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Journal Articles

Apolipoprotein Α-IV Is a Novel Ligand of Platelet αIIbβ3 Integrin and an Endogenous Thrombosis Inhibitor: Measurement of Single-Molecular Interactions By Biomembrane Force Probe

Blood (2014) 124 (21): 92.

https://doi.org/10.1182/blood.V124.21.92.92

Published: 2014

Journal Articles

CD8+ T Cells Are Predominantly Protective In a Murine Model Of ITP and Is Required For Effective Steroid Therapy

Li Ma, Elisa K. Simpson, H.B.Sc., June Li, BSc, Guangheng Zhu, MD, Pingguo Chen, PhD, John W. Semple, PhD, John Freedman, MD, Heyu Ni, MD, PhD

Blood (2013) 122 (21): 1076.

https://doi.org/10.1182/blood.V122.21.1076.1076

Published: 2013

Journal Articles

Desialylation: A Novel Platelet Clearance Mechanism and a Potential New Therapeutic Target in Anti-GPIb Antibody Mediated Thrombocytopenia

Dianne E. van Der Wal, PhD, Guangheng Zhu, MD, June Li, BSc, Brian Vadasz, BSc, Yougbare Issaka, PhD, Sean Lang, MSc, John Freedman, MD, Heyu Ni, MD, PhD

Blood (2012) 120 (21): 265.

https://doi.org/10.1182/blood.V120.21.265.265

Published: 2012

Journal Articles

Thymic Retention of CD4+CD25 hi +FoxP3+ T Regulatory (Treg) Cells Is Responsible for Peripheral Treg Deficiency and Platelet and Megakaryocyte Destruction in Active Immune Thrombocytopenia (ITP)

John W. Semple, PhD, Simon Gebremeskel, BSc, Rukhsana Aslam, Ph.D., Heyu Ni, John Freedman, MD

Blood (2011) 118 (21): 523.

https://doi.org/10.1182/blood.V118.21.523.523

Published: 2011

Journal Articles

Apolipoprotein AIV (ApoA-IV) Is a Novel Ligand of Platelet β3 Integrin That Negatively Regulates Platelet Adhesion, Aggregation, and Thrombosis.

Christopher M. Spring, MSc, Wuxun Jin, PhD, Hong Yang, MD, Adili Reheman, MD, Guangheng Zhu, MD, Yimin She, PhD, Terry Cyr, PhD, Patrick Tso, PhD, Sean Davidson, PhD, John Freedman, MD, Heyu Ni, MD, PhD

Blood (2009) 114 (22): 156.

https://doi.org/10.1182/blood.V114.22.156.156

Published: 2009

Journal Articles

The GPIIbIIIa Antagonist Drugs Eptifibatide and Tirofiban Inhibit Caspase-3 Activation in Thrombin- and Calcium Ionophore-Stimulated Human Platelets.

Valery Leytin, PhD, Asuman Mutlu, PhD, Sergiy Mykhaylov, PhD, David J. Allen, BSc, Armen V. Gyulkhandanyan, PhD, Elena Lyubimov, PhD, John Freedman, MD

Blood (2009) 114 (22): 2998.

https://doi.org/10.1182/blood.V114.22.2998.2998

Published: 2009

Journal Articles

Robotic High Thoroughput Multiplex PCR Single-Nucleotide Polymorphism Genotyping of Apheresis Platelet Donors.

Nadine Shehata, MD, MSC, Barbara Hannach, MD, Nancy Banning, John Freedman, MD, Greg Denomme, PhD

Blood (2009) 114 (22): 2106.

https://doi.org/10.1182/blood.V114.22.2106.2106

Published: 2009

Journal Articles

Recipient T and B Lymphocytes Dictate the Severity of Antibody-Mediated Transfusion-Related Acute Lung Injury (TRALI).

Yoke Lin Fung, PhD, Michael Kim, Edwin R Speck, John Freedman, MD, John W. Semple, PhD

Blood (2009) 114 (22): 641.

https://doi.org/10.1182/blood.V114.22.641.641

Published: 2009

Journal Articles

Platelet Activation Rather Than Apoptosis Contributes Most to the Platelet Storage Lesion during Conventional and Extended Storage of Platelet Concentrates

Valery Leytin, David J. Allen, Asuman Mutlu, Sergiy Mykhaylov, Elena Lyubimov, Armen V. Gyulkhandanyan, John Freedman, MD

Blood (2008) 112 (11): 996.

https://doi.org/10.1182/blood.V112.11.996.996

Published: 2008

Journal Articles

Antibody- and Cell-Mediated Immune Thrombocytopenia Are Differentially Sensitive to Intravenous Gammaglobulin Therapy

