL Study

John G. Gribben, MD DSc, FRCP, FRCPath, FMedSci, Wojciech Jurczak, MD PhD, Ryan W. Jacobs, MD, Sebastian Grosicki, MD PhD, Krzysztof Giannopoulos, MD PhD, Tomasz Wrobel, MDPhD, Syed F. Zafar, MD, Jennifer L. Cultrera, MD, Suman Kambhampati, MD, Alexey Danilov, MD, John M. Burke, MD, Jerome Goldschmidt, MD, Douglas F. Beach, MD, Scott F. Huntington, MD MPH, Javier Pinilla Ibarz, MD PhD, Jeff P Sharman, MD, Tanya Siddiqi, MD, Danielle M. Brander, MD, John M. Pagel, MDPhD, Kathryn S. Kolibaba, MD, Monika Dlugosz-Danecka, MD PhD, Nilanjan Ghosh, MD PhD, Peter Sportelli, BS, Hari P. Miskin, MSc, Owen A. O'Connor, MD PhD, Michael S. Weiss, Ian W. Flinn, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 37–39.
https://doi.org/10.1182/blood-2020-134783
Published: 2020
Journal Articles

Treatment with Acalibrutinib, Ibrutinib and CD19 CAR T Cells Restore the Number of Granulocytic Myeloid Derived Supressor Cells in CLL-Bearing Mice

Arantxa Romero-Toledo, MSc, Robin Sanderson, MRCP,FRCPath, John G. Gribben, MD DSc
Journal: Blood
Blood (2019) 134 (Supplement_1): 3032.
https://doi.org/10.1182/blood-2019-126697
Published: 2019
Journal Articles

Sustained Overall Survival Benefit of Obinutuzumab Plus Bendamustine Followed By Obinutuzumab Maintenance Compared with Bendamustine Alone in Patients with Rituximab-Refractory Indolent Non-Hodgkin Lymphoma: Final Results of the Gadolin Study

Laurie H Sehn, MD, Marek Trněný, MD, Kamal Bouabdallah, MD, Gregory Dueck, MD, John G. Gribben, MD DSc, P.J. Lugtenburg, MD PhD, Gilles A. Salles, MD PhD, Andrea Knapp, PhD, Tina G Nielsen, MD PhD, Wenxin Liu, PhD, Bruce D. Cheson, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2822.
https://doi.org/10.1182/blood-2019-123422
Published: 2019
Journal Articles

CRISPR/Cas9-Targeted De Novo DNA Methylation Is Maintained and Impacts the Colony Forming Potential of Human Hematopoietic CD34 + Cells

Emily A Saunderson, PhDBSc, Kevin Rouault-Pierre, PhDBSc, John G. Gribben, MD DSc, Gabriella Ficz, PhDBSc
Journal: Blood
Blood (2019) 134 (Supplement_1): 2517.
https://doi.org/10.1182/blood-2019-130267
Published: 2019
Journal Articles

Integrated Immune Signature Analyses Identifies Evolution of Distinct Immunoregulatory Cell Populations Which Control Alloreactivity after Allogeneic HSCT

James Aries, Sarah Charrot, Jennifer Ball, Matthew Mee, Symeon Theocharidis, Sofie Van Gassen, Sameena Iqbal, John G. Gribben, MD DSc, Jeff Davies, MBBS, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 595.
https://doi.org/10.1182/blood-2019-124875
Published: 2019
Journal Articles

Beyond Exhaustion: The PDL1-PD1 Axis Shapes the Classical Hodgkin Lymphoma Microenvironment

Joseph G Taylor, MBBS, BSc, Andrew James Clear, BSc, Edward Truelove, MBBS, BSc, MRCP, FRCPath, Mariarita Calaminici, John G. Gribben, MD DSc
Journal: Blood
Blood (2019) 134 (Supplement_1): 658.
https://doi.org/10.1182/blood-2019-125247
Published: 2019
Journal Articles

Subgroup Analyses of Elderly Patients Aged ≥ 70 Years in AUGMENT: A Phase III Randomized Study of Lenalidomide Plus Rituximab (R 2 ) vs Rituximab Plus Placebo (R-Placebo) in Patients with Relapsed/Refractory (R/R) Indolent Non-Hodgkin Lymphoma (iNHL)

Marek Trněný, MD, John P. Leonard, MD, Huilai Zhang, MD, Grzegorz Nowakowski, MD, Koji Izutsu, MD PhD, Nathan H. Fowler, MD, Catherine Thieblemont, MD PhD, Pier Luigi Zinzani, MD PhD, Stacey Kalambakas, MD, Myron Czuczman, Pierre Fustier, PhD, Chengqing Wu, PhD, John G. Gribben, MD DSc
Journal: Blood
Blood (2019) 134 (Supplement_1): 347.
https://doi.org/10.1182/blood-2019-122461
Published: 2019
Journal Articles

Comparison of Different Upfront Transplant Strategies in Multiple Myeloma - a Large Registry Study from Chronic Malignancies Working Party of EBMT

Stefan O. Schönland, MD, Simona Iacobelli, Linda Koster, Didier Blaise, MD PhD, Michael Potter, MD, Jan J Cornelissen, MD PhD, Patrice Chevallier, MD, Jiri Mayer, MD, Péter Reményi, John G. Gribben, MD DSc, Ellen Meijer, MD PhD, Ben Carpenter, PhD, Matthew P. Collin, MD PhD, Tobias Gedde-Dahl, Victoria Potter, MD PhD, Ram Malladi, Matthias Stelljes, MD, Adrian Bloor, FRCPath, Tulin Tuglular, MD, Florian Weissinger, Meral Beksac, MD, Patrick J Hayden, MD, Ibrahim Yakoub-Agha, MD PhD, Nicolaus Kröger
Journal: Blood
Blood (2019) 134 (Supplement_1): 324.
https://doi.org/10.1182/blood-2019-128795
Published: 2019
Journal Articles

