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Journal Articles

Preliminary Safety and Biomarker Results of the NLRP3 Inflammasome Inhibitor DFV890 in Adult Patients with Myeloid Diseases: A Phase 1b Study

Guillermo Garcia-Manero, Yasmin Abaza, Peter L. Greenberg, Tamanna Haque, Kyra Velázquez Kennedy, Matteo Giovanni Della Porta, Melissa G Ooi, Maximilian Stahl, Zhuoer Xie, Abhishek A. Mangaonkar, Pinkal Desai, Amy E. DeZern, Alice Garnier, Mathieu Meunier, Anna Maria Pelizzari, Uwe Platzbecker, Katja Sockel, Ashwin Kishtagari, Hongbo Lu, Luca Manganelli, Lexiang Ji, Zheng Yan, Yutong Li, Mike Roy, Ewa Gatlik, Arti Singh, Valerie Beaulieu, Marc Pelletier, Philipp Rauch, Harinder Gill
Journal: Blood
Blood (2024) 144 (Supplement 1): 353.
https://doi.org/10.1182/blood-2024-198326
Published: 2024
Journal Articles

Proteomic Profiling Identifies c-KIT and 53BP1 As Resistance Factors of AML Relapse Post Allogeneic Stem Cell Transplantation with G-CSF/Plerixafor/Busulfan-Fludarabine Conditioning

Zhihong Zeng, MD, Hongbo Lu, MD, Rui-Yu Wang, MD, Wenbin Lu, PhD, Julianne Chen, Christopher B Benton, MD, Keith Baggerly, PhD, Elizabeth J Shpall, MD, Richard E Champlin, MD, Marina Konopleva, MD PhD, Michael Andreeff, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2528.
https://doi.org/10.1182/blood.V130.Suppl_1.2528.2528
Published: 2017
Journal Articles

Final Report of a Phase I/II Study of Hyper-CVAD Plus RAD001 (Everolimus) in Patients with Relapsed/Refractory Acute Lymphoblastic Leukemia

Yanis Boumber, MD, PhD, Deborah A. Thomas, MD, Farhad Ravandi, MD, Michael E. Rytting, MD, Marian R Love, Hongbo Lu, MMSC, Rebecca Garris, BSc, Jorge E. Cortes, MD, Susan O'Brien, M.D., Jan A. Burger, MD, PhD, Hagop M. Kantarjian, MD, Marina Konopleva, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 3567.
https://doi.org/10.1182/blood.V120.21.3567.3567
Published: 2012
Journal Articles

Leukemia Cell Mobilization with Plerixafor Plus G-CSF with Busulfan/Fludarabine and Allogeneic Hematopoietic Cell Transplantation in Patients with AML/MDS Is Associated with Decreased Complete Chimerism and GvHD, and Increased Risk of Relapse

Christopher B. Benton, MD, Marina Konopleva, MD, PhD, Rima M Saliba, PhD, Elizabeth J. Shpall, MD, Stefan O. Ciurea, Partow Kebriaei, M.D., Amin M. Alousi, M.D., Uday R. Popat, M.D., Paolo Anderlini, MD, Yago Nieto, M.D., Ph.D., Simrit Parmar, M.D., Zhihong Zeng, MD, Julianne J Chen, Gabriela Rondon, MD, Becky McMullin, RN, Rui-Yu Wang, MD, PhD, Hongbo Lu, MMSC, Wendy D. Schober, MLT (ASCP), Glenda G Woodworth, RN, Alison Gulbis, Pharm.D., Rita Cool, Wei Qiao, Peter F Thall, PhD, Michael Andreeff, MD, PhD, Richard E. Champlin
Journal: Blood
Blood (2012) 120 (21): 360.
https://doi.org/10.1182/blood.V120.21.360.360
Published: 2012
Journal Articles

Targeting Hypoxia and AKR1C3 with PR104 in Patients with Acute Leukemia

Juliana M Benito, PhD, Hongbo Lu, William R Wilson, PhD, Teresa J Melink, NP, MSN, Jennie Bretz, Sergej Konoplev, MD, PhD, Elihu H. Estey, MD, Hagop M. Kantarjian, MD, John C Gutheil, MD, Michael Andreeff, MD, PhD, Marina Konopleva, M.D., Ph.D.
Journal: Blood
Blood (2012) 120 (21): 3615.
https://doi.org/10.1182/blood.V120.21.3615.3615
Published: 2012
Journal Articles

Role of Connective Tissue Growth Factor (CTGF) in Survival and Chemosensitivity of Acute Lymphoblastic Leukemia

Hongbo Lu, MMSC, Venkata Lokesh Battula, Ph.D., Yuexi Shi, Richard B Lock, PhD, Suzanne Spong, Ph.D, Michael Andreeff, M.D., Ph.D., Marina Konopleva, M.D., Ph.D.
Journal: Blood
Blood (2011) 118 (21): 2593.
https://doi.org/10.1182/blood.V118.21.2593.2593
Published: 2011
Journal Articles

Targeting the Leukemia-Associated Hypoxic Microenvironment with Hypoxia-Activated Prodrug PR-104

