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Journal Articles

Dichotomous Regulation of Lysosomes By MYC and Tfeb Controls Hematopoietic Stem Cell Fate

Laura Garcia Prat, PhD BSc, MSc, Kerstin B Kaufmann, PhD, Florin Schneiter, Veronique Voisin, PhD, Alex Murison, Michelle Chan-Seng-Yue, Olga I. Gan, PhD, Jessica L. McLeod, Michelle Shoong, Kristele Pan, Kinam Gupta, Shin-Ichiro Takayanagi, PhD, Elvin Wagenblast, PhD, Weijia Wang, Timm Schroeder, PhD, Stephanie Zhi-Juan Xie, PhD, John E. Dick, PhD FRS

Blood (2020) 136 (Supplement 1): 34.

https://doi.org/10.1182/blood-2020-142671

Published: 2020

Journal Articles

Erythropoiesis Failure in Diamond-Blackfan Anemia Starts at the Oligopotent Common Myeloid and Megakaryocyte-Erythroid Progenitor Stage

Richard N Armstrong, PhDBSc, Mariana Benicio, PhD, Houtan Moshiri, PhD, Hongbing Li, PhD, Bozana Zlateska, MD MSc, Olga I. Gan, PhD, Eric R Lechman, PhD, John E. Dick, PhD FRS, Yigal Dror, MD FRCPC

Blood (2020) 136 (Supplement 1): 37.

https://doi.org/10.1182/blood-2020-143103

Published: 2020

Journal Articles

Nicotinamide Phosphoribosyltransferase Inhibitors Induce Apoptosis of AML Stem Cells through Dysregulation of Lipid Metabolism

Amit Subedi, PhD, Qiang Liu, PhD BSc, David Sharon, PhD, Severine Cathelin, PhD, Gary D Bader, Changjiang Xu, Veronique Voisin, PhD, Angelo D'Alessandro, PhD, Eric R Lechman, PhD, John E. Dick, PhD FRS, Mark D. Minden, Jean C.Y. Wang, MD, Steven M Chan, MD PhD

Blood (2020) 136 (Supplement 1): 25–26.

https://doi.org/10.1182/blood-2020-142404

Published: 2020

Journal Articles

The Metabolic Enzyme Hexokinase 2 Localizes to the Nucleus in AML and Normal Hematopoietic Stem/Progenitor Cells to Maintain Stemness

Blood (2020) 136 (Supplement 1): 1–2.

https://doi.org/10.1182/blood-2020-135858

Published: 2020

Journal Articles

Divergent Levels of CD112 and INKA1 Define a Subset of Human Hematopoietic Stem Cells That Resists Regenerative Stress to Preserve Stemness

Kerstin B Kaufmann, PhD, Andy G.X. Zeng, BSc, Etienne Coyaud, Laura Garcia Prat, PhD BSc, MSc, Efthymia Papalexi, BA, Estelle MN Laurent, Michelle Chan-Seng-Yue, Olga I. Gan, PhD, Kristele Pan, Jessica L. McLeod, Sasan Zandi, Shin-Ichiro Takayanagi, PhD, Rahul Satija, Brian Raught, Stephanie Zhi-Juan Xie, PhD, John E. Dick, PhD FRS

Blood (2020) 136 (Supplement 1): 5.

https://doi.org/10.1182/blood-2020-137725

Published: 2020

Journal Articles

A Human Model of Down Syndrome Associated Leukemia Reveals Different Cell of Origins for Initiation and Progression

Elvin Wagenblast, PhD, Joana Araújo, MD, Olga I. Gan, PhD, Sarah K Cutting, Alex Murison, Jessica L. McLeod, Gabriela Krivdova, BSc, Maria Azkanaz, Sabrina A Smith, Johann K Hitzler, MD, John E. Dick, PhD FRS, Eric R Lechman, PhD

Blood (2020) 136 (Supplement 1): 11–12.

https://doi.org/10.1182/blood-2020-135867

Published: 2020

Journal Articles

Mir-125b Regulates the Self-Renewal of Acute Myeloid Leukemia Stem Cells through PTPN18 and GSK3

