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Journal Articles

Isolation and Validation of the First Functional HLA-a*01:01 Restricted EBV-LMP2 Specific T Cells for Treatment of EBV Associated Type II/III Lymphomas

Wesley Huisman, MSc, Lieve E. van der Maarel, Lois Hageman, Rob C.M. de Jong, Derk Amsen, PhD, J.H. Frederik Falkenburg, MD PhD, Inge Jedema, PhD

Blood (2018) 132 (Supplement 1): 1578.

https://doi.org/10.1182/blood-2018-99-116127

Published: 2018

Journal Articles

Prophylactic Infusion of Multi-Antigen Specific T-Cell Products to Prevent Complications after T Cell Depleted Allogeneic Stem Cell Transplantation — a Phase I/II Study

Marthe C.J. Roex, MD, Peter van Balen, MD, Lothar Germeroth, PhD, Lois Hageman, Esther van Egmond, Sabrina A.J. Veld, Conny Hoogstraten, Ellis van Liempt, PhD, Jaap J. Zwaginga, MD PhD, Liesbeth C. de Wreede, PhD, Hermann Einsele, MD PhD, Hendrik Veelken, MD PhD, Constantijn J.M. Halkes, MD, Inge Jedema, PhD, J.H. Frederik Falkenburg, MD PhD

Blood (2018) 132 (Supplement 1): 119.

https://doi.org/10.1182/blood-2018-99-111749

Published: 2018

Journal Articles

First Results of a Prospective I/II Clinical Trial in Adult Patients Using TCR Alpha/Beta Depleted Stem Cell Transplantation from Matched Related and Unrelated Donors

Moniek De Witte, MD PhD, Anna Van Rhenen, MD PhD, Geerte Van Sluis, MD PhD, Rick Admiraal, MD PhD, Lotte van der Wagen, MD, Eefke J. Petersen, MD PhD, Reinier Raymakers, MD PhD, Monique C Minnema, MD PhD, Anke Janssen, MD, Kasper Westinga, BSc, Constantijn J.M. Halkes, MD, J.H. Frederik Falkenburg, MD PhD, Jaap Jan Boelens, MD PhD, Jurgen Kuball, MD

Blood (2018) 132 (Supplement 1): 2164.

https://doi.org/10.1182/blood-2018-99-112758

Published: 2018

Journal Articles

Patient Bone Marrow Chimerism at Time of Donor Lymphocyte Infusion Predicts Development of Graft Versus Host Disease

Eva AS Koster, MD, Liesbeth C. de Wreede, PhD, Sylwia Wallet-Malicka, Lisette Bogers, Peter van Balen, MD, Waf Marijt, MD, Inge Jedema, PhD, Peter von dem Borne, MD PhD, Hendrik Veelken, MD PhD, J.H. Frederik Falkenburg, MD PhD, Constantijn J.M. Halkes, MD

Blood (2018) 132 (Supplement 1): 2132.

https://doi.org/10.1182/blood-2018-99-113839

Published: 2018

Journal Articles

The Scope of Allo-HLA Cross-Reactivity By (Third Party) Virus Specific T Cells Is Surprisingly Affected By HLA Restriction Rather Than Virus Specificity

Wesley Huisman, MSc, Didier A.T. Leboux, Lieve E. van der Maarel, Lois Hageman, Derk Amsen, PhD, J.H. Frederik Falkenburg, MD PhD, Inge Jedema, PhD

Blood (2018) 132 (Supplement 1): 2048.

https://doi.org/10.1182/blood-2018-99-116028

Published: 2018

Journal Articles

Mutated NPM1 As Target for Immunotherapy of Acute Myeloid Leukemia

Dyantha I. Van Der Lee, BSc., Helena M. Bijen, MSc, Renate S. Hagedoorn, ing., Willy M. Honders, ing., Michel G.D. Kester, ing., Dirk M. van der Steen, ing., Arnoud H. de Ru, ing., Inge Jedema, PhD, Hendrik Veelken, MD PhD, Mirjam H.M. Heemskerk, PhD, Peter A. van Veelen, PhD, J.H. Frederik Falkenburg, MD PhD, Marieke Griffioen, PhD

