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Journal Articles

Loss of the Interaction Linking the αIIb Thigh Domain K514 to the β3 I-EGF2 Domain E500 Results in Constitutive Fibrinogen Binding to αIIbβ3

Lu Wang, Jihong Li, Barry S. Coller

Blood (2024) 144 (Supplement 1): 5416.

https://doi.org/10.1182/blood-2024-205370

Published: 2024

Journal Articles

Studies of Protein Disulfide Isomerase (PDI) Binding to Platelets and Production of a Murine Monoclonal Antibody (mAb) to Integrin αIIbβ3 That Inhibits PDI Binding and Platelet Aggregation

Lu Wang, Jialing Wang, Jihong Li, Thomas Walz, Barry S. Coller

Blood (2023) 142 (Supplement 1): 1200.

https://doi.org/10.1182/blood-2023-180174

Published: 2023

Journal Articles

Cryo-Electron Microscopy Structure of the aIIbβ3-Abciximab Complex

Dragana Nesic, PhD, Yixiao Zhang, PhD, Aleksandar Spasic, PhD, Jihong Li, MD, Davide Provasi, PhD, Marta Filizola, PhD, Thomas Walz, PhD, Barry S. Coller, MD

Blood (2019) 134 (Supplement_1): 3617.

https://doi.org/10.1182/blood-2019-126985

Published: 2019

Journal Articles

The Interaction of Cross-Linked Fibrin Fragment D-Dimer with αIIbβ3 Requires Receptor Activation, Occurs at Sites Other Than the γ-404-411 Sequence, and Contributes to Clot Retraction

Hina Zafar, MS, Jihong Li, MD, Claudia Buitrago, PhD, Dragana Nesic, PhD, Barry S. Coller, MD

Blood (2018) 132 (Supplement 1): 870.

https://doi.org/10.1182/blood-2018-99-116871

Published: 2018

Journal Articles

Pharmacokinetic (PK) and Pharmacodynamic (PD) Studies of RUC-4 Succinate, a Novel αIIbβ3 Pure Antagonist for First Point of Contact Treatment of ST Segment Elevated Myocardial Infarction (STEMI)

Spandana Vootukuri, MS, Jihong Li, MD, Mark Nedelman, MS, MBA, Mariana Babayeva, MD, PhD, Barry S. Coller, MD

Blood (2018) 132 (Supplement 1): 1243.

https://doi.org/10.1182/blood-2018-99-112233

Published: 2018

Journal Articles

Development of a Pure Small Molecule αVβ3 Antagonist

Jihong Li, MD, Yoshiyuki Fukase, PhD, Yi Shang, PhD, Wei Zou, PhD, Ryoma Hara, PhD, Yuta Tanaka, PhD, Rei Okamoto, PhD, Takeshi Yasui, PhD, Takashi Nakahata, PhD, Toshihiro Imaeda, PhD, Kazuyoshi Aso, PhD, Charles Locuson, PhD, Dragana Nesic, PhD, Mark Duggan, PhD, Steven Teitelbaum, MD, Marta Filizola, PhD, Michael Foley, PhD, Barry S. Coller, MD

Blood (2017) 130 (Supplement 1): 548.

https://doi.org/10.1182/blood.V130.Suppl_1.548.548

Published: 2017

Journal Articles

Activated, But Not Unactivated, αIIbβ3 Can Mediate Adhesion to Fibrinogen Lacking the γ Chain Dodecapeptide

Hina Zafar, M.S., Jihong Li, MD, George A David, III, B.A., Barry S. Coller, MD

Blood (2015) 126 (23): 1035.

https://doi.org/10.1182/blood.V126.23.1035.1035

Published: 2015

Journal Articles

Inverse Effects of EDTA on αIIbβ3-Mediated Adhesion to Immobilized Fibrinogen Versus the D98 Plasmin Fragment of Fibrinogen

Hina Zafar, M.S., Jihong Li, MD, George A David, III, B.A., Barry S. Coller, MD

Blood (2015) 126 (23): 1036.

https://doi.org/10.1182/blood.V126.23.1036.1036

Published: 2015

Journal Articles

Structure-Guided Design of A Novel High Affinity Integrin αIIbβ3 Receptor Antagonist (RUC-2) That Displaces Mg 2+ From the β3 MIDAS,