CAR T Cells Derived from Healthy Mice Lead to Cytokine Release Syndrome (CRS) in the TCL1 Chronic Lymphocytic Leukemia Model; Mice with CLL Treated with Acalabrutinib or Ibrutinib Have Improved CAR T Cell Function without Increasing the Cytokines of CRS

Robin Sanderson, MRCP,FRCPath, Arantxa Romero-Toledo, MSc, John G. Gribben, MD DSc
Journal: Blood
Blood (2019) 134 (Supplement_1): 249.
https://doi.org/10.1182/blood-2019-125647
Published: 2019
Journal Articles

Trends in Autologous Transplantation for Myeloma in EBMT Centres between 1993 and 2017

Patrick J Hayden, MD, Dirk-Jan Eikema, Linda Koster, Hartmut Goldschmidt, MD, Didier Blaise, MD PhD, Michael Potter, MD, Cyrille Touzeau, MD, Anne Huynh, MD, Jenny Byrne, MD PhD, Cyrille Hulin, MD, Neil K Rabin, Reuben Benjamin, FRCPath, MRCP, MBBS, PhD, Jan J Cornelissen, MD PhD, Hareth Nahi, MD, Gordon Cook, MB ChB, PhD FRCP(Glas), FRCPath, John G. Gribben, MD DSc, Ellen Meijer, MD PhD, Péter Reményi, MD, Jiri Mayer, MD, Panagiotis Tsirigotis, Paolo Bernardeschi, MD, Meral Beksac, MD, Stefan O. Schönland, MD, Ibrahim Yakoub-Agha, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4575.
https://doi.org/10.1182/blood-2019-127166
Published: 2019
Journal Articles

The Immune Micro-Environment in Diffuse Large B Cell Lymphoma Is Characterised By an Immunosuppressive Shift in T Cell Subsets

Edward Truelove, MBBS, BSc, MRCP, FRCPath, Frances Seymour, MRCP, BSc, MBBS, Joseph G Taylor, MBBS, BSc, Mariarita Calaminici, Andrew James Clear, BSc, John G. Gribben, MD DSc
Journal: Blood
Blood (2019) 134 (Supplement_1): 5240.
https://doi.org/10.1182/blood-2019-130712
Published: 2019
Journal Articles

Longitudinal Analyses of Diagnostic-Relapse Biopsies of Diffuse Large B Cell Lymphoma Reveal a Poor Risk Subset of ABC Patients Based on the Expression of a 30 Gene Panel

Findlay Bewicke-Copley, PhD MSc, BSc, Koorosh Korfi, PhD BSc, Shamzah Araf, MRCP, MBBS, PhD, Emil Arjun Kumar, BCh,BM, Thomas E C Cummin, MRCP MBBCh BSc, Margaret Ashton-Key, MD, Sharon Barrans, Suzan Van Hoppe, Cathy Burton, Mohamed Elshiekh, Simon Rule, Nicola Crosbie, Andrew James Clear, BSc, Maria Calaminici, MD PhD, David W. Scott, MBChB, PhD, Lisa M. Rimsza, MD, Menon Geetha, Chulin Sha, Michael A Bentley, Ai Nagano, PhD, Andrew Davies, MD PhD, Daniel Painter, BSc, Alexandra Smith, PhD, John G. Gribben, MD DSc, Kikkeri Naresh, David R Westhead, Jessica Okosun, MD PhD, Peter Johnson, MDFRCP, Jun Wang, PhD, Jude Fitzgibbon, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2769.
https://doi.org/10.1182/blood-2019-124352
Published: 2019
Journal Articles

Rituximab and Obinutuzumab Induce Direct B-Cell Death Via B-Cell Receptor (BCR) Signaling, but Rituximab Elicits Stronger BCR-Derived Pro-Survival Signals Diminishing Apoptosis

Jennifer Edelmann, MD PhD, Arran Dokal, MSc, PhD, Karlheinz Holzmann, Dr. rer. nat., David James Britton, BSc, PhD, Emma Vilventhraraja, MSc, PhD, Ryan Jack Smith, PhD, Mark S Cragg, Prof, Andrejs Braun, PhD, Hartmut Döhner, MD, Pedro Cutillas, PhD, John G. Gribben, MD DSc
Journal: Blood
Blood (2019) 134 (Supplement_1): 1579.
https://doi.org/10.1182/blood-2019-128704
Published: 2019
Journal Articles

Aberrant PD-L1 Expression in CLL As a Result of Adaptive Immune Resistance Mediated By Tumor-Secreted Circulating miRNA Binding to Toll-like Receptor 7

Fabienne McClanahan, MD, Federica Calore, PhD, Nicola Zanesi, PhD, John G. Gribben, MD DSc, Carlo M. Croce, MD
Journal: Blood
Blood (2014) 124 (21): 716.
https://doi.org/10.1182/blood.V124.21.716.716
Published: 2014
Journal Articles

Immune Checkpoint Blockade with Anti-PD-L1 Prevents Immune Dysfuntion and CLL Development in the TCL1 Adoptive Transfer Mouse Model

Bola Hanna, Fabienne McClanahan, MD, Andrew James Clear, BSc, Shaun Miller, Peter Lichter, PhD, Martina Seiffert, PhD, John G. Gribben, MD DSc
Journal: Blood
Blood (2014) 124 (21): 717.
https://doi.org/10.1182/blood.V124.21.717.717
Published: 2014