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Journal Articles

Uncovering Non-Canonical Signalling Mediated By JAK2V617F in Myeloproliferative Neoplasms

Lucas Wadley, Hew Yeng Lai, Eshika Arora, Helen Huang, Jianhong C Heidmann, Dennis Jing, Lauren Chen, Angela G. Fleischman

Blood (2024) 144 (Supplement 1): 3134.

https://doi.org/10.1182/blood-2024-198767

Published: 2024

Journal Articles

JAK2V617F Activates IL-10R Signalling Potentially through Transactivation of JAK1

Lucas Wadley, Hew Yeng Lai, Eshika Arora, Helen Huang, Dennis Jing, Angela G. Fleischman

Blood (2023) 142 (Supplement 1): 6333.

https://doi.org/10.1182/blood-2023-187871

Published: 2023

Journal Articles

IL-10R Inhibition Selects for Jak2V617F Hematopoiesis By Augmenting Inflammation Induced Exhaustion of Wild-Type but Not Jak2V617F Hematopoietic Stem Cells

Angela Fleischman, Hew Yeng Lai, Nitya Mehrota-Venkat, Tiffany Trieu, Tiffany Han, Gajalakshmi Ramanathan, Brianna Hoover

Blood (2021) 138 (Supplement 1): 3595.

https://doi.org/10.1182/blood-2021-154107

Published: 2021

Journal Articles

Utilization of Non-Invasive Sample Sources for Identification of Somatic and Germline Mutations in Hematologic Malignancies and Clonal Hematopoiesis

Eli M Soyfer, Hellen Nguyen, Simran Bhardwaj, Hew Yeng Lai, Nahid Haghighi, Angela Fleischman

Blood (2021) 138 (Supplement 1): 4926.

https://doi.org/10.1182/blood-2021-154007

Published: 2021

Journal Articles

JAK2V617F Hematopoietic Stem and Progenitors Are More Resistant to Chronic Blockage of IL-10 Signaling in a Murine Model of Myeloproliferative Neoplasms

Hew Yeng Lai, PhD, Tiffany Trieu, Tiffany Han, Stefan Brooks, Brianna Craver, MS, Gajalakshmi Ramanathan, PhD, Angela G. Fleischman, MD PhD

Blood (2019) 134 (Supplement_1): 4206.

https://doi.org/10.1182/blood-2019-131166

Published: 2019

Journal Articles

N-Acetylcysteine As a Therapeutic for JAK2V617F Myeloproliferative Neoplasms

Brianna Craver, MS, Gajalakshmi Ramanathan, PhD, Laura Mendez Luque, Summer Hoang, Kenza Elalaoui, MD, Stefan Brooks, Hew Yeng Lai, Angela Fleischman, MD PhD

Blood (2018) 132 (Supplement 1): 1786.

https://doi.org/10.1182/blood-2018-99-117395

Published: 2018

Journal Articles

Investigating the Role of the Gut Microbiome in the Inflammatory State of Myeloproliferative Neoplasms

Kenza Elalaoui, MD, Claudia Weihe, PhD, Andrew Oliver, MS, Brianna Craver, MS, Hew Yeng Lai, Stefan Brooks, Daniel Kim, Jennifer Martiny, PhD, Katrine Whiteson, PhD, Angela Fleischman, MD PhD

Blood (2018) 132 (Supplement 1): 3051.

https://doi.org/10.1182/blood-2018-99-109761

Published: 2018

Journal Articles

JAK2 V617F Hematopoietic Stem Cells Exhibit a Blunted Response to Acute Inflammation

Brianna Craver, MS, Hew Yeng Lai, Sarah Morse, MS, Stefan Brooks, Daniel Kim, Angela G. Fleischman, MD PhD

Blood (2017) 130 (Supplement 1): 4211.

https://doi.org/10.1182/blood.V130.Suppl_1.4211.4211

Published: 2017

Journal Articles

Needs and Preferences Regarding Nutrition and Supplement Use Among Individuals with Myeloproliferative Neoplasms: A Focus Group Study

Robyn M. Scherber, MD, Sarah Morse, MS, Anais Leproux, PhD, Brianna M Craver, MS, Hew Yeng Lai, Holly Geyer, MD, Amylou C. Dueck, PhD, Jeanne Palmer, MD, Leslie Padrnos, MD, Ruben A Mesa, MD, Angela G. Fleischman, MD PhD

Blood (2017) 130 (Supplement 1): 5669.

https://doi.org/10.1182/blood.V130.Suppl_1.5669.5669

Published: 2017

Journal Articles

Overexpression of Calreticulin Impairs Self-Renewal Capacity of Hematopoietic Stem Cells

Stefan Brooks, Sarah Morse, MS, Brianna Craver, MS, Hew Yeng Lai, Thanh Kim Nguyen, PhD, Daniel Kim, Angela G. Fleischman, MD PhD, Prasanthi Tata, Nilamani Jena, PhD, Zhong-Ying Liu, Richard A. Van Etten, MD PhD