Jieqing Zhu, PhD, Won-Seok Choi, PhD, Joshua G. McCoy, BS, MS, Ana Negri, PhD, Jianghai Zhu, PhD, Sarasija Naini, BS, MS, Jihong Li, MD, Min Shen, PhD, Wenwei Huang, PhD, Craig J. Thomas, PhD, Marta Filizola, PhD, Timothy Springer, PhD, Barry S. Coller, MD

Blood (2011) 118 (21): 3255.

https://doi.org/10.1182/blood.V118.21.3255.3255

Published: 2011

Journal Articles

Structural and therapeutic insights from the species specificity and in vivo antithrombotic activity of a novel αIIb-specific αIIbβ3 antagonist

Robert Blue, M. Anna Kowalska, Jessica Hirsch, Marta Murcia, Christin A. Janczak, Amanda Harrington, Marketa Jirouskova, Jihong Li, Rudy Fuentes, Michael A. Thornton, Marta Filizola, Mortimer Poncz, Barry S. Coller

Blood (2009) 114 (1): 195–201.

https://doi.org/10.1182/blood-2008-08-169243

Published: 2009

Includes: Multimedia, Supplemental data

Journal Articles

Limiting αIIb Extension at the Genu Differentially Affects Binding of Small and Large Ligands to αIIbβ3

Robert Blue, Jonathan Steinberger, MD, Jihong Li, MD, Marta Murcia, PhD, Marta Filizola, Barry S. Coller, MD

Blood (2008) 112 (11): 255.

https://doi.org/10.1182/blood.V112.11.255.255

Published: 2008

Journal Articles

Structural and Therapeutic Insights from the Species Specificity and in Vivo Antithrombotic Activity of a Novel αIIb-Specific αIIbβ3 Antagonist

Robert Blue, M. Anna Kowalska, PhD, Marta Murcia, PhD, Christin A. Janczak, Marketa Jirouskova, PhD, Jihong Li, MD, Amanda Harrington, Rudy Fuentes, Michael A. Thornton, PhD, Marta Filizola, Mortimer Poncz, MD, Barry S. Coller, MD

Blood (2008) 112 (11): 256.

https://doi.org/10.1182/blood.V112.11.256.256

Published: 2008

Journal Articles

Activation of Transforming Growth Factor β1 (TGF-β1) Released by Platelets Is Enhanced by Shear and Occurs in Platelet-Rich Thrombi In Vivo.

Jasimuddin Ahamed, PhD, Nathalie Burg, MD, Christin Janczak, BS, Jihong Li, MS, Barry S. Coller, MD

Blood (2007) 110 (11): 3632.

https://doi.org/10.1182/blood.V110.11.3632.3632

Published: 2007

Journal Articles

Mapping early conformational changes in αIIb and β3 during biogenesis reveals a potential mechanism for αIIbβ3 adopting its bent conformation

W. Beau Mitchell, Jihong Li, Marta Murcia, Nathalie Valentin, Peter J. Newman, Barry S. Coller

Blood (2007) 109 (9): 3725–3732.

https://doi.org/10.1182/blood-2006-11-058420

Published: 2007

Includes: Supplemental data

Journal Articles

Functional and Computational Analysis of the Role of the Adjacent to Metal Ion-Dependent Adhesion Site (ADMIDAS) of Integrin αIIbβ3.

Marketa Jirouskova, PhD, Marta Murcia, PhD, JiHong Li, MD, Marta Filizola, PhD, Barry S. Coller, MD

Blood (2006) 108 (11): 143.

https://doi.org/10.1182/blood.V108.11.143.143

Published: 2006

Journal Articles

Equilibrium and Non-Equilibrium Molecular Dynamics Simulations Provide Potential Mechanisms for the Loss of Ligand Binding to αIIbβ3 Mutants Affecting the Ligand-Induced Metal Binding Site (LIMBS).

Marta Murcia, PhD, Marketa Jirouskova, PhD, Jihong Li, MD, Barry S. Coller, MD, Filizola Marta, PhD

Blood (2006) 108 (11): 1805.

https://doi.org/10.1182/blood.V108.11.1805.1805

Published: 2006

Journal Articles

αIIbβ3 biogenesis is controlled by engagement of αIIb in the calnexin cycle via the N15-linked glycan

W. Beau Mitchell, JiHong Li, Deborah L. French, Barry S. Coller

Blood (2006) 107 (7): 2713–2719.

https://doi.org/10.1182/blood-2005-07-2990

Published: 2006

Journal Articles

Three Separate Glanzmann Thrombasthenia Mutants Affecting the αIIb β-Propeller Result in Production of Normally Stable Pro-αIIb, but Impaired Progression from Endoplasmic Reticulum to Golgi.