Qiang Liu, PhD BSc, Olga I. Gan, PhD, Gabriela Krivdova, BSc, Aaron Trotman-Grant, Stephanie M. Dobson, PhD, Karin G. Hermans, Mark D. Minden, Shai Izraeli, MD, John E. Dick, PhD FRS, Jean C.Y. Wang, MD PhD, Eric R. Lechman,, PhD

Blood (2020) 136 (Supplement 1): 16–17.

https://doi.org/10.1182/blood-2020-141733

Published: 2020

Journal Articles

Functional Investigation of the Argonaute Proteins in Human Hematopoietic Stem and Progenitor Cells

Gordon G. L. Wong, BS, Gabriela Krivdova, BSc, Olga I. Gan, PhD, Jessica L. McLeod, John E. Dick, PhD FRS, Eric R. Lechman, PhD

Blood (2020) 136 (Supplement 1): 32.

https://doi.org/10.1182/blood-2020-142963

Published: 2020

Journal Articles

Variation in Stem Cell Driven Hierarchies Underlies Clinical Outcome and Drug Response in AML

Andy G.X. Zeng, BSc, Amanda Mitchell, PhD, Oleksandr Galkin, PhD, Jean C.Y. Wang, MD PhD, James A. Kennedy, MDPhD, John E. Dick, PhD FRS

Blood (2020) 136 (Supplement 1): 27–28.

https://doi.org/10.1182/blood-2020-140895

Published: 2020

Journal Articles

Opposing Evolutionary Pressures Drive Clonal Evolution and Health Outcomes in the Aging Blood System

Kimberly Skead, Armande Ang Houle, Sagi Abelson, PhD, Marie-Julie Fave, PhD, Boxi Lin, David Soave, PhD, Stephen Wright, PhD, John E. Dick, PhD FRS, Quaid Morris, PhD, Phillip Awadalla, PhD

Blood (2020) 136 (Supplement 1): 37.

https://doi.org/10.1182/blood-2020-142086

Published: 2020

Journal Articles

Elevated Expression of Mir-130a in t(8,21) AML Reinforces the Aberrant Molecular Program of AML1-ETO

Gabriela Krivdova, BSc, Veronique Voisin, PhD, Sajid Marhon, Schoof E Erwin, Martino Gabra, Jessica L. McLeod, Leonardo Salmena, Mark D. Minden, Eric R. Lechman,, PhD, John E. Dick, PhD FRS

Blood (2020) 136 (Supplement 1): 41–42.

https://doi.org/10.1182/blood-2020-142652

Published: 2020

Journal Articles

Cellular and Molecular Architecture of Hematopoietic Stem Cells and Progenitors in Genetic Models of Bone Marrow Failure

Stephanie C. Heidemann, MD, Brian Bursic, Sasan Zandi, MD PhD, Hongbing Li, PhD, Robert J Klaassen, MD FRCPC, Sharon Abish, MD, Meera Rayar, Vicky R. Breakey, BSc,MDFRCPC, Houtan Moshiri, PhD, Santhosh Dhanraj, PhD, Richard de Borja, PhD, Adam Shlien, PhD, John E. Dick, PhD, Yigal Dror, MDFRCPC, Sagi Abelson, PhD

Blood (2019) 134 (Supplement_1): 1223.

https://doi.org/10.1182/blood-2019-130534

Published: 2019

Journal Articles

A Novel Cereblon E3 Ligase Modulator Eradicates Acute Myeloid Leukemia Stem Cells through Degradation of Translation Termination Factor GSPT1

Liqing Jin, MD, Nathan Mbong, Stanley W.K. Ng, PhD, Jean C.Y. Wang, MD, Mark D. Minden, MD PhD, Jinhong Fan, Daniel W. Pierce, Michael Pourdehnad, MD, John E. Dick, PhD

Blood (2019) 134 (Supplement_1): 3940.