Juliana Benito, Ph.D., Yuexi Shi, Barbara Szymanska, Hernan Carol, Ingrid Bohem, Hongbo Lu, MMSC, Sergej Konoplev, MD, PhD, Wendy Fang, Steven M. Kornblau, MD, Patrick Zweidler-McKay, MD, PhD, William Wilson, PhD, Dario Campana, MD, PhD, Gautam Borthakur, MD, Carlos E. Bueso-Ramos, Hagop M. Kantarjian, MD, Elizabeth J. Shpall, Deborah A Thomas, MD, Craig T. Jordan, PhD, Richard B Lock, PhD, Michael Andreeff, MD, PhD, Marina Konopleva, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 868.
https://doi.org/10.1182/blood.V116.21.868.868
Published: 2010
Journal Articles

Targeting Connective Tissue Growth Factor (CTGF) In Acute Lymphoblastic Leukemia Pre-Clinical Models: Anti-CTGF Monoclonal Antibody Attenuates Tumor Growth In Mouse Models of ALL

Hongbo Lu, MMSC, Venkata Lokesh Battula, Ph.D., Borys Korchin, MD, Suzanne Spong, Ph.D, Martin Canizales, Ph.D, Richard B Lock, PhD, Michael Andreeff, MD, PhD, Marina Konopleva, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 3257.
https://doi.org/10.1182/blood.V116.21.3257.3257
Published: 2010
Journal Articles

The Synergistic Effect of DNA Methylation Inhibitor 5-Azacytidine and Bcl-2 Signaling Blockade ABT-737 Combination Treatment Induce Apoptosis In AML

Yuexi Shi, Twee Tsao, Hongbo Lu, MMSC, Sergej Konoplev, MD, PhD, Wendy D. Schober, Michael Andreeff, MD, PhD, Marina Konopleva, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 3311.
https://doi.org/10.1182/blood.V116.21.3311.3311
Published: 2010
Journal Articles

A Phase I/II Trial of Plerixafor/G-CSF Combined with IV Bu/Flu Conditioning Regimen In AML/MDS Patients Undergoing Allogenic Stem Cell Transplantation

Marina Konopleva, MD, PhD, Zeng Zhihong, Rui-Yu Wang, MD, PhD, Peter F. Thall, PhD, Gloria McCormick, Hongbo Lu, MMSC, Julianne J Chen, Elizabeth J. Shpall, Stefan O. Ciurea, MD, Partow Kebriaei, MD, Amin M Alousi, MD, Uday Popat, MD, Paolo Anderlini, MD, Yago Nieto, MD, PhD, Simrit Parmar, M.D., Becky McMullin, Gabriela Rondon, MD, Wendy D. Schober, Alison Gulbis, Rita Cool, E. Lin, Michael Andreeff, MD, PhD, Richard Champlin
Journal: Blood
Blood (2010) 116 (21): 2358.
https://doi.org/10.1182/blood.V116.21.2358.2358
Published: 2010
Journal Articles

Role of Hypoxia and Hypoxia-Inducible-Factor 1α (HIF1A) In the BM Microenvironment-Mediated Protection of Leukemic Cells.

Rodrigo Jacamo, Juliana Benito, Ph.D., Olga Frolova, MD, PhD, Ye Chen, Hongbo Lu, MMSC, Marina Konopleva, MD, PhD, Michael Andreeff, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 2586.
https://doi.org/10.1182/blood.V116.21.2586.2586
Published: 2010
Journal Articles

Therapeutic Targeting of the Hypoxic Microenvironment in Acute Lymphocytic Leukemia.

Marina Konopleva, MD, PhD, Juliana Benito, PhD, Yue-Xi Shi, Sergej Konoplev, MD, PhD, Steven M. Kornblau, MD, Olga Frolova, MD, PhD, Patrick A. Zweidler-McKay, MD, PhD, YiHua Qiu, MD, MS, William R. Wilson, PhD, Dario Campana, MD, PhD, Rodrigo Jacamo, PhD, Hongbo Lu, MMSC, Wendy Fang, MD, Gautam Borthakur, MD, Carlos E. Bueso-Ramos, MD, Hagop M. Kantarjian, MD, Deborah A. Thomas, MD, Michael Andreeff, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 2040.
https://doi.org/10.1182/blood.V114.22.2040.2040
Published: 2009
Journal Articles

Targeting the Hypoxic Microenvironment by mTOR Inhibitors Sensitizes ALL Cells to Chemotherapy

Olga Frolova, MD, PhD, Ismael J. Samudio, PhD, Zakar H. Mnjoyan, PhD, Hongbo Lu, Sergej Konoplev, MD, PhD, Deborah A. Thomas, MD, Hagop M. Kantarjian, MD, Elizabeth J. Shpall, MD, Michael Andreeff, MD, PhD, Marina Konopleva, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 18.
https://doi.org/10.1182/blood.V112.11.18.18
Published: 2008
Journal Articles

Disruption of Leukemia/Stroma Cell Interactions by CXCR4 Antagonist CTCE-9908 Enhances Chemotherapy-Induced Apoptosis in AML

Hongbo Lu, Zhihong Zeng, PhD, Yuexi Shi, Sergej Konoplev, MD, PhD, Donald Wong, PhD, Marina Konopleva, MD, PhD, Michael Andreeff, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 2415.
https://doi.org/10.1182/blood.V112.11.2415.2415
Published: 2008
Journal Articles

Expression and Function of the CXCR7 Chemokine Receptor in Leukemias

Sergej Konoplev, MD, PhD, Hongbo Lu, MMSC, Michael A Fiegl, MD, Zhihong Zeng, PhD, Wenjing Chen, MD, Michael Andreeff, MD, PhD, Marina Konopleva, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 2423.
https://doi.org/10.1182/blood.V112.11.2423.2423
Published: 2008