Everette J.R. Nelson, PhD, Jihong Li, MD, Mammen Chandy, MD, FRACP, FRCPA, Alok Srivastava, MD, FRACP, FRCPA, Barry S. Coller, MD

Blood (2004) 104 (11): 741.

https://doi.org/10.1182/blood.V104.11.741.741

Published: 2004

Journal Articles

Differences in αIIbβ3 Biogenesis Dynamics between Umbilical Cord Blood-Derived Human Megakaryocyte-Like Cells and Transfected HEK293 Cells as Revealed by a Mathematical Model.

W. Beau Mitchell, MD, Marketa Jirouskova, PhD, JiHong Li, MD, Barry S. Coller, MD

Blood (2004) 104 (11): 1559.

https://doi.org/10.1182/blood.V104.11.1559.1559

Published: 2004

NARROW

Loss of the Interaction Linking the αIIb Thigh Domain K514 to the β3 I-EGF2 Domain E500 Results in Constitutive Fibrinogen Binding to αIIbβ3

Studies of Protein Disulfide Isomerase (PDI) Binding to Platelets and Production of a Murine Monoclonal Antibody (mAb) to Integrin αIIbβ3 That Inhibits PDI Binding and Platelet Aggregation

Cryo-Electron Microscopy Structure of the aIIbβ3-Abciximab Complex

The Interaction of Cross-Linked Fibrin Fragment D-Dimer with αIIbβ3 Requires Receptor Activation, Occurs at Sites Other Than the γ-404-411 Sequence, and Contributes to Clot Retraction

Pharmacokinetic (PK) and Pharmacodynamic (PD) Studies of RUC-4 Succinate, a Novel αIIbβ3 Pure Antagonist for First Point of Contact Treatment of ST Segment Elevated Myocardial Infarction (STEMI)

Development of a Pure Small Molecule αVβ3 Antagonist

Activated, But Not Unactivated, αIIbβ3 Can Mediate Adhesion to Fibrinogen Lacking the γ Chain Dodecapeptide

Inverse Effects of EDTA on αIIbβ3-Mediated Adhesion to Immobilized Fibrinogen Versus the D98 Plasmin Fragment of Fibrinogen

Structure-Guided Design of A Novel High Affinity Integrin αIIbβ3 Receptor Antagonist (RUC-2) That Displaces Mg 2+ From the β3 MIDAS,

Structural and therapeutic insights from the species specificity and in vivo antithrombotic activity of a novel αIIb-specific αIIbβ3 antagonist

Limiting αIIb Extension at the Genu Differentially Affects Binding of Small and Large Ligands to αIIbβ3

Structural and Therapeutic Insights from the Species Specificity and in Vivo Antithrombotic Activity of a Novel αIIb-Specific αIIbβ3 Antagonist

Activation of Transforming Growth Factor β1 (TGF-β1) Released by Platelets Is Enhanced by Shear and Occurs in Platelet-Rich Thrombi In Vivo.

Mapping early conformational changes in αIIb and β3 during biogenesis reveals a potential mechanism for αIIbβ3 adopting its bent conformation

Functional and Computational Analysis of the Role of the Adjacent to Metal Ion-Dependent Adhesion Site (ADMIDAS) of Integrin αIIbβ3.

Equilibrium and Non-Equilibrium Molecular Dynamics Simulations Provide Potential Mechanisms for the Loss of Ligand Binding to αIIbβ3 Mutants Affecting the Ligand-Induced Metal Binding Site (LIMBS).

αIIbβ3 biogenesis is controlled by engagement of αIIb in the calnexin cycle via the N15-linked glycan

Three Separate Glanzmann Thrombasthenia Mutants Affecting the αIIb β-Propeller Result in Production of Normally Stable Pro-αIIb, but Impaired Progression from Endoplasmic Reticulum to Golgi.

Differences in αIIbβ3 Biogenesis Dynamics between Umbilical Cord Blood-Derived Human Megakaryocyte-Like Cells and Transfected HEK293 Cells as Revealed by a Mathematical Model.

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American Society of Hematology

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American Society of Hematology

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