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Journal Articles

Successful Treatment of Thrombocytopenia with Staphylococcal Protein A (PRTX-100) in a Murine Model of Immune Thrombocytopenia (ITP)

John W. Semple, PhD, Edwin R. Speck, BRT, Rukhsana Aslam, PhD, Michael Kim, BSc, Anne Zufferey, PhD, Heyu Ni, MD PhD, Michelle Catalina, PhD, Richard Francovitch, PhD

Blood (2015) 126 (23): 1045.

https://doi.org/10.1182/blood.V126.23.1045.1045

Published: 2015

Journal Articles

Effects of Anti-Glycoprotein Antibodies on Response of Immune Thrombocytopenia Patients to Thrombopoietin Receptor Agonists and on Megakaryocytes Viability

Marina Izak Karaev, MD, Alexandra Kruse, Margaret Morrisey, Heyu Ni, MD PhD, Zhu Guangheng, Petra Pham, MS, W. Beau Mitchell, MD, James B Bussel, MD

Blood (2015) 126 (23): 1048.

https://doi.org/10.1182/blood.V126.23.1048.1048

Published: 2015

Journal Articles

Platelet GPIba Is Important for Thrombopoietin Production and Thrombopoietin-Induced Platelet Generation

Miao Xu, MSc, MD, Li Ma, PhD, Naadiya Carrim, PhD, Issaka Yougbare, PhD, June Li, MSc, Pingguo Chen, MD PhD, Guangheng Zhu, MD, Heyu Ni, MD PhD

Blood (2015) 126 (23): 12.

https://doi.org/10.1182/blood.V126.23.12.12

Published: 2015

Journal Articles

Thymic-Derived Tolerizing Dendritic Cells Are up-Regulated upon Treatment with Intravenous Immunoglobulin or Splenectomy in a Murine Model of Immune Thrombocytopenia

Rick Kapur, MD PhD, Rukhsana Aslam, PhD, Edwin R. Speck, BRT, Michael Kim, BSc, Anne Zufferey, PhD, Li Guo, MD, George B. Segel, MD, Heyu Ni, MD PhD, John W. Semple, PhD

Blood (2015) 126 (23): 2251.

https://doi.org/10.1182/blood.V126.23.2251.2251

Published: 2015

Journal Articles

Natural Killer Cells Contribute to Pathophysiology of Placenta Leading to Miscarriage in Fetal and Neonatal Alloimmune Thrombocytopenia

Issaka Yougbare, PhD, Tai Wei-she, Bsc, Darko Zdravic, MSc, Pingguo Chen, MD PhD, Guangheng Zhu, MD, Howard Leong-Poi, MD, Qu Dawei, PhD, X. Lisa Yu, MD, S. Adamson Lee, PhD, John Sled, PhD, Freedman John, MD, Heyu Ni, MD PhD

Blood (2015) 126 (23): 2254.

https://doi.org/10.1182/blood.V126.23.2254.2254

Published: 2015

Journal Articles

Response to TPO-Receptor Agonists: Role of Immature Platelet Fraction and Anti-GP1b

Alexandra Kruse, Alexa M. Sughroue, Patrick Morrissey, Claudia Tchatchouang, M.A., Guangheng Zhu, MD, Marina Izak, MD, Heyu Ni, MD PhD, James B. Bussel, MD

Blood (2014) 124 (21): 4190.

https://doi.org/10.1182/blood.V124.21.4190.4190

Published: 2014

Journal Articles

CD20 B Cell Depleting Therapy Is Associated with up-Regulation of CD8 + CD25 high Foxp3 + T Regulatory Cells in a Murine Model of Immune Thrombocytopenia (ITP)

Li Guo, MD, Rukhsana Aslam, PhD, Yajing Zhao, Edwin R. Speck, BRT, Heyu Ni, MD PhD, John W. Semple, PhD

Blood (2014) 124 (21): 2785.

https://doi.org/10.1182/blood.V124.21.2785.2785

Published: 2014

Journal Articles

Maternal Anti-Platelet β3 Integrin Antibodies Impair Angiogenesis and Cause Intracranial Hemorrhage in Fetal and Neonatal Alloimmune Thrombocytopenia

Blood (2014) 124 (21): 2772.

https://doi.org/10.1182/blood.V124.21.2772.2772

Published: 2014

Journal Articles

Unveiling the Regulatory Role of CD8+ T-Cells in the Pathogenesis and Effective Steroid Treatment in ITP