https://doi.org/10.1182/blood-2019-128450

Published: 2019

Journal Articles

Understanding Pre-Leukemia in Trisomy 21 Human HSC and Modeling Progression Towards Down Syndrome Associated Leukemia Using CRISPR/Cas9 at Single Cell Resolution

Elvin Wagenblast, PhD, Olga I. Gan, PhD, Maria Azkanaz, Sabrina A. Smith, Joana Araújo, MD, Lorien Shakib, Jessica L. McLeod, Gabriela Krivdova, Johann K. Hitzler, MD, Eric R. Lechman, PhD, John E. Dick, PhD

Blood (2019) 134 (Supplement_1): 2531.

https://doi.org/10.1182/blood-2019-129259

Published: 2019

Journal Articles

The Metabolic Enzyme Hexokinase 2 Localizes to the Nucleus in AML and Normal Hematopoietic Stem/Progenitor Cells to Maintain Stemness

Geethu Emily Thomas, PhDMSc,BSc, Grace Egan, MD, Laura Garcia Prat, Boaz Nachmias, MD PhD, Jordan M Chin, Fieke W Hoff, BSc, Kerstin Kaufmann, PhD, Rose Hurren, BSc, Marcela Gronda, MSc, Neil MacLean, Xiaoming Wang, Veronique Voisin, PhD, Aaron Botham, Andrea Arruda, Mark D. Minden, MD PhD, Gary D Bader, Steven M. Kornblau, MD, John E. Dick, PhD, Aaron D Schimmer, MD PhD

Blood (2019) 134 (Supplement_1): 2532.

https://doi.org/10.1182/blood-2019-123121

Published: 2019

Journal Articles

HSCs Fated to Progress to Blast Phase Can be Detected in Myelofibrosis Patients Several Years Prior to Leukemic Transformation

Jenny M. Ho, MD, Jessie J.F. Medeiros, BSc, Michelle Chan-Seng-Yue, Lauren Hummel, BSc, Andrea Arruda, Amanda Mitchell, PhD, Caroline J McNamara, MBBS, James A Kennedy, MD PhD, Anne Tierens, MD PhD, Dawn Maze, MDFRCPC,MSc, Hubert Tsui, MD PhD, Mark D. Minden, MD PhD, Vikas Gupta, MD FRCP, FRCPath, John E. Dick, PhD

Blood (2019) 134 (Supplement_1): 1676.

https://doi.org/10.1182/blood-2019-130923

Published: 2019

Journal Articles

AML-Fated Clones Arise in Stem and Progenitor Cells in Myelofibrosis Patients Several Years Prior to AML Diagnosis

Jenny M. Ho, MD, Jessie James Franco Medeiros, BSc, Michelle Chan-Seng-Yue, Lauren Hummel, BSc, Andrea Arruda, Amanda Mitchell, PhD, Caroline J McNamara, MBBS, James Kennedy, MD PhD, Anne Tierens, MD PhD, Hubert Tsui, MD PhD, Mark D. Minden, MD PhD, Vikas Gupta, MD FRCP, FRCPath, John E. Dick, PhD

Blood (2018) 132 (Supplement 1): 4321.

https://doi.org/10.1182/blood-2018-99-118889

Published: 2018

Journal Articles

Genetic Analysis of B-Cell Acute Lymphoblastic Leukemia Dissemination to the Central Nervous System Identifies Clonal Selection and Therapeutic Vulnerability

Robert Vanner, MD PhD, Stephanie M. Dobson, PhD, Ildiko Grandal, MSc, Olga I. Gan, PhD, Jessica McLeod, BSc, James Kennedy, MD PhD, Veronique Voisin, PhD, Cynthia Guidos, PhD, Jayne S. Danska, PhD, Esme Waanders, PhD, Mark D. Minden, MD PhD, Charles G. Mullighan, MBBS, MD, John E. Dick, PhD

Blood (2018) 132 (Supplement 1): 1542.

https://doi.org/10.1182/blood-2018-99-115191

Published: 2018

Journal Articles

Sphingolipid Perturbation Activates Proteostasis Programs to Govern Human Hematopoietic Stem Cell Self-Renewal