Blood (2017) 130 (Supplement 1): 168.

https://doi.org/10.1182/blood.V130.Suppl_1.168.168

Published: 2017

Journal Articles

Prevention of Viral Infections after T Cell Depleted Allogeneic Stem Cell Transplantation By Infusion of Multi-Antigen Specific T Cell Products

Marthe C.J. Roex, MD, Peter Van Balen, MD, Lois Hageman, Esther Van Egmond, Sabrina A.J. Veld, Conny Hoogstraten, Ellis van Liempt, PhD, Lothar Germeroth, PhD, Hermann Einsele, MD, Constantijn J.M. Halkes, MD PhD, Inge Jedema, PhD, J.H. Frederik Falkenburg, MD PhD

Blood (2016) 128 (22): 1228.

https://doi.org/10.1182/blood.V128.22.1228.1228

Published: 2016

Journal Articles

Endogenous Immunoglobulin-Derived Neoepitopes Are Processed and Form a Sizeable Fraction of the HLA Class I Ligandome of Human Lymphoma Cells

Cornelis A.M. van Bergen, PhD, Dirk M. van der Steen, Michel G.D. Kester, Marvyn T. Koning, BSc, Peter A. van Veelen, PhD, Marieke Griffioen, PhD, J.H. Frederik Falkenburg, MD PhD, Mirjam H.M. Heemskerk, PhD, Hendrik Veelken, MD PhD, Marcelo A Navarrete, MD PhD

Blood (2016) 128 (22): 914.

https://doi.org/10.1182/blood.V128.22.914.914

Published: 2016

Journal Articles

Early CD4+ T-Cell Effector Alloreactivity Towards Multiple Mismatched HLA Class II Alleles Is Associated with Graft Predominance after Double Umbilical Cord Blood Transplantation (dUCBT)

Jan J. Cornelissen, MD PhD, Rebecca Wijers, Cornelis A.M. van Bergen, Judith Somers, MD, Eric Braakman, PhD, Jan W. Gratama, MD PhD, Reno Debets, PhD, J.H. Frederik Falkenburg, MD PhD, Cor Lamers

Blood (2015) 126 (23): 387.

https://doi.org/10.1182/blood.V126.23.387.387

Published: 2015

Journal Articles

T Cell Receptor Gene Therapy Targeting the Intracellular Transcription Factor Bob1 for the Treatment of Multiple Myeloma and Other B Cell Malignancies

Lorenz Jahn, Renate S. Hagedoorn, Pleun Hombrink, PhD, Michel G.D. Kester, Dirk M. van der Steen, Chopie Hassan, Marjolein P. Schoonakker, Erwin van der Pijl, Peter A. van Veelen, PhD, J.H. Frederik Falkenburg, MD PhD, Mirjam H.M. Heemskerk, PhD

Blood (2015) 126 (23): 3002.

https://doi.org/10.1182/blood.V126.23.3002.3002

Published: 2015

Journal Articles

A Polyclonal Population of Piga Mutant CD52 and GPI Anchor Negative T Cells Can Give Early Immune Protection after Alemtuzumab-Based T Cell Depleted Allogeneic Stem Cell Transplantation

Floris C. Loeff, J.H. Frederik Falkenburg, MD PhD, Lois Hageman, Sabrina A.J. Veld, Marian van de Meent, Constantijn J.M. Halkes, MD PhD, Inge Jedema, PhD

Blood (2015) 126 (23): 3134.

https://doi.org/10.1182/blood.V126.23.3134.3134

Published: 2015

Journal Articles

Loss of Pigh Expression Frequently Results in a GPI-Negative Subclone Lacking CD52 Membrane Expression, Conferring Alemtuzumab Resistance to B Cell Acute Lymphoblastic Leukemia

Floris C. Loeff, Kevin Rijs, Willem H. Zoutman, Esther H.M. Egmond, Maarten H. Vermeer, MD PhD, J.H. Frederik Falkenburg, MD PhD, Constantijn J.M. Halkes, MD PhD, Inge Jedema, PhD

Blood (2015) 126 (23): 1435.

