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Journal Articles

Targeting T-ALL Cells with Potent Activators of the PP2A Protein Phosphatase Tumor Suppressor

Ken Morita, MD PhD, Shuning He, PhD, Radosław P. Nowak, PhD, Jinhua Wang, PhD, Nathanael Gray, PhD, Eric S. Fischer, PhD, A. Thomas Look, MD

Blood (2019) 134 (Supplement_1): 406.

https://doi.org/10.1182/blood-2019-123573

Published: 2019

Journal Articles

A Novel HCK and BTK Dual Inhibitor Kin-8194 Shows Superior Activity over Ibrutinib and Overcomes BTK C481S Mediated Ibrutinib Resistance in Vitro and In Vivo in MYD88 Mutated B-Cell Lymphomas

Guang Yang, PhD, Jinhua Wang, PhD, Xia Liu, MD, Manit Munshi, MS, Jiaji G Chen, Amanda Kofides, Lian Xu, MS, Nicholas Tsakmaklis, Maria Demos, Maria Luisa Guerrera, MD, Gloria G Chan, MS, Cristina Jimenez, PhD, Zachary R Hunter, PhD, Christopher Patterson, Jorge J. Castillo, MD, Sara J Buhrlage, PhD, Nathanael Gray, Steven P Treon, MD PhD FRCP

Blood (2019) 134 (Supplement_1): 394.

https://doi.org/10.1182/blood-2019-130636

Published: 2019

Journal Articles

Targeting Salt-Inducible Kinase 3 As a Therapeutic Approach for Acute Myeloid Leukemia

Shan Lin, Yusuke Tarumoto, Jinhua Wang, PhD, Joseph Milazzo, Yali Xu, Nathanael Gray, Christopher Vakoc, Kimberly Stegmaier, MD

Blood (2019) 134 (Supplement_1): 3941.

https://doi.org/10.1182/blood-2019-125278

Published: 2019

Journal Articles

MYD88 Triggered SYK Activation Promotes BCR Cross-Talk, and Identifies SYK As a Novel Therapeutic Target of Mutated MYD88 Signaling

Manit Munshi, MS, Jiaji Chen, BS, Xia Liu, MD, Lian Xu, MS, Nickolas Tsakmaklis, BA, Maria Demos, Amanda Kofides, Maria Luisa Guerrera, MD, Gloria G Chan, MS, Christopher Patterson, MAcc, Kirsten Meid, MPH, Joshua Gustine, MPH, Jorge J. Castillo, MD, Zachary R Hunter, PhD, Jinhua Wang, PhD, Sara J Buhrlage, PhD, Nathanael S. Gray, PhD, Steven P Treon, MD PhD FRCP, Guang Yang, PhD

Blood (2018) 132 (Supplement 1): 4116.

https://doi.org/10.1182/blood-2018-99-117372

Published: 2018

Journal Articles

Chromatin Accessibility Profiling Reveals Cis-Regulatory Heterogeneity and Novel Transcription Factor Dependencies in Multiple Myeloma

Christopher J. Ott, PhD, Raphael Szalat, MD, Matthew Lawlor, Mehmet Kemal Samur, PhD, Yan Xu, MD, Charles B Epstein, Charles Y Lin, PhD, Rao Prabhala, PhD, Nina Farrell, Lauren D Walter, Logan Schwartz, Kenneth Wen, BS, Yu-Tzu Tai, PhD, Mariateresa Fulciniti, PhD, Jinhua Wang, PhD, Nathanael Gray, PhD, Kenneth Anderson, MD, Richard A. Young, PhD, Nikhil Munshi, MD

Blood (2018) 132 (Supplement 1): 1313.

https://doi.org/10.1182/blood-2018-99-119941

Published: 2018

Journal Articles

A Novel HCK Inhibitor Kin-8193 Blocks BTK Activity in BTK Cys481 Mutated Ibrutinib Resistant B-Cell Lymphomas Driven By Mutated MYD88

