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James G Phillips, PhD
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Journal Articles

Inhibition of Critical DNA Dioxygenase Activity in IDH1/2 Mutant Myeloid Neoplasms

Simona Pagliuca, MD, Yihong Guan, PhD, Anand D. Tiwari, PhD, Dale Grabowski, BS, Carmelo Gurnari, MD, Cassandra M Kerr, MS, Sunisa Kongkiatkamon, MD, Metis Hasipek, PhD, Laila Terkawi, Misam Zawit, MBBS, Hassan Awada, MD, Valeria Visconte, PhD, Yogenthiran Saunthararajah, MD, James G Phillips, PhD, Jaroslaw P. Maciejewski, MD PhD, Babal K. Jha, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 28.
https://doi.org/10.1182/blood-2020-143094
Published: 2020
Journal Articles

A Novel Therapeutic Strategy for Preferential Elimination of Multiple Myeloma Cells By Targeting Protein Disulfide Isomerase

Metis Hasipek, PhD, Dale Grabowski, BS, Yihong Guan, PhD, Anand D. Tiwari, PhD, Xiaorong Gu, PhD, Jason Valent, MD, Jaroslaw Maciejewski, PhD, Frederic Joel Reu, James G Phillips, PhD, Babal K. Jha, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 32–33.
https://doi.org/10.1182/blood-2020-142847
Published: 2020
Journal Articles

TET Dioxygenase Inhibition As a Therapeutic Strategy in TET2 Mutant Myeloid Neoplasia

Yihong Guan, PhD, Anand D. Tiwari, PhD, James G Phillips, PhD, Metis Hasipek, PhD, Dale Grabowski, BS, Cassandra M Kerr, MS, Vera Adema, PhD, Yasunobu Nagata, MD PhD, Valeria Visconte, PhD, Tomas Radivoyevitch, PhD, Daniel Lindner, MD PhD, Manja Meggendorfer, PhD, Mohamed Abazeed, Mikkael A. Sekeres, MD MS, Torsten Haferlach, MD, Jaroslaw P. Maciejewski, MD PhD, Babal K. Jha, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 880.
https://doi.org/10.1182/blood-2019-131920
Published: 2019
Journal Articles

Therapeutic Applications of a Unique Calcium Channel Blocker to Target SF3B1 MDS

Sunisa Kongkiatkamon, Anand Tiwari, Vera Adema, PhD, Cassandra M Kerr, MS, Bartlomiej Przychodzen, Hassan Awada, Jibran Durrani, Yvonne Parker, Drew Adams, Yuriy Fedorov, Hetty E. Carraway, MD MBA, Chao-Yie Yang, Mikkael A. Sekeres, MD MS, Daniel J. Lindner, James G Phillips, PhD, Jaroslaw P. Maciejewski, MD PhD, Valeria Visconte, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 881.
https://doi.org/10.1182/blood-2019-128671
Published: 2019
Journal Articles

Reversible TET Inhibitor As a Hematopoietic Stem Cell Booster: A Novel Strategy to Improve Stem Cell Function

Sunisa Kongkiatkamon, Yihong Guan, PhD, Anand Tiwari, Phillip J Maciejewski, Dale Grabowski, BS, Sergei Vatolin, PhD, Vera Adema, PhD, Cassandra M Kerr, MS, Yasunobu Nagata, MD PhD, Milo Co, Christina Snider, Hassan Awada, Jibran Durrani, Yvonne Parker, Daniel J. Lindner, Mikkael A. Sekeres, MD MS, Valeria Visconte, PhD, James G Phillips, PhD, Jaroslaw P. Maciejewski, MD PhD, Babal K. Jha, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2472.
https://doi.org/10.1182/blood-2019-129056
Published: 2019
Journal Articles

Pharmacologic Normalization of Altered Transcriptome of SF3B1 Mutant Myeloid Neoplasia

Valeria Visconte, PhD, Vera Adema, PhD, Anand D. Tiwari, PhD, Cassandra M Kerr, MS, Hassan Awada, Bartlomiej Przychodzen, Allison Noe, Rachel Toth, Christina Snider, Yvonne Parker, Yuriy Fedorov, Drew Adams, Hetty E. Carraway, MD MBA, Anjali S. Advani, MD, Kevin R Kelly, MD PhD, Steffan T. Nawrocki, PhD, Jennifer S. Carew, PhD, Heesun J. Rogers, MD PhD, Daniel J. Lindner, Mikkael A. Sekeres, MD MS, James G Phillips, PhD, Jaroslaw P. Maciejewski, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 564.
https://doi.org/10.1182/blood-2019-129189
Published: 2019
Journal Articles