Stephanie Zhi-Juan Xie, PhD, Laura Garcia Prat, Veronique Voisin, PhD, Alex Murison, Olga I. Gan, Robin Ferrari, Naoya Takayama, MD PhD, Kerstin B. Kaufmann, PhD, Ishita Patel, Esther Lee, Gareth Holmes, Tiago Medina, PhD, Aditi Vedi, Chiara Luberto, PhD, Gary D Bader, Elisa Laurenti, PhD, Mathieu Lupien, John E. Dick, PhD

Blood (2018) 132 (Supplement 1): 170.

https://doi.org/10.1182/blood-2018-170

Published: 2018

Journal Articles

Myelofibrosis Is Initiated and Sustained By Rare Multipotent Stem Cells

Jessie J.F. Medeiros, BSc, Amanda Mitchell, PhD, Aaron Trotman-Grant, Tristan Woo, Jenny M. Ho, MD, Andrea Arruda, Mark D. Minden, MD PhD, John E. Dick, PhD, Vikas Gupta, MD FRCP, FRCPath, Liran I. Shlush, MD PhD

Blood (2018) 132 (Supplement 1): 1790.

https://doi.org/10.1182/blood-2018-99-119088

Published: 2018

NARROW

Dichotomous Regulation of Lysosomes By MYC and Tfeb Controls Hematopoietic Stem Cell Fate

Erythropoiesis Failure in Diamond-Blackfan Anemia Starts at the Oligopotent Common Myeloid and Megakaryocyte-Erythroid Progenitor Stage

Nicotinamide Phosphoribosyltransferase Inhibitors Induce Apoptosis of AML Stem Cells through Dysregulation of Lipid Metabolism

The Metabolic Enzyme Hexokinase 2 Localizes to the Nucleus in AML and Normal Hematopoietic Stem/Progenitor Cells to Maintain Stemness

Divergent Levels of CD112 and INKA1 Define a Subset of Human Hematopoietic Stem Cells That Resists Regenerative Stress to Preserve Stemness

A Human Model of Down Syndrome Associated Leukemia Reveals Different Cell of Origins for Initiation and Progression

Mir-125b Regulates the Self-Renewal of Acute Myeloid Leukemia Stem Cells through PTPN18 and GSK3

Functional Investigation of the Argonaute Proteins in Human Hematopoietic Stem and Progenitor Cells

Variation in Stem Cell Driven Hierarchies Underlies Clinical Outcome and Drug Response in AML

Opposing Evolutionary Pressures Drive Clonal Evolution and Health Outcomes in the Aging Blood System

Elevated Expression of Mir-130a in t(8,21) AML Reinforces the Aberrant Molecular Program of AML1-ETO

Cellular and Molecular Architecture of Hematopoietic Stem Cells and Progenitors in Genetic Models of Bone Marrow Failure

A Novel Cereblon E3 Ligase Modulator Eradicates Acute Myeloid Leukemia Stem Cells through Degradation of Translation Termination Factor GSPT1

Understanding Pre-Leukemia in Trisomy 21 Human HSC and Modeling Progression Towards Down Syndrome Associated Leukemia Using CRISPR/Cas9 at Single Cell Resolution

The Metabolic Enzyme Hexokinase 2 Localizes to the Nucleus in AML and Normal Hematopoietic Stem/Progenitor Cells to Maintain Stemness

HSCs Fated to Progress to Blast Phase Can be Detected in Myelofibrosis Patients Several Years Prior to Leukemic Transformation

AML-Fated Clones Arise in Stem and Progenitor Cells in Myelofibrosis Patients Several Years Prior to AML Diagnosis

Genetic Analysis of B-Cell Acute Lymphoblastic Leukemia Dissemination to the Central Nervous System Identifies Clonal Selection and Therapeutic Vulnerability

Sphingolipid Perturbation Activates Proteostasis Programs to Govern Human Hematopoietic Stem Cell Self-Renewal

Myelofibrosis Is Initiated and Sustained By Rare Multipotent Stem Cells

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American Society of Hematology

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American Society of Hematology

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