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Journal Articles

Ribosomal Deficiency Due to Activation of the Thrombopoietin Axis May be Involved in the Reduced Levels of GATA1 Expressed By Megakaryocytes (MKs) from the Gata1 low Model of Myelofibrosis

Anna Rita F Migliaccio, PhD, Maria Zingariello, MD, Laura Sancillo, MS, Fabrizio Martelli, PhD, Fiorella Ciaffoni, PhD, Francesca Masiello, MS, Ilaria Ceglia, PhD, Lilian Varricchio, PhD, Rosa Alba Rana, MD, Changsheng Zhao, PhD, John Crispino, PhD

Blood (2016) 128 (22): 4275.

https://doi.org/10.1182/blood.V128.22.4275.4275

Published: 2016

Journal Articles

DYRK1A Is a Therapeutic Target in B-ALL in Children with Down Syndrome

Paul Lee, MD PhD, Rahul Bhansali, BA, Malini Rammohan, BS, MS, Nobuko Hijiya, MD, Shai Izraeli, MD Prof, Jean-Pierre Bourquin, MD PhD, Sebastien Malinge, PhD, John Crispino, PhD MBA

Blood (2016) 128 (22): 2721.

https://doi.org/10.1182/blood.V128.22.2721.2721

Published: 2016

Journal Articles

Therapeutic Targeting of the Histone Ubiquitination-Methylation Axis in T Cell Leukemia

Panagiotis Ntziachristos, PhD, Kelly Arcipowski, PhD, Carlos Alberto Martinez, Yixing Zhu, Andrew G. Volk, PhD, Suresh Kumar, Paul M Thomas, PhD, Pieter Van Vlierberghe, PhD, Nobuko Hijiya, MD, Stacy Marshall, Jack Wang, Jian Wu, Neil L Kelleher, PhD, John Crispino, PhD MBA

Blood (2016) 128 (22): 1532.

https://doi.org/10.1182/blood.V128.22.1532.1532

Published: 2016

Journal Articles

The Cohesin Subunit Rad21 Is a Negative Regulator of Hematopoietic Self-Renewal through Epigenetic Repression of HoxA7 and HoxA9

Joseph B. Fisher, PhD, Jonathan Peterson, B.S., Michael Reimer, Jr., B.S., Cary Stelloh, BA, Kirthi Pulakanti, MS, Zachary Gerbec, BS, Alex M Abel, MS, Jennifer Strouse, MD, Christopher Strouse, MD, Maureen McNulty, BS, Subramaniam Malarkannan, PhD, John Crispino, PhD MBA, Samuel Milanovich, MD, Sridhar Rao, MD PhD

Blood (2016) 128 (22): 1708.

https://doi.org/10.1182/blood.V128.22.1708.1708

Published: 2016

Journal Articles

A PDZ-Binding Motif in DCAF7 Maintains Hematopoietic Homeostasis and Prevents Malignancy in DS-AMKL

Gina Kirsammer, PhD, Rachael F Schultz, BA, Ritika Rastogi, BA, Sandeep Gurbuxani, MBBS, PhD, John Crispino, PhD

Blood (2016) 128 (22): 1205.

https://doi.org/10.1182/blood.V128.22.1205.1205

Published: 2016

Journal Articles

ETO2-GLIS2 Controls Differentiation Arrest and Self-Renewal through Aberrant Enhancers Regulation in Pediatric Leukemia

Blood (2016) 128 (22): 572.

https://doi.org/10.1182/blood.V128.22.572.572

Published: 2016

Journal Articles

Pleckstrin-2 Plays an Essential Role in the Pathogenesis of JAK2 V617F -Induced Myeloproliferative Neoplasms

Baobing Zhao, PhD, Yang Mei, PhD, Ronen Sumagin, PhD, Jing Yang, Chelsea Thorsheim, Liang Zhao, PhD, Timothy J. Stalker, PhD, Jeremy Q. Wen, John Crispino, PhD MBA, Charles S. Abrams, MD, Peng Ji, MD PhD

Blood (2016) 128 (22): 798.

https://doi.org/10.1182/blood.V128.22.798.798

Published: 2016

Journal Articles

Activation of JAK/STAT Signaling in Megakaryocytes Is Necessary and Sufficient for Myeloproliferation In Vivo

Q. Jeremy Wen, Brittany Woods, PhD, Qiong Yang, MD, Chiu Sophia, Gu Lillu, Franck Rapaport, PhD, Ross L. Levine, MD, John Crispino, PhD MBA