https://doi.org/10.1182/blood.V126.23.1435.1435

Published: 2015

Journal Articles

Tumor Associated Antigen Reactive Donor T Cells As Elementary Components of Streptamer Isolated Multi-Antigen Specific T Cells

Marthe C.J. Roex, MD, Ellis van Liempt, PhD, Lois Hageman, Lothar Germeroth, PhD, Constantijn J.M. Halkes, MD PhD, J.H. Frederik Falkenburg, MD PhD, Inge Jedema, PhD

Blood (2014) 124 (21): 313.

https://doi.org/10.1182/blood.V124.21.313.313

Published: 2014

Journal Articles

T Cell Receptors Specific for the Intracellular Transcription Factor Bob1 Allow Efficient Targeting of Human B Cell Leukemia and Multiple Myeloma

Lorenz Jahn, Pleun Hombrink, Michel G.D. Kester, Dirk M. van der Steen, Renate S. Hagedoorn, Chopie Hassan, Marjolein P. Schoonakker, Erwin van der Pijl, Peter A. van Veelen, PhD, J.H. Frederik Falkenburg, MD PhD, Mirjam H.M. Heemskerk, PhD

Blood (2014) 124 (21): 3832.

https://doi.org/10.1182/blood.V124.21.3832.3832

Published: 2014

Journal Articles

High-Affinity CD20-Specific T-Cell Receptors Suitable for Adoptive Immunotherapy in the Treatment of CD20 low B-Cell Malignancies

Lorenz Jahn, Pleun Hombrink, Chopie Hassan, Michel G.D. Kester, Renate S. Hagedoorn, Dirk M. van der Steen, Marjolein P. Schoonakker, J.H. Frederik Falkenburg, MD PhD, Peter A. van Veelen, PhD, Mirjam H.M. Heemskerk, PhD

Blood (2014) 124 (21): 3837.

https://doi.org/10.1182/blood.V124.21.3837.3837

Published: 2014

Journal Articles

Effectivity Of Complement-Dependent Cytotoxicity Induced By Therapeutic Antibodies In Acute Lymphoblastic Leukemia Is Dictated By Antigen Expression Levels and Curtailed By Membrane-Bound Complement Regulatory Proteins

Floris C Loeff, MSc, Esther H.M. van Egmond, Judith Olde Wolbers, J.H. Frederik Falkenburg, MD, PhD, Constantijn J.M. Halkes, MD, PhD, Inge Jedema, PhD

Blood (2013) 122 (21): 3909.

https://doi.org/10.1182/blood.V122.21.3909.3909

Published: 2013

Journal Articles

Graft Versus Leukemia Separates From Graft Versus Host Disease By Magnitude and Avidity Of The Allo-Reactive T Cell Response After Allogeneic Stem Cell Transplantation and Donor Lymphocyte Infusion

Cornelis A.M. van Bergen, Simone A.P. Van Luxemburg-Heijs, Matthijs Eefting, MD, Maria W. Honders, Inge Jedema, PhD, Constantijn J.M. Halkes, MD, PhD, Marieke Griffioen, PhD, J.H. Frederik Falkenburg, MD, PhD

Blood (2013) 122 (21): 2014.

https://doi.org/10.1182/blood.V122.21.2014.2014

Published: 2013

Journal Articles

LB-ARHGDIB-1R As Novel Minor Histocompatibility Antigen For Therapeutic Application

Margot J Pont, Willemijn Hobo, PhD, M. Willy Honders, Simone A.P. van Luxemburg-Heijs, Michel G.D. Kester, Cornelis A.M. van Bergen, Harry Dolstra, PhD, J.H. Frederik Falkenburg, MD, PhD, Marieke Griffioen, PhD

Blood (2013) 122 (21): 4465.

https://doi.org/10.1182/blood.V122.21.4465.4465

Published: 2013

Journal Articles

Immune Surveillance By Autoreactive Helper But Not Cytolytic T Cells Is a Common Phenomenon In Patients With Acute Myeloid Leukemia

Tin Sing Lam, Marian van de Meent, J.H. Frederik Falkenburg, MD, PhD, Inge Jedema, PhD

Blood (2013) 122 (21): 1044.

https://doi.org/10.1182/blood.V122.21.1044.1044

Published: 2013

Journal Articles

Effectiveness of a Strategy to Proceed to Allogeneic Stem Cell Transplantation in All Elderly AML Patients Treated with Intensive Chemotherapy: Only Patients in Complete Remission After First Induction Show Long Term Survival.