CUL1: Novel Therapeutic Target in Myeloid Neoplasms Harboring -7/Del(7q)

Vera Adema, PhD, Cassandra M Kerr, MS, Sunisa Kongkiatkamon, Jibran Durrani, Hassan Awada, MD, Stephan Hutter, PhD, Kevin Fung, Francesca Gould, Christina A. Snider, BA, Anjali S. Advani, MD, Hetty E. Carraway, MD MBA, Kevin R Kelly, MD PhD, Steffan T. Nawrocki, PhD, Yogenthiran Saunthararajah, MD, Jennifer S. Carew, PhD, Manja Meggendorfer, PhD, James G Phillips, PhD, Mikkael A. Sekeres, MD MS, Michael R. Savona, MD, Torsten Haferlach, MD, Jaroslaw P. Maciejewski, MD PhD, Valeria Visconte, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1281.
https://doi.org/10.1182/blood-2019-129196
Published: 2019
Journal Articles

Targeting NAD + Modulating Enzymes to Improve HSC Function in Aging and Bone Marrow Failure

Phillip J Maciejewski, Yihong Guan, Metis Hasipek, PhD, Anand D. Tiwari, PhD, Dale Grabowski, BS, James G Phillips, PhD, Yogenthiran Saunthararajah, MD, Jaroslaw P. Maciejewski, Babal K. Jha
Journal: Blood
Blood (2018) 132 (Supplement 1): 3840.
https://doi.org/10.1182/blood-2018-99-119300
Published: 2018
Journal Articles

Targeting Antagonists of Retinoic Acid Signaling in Acute Myeloid Leukemia

Metis Hasipek, PhD, Dale Grabowski, BS, Yihong Guan, James G Phillips, PhD, Jaroslaw P. Maciejewski, Hetty E. Carraway, MD MBA, Babal K. Jha
Journal: Blood
Blood (2018) 132 (Supplement 1): 4067.
https://doi.org/10.1182/blood-2018-99-118924
Published: 2018
Journal Articles

Development of a Novel Class of Agents Targeting the RNA-Splicing Machinery in Myeloid Malignancies

Valeria Visconte, PhD, Bartlomiej P. Przychodzen, Vera Adema, PhD, Cassandra M. Hirsch, Allison Noe, Rachel Toth, Christina Snider, BA, Hassan Awada, MD, Amy C Graham, BS, MS, Yvonne Parker, Yuriy Fedorov, Drew Adams, Hetty E. Carraway, MD MBA, Anjali S. Advani, MD, Tomas Radivoyevitch, Heesun J. Rogers, MD PhD, Kevin R Kelly, MD PhD, Steffan T. Nawrocki, PhD, Jennifer S. Carew, PhD, Daniel Lindner, MD PhD, Richard A Padgett, Mikkael A. Sekeres, MD MS, James G Phillips, PhD, Jaroslaw P. Maciejewski
Journal: Blood
Blood (2018) 132 (Supplement 1): 211.
https://doi.org/10.1182/blood-2018-99-116411
Published: 2018
Journal Articles

A First-in-Class Inhibitor of ISWI-Mediated (ATP-Dependent) Transcription Repression Releases Terminal-Differentiation in AML Cells While Sparing Normal Hematopoiesis

Ashwin Kishtagari, MBBS, Kwok Peng Ng, PhD, Charlotte Jarman, Anand D. Tiwari, PhD, James G Phillips, PhD, Caroline Schuerger, Babal K. Jha, Yogenthiran Saunthararajah, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 216.
https://doi.org/10.1182/blood-2018-99-119311
Published: 2018
Journal Articles

Lessons from Nature: A Novel Class of TET Inhibitors for TET2 Mutant Associated Diseases

Yihong Guan, Anand D. Tiwari, PhD, Metis Hasipek, PhD, Dale Grabowski, BS, Yvonne Parker, Cassandra M. Hirsch, Amy C Graham, BS, MS, Yasunobu Nagata, Bartlomiej P. Przychodzen, Aziz Nazha, Daniel Lindner, MD PhD, Tomas Radivoyevitch, PhD, James G Phillips, PhD, Jaroslaw P. Maciejewski, Babal K. Jha
Journal: Blood
Blood (2018) 132 (Supplement 1): 4345.
https://doi.org/10.1182/blood-2018-99-117186
Published: 2018
Journal Articles