Guang Yang, PhD, Jinhua Wang, PhD, Li Tan, PhD, Xia Liu, MD, Manit Munshi, MS, Jiaji G Chen, Lian Xu, MS, Nickolas Tsakmaklis, Maria Demos, Amanda Kofides, Maria Luisa Guerrera, MD, Gloria G Chan, MS, Zachary R Hunter, PhD, Christopher Patterson, MAcc, Jorge J. Castillo, MD, Sara J Buhrlage, PhD, Nathanael S. Gray, PhD, Steven P Treon, MD PhD FRCP

Blood (2018) 132 (Supplement 1): 40.

https://doi.org/10.1182/blood-2018-99-119171

Published: 2018

Journal Articles

A Novel, Highly Selective IRAK1 Inhibitor Jh-X-119-01 Shows Synergistic Tumor Cell Killing with Ibrutinib in MYD88 Mutated B-Cell Lymphoma Cells

Guang Yang, PhD, John Hatcher, PhD, Jinhua Wang, PhD, Xia Liu, MD, Manit Munshi, MS, Jiaji Chen, BS, Lian Xu, Nickolas Tsakmaklis, BA, Maria Demos, BS, Amanda Kofides, BS, Gloria Chan, MS, Zachary Hunter, PhD, Christopher Patterson, MAcc, Joshua Gustine, Jorge J. Castillo, MD, Nathanael Gray, PhD, Steven P Treon, MDPhDFRCP, Sara Buhrlage, PhD

Blood (2017) 130 (Supplement 1): 719.

https://doi.org/10.1182/blood.V130.Suppl_1.719.719

Published: 2017

Journal Articles

Using Whole Exome Sequencing in Pediatric Acute Lymphoblastic Leukemia Germline, Diagnosis, and Relapse Trios to Discover Novel Relapse Enriched Mutations for Clonal Backtracking By Ddpcr

Jason Saliba, PhD, Nikki Ann Evensen, PhD BS, Julia Meyer, PhD, Igor Dolgalev, MS, Daniel Newman, BA, BSc, Ashfiyah Chowdhury, BSc, Jacob Nersting, PhD, Jinhua Wang, PhD, Kjeld Schmiegelow, MD DMSc, William L. Carroll, MD

Blood (2016) 128 (22): 4085.

https://doi.org/10.1182/blood.V128.22.4085.4085

Published: 2016

Journal Articles

MAPK Signaling Cascades Mediate Distinct Glucocorticoid Resistance Mechanisms in Pediatric B-Precursor ALL

Courtney L Jones, PhD, Christy M Gearheart, PhD, Susan Fosmire, Cristina Delgado-Martin, PhD, Faye Pais, MD, Jinhua Wang, PhD, Teena Bhatla, MD, Danielle S Bitterman, Simone R de Rijk, Wallace Bourgeois, Smita C. Dandekar, MD, Elizabeth A. Raetz, MD, Michelle L. Hermiston, MD PhD, Michael J Garabedian, PhD, Christopher C. Porter, MD, William L. Carroll, MD

Blood (2014) 124 (21): 789.

https://doi.org/10.1182/blood.V124.21.789.789

Published: 2014

Journal Articles

Development and Repurposing of Small-Molecule Kinase Inhibitors to Target Novel Leukemogenic TNK2 Mutations

Julia Elizabeth Maxson, PhD, Abel L Melissa, BS, Jinhua Wang, PhD, Xianming Deng, PhD, Samuel B Luty, BS, Huahang Sun, MA, Julie Gorenstein, MS, Richard Middleton, PhD, Nathanael S. Gray, PhD, Brian J. Druker, Jeffrey W. Tyner, PhD

Blood (2014) 124 (21): 435.

https://doi.org/10.1182/blood.V124.21.435.435

Published: 2014

Journal Articles

Deciphering the Epigenetic Landscape of Relapsed Pediatric Acute Lymphoblastic Leukemia

Teena Bhatla, MD, Roy Blum, PhD, Jinhua Wang, PhD, Courtney L Jones, PhD, Debra J. Morrison, PhD, Elizabeth A Raetz, MD, Michael J. Burke, MD, Patrick Brown, MD, Richard C. Harvey, PhD, Cheryl L. Willman, MD, Mignon Loh, MD, Stephen P. Hunger, MD, William L. Carroll, MD

Blood (2014) 124 (21): 612.