Peter A. Von Dem Borne, MD, PhD, Constantijn J.M. Halkes, MD, PhD, Erik W.A. Marijt, MD, PhD, Sabina Kersting, MD, PhD, J.H. Frederik Falkenburg, MD, PhD, J.Hendrik Veelken, MD, PhD

Blood (2012) 120 (21): 3085.

https://doi.org/10.1182/blood.V120.21.3085.3085

Published: 2012

NARROW

Isolation and Validation of the First Functional HLA-a*01:01 Restricted EBV-LMP2 Specific T Cells for Treatment of EBV Associated Type II/III Lymphomas

Prophylactic Infusion of Multi-Antigen Specific T-Cell Products to Prevent Complications after T Cell Depleted Allogeneic Stem Cell Transplantation — a Phase I/II Study

First Results of a Prospective I/II Clinical Trial in Adult Patients Using TCR Alpha/Beta Depleted Stem Cell Transplantation from Matched Related and Unrelated Donors

Patient Bone Marrow Chimerism at Time of Donor Lymphocyte Infusion Predicts Development of Graft Versus Host Disease

The Scope of Allo-HLA Cross-Reactivity By (Third Party) Virus Specific T Cells Is Surprisingly Affected By HLA Restriction Rather Than Virus Specificity

Mutated NPM1 As Target for Immunotherapy of Acute Myeloid Leukemia

Prevention of Viral Infections after T Cell Depleted Allogeneic Stem Cell Transplantation By Infusion of Multi-Antigen Specific T Cell Products

Endogenous Immunoglobulin-Derived Neoepitopes Are Processed and Form a Sizeable Fraction of the HLA Class I Ligandome of Human Lymphoma Cells

Early CD4+ T-Cell Effector Alloreactivity Towards Multiple Mismatched HLA Class II Alleles Is Associated with Graft Predominance after Double Umbilical Cord Blood Transplantation (dUCBT)

T Cell Receptor Gene Therapy Targeting the Intracellular Transcription Factor Bob1 for the Treatment of Multiple Myeloma and Other B Cell Malignancies

A Polyclonal Population of Piga Mutant CD52 and GPI Anchor Negative T Cells Can Give Early Immune Protection after Alemtuzumab-Based T Cell Depleted Allogeneic Stem Cell Transplantation

Loss of Pigh Expression Frequently Results in a GPI-Negative Subclone Lacking CD52 Membrane Expression, Conferring Alemtuzumab Resistance to B Cell Acute Lymphoblastic Leukemia

Tumor Associated Antigen Reactive Donor T Cells As Elementary Components of Streptamer Isolated Multi-Antigen Specific T Cells

T Cell Receptors Specific for the Intracellular Transcription Factor Bob1 Allow Efficient Targeting of Human B Cell Leukemia and Multiple Myeloma

High-Affinity CD20-Specific T-Cell Receptors Suitable for Adoptive Immunotherapy in the Treatment of CD20 low B-Cell Malignancies

Effectivity Of Complement-Dependent Cytotoxicity Induced By Therapeutic Antibodies In Acute Lymphoblastic Leukemia Is Dictated By Antigen Expression Levels and Curtailed By Membrane-Bound Complement Regulatory Proteins

Graft Versus Leukemia Separates From Graft Versus Host Disease By Magnitude and Avidity Of The Allo-Reactive T Cell Response After Allogeneic Stem Cell Transplantation and Donor Lymphocyte Infusion

LB-ARHGDIB-1R As Novel Minor Histocompatibility Antigen For Therapeutic Application

Immune Surveillance By Autoreactive Helper But Not Cytolytic T Cells Is a Common Phenomenon In Patients With Acute Myeloid Leukemia

Effectiveness of a Strategy to Proceed to Allogeneic Stem Cell Transplantation in All Elderly AML Patients Treated with Intensive Chemotherapy: Only Patients in Complete Remission After First Induction Show Long Term Survival.

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American Society of Hematology

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American Society of Hematology

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