Novel Therapeutic Targets for DNMT3A Mutant Myeloid Neoplasms

Vera Adema, PhD, Suresh K. Balasubramanian, MD, Cassandra M. Hirsch, BS, Bartlomiej P. Przychodzen, MSc, James G Phillips, PhD, Daniel Lindner, MD PhD, Tomas Radivoyevitch, PhD, Sudipto Mukherjee, MD PhD MPH, Aziz Nazha, MD, Hetty E. Carraway, MD MBA, Francesc Sole, PhD, Mikkael A. Sekeres, MD MS, Valeria Visconte, PhD, Jaroslaw P. Maciejewski, PhD MD FACP
Journal: Blood
Blood (2017) 130 (Supplement 1): 106.
https://doi.org/10.1182/blood.V130.Suppl_1.106.106
Published: 2017
Journal Articles

Activation of Autophagy in Models of SF3B1 Mutant MDS

Valeria Visconte, PhD, Vera Adema, PhD, Bartlomiej P. Przychodzen, MSc, Allison Noe, Rachel Toth, Yasmine Hirbawi, Cassandra M. Hirsch, BS, Jack Khouri, MD, Elise LeMelle, BS, Suresh K. Balasubramanian, MD, Hetty E. Carraway, MD MBA, Daniel Lindner, MD PhD, Anjali S. Advani, MD, Heesun J. Rogers, MD PhD, James G Phillips, PhD, Tomas Radivoyevitch, Kevin R Kelly, MD PhD, Steffan T. Nawrocki, PhD, Mikkael A. Sekeres, MD MS, Jaroslaw P. Maciejewski, PhD MD FACP, Jennifer Carew, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4230.
https://doi.org/10.1182/blood.V130.Suppl_1.4230.4230
Published: 2017
Journal Articles

Therapeutic Targeting of GLI1 in Acute Myeloid Leukemia

Metis Hasipek, PhD, Sayer Al-Harbi, PhD, James G Phillips, PhD, Bartlomiej P. Przychodzen, MSc, Alek Nielsen, BS, Yihong Guan, PhD, Dale Grabowski, BS, Phillip J Maciejewski, Aziz Nazha, MD, Hetty E. Carraway, MD MBA, Jaroslaw P. Maciejewski, PhD MD FACP, Babal K Jha, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2654.
https://doi.org/10.1182/blood.V130.Suppl_1.2654.2654
Published: 2017
Journal Articles

The GLI-Code As a Potential Therapeutic Target in Myeloid Neoplasms

Sayer Alharbi, PhD, Alek d Nielsen, B.S., Metis Hasipek, PhD, Bartlomiej P Przychodzen, MSc, James G Phillips, PhD, Jaroslaw P Maciejewski, MD PhD FACP, Babal Jha, PhD
Journal: Blood
Blood (2016) 128 (22): 1655.
https://doi.org/10.1182/blood.V128.22.1655.1655
Published: 2016
Journal Articles

Development of ROC-325: A Novel Small Molecule Inhibitor of Autophagy with Promising Anti-Leukemic Activity

Steffan T. Nawrocki, PhD, Yingchun Han, MD, Valeria Visconte, PhD, James G Phillips, PhD, Bartlomiej P Przychodzen, MSc, Jaroslaw P Maciejewski, MD PhD FACP, Kevin R. Kelly, MD PhD, Jennifer S. Carew, PhD
Journal: Blood
Blood (2016) 128 (22): 525.
https://doi.org/10.1182/blood.V128.22.525.525
Published: 2016
Journal Articles

A Novel in Vitro Three Organ System Assay Identifies a Small Molecule Ubiquitin Analog with in Vivo Activity Against Myeloma

Sergei Vatolin, PhD, James G Phillips, PhD, Shravya Govindgari, Dale Grabowski, Yvonne Parker, Daniel Lindner, MD PhD, Claudiu Cotta, MD PhD, Frederic J. Reu, MD
Journal: Blood
Blood (2014) 124 (21): 2085.
https://doi.org/10.1182/blood.V124.21.2085.2085
Published: 2014