Blood (2016) 128 (22): 949.

https://doi.org/10.1182/blood.V128.22.949.949

Published: 2016

Journal Articles

ANP32A Dysregulation Involves Histone Modifications and Contributes to Myeloid Leukemia

Bin Lu, PhD, Xueqin Sun, PhD, John Crispino, PhD, Zan Huang

Blood (2015) 126 (23): 2456.

https://doi.org/10.1182/blood.V126.23.2456.2456

Published: 2015

Journal Articles

Tyrosine 599 Plays an Essential Role and Cooperates with Tyrosine 604 in MPL W515L-Indiced Myeloproliferative Neoplasms

Zan Huang, Chunjie Yu, PhDcandidate, Qiang Jeremy Wen, PhD MD, Qiong Yang, John Crispino, PhD, Demin Wang, PhD, Yuhong Chen

Blood (2014) 124 (21): 4580.

https://doi.org/10.1182/blood.V124.21.4580.4580

Published: 2014

Journal Articles

Aberrant Megakaryocyte Gene Expression Contributes to Primary Myelofibrosis.

Laure Gilles, PhD, Christy Finke, BS, Terra L Lasho, MT, (ASCP), Animesh Pardanani, MBBS, PhD, Ayalew Tefferi, MD, John Crispino, PhD

Blood (2012) 120 (21): 2867.

https://doi.org/10.1182/blood.V120.21.2867.2867

Published: 2012

Journal Articles

Trisomy of the Down Syndrome Critical Region Suppresses Precursor B-Cell Differentiation and Promotes B-Cell Transformation Associated with Altered Expression of Polycomb Repressor Complex 2 Targets

Andrew A. Lane, MD, PhD, Diederik van Bodegom, PhD, Bjoern Chapuy, MD, PhD, Gabriela Alexe, PhD, Timothy J Sullivan, PhD, Trevor Tivey, Tovah Day, PhD, John Crispino, PhD, Edward Fox, PhD, Kimberly Stegmaier, MD, David Weinstock, MD

Blood (2012) 120 (21): 115.

https://doi.org/10.1182/blood.V120.21.115.115

Published: 2012

Journal Articles

Aurora A Kinase Is Required for Hematopoiesis

Benjamin Goldenson, BS, Jeremy Q Wen, PhD, MD, John Crispino, PhD

Blood (2012) 120 (21): 1201.

https://doi.org/10.1182/blood.V120.21.1201.1201

Published: 2012

Journal Articles

Aryl Hydrocarbon Receptor (AhR) Antagonist Stemregenin 1 (SR1) Enhances in Vitro- and in Vivo-Derived Platelets (PLTs) From Human Megakaryocytes (MKs)

Yuhuan Wang, PhD, Vincent M. Hayes, Lin Lu, Ph.D, Xiaoji Chen, Rudy Fuentes, PhD, Qiang Jeremy Wen, MD, PhD, Stella T Chou, MD, John Crispino, PhD, Patrick Paddison, PhD, Deborah L. French, PhD, Beverly Torok-Storb, PhD, Mortimer Poncz, MD

Blood (2012) 120 (21): 3450.

https://doi.org/10.1182/blood.V120.21.3450.3450

Published: 2012

Journal Articles

Dysregulation of PSTPIP2 Due to Loss of GATA-1 Contributes to Aberrant Megakaryopoiesis

Lu Liu, Shangqin Liu, Sr., Qiang Jeremy Wen, MD, PhD, John Crispino, PhD, Zan Huang

Blood (2012) 120 (21): 854.

https://doi.org/10.1182/blood.V120.21.854.854

Published: 2012

Journal Articles

Inhibition of AKT Signaling Potently Inhibits the Growth of JAK and MPL-Mutant Cells in the Myeloproliferative Neoplasms In Vitro and In Vivo,

Irum Khan, MBBS, Zan Huang, PhD, Qiang Jeremy Wen, MD, PhD, Priya Koppikar, Ross L Levine, MD, Ayalew Tefferi, MD, John Crispino, PhD

Blood (2011) 118 (21): 3862.

https://doi.org/10.1182/blood.V118.21.3862.3862

Published: 2011

Journal Articles

Induction of Megakaryocyte Polyploidization in Combination with JAK Inhibition As a Novel Therapeutic Strategy for Myeloproliferative Neoplasms

Qiang Jeremy Wen, MD, PhD, Benjamin Goldenson, Sebastien Malinge, PhD, Priya Koppikar, Ross L Levine, MD, Ayalew Tefferi, MD, John Crispino, PhD

