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Jenn Lachey
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Journal Articles

Rker-050, a Modified Activin Receptor Type Iia Ligand Trap, Promoted Erythropoiesis in a Murine Model of Myelofibrosis

Blake Moses, Mike Dills, Ashlyn Wheeler, Radina Todorova, Savanna Macaluso, Tyler Damen, Samuel Cadena, Lorena Lerner, Jasbir Seehra, Jenn Lachey
Journal: Blood
Blood (2023) 142 (Supplement 1): 4524.
https://doi.org/10.1182/blood-2023-178741
Published: 2023
Journal Articles

Rker-216 Reversed Microcytic Anemia in a Mouse Model of Iron Refractory Iron Deficiency Anemia

Chia-Yu Wang, Emiliano Melgar-Bermudez, Diana Welch, Samuel Cadena, Lorena Lerner, Jasbir Seehra, Jenn Lachey
Journal: Blood
Blood (2023) 142 (Supplement 1): 2466.
https://doi.org/10.1182/blood-2023-179253
Published: 2023
Journal Articles

Rker-050, a Novel Activin Receptor Type II Ligand Trap, Rescued Anemia and Reduced Bone Loss in a Mouse Model of Myelodysplastic Syndromes

Blake S Moses, Chris Materna, Remya Nathan, Tandicka Nurse, Keith Babbs, Claire Tseng, Ffolliott Fisher, Jasbir Seehra, Jenn Lachey
Journal: Blood
Blood (2022) 140 (Supplement 1): 9763–9764.
https://doi.org/10.1182/blood-2022-169360
Published: 2022
Journal Articles

Preliminary Results of a Phase-2 Clinical Trial of the ALK-2 Inhibitor Ker-047 for Treatment of Iron Refractory Iron Deficiency Anemia

Vera Hoving, Albertine Donker, Enrikas Vainorius, Harveen Dhillon Natarajan, Jenn Lachey, Simon Cooper, Dorine W. Swinkels, Saskia Schols
Journal: Blood
Blood (2022) 140 (Supplement 1): 2475–2476.
https://doi.org/10.1182/blood-2022-163698
Published: 2022
Journal Articles

ALK2 Inhibition and a Modified Activin Receptor Type Iia Ligand Trap Cotherapy Maximized Hematologic Improvements in a Mouse Model of Anemia of Inflammation

Chia-Yu Wang, Emiliano Melgar-Bermudez, Diana Welch, Claire C Tseng, Ffolliott Fisher, Samuel M Cadena, Lorena Lerner, Jasbir Seehra, Jenn Lachey
Journal: Blood
Blood (2022) 140 (Supplement 1): 5337–5338.
https://doi.org/10.1182/blood-2022-166838
Published: 2022
Journal Articles

Rker-050 Rescued Ruxolitinib (Rux)-Associated Reductions in Red Blood Cell Volume

Remya Nathan, Marina Feigenson, Joshua Lamora, Claire C Tseng, Ffolliott Fisher, Jasbir Seehra, Jenn Lachey
Journal: Blood
Blood (2021) 138 (Supplement 1): 934.
https://doi.org/10.1182/blood-2021-152729
Published: 2021
Journal Articles

A Phase 2, Open-Label, Ascending Dose Study of Ker-050 for the Treatment of Anemia in Patients with Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes

David M Ross, Alejandro Arbelaez, Lynette C.Y. Chee, Chun Yew Fong, Devendra Hiwase, George Kannourakis, John Kwan, James Liang, Anish Puliyayil, Hannah Rose, Shuhying Tan, Tse-Chieh Teh, David Alan Westerman, Joel Wight, Chris Rovaldi, Elissa M. Furutani, Adrienne Gaggi, Ying Jiang, Jenn Lachey, Harveen Dhillon Natarajan, Claudia Ordonez
Journal: Blood
Blood (2021) 138 (Supplement 1): 3675.
https://doi.org/10.1182/blood-2021-147335
Published: 2021
Journal Articles

Ker-050, an Inhibitor of TGF- β Superfamily Signaling, Promoted Thrombopoiesis and Reversed Immune Thrombocytopenia in a Mouse Model of Disease

Marina Feigenson, Remya Nathan, Joshua Lamora, Ffolliott Fisher, Claire C Tseng, Jasbir Seehra, Jenn Lachey
Journal: Blood
Blood (2021) 138 (Supplement 1): 2068.
https://doi.org/10.1182/blood-2021-152814
Published: 2021
Journal Articles

A Monoclonal Antibody Targeting ALK2 As a Potential Therapeutic Agent for Anemia of Inflammation

Natalia Medeiros, Thomas A Backus, Christopher Materna, Ffolliott Fisher, Jenn Lachey, Jasbir Seehra
Journal: Blood
Blood (2021) 138 (Supplement 1): 2007.
https://doi.org/10.1182/blood-2021-153160
Published: 2021
Journal Articles

Ker-050, a Novel Inhibitor of Tgfβ Superfamily Signaling, Induces Red Blood Cell Production By Promoting Multiple Stages of Erythroid Differentiation

Marina Feigenson, PhD, Remya Nathan, Christopher Materna, Alana Gudelsky, Evan Lema, Claire C Tseng, PhD, Ffolliott Fisher, Jasbir Seehra, Jenn Lachey
Journal: Blood
Blood (2020) 136 (Supplement 1): 34.
https://doi.org/10.1182/blood-2020-140364
Published: 2020
Journal Articles

Ker-050, a Modified Actriia Ligand Trap, Alleviates Cytopenia Arising from Multiple Etiologies

Marina Feigenson, PhD, Remya Nathan, Keith Babbs, Christopher Materna, Claire C Tseng, PhD, Ffolliott Fisher, Jasbir Seehra, Jenn Lachey
Journal: Blood
Blood (2020) 136 (Supplement 1): 38.
https://doi.org/10.1182/blood-2020-140167
Published: 2020
Journal Articles

Administration of KER-047, a Novel ALK2 Inhibitor, Elicited Robust and Sustained Increases in Serum Iron in Healthy Participants

Claudia Ordonez, MD, Snyder Ben, MD, Rachel Barger, Timna Serino, Claire C Tseng, PhD, Christopher Rovaldi, M.Sc, Jenn Lachey, Jasbir Seehra
Journal: Blood
Blood (2020) 136 (Supplement 1): 13.
https://doi.org/10.1182/blood-2020-140323
Published: 2020