Li Ma, PhD, Elisa K. Simpson, MSc., June Li, MSc, Min Xuan, PhD, Miao Xu, MSc, MD, Laura Baker, BSc., Yan Shi, MD, Guangheng Zhu, MD, Pingguo Chen, MD PhD, Alan H Lazarus, PhD, John J. Freedman, MD, Heyu Ni, MD PhD

Blood (2014) 124 (21): 576.

https://doi.org/10.1182/blood.V124.21.576.576

Published: 2014

Journal Articles

Apolipoprotein Α-IV Is a Novel Ligand of Platelet αIIbβ3 Integrin and an Endogenous Thrombosis Inhibitor: Measurement of Single-Molecular Interactions By Biomembrane Force Probe

Blood (2014) 124 (21): 92.

https://doi.org/10.1182/blood.V124.21.92.92

Published: 2014

Journal Articles

Plant Food Anthocyanins Induced Platelet Apoptosis Via BCL-2/BCL-XL Pathway

Yang Yan, PhD, Ma Jing, Tian Jinju, Chen Liyi, Songmei Yin, MD, Heyu Ni, MD PhD, Ling Wenhua

Blood (2014) 124 (21): 4988.

https://doi.org/10.1182/blood.V124.21.4988.4988

Published: 2014

Journal Articles

Platelet Desialylation: A Novel Mechanism of Fc-Independent Platelet Clearance and a Potential Diagnostic Biomarker and Therapeutic Target in immune Thrombocytopenia

June Li, MSc, Dianne Evertdina van der Wal, PhD, Guangheng Zhu, MD, Miao Xu, MSc, MD, Issaka Yougbare, PhD, Li Ma, PhD, Brian Vadasz, BSc, Renata Grozovsky, PhD, Min Ruan, MD, Lingyan Zhu, MD, Qingshu Zeng, MD, Lili Tao, MD, Zhi-min Zhai, MD, Jun Peng, MD, Ming Hou, MD, Valery Leytin, PhD, John J. Freedman, MD, Karin M Hoffmeister, MD, Heyu Ni, MD PhD

Blood (2014) 124 (21): 467.

https://doi.org/10.1182/blood.V124.21.467.467

Published: 2014

Journal Articles

CD8+ T Cells Are Predominantly Protective In a Murine Model Of ITP and Is Required For Effective Steroid Therapy

Li Ma, Elisa K. Simpson, H.B.Sc., June Li, BSc, Guangheng Zhu, MD, Pingguo Chen, PhD, John W. Semple, PhD, John Freedman, MD, Heyu Ni, MD, PhD

Blood (2013) 122 (21): 1076.

https://doi.org/10.1182/blood.V122.21.1076.1076

Published: 2013

Journal Articles

Megakaryocyte Abnormalities Occur In The Absence Of Cell-Mediated Immunity In a Murine Model Of Passive Immune Thrombocytopenia (ITP)

John W. Semple, PhD, Kristin Hunt, Yu Hou, Rukhsana Aslam, PhD, Edwin R. Speck, Heyu Ni, MD, PhD, Alan H Lazarus, PhD

Blood (2013) 122 (21): 3537.

https://doi.org/10.1182/blood.V122.21.3537.3537

Published: 2013

Journal Articles

Fetal and Neonatal Alloimmune Thrombocytopenia: Lessons Learned from Animal Models

Heyu Ni, MD, PhD

Blood (2013) 122 (21): SCI-50.

https://doi.org/10.1182/blood.V122.21.SCI-50.SCI-50

Published: 2013

Journal Articles

Novel Murine Models Of Fetal and Neonatal Alloimmune Thrombocytopenia Established In αIIb Deficient and Human αIIb Transgenic Mice

Brian Vadasz, BSc, Pingguo Chen, PhD, Yougbare Issaka, PhD, Guangheng Zhu, MD, Frampton Jonathan, Ph.D, Mortimer Poncz, MD, John J. Freedman, MD, Heyu Ni, MD, PhD

Blood (2013) 122 (21): 2314.

https://doi.org/10.1182/blood.V122.21.2314.2314

Published: 2013

Journal Articles

The First In Vitro and In Vivo Assessment Of Anfibatide, a Novel Glycoprotein Ib Antagonist, In Mice and In a Phase I Human Clinical Trial

Yan Hou, Xi Lei, Benjamin Xiaoyi Li, Xiangrong Dai, Zhongqiang Yang, Fang Qian, Guohui Zhang, Zhengyu Xu, Jing Liu, Chaofan Liang, Yanan Zhao, Jie Shen, Hui Zhou, Yiming Wang, Alexandra H. Marshall, Heyu Ni, MD, PhD

Blood (2013) 122 (21): 577.