Leola Chow, PhD, Michael Kim, BSc, Edwin R. Speck, BRT, Rukhsana Aslam, PhD, Michelle Lee Webster, MSc, Pingguo Chen, PhD, Heyu Ni, MD, PhD, John Freedman, MD, John W. Semple, PhD

Blood (2008) 112 (11): 399.

https://doi.org/10.1182/blood.V112.11.399.399

Published: 2008

Journal Articles

Engagement of Fibrinogen and β3 Integrin Is Required for Maintenance of Platelet Intracellular and Cell Surface P-Selectin Expression

Hong Yang, MD, Sean Lang, BSc, Zhimin Zhai, MD, Christopher M. Spring, MSc, Adili Reheman, MD, Pingguo Chen, PhD, Matthew J. Flick, PhD, Jay L. Degen, PhD, Ling Li, MSc, Walter H.A. Kahr, MD, PhD, John Freedman, MD, Heyu Ni, MD, PhD

Blood (2008) 112 (11): 2868.

https://doi.org/10.1182/blood.V112.11.2868.2868

Published: 2008

Journal Articles

Maternal Immune Response to Fetal Platelet GPIbα Causes More Frequent Miscarriage in An Animal Model: A Potential Explanation for Low Reported Incidence of Fetal and Neonatal Immune Thrombocytopenia Mediated by Anti-GPIbα Antibodies.

Conglei Li, MD, Siavash Piran, MSc., Pingguo Chen, PhD, Sean Lang, BSc., Jerry Ware, PhD, Zaverio M. Ruggeri, MD, John Freedman, MD, Heyu Ni, MD, PhD

Blood (2008) 112 (11): 3426.

https://doi.org/10.1182/blood.V112.11.3426.3426

Published: 2008

Journal Articles

The Use of IVIG for Solid Organ Transplantation: An Evidence Based Practice Guideline

Nadine Shehata, MD, MSC, Heather Ann Hume, MD, Valerie Palda, MD, MSc, Ralph Meyer, MD, Patricia Campbell, MBChB, Peter Nickerson, MD, Tom D Blydt-Hansen, MD, Lori West, MD, PhD, Heather Ross, MD, Steven Martin, MD, Tom Waddell, MD, Carl Cardella, MD, Davi d Anderson, MD, MSc, John Freedman, MD, Kevork Peltekian, MD

Blood (2008) 112 (11): 4666.

https://doi.org/10.1182/blood.V112.11.4666.4666

Published: 2008

Journal Articles

IVIg-Primed Splenocytes Ameliorate Murine ITP in an MHC Class II-Unrestricted Manner.

Andrew R. Crow, BRT, Vinayakumar Siragam, PhD, John Freedman, MD, Alan H. Lazarus, PhD

Blood (2007) 110 (11): 102.

https://doi.org/10.1182/blood.V110.11.102.102

Published: 2007

Journal Articles

Novel Mouse Anti-Mouse β3 Integrin Monoclonal Antibodies: Development and Characterization of New Reagents for Research in Thrombosis and Thrombocytopenia.

Guangheng Zhu, MD, Michelle Lee Webster, MSc, Adili Reheman, MD, Pingguo Chen, MD, PhD, Ebrahim Sayeh, PhD, Hong Yang, MD, Ming Wang, MSc, John Freedman, MD, Heyu Ni, MD, PhD

Blood (2007) 110 (11): 2107.

https://doi.org/10.1182/blood.V110.11.2107.2107

Published: 2007

Journal Articles

A New Murine Model of Immune Thrombocytopenia: Evidence of Both Antibody- and CD8+ T Cell-Mediated Platelet Destruction.

Leola Chow, PhD, Heyu Ni, MD, PhD, Michael Kim, BSc, Edwin R. Speck, BRT, Rukhsana Aslam, PhD, Pingguo Chen, John Freedman, MD, John W. Semple, PhD

Blood (2007) 110 (11): 99.

https://doi.org/10.1182/blood.V110.11.99.99

Published: 2007

Journal Articles

Constitutive Activation of Hemostasis in Children with Sickle Cell Disease.

MacGregor Steele, MD, Suzan Williams, MD, Fred Pluthero, PhD, K.W. Annie Bang, Ran Goldman, MD, Jeremy Friedman, MD, John Freedman, MD, Melanie Kirby, MD, Margaret L. Rand, PhD, Victor S. Blanchette, FRCP, Walter H. Kahr, MD,PhD

Blood (2006) 108 (11): 1216.

https://doi.org/10.1182/blood.V108.11.1216.1216

Published: 2006

Journal Articles

Lipopolysaccharide Binds Platelet Toll-Like Receptor 4 and Mediates the Activation of Phagocytes in the Reticuloendothelial System (RES): A Novel Mechanism of Host Immunity.