https://doi.org/10.1182/blood.V124.21.612.612

Published: 2014

Journal Articles

Deletions In TBL1XR1 Results In Glucocorticoid Resistance By Decreasing Glucocorticoid Signaling In Childhood B-Lymphoblastic Leukemia

Courtney L Jones, Teena Bhatla, MD, Jinhua Wang, PhD, Wallace Bourgeois, Bitterman S Danielle, Elizabeth A. Raetz, MD, Debra J. Morrison, PhD, David T. Teachey, MD, Garabedian Michael, William L. Carroll, MD

Blood (2013) 122 (21): 602.

https://doi.org/10.1182/blood.V122.21.602.602

Published: 2013

Journal Articles

Epigenetic Modulation Leads to Re-Expression of Relapse Specific Silenced Genes and Induces Chemosensitivity in Childhood Acute Lymphoblastic Leukemia (ALL),

Teena Bhatla, MD, Debra J. Morrison, PhD, Jinhua Wang, PhD, Elizabeth A. Raetz, MD, Michael Burke, MD, Patrick Brown, MD, William L. Carroll, MD

Blood (2011) 118 (21): 3455.

https://doi.org/10.1182/blood.V118.21.3455.3455

Published: 2011

Journal Articles

High Throughput Transcriptome Sequencing of Pediatric Relapsed Acute Lymphoblastic Leukemia (ALL) Identifies Relapse Specific Mutations and Expression

Julia A. Meyer, BSc, Laura E. Hogan, MD, Jinhua Wang, PhD, Jun J. Yang, PhD, Jay Patel, BSc, Ross L. Levine, MD, Stephen P. Hunger, MD, Elizabeth Raetz, MD, Christopher Mason, PhD, William L. Carroll, MD

Blood (2010) 116 (21): 3233.

https://doi.org/10.1182/blood.V116.21.3233.3233

Published: 2010

Journal Articles

Vorinostat Reverses Relapse-Specific Drug Resistance Gene Expression Signatures In Childhood Acute Lymphoblastic Leukemia (ALL).

Teena Bhatla, MD, Jinhua Wang, PhD, Debra J. Morrison, PhD, Wafik T. Zaky, MD, Elizabeth A. Raetz, MD, William L. Carroll, MD

Blood (2010) 116 (21): 3630.

https://doi.org/10.1182/blood.V116.21.3630.3630

Published: 2010

Journal Articles

Up-Regulation of Genes Involved in Folate Metabolism Characterize Late but Not Early Relapse in Childhood Acute Lymphoblastic Leukemia.

Laura Hogan, MD, Deepa Bhojwani, MD, Jinhua Wang, PhD, Debra Morrison, PhD, Jun J Yang, PhD, Yutong Zhang, Jiri Zavadil, PhD, Gregory Condos, Stephen P Hunger, MD, Cheryl L. Willman, MD, Mary V. Relling, PharmD, Elizabeth Raetz, MD, William L. Carroll, MD

Blood (2009) 114 (22): 1733.

https://doi.org/10.1182/blood.V114.22.1733.1733

Published: 2009

Journal Articles

Gene Expression Profiling in Down Syndrome Acute Lymphoblastic Leukemia Identifies Distinct Profiles Associated with CRLF2 Expression Status.

Karen R. Rabin, MD, Jinhua Wang, PhD, Julia Meyer, Michael G. Loudin, Deepa Bhojwani, MD, Debra Morrison, PhD, Meenakshi Devidas, Children's, Oncology, Group, pri, Nyla A. Heerema, PhD, Andrew J. Carroll, PhD, Andrea Pession, Giuseppe Basso, MD, Charles G. Mullighan, MBBS(Hons), MSc, MD, Stephen P Hunger, MD, William L. Carroll, MD

Blood (2009) 114 (22): 2389.

https://doi.org/10.1182/blood.V114.22.2389.2389

Published: 2009

Journal Articles

Gene Expression Profiling Differentiates Childhood Acute Lymphoblastic Leukemia in Down Syndrome Versus Non-Down Syndrome Patients.