Blood (2011) 118 (21): 64.

https://doi.org/10.1182/blood.V118.21.64.64

Published: 2011

Journal Articles

Vacuolin-1 Promotes Enucleation of Cultured Human and Murine Erythroblasts

Ganesan Keerthivasan, MBBS, MD, Barbara Ghinassi, PhD, John S. Wilmes, Amittha Wickrema, PhD, Anna Rita F Migliaccio, PhD, Mark-Eugene Duban, John Crispino, PhD

Blood (2011) 118 (21): 2321.

https://doi.org/10.1182/blood.V118.21.2321.2321

Published: 2011

Journal Articles

Development of Acute Megakaryoblastic Leukemia in Down Syndrome Is Associated with Sequential Epigenetic Changes That Target the Down Syndrome Critical Region on Chromosome 21,

Maria E Figueroa, MD, Sebastien Malinge, PhD, Timothy M Chlon, Yushan Li, Elisabeth Paietta, PhD, Hugo F. Fernandez, MD, Martin S. Tallman, MD, Mitchell J Weiss, MD, Stella T Chou, MD, Ari Melnick, MD, John Crispino, PhD

Blood (2011) 118 (21): 3451.

https://doi.org/10.1182/blood.V118.21.3451.3451

Published: 2011

Journal Articles

Gabp Transcription Factor Is Required for the Development of Mouse Megakaryocytes.

Zhong-Fa Yang, PhD, Timothy M Chlon, John Crispino, PhD, Alan G. Rosmarin, MD

Blood (2010) 116 (21): 2604.

https://doi.org/10.1182/blood.V116.21.2604.2604

Published: 2010

NARROW

Ribosomal Deficiency Due to Activation of the Thrombopoietin Axis May be Involved in the Reduced Levels of GATA1 Expressed By Megakaryocytes (MKs) from the Gata1 low Model of Myelofibrosis

DYRK1A Is a Therapeutic Target in B-ALL in Children with Down Syndrome

Therapeutic Targeting of the Histone Ubiquitination-Methylation Axis in T Cell Leukemia

The Cohesin Subunit Rad21 Is a Negative Regulator of Hematopoietic Self-Renewal through Epigenetic Repression of HoxA7 and HoxA9

A PDZ-Binding Motif in DCAF7 Maintains Hematopoietic Homeostasis and Prevents Malignancy in DS-AMKL

ETO2-GLIS2 Controls Differentiation Arrest and Self-Renewal through Aberrant Enhancers Regulation in Pediatric Leukemia

Pleckstrin-2 Plays an Essential Role in the Pathogenesis of JAK2 V617F -Induced Myeloproliferative Neoplasms

Activation of JAK/STAT Signaling in Megakaryocytes Is Necessary and Sufficient for Myeloproliferation In Vivo

ANP32A Dysregulation Involves Histone Modifications and Contributes to Myeloid Leukemia

Tyrosine 599 Plays an Essential Role and Cooperates with Tyrosine 604 in MPL W515L-Indiced Myeloproliferative Neoplasms

Aberrant Megakaryocyte Gene Expression Contributes to Primary Myelofibrosis.

Trisomy of the Down Syndrome Critical Region Suppresses Precursor B-Cell Differentiation and Promotes B-Cell Transformation Associated with Altered Expression of Polycomb Repressor Complex 2 Targets

Aurora A Kinase Is Required for Hematopoiesis

Aryl Hydrocarbon Receptor (AhR) Antagonist Stemregenin 1 (SR1) Enhances in Vitro- and in Vivo-Derived Platelets (PLTs) From Human Megakaryocytes (MKs)

Dysregulation of PSTPIP2 Due to Loss of GATA-1 Contributes to Aberrant Megakaryopoiesis

Inhibition of AKT Signaling Potently Inhibits the Growth of JAK and MPL-Mutant Cells in the Myeloproliferative Neoplasms In Vitro and In Vivo,

Induction of Megakaryocyte Polyploidization in Combination with JAK Inhibition As a Novel Therapeutic Strategy for Myeloproliferative Neoplasms

Vacuolin-1 Promotes Enucleation of Cultured Human and Murine Erythroblasts

Development of Acute Megakaryoblastic Leukemia in Down Syndrome Is Associated with Sequential Epigenetic Changes That Target the Down Syndrome Critical Region on Chromosome 21,

Gabp Transcription Factor Is Required for the Development of Mouse Megakaryocytes.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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