John W. Semple, PhD, Rukhsana Aslam, PhD, Edwin R. Speck, BRT, John Freedman, MD

Blood (2006) 108 (11): 1093.

https://doi.org/10.1182/blood.V108.11.1093.1093

Published: 2006

Journal Articles

The Specificity and Isotype of Monoclonal Anti-D Antibodies Dictates Their Ability To Inhibit Opsonized Platelet Phagocytosis.

John W. Semple, PhD, Rukhsana Aslam, PhD, Michael Kim, BSc, Edwin R. Speck, BRT, Donald I.H. Stewart, PhD, Erik Weirsma, PhD, John Freedman, MD, Mimi Kjaersgaard, MD

Blood (2006) 108 (11): 21.

https://doi.org/10.1182/blood.V108.11.21.21

Published: 2006

Journal Articles

IVIg-Primed Leukocytes Offer Longer Protection in the Amelioration of ITP Than IVIg.

Andrew R. Crow, BSc, Davor Brinc, BSc, Vinayakumar Siragam, PhD, John Freedman, MD, Alan H. Lazarus, PhD

Blood (2006) 108 (11): 703.

https://doi.org/10.1182/blood.V108.11.703.703

Published: 2006

NARROW

Apolipoprotein Α-IV Is a Novel Ligand of Platelet αIIbβ3 Integrin and an Endogenous Thrombosis Inhibitor: Measurement of Single-Molecular Interactions By Biomembrane Force Probe

CD8+ T Cells Are Predominantly Protective In a Murine Model Of ITP and Is Required For Effective Steroid Therapy

Desialylation: A Novel Platelet Clearance Mechanism and a Potential New Therapeutic Target in Anti-GPIb Antibody Mediated Thrombocytopenia

Thymic Retention of CD4+CD25 hi +FoxP3+ T Regulatory (Treg) Cells Is Responsible for Peripheral Treg Deficiency and Platelet and Megakaryocyte Destruction in Active Immune Thrombocytopenia (ITP)

Apolipoprotein AIV (ApoA-IV) Is a Novel Ligand of Platelet β3 Integrin That Negatively Regulates Platelet Adhesion, Aggregation, and Thrombosis.

The GPIIbIIIa Antagonist Drugs Eptifibatide and Tirofiban Inhibit Caspase-3 Activation in Thrombin- and Calcium Ionophore-Stimulated Human Platelets.

Robotic High Thoroughput Multiplex PCR Single-Nucleotide Polymorphism Genotyping of Apheresis Platelet Donors.

Recipient T and B Lymphocytes Dictate the Severity of Antibody-Mediated Transfusion-Related Acute Lung Injury (TRALI).

Platelet Activation Rather Than Apoptosis Contributes Most to the Platelet Storage Lesion during Conventional and Extended Storage of Platelet Concentrates

Antibody- and Cell-Mediated Immune Thrombocytopenia Are Differentially Sensitive to Intravenous Gammaglobulin Therapy

Engagement of Fibrinogen and β3 Integrin Is Required for Maintenance of Platelet Intracellular and Cell Surface P-Selectin Expression

Maternal Immune Response to Fetal Platelet GPIbα Causes More Frequent Miscarriage in An Animal Model: A Potential Explanation for Low Reported Incidence of Fetal and Neonatal Immune Thrombocytopenia Mediated by Anti-GPIbα Antibodies.

The Use of IVIG for Solid Organ Transplantation: An Evidence Based Practice Guideline

IVIg-Primed Splenocytes Ameliorate Murine ITP in an MHC Class II-Unrestricted Manner.

Novel Mouse Anti-Mouse β3 Integrin Monoclonal Antibodies: Development and Characterization of New Reagents for Research in Thrombosis and Thrombocytopenia.

A New Murine Model of Immune Thrombocytopenia: Evidence of Both Antibody- and CD8+ T Cell-Mediated Platelet Destruction.

Constitutive Activation of Hemostasis in Children with Sickle Cell Disease.

Lipopolysaccharide Binds Platelet Toll-Like Receptor 4 and Mediates the Activation of Phagocytes in the Reticuloendothelial System (RES): A Novel Mechanism of Host Immunity.

The Specificity and Isotype of Monoclonal Anti-D Antibodies Dictates Their Ability To Inhibit Opsonized Platelet Phagocytosis.

IVIg-Primed Leukocytes Offer Longer Protection in the Amelioration of ITP Than IVIg.

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American Society of Hematology

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American Society of Hematology

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