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Journal Articles

BH-30236, a Novel Macrocyclic Clk Inhibitor Modulating Aberrant RNA Splicing, Demonstrates Potent Anti-Cancer Activity Against Myeloid Malignancies

Wei Deng, Ping Jiang, Danan Li, Dayong Zhai, Nancy Ling, Zhenping Wang, Yue Hu, Evan Rogers, Levan Darjania, Jeff Whitten, Jesse Shao, Antonio Montalban, Eugene Rui, J. Jean Cui

Blood (2024) 144 (Supplement 1): 5807.

https://doi.org/10.1182/blood-2024-208789

Published: 2024

Journal Articles

Novel Multikinase Clk Inhibitor BH-30236 Targets Hematological Malignancies through Alternative Splicing Regulation

Nancy Ling, Gregory Sims, Ping Jiang, Wei Deng, Dayong Zhai, Danan Li, Zhenping Wang, Yue Hu, Eric Wang, Armin Graber, J. Jean Cui

Blood (2024) 144 (Supplement 1): 5806.

https://doi.org/10.1182/blood-2024-208576

Published: 2024

Journal Articles

A Phase 1/1b Open-Label, Dose Escalation, First-in-Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Anti-Leukemic Activity of the Orally Available CDC-like Kinase Inhibitor, BH-30236, in Adults with R/R AML or HR-MDS

Eytan M. Stein, Leora Boussi, Alice Mims, Justin M. Watts, Gabriel N Mannis, Hongtao Liu, David Sallman, Farhad Ravandi, Gary J. Schiller, Eunice S. Wang, Brian J. Ball, J. Jean Cui, Jihao Zhou, Armin Graber, Zachary Zimmerman, Stephen Anthony Strickland

Blood (2024) 144 (Supplement 1): 5998.

https://doi.org/10.1182/blood-2024-204046

Published: 2024