https://doi.org/10.1182/blood.V122.21.577.577

Published: 2013

Journal Articles

Human and Murine Immune Thrombocytopenia (ITP) Is Associated with a Peripheral Deficiency of CD4- T Regulatory Cells (Tc-regs)

John W. Semple, PhD, Daoxin Ma, PhD, Rukhsana Aslam, PhD, Ming Hou, Heyu Ni, MD, PhD, Yu Hu

Blood (2012) 120 (21): 3333.

https://doi.org/10.1182/blood.V120.21.3333.3333

Published: 2012

Journal Articles

Psi Domain of b3 Integrin Has Endogenous Thiol Isomerase Function and Is a Potential New Target for Anti-Thrombotic Therapy

Guangheng Zhu, MD, Pingguo Chen, PhD, Adili Reheman, MD, June Li, BSc, Heyu Ni, MD, PhD

Blood (2012) 120 (21): 382.

https://doi.org/10.1182/blood.V120.21.382.382

Published: 2012

Journal Articles

Thrombopoietin Can Induce Tolerogenic Responses Via the Modulation of Thymic and Splenic T Lymphocyte Populations in a Murine Model of Immune Thrombocytopenia (ITP)

John W. Semple, PhD, Xu Zhang, Yu Hu, Li Guo, Edwin R. Speck, Heyu Ni, MD, PhD, Rukhsana Aslam, PhD

Blood (2012) 120 (21): 1088.

https://doi.org/10.1182/blood.V120.21.1088.1088

Published: 2012

NARROW

Successful Treatment of Thrombocytopenia with Staphylococcal Protein A (PRTX-100) in a Murine Model of Immune Thrombocytopenia (ITP)

Effects of Anti-Glycoprotein Antibodies on Response of Immune Thrombocytopenia Patients to Thrombopoietin Receptor Agonists and on Megakaryocytes Viability

Platelet GPIba Is Important for Thrombopoietin Production and Thrombopoietin-Induced Platelet Generation

Thymic-Derived Tolerizing Dendritic Cells Are up-Regulated upon Treatment with Intravenous Immunoglobulin or Splenectomy in a Murine Model of Immune Thrombocytopenia

Natural Killer Cells Contribute to Pathophysiology of Placenta Leading to Miscarriage in Fetal and Neonatal Alloimmune Thrombocytopenia

Response to TPO-Receptor Agonists: Role of Immature Platelet Fraction and Anti-GP1b

CD20 B Cell Depleting Therapy Is Associated with up-Regulation of CD8 + CD25 high Foxp3 + T Regulatory Cells in a Murine Model of Immune Thrombocytopenia (ITP)

Maternal Anti-Platelet β3 Integrin Antibodies Impair Angiogenesis and Cause Intracranial Hemorrhage in Fetal and Neonatal Alloimmune Thrombocytopenia

Unveiling the Regulatory Role of CD8+ T-Cells in the Pathogenesis and Effective Steroid Treatment in ITP

Apolipoprotein Α-IV Is a Novel Ligand of Platelet αIIbβ3 Integrin and an Endogenous Thrombosis Inhibitor: Measurement of Single-Molecular Interactions By Biomembrane Force Probe

Plant Food Anthocyanins Induced Platelet Apoptosis Via BCL-2/BCL-XL Pathway

Platelet Desialylation: A Novel Mechanism of Fc-Independent Platelet Clearance and a Potential Diagnostic Biomarker and Therapeutic Target in immune Thrombocytopenia

CD8+ T Cells Are Predominantly Protective In a Murine Model Of ITP and Is Required For Effective Steroid Therapy

Megakaryocyte Abnormalities Occur In The Absence Of Cell-Mediated Immunity In a Murine Model Of Passive Immune Thrombocytopenia (ITP)

Fetal and Neonatal Alloimmune Thrombocytopenia: Lessons Learned from Animal Models

Novel Murine Models Of Fetal and Neonatal Alloimmune Thrombocytopenia Established In αIIb Deficient and Human αIIb Transgenic Mice

The First In Vitro and In Vivo Assessment Of Anfibatide, a Novel Glycoprotein Ib Antagonist, In Mice and In a Phase I Human Clinical Trial

Human and Murine Immune Thrombocytopenia (ITP) Is Associated with a Peripheral Deficiency of CD4- T Regulatory Cells (Tc-regs)

Psi Domain of b3 Integrin Has Endogenous Thiol Isomerase Function and Is a Potential New Target for Anti-Thrombotic Therapy

Thrombopoietin Can Induce Tolerogenic Responses Via the Modulation of Thymic and Splenic T Lymphocyte Populations in a Murine Model of Immune Thrombocytopenia (ITP)

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American Society of Hematology

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American Society of Hematology

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