Blood (2017) 130 (Supplement 1): 4937.

https://doi.org/10.1182/blood.V130.Suppl_1.4937.4937

Published: 2017

Journal Articles

The MEK/ERK Inhibitor Trametinib Reduces Fibrosis in a Transduction-Transplantation Model of Mutated Calreticulin

Thanh Kim Nguyen, PhD, Prasanthi Tata, Stefan Brooks, BA, Nilamani Jena, PhD, Sarah J Morse, MS, BS, Zhong-ying Liu, Hew Yeng Lai, BS, Sherif Rezk, MD, Richard A. Van Etten, MD PhD, Angela G Fleischman, MD PhD

Blood (2016) 128 (22): 635.

https://doi.org/10.1182/blood.V128.22.635.635

Published: 2016

Journal Articles

A Blunted Response to the Anti-Inflammatory Cytokine IL-10 Contributes to Excessive TNF Production in Myeloproliferative Neoplasm

Hew Yeng Lai, BS, Sarah J Morse, MS, BS, Thanh Kim Nguyen, MS PhD, Samuel B Luty, BS, Michael Garbati, PhD BS, Grover C. Bagby, Jr., MD MACP, Brian J. Druker, MD, Angela G Fleischman, MDPhD

Blood (2015) 126 (23): 1632.

https://doi.org/10.1182/blood.V126.23.1632.1632

Published: 2015

Journal Articles

T Cell Mediated Suppression of Hematopoiesis in Myeloproliferative Neoplasm

Sarah J Morse, MS, Samuel B Luty, BS, Hew Yeng Lai, BS, Brian J. Druker, Angela G Fleischman, MDPhD

Blood (2014) 124 (21): 1886.

https://doi.org/10.1182/blood.V124.21.1886.1886

Published: 2014

Journal Articles

Exaggerated Response to Toll-like Receptor Agonist Contributes to Excessive TNF Production in Myeloproliferative Neoplasm

Hew Yeng Lai, BS, Sarah J Morse, MS, Samuel B Luty, BS, Michael R Garbati, PhD, J Blair Edmiston, BS, Grover C. Bagby, MD MACP, Brian J. Druker, Angela G Fleischman, MDPhD

Blood (2014) 124 (21): 4584.

https://doi.org/10.1182/blood.V124.21.4584.4584

Published: 2014

Journal Articles

Expression of JAK2 V617I Does Not Result in Overt Myeloproliferative Disorder, but Results in Cytokine Hypersensitivity

Stefan Brooks, BS, Samuel B Luty, BS, Hew Yeng Lai, BS, Lacey R Royer, Sarah J Morse, MS, Angela G Fleischman, MDPhD

Blood (2014) 124 (21): 3218.

https://doi.org/10.1182/blood.V124.21.3218.3218

Published: 2014

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Uncovering Non-Canonical Signalling Mediated By JAK2V617F in Myeloproliferative Neoplasms

JAK2V617F Activates IL-10R Signalling Potentially through Transactivation of JAK1

IL-10R Inhibition Selects for Jak2V617F Hematopoiesis By Augmenting Inflammation Induced Exhaustion of Wild-Type but Not Jak2V617F Hematopoietic Stem Cells

Utilization of Non-Invasive Sample Sources for Identification of Somatic and Germline Mutations in Hematologic Malignancies and Clonal Hematopoiesis

JAK2V617F Hematopoietic Stem and Progenitors Are More Resistant to Chronic Blockage of IL-10 Signaling in a Murine Model of Myeloproliferative Neoplasms

N-Acetylcysteine As a Therapeutic for JAK2V617F Myeloproliferative Neoplasms

Investigating the Role of the Gut Microbiome in the Inflammatory State of Myeloproliferative Neoplasms

JAK2 V617F Hematopoietic Stem Cells Exhibit a Blunted Response to Acute Inflammation

Needs and Preferences Regarding Nutrition and Supplement Use Among Individuals with Myeloproliferative Neoplasms: A Focus Group Study

Overexpression of Calreticulin Impairs Self-Renewal Capacity of Hematopoietic Stem Cells

The MEK/ERK Inhibitor Trametinib Reduces Fibrosis in a Transduction-Transplantation Model of Mutated Calreticulin

A Blunted Response to the Anti-Inflammatory Cytokine IL-10 Contributes to Excessive TNF Production in Myeloproliferative Neoplasm

T Cell Mediated Suppression of Hematopoiesis in Myeloproliferative Neoplasm

Exaggerated Response to Toll-like Receptor Agonist Contributes to Excessive TNF Production in Myeloproliferative Neoplasm

Expression of JAK2 V617I Does Not Result in Overt Myeloproliferative Disorder, but Results in Cytokine Hypersensitivity

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American Society of Hematology

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