Karen R. Rabin, MD, Jinhua Wang, PhD, Anna Tsimelzon, PhD, Debra Morrison, PhD, Amos S. Gaikwad, PhD, Laura Hogan, MD, Cassia L. Rye, Susan G. Hilsenbeck, PhD, Meenakshi Devidas, PhD, Nyla A. Heerema, PhD, Andrew J. Carroll, PhD, Giuseppe Basso, MD, William L. Carroll, MD, Andrea Pession, MD, PhD, Deepa Bhojwani, MD

Blood (2008) 112 (11): 1203.

https://doi.org/10.1182/blood.V112.11.1203.1203

Published: 2008

Journal Articles

Evolution of Gene Expression Signatures in Relapsed Childhood Acute Lymphoblastic Leukemia Differs Based on Timing of Relapse.

Deepa Bhojwani, MD, Jinhua Wang, PhD, Jun J Yang, PhD, Debra Morrison, PhD, Meenakshi Devidas, PhD, Elizabeth Raetz, MD, Stephen P. Hunger, MD, Mary V. Relling, PharmD, William L. Carroll, MD

Blood (2008) 112 (11): 3345.

https://doi.org/10.1182/blood.V112.11.3345.3345

Published: 2008

NARROW

Targeting T-ALL Cells with Potent Activators of the PP2A Protein Phosphatase Tumor Suppressor

A Novel HCK and BTK Dual Inhibitor Kin-8194 Shows Superior Activity over Ibrutinib and Overcomes BTK C481S Mediated Ibrutinib Resistance in Vitro and In Vivo in MYD88 Mutated B-Cell Lymphomas

Targeting Salt-Inducible Kinase 3 As a Therapeutic Approach for Acute Myeloid Leukemia

MYD88 Triggered SYK Activation Promotes BCR Cross-Talk, and Identifies SYK As a Novel Therapeutic Target of Mutated MYD88 Signaling

Chromatin Accessibility Profiling Reveals Cis-Regulatory Heterogeneity and Novel Transcription Factor Dependencies in Multiple Myeloma

A Novel HCK Inhibitor Kin-8193 Blocks BTK Activity in BTK Cys481 Mutated Ibrutinib Resistant B-Cell Lymphomas Driven By Mutated MYD88

A Novel, Highly Selective IRAK1 Inhibitor Jh-X-119-01 Shows Synergistic Tumor Cell Killing with Ibrutinib in MYD88 Mutated B-Cell Lymphoma Cells

Using Whole Exome Sequencing in Pediatric Acute Lymphoblastic Leukemia Germline, Diagnosis, and Relapse Trios to Discover Novel Relapse Enriched Mutations for Clonal Backtracking By Ddpcr

MAPK Signaling Cascades Mediate Distinct Glucocorticoid Resistance Mechanisms in Pediatric B-Precursor ALL

Development and Repurposing of Small-Molecule Kinase Inhibitors to Target Novel Leukemogenic TNK2 Mutations

Deciphering the Epigenetic Landscape of Relapsed Pediatric Acute Lymphoblastic Leukemia

Deletions In TBL1XR1 Results In Glucocorticoid Resistance By Decreasing Glucocorticoid Signaling In Childhood B-Lymphoblastic Leukemia

Epigenetic Modulation Leads to Re-Expression of Relapse Specific Silenced Genes and Induces Chemosensitivity in Childhood Acute Lymphoblastic Leukemia (ALL),

High Throughput Transcriptome Sequencing of Pediatric Relapsed Acute Lymphoblastic Leukemia (ALL) Identifies Relapse Specific Mutations and Expression

Vorinostat Reverses Relapse-Specific Drug Resistance Gene Expression Signatures In Childhood Acute Lymphoblastic Leukemia (ALL).

Up-Regulation of Genes Involved in Folate Metabolism Characterize Late but Not Early Relapse in Childhood Acute Lymphoblastic Leukemia.

Gene Expression Profiling in Down Syndrome Acute Lymphoblastic Leukemia Identifies Distinct Profiles Associated with CRLF2 Expression Status.

Gene Expression Profiling Differentiates Childhood Acute Lymphoblastic Leukemia in Down Syndrome Versus Non-Down Syndrome Patients.

Evolution of Gene Expression Signatures in Relapsed Childhood Acute Lymphoblastic Leukemia Differs Based on Timing of Relapse.

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American Society of Hematology

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American Society of Hematology

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