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H. Leighton Grimes, PhD
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Journal Articles

Neutrophil Development and Neutropenia

H. Leighton Grimes, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): SCI4.
https://doi.org/10.1182/blood-2020-133029
Published: 2020
Journal Articles

In Situ Fate Mapping of Native and Stress Myelopoiesis Reveals a Unique Niche for Mono- and Dendritic Cell -Poiesis

Jizhou Zhang, Qingqing Wu, PhD, Courtney Johnson, BS, Giang Pham, PhD, Jeremy M. Kinder, Immanuel Kwok, Keith Leong, André Olsson, MS, PhD, Anastasiya Slaughter, BA, Margot Lindsay May, BS, Benjamin Weinhaus, BS, Angelo D'Alessandro, James Douglas Engel, PhD, Jean X. Jiang, PhD, J.Matthew Koffron, Lei Huang, PhD, Lai Guang Ng, Sing Sing Way, MDPhD, Nathan Salomonis, PhD, H. Leighton Grimes, PhD, Daniel Lucas-Alcaraz, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 38–39.
https://doi.org/10.1182/blood-2020-143123
Published: 2020
Journal Articles

Selective Targeting of Histone Deacetylase 11 Disables Metabolism of Myeloproliferative Neoplasms

Vasundhara Sharma, PhD, Lanzhu Yue, MD, Nathan P. Horvat, MDCandidate, Agni Christodoulidou, PhD, Afua Adutwumwa Akuffo, PhDCandidate, Mathew Beatty, PhD, Cem Murdun, MS, Julia Billington, PhDCandidate, William E Goodheart, MS, PhDCandidate, Eva Sahakian, PhD, Ling Zhang, MD, John J. Powers, BS, Narmin E. Amin, Que T. Lambert-Showers, Lancia Darville, PhD, Javier Pinilla Ibarz, MD PhD, Gary W. Reuther, Jennifer Lee, PhD, Xiaozhang Zheng, PhD, Pui Yee Ng, PhD, Mathew W. Martin, PhD, Gary C. Marshall, PhD, John M. Koomen, PhD, Ross L. Levine, MD, Amit Verma, MBBS, H. Leighton Grimes, PhD, Eduardo Sotomayor, MD, Zonghong Shao, MD, Kenneth Wright, PhD, Pearlie K. Epling-Burnette
Journal: Blood
Blood (2019) 134 (Supplement_1): 474.
https://doi.org/10.1182/blood-2019-127235
Published: 2019
Journal Articles

Spatial Mapping of Myelopoiesis Reveals the Bone Marrow Niche for Monocyte Dendritic Cell Progenitors

Jizhou Zhang, Qingqing Wu, PhD, Courtney Johnson, BS, André Olsson, MS, PhD, Anastasiya Slaughter, BA, Margot Lindsay May, BS, Benjamin Weinhaus, BS, Emily Bowers, PhD, James Douglas Engel, PhD, Jean X. Jiang, PhD, Sherry L. Abboud-Werner, PhD, Nathan Salomonis, PhD, H. Leighton Grimes, PhD, Daniel Lucas-Alcaraz, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 528.
https://doi.org/10.1182/blood-2019-128809
Published: 2019
Journal Articles

V2 Trial: A Phase I Study of Venetoclax Combined with CPX-351 for Children, Adolescents and Young Adults with Relapsed or Refractory Acute Leukemia

Laura Agresta, MD, Maureen M O'Brien, MD, Kana Mizuno, PhD, Robin Norris, MD MS, MPH, Erin H. Breese, MD PhD, Christine L Phillips, MD, Karen Burns, MD, Benjamin Mizukawa, Lynn Lee, MD, Adam Lane, PhD, Robert B. Lorsbach, MD PhD, Thomas D. Ryan, MD PhD, Pankaj B. Desai, PhD, Alexander A. Vinks, PharmD, PhD, H. Leighton Grimes, PhD, John P Perentesis, Michael J. Absalon, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3830.
https://doi.org/10.1182/blood-2019-121514
Published: 2019
Journal Articles

A Prognostic Human Splicing Signature That Precurses Leukemia

Meenakshi Venkatasubramanian, BS, Xiaoting Chen, PhD, Kashish Chetal, MS, Aishwarya Kulkarni, MS, Kasiani C. Myers, MD, Matthew T. Weirauch, PhD, H. Leighton Grimes, PhD, Nathan Salomonis, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 877.
https://doi.org/10.1182/blood-2018-99-115000
Published: 2018
Journal Articles

The Erythro-Myeloblastic Island (EMBI): A Hematopoietic Niche Balancing Erythropoiesis and Myelopoiesis

Katie Giger Seu, PhD, Laurel Romano, Julien Papoin, MS, Edward David Muench, Diamantis Konstantinidis, PhD BSc, André Olsson, MSc, PhD, Kashish Chetal, MS, Joel Anne Chasis, MD, Mohandas Narla, DSc, Nathan Salomonis, PhD, H Leighton Grimes, PhD, Lionel Blanc, PhD, Theodosia A. Kalfa, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 842.
https://doi.org/10.1182/blood-2018-99-118728
Published: 2018
Journal Articles

SKI Controls MDS-Associated Chronic TGFb Signaling, Aberrant Splicing, and Stem Cell Fitness

David Muench, BS, Kyle Ferchen, BS, Chinavenmeni S. Velu, PhD, Kith Pradhan, PhD, Kashish Chetal, MS, Clemencia Colmenares, PhD, Amit Verma, MD, Nathan Salomonis, PhD, H. Leighton Grimes, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4350.
https://doi.org/10.1182/blood-2018-99-119441
Published: 2018
Journal Articles

Neutropenia-Associated Mutations Differentially Impact Developmental Cell-States

David Muench, BS, Kyle Ferchen, BS, Giang Pham, PhD, Somchai Chutipongtanate, MDPhD, Pankaj Dwivedi, PhD, Stuart Hay, Kashish Chetal, MS, Jayati Mookerjee-Basu, PhD, Kejian Zhang, MD MBA, Kasiani C. Myers, MD, Kristopher Nazor, PhD, Kenneth D Greis, PhD, Dietmar J Kappes, PhD, Sing Sing Way, MDPhD, Nathan Salomonis, PhD, H. Leighton Grimes, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 18.
https://doi.org/10.1182/blood-2018-99-116549
Published: 2018
Journal Articles

Mitochondrial Morphology Controls Hematopoietic Stem Cell Self-Renewal and Confers Them Divisional Memory

Ashwini S. Hinge, PhD, Jingyi He, MD, Eucabeth Mose, BS, Jose Javier, BS, James Bartram, BS, Ellen Fjellman, BS, Hiromi Sesaki, PhD, H Leighton Grimes, PhD, Nathan Salomonis, PhD, Marie-Dominique Filippi, PhD, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 633.
https://doi.org/10.1182/blood.V130.Suppl_1.633.633
Published: 2017
Journal Articles

A Common Signaling Node Constitute Non-Oncogene Addiction in Kinase Driven Leukemia:Mechanism of Oncogne Addiction in CML

Meenu Kesarwani, PhD, Zachary Kincaid, BS, Ahmed Ramadan Gomma, PhD, Erika Huber, Sara Rohrabaugh, PhD, H. Leighton Grimes, PhD, Mohammad Azam, PhD
Journal: Blood
Blood (2016) 128 (22): 3056.
https://doi.org/10.1182/blood.V128.22.3056.3056
Published: 2016
Journal Articles

Enhanced MAPK Signaling Constitute Non-Oncogene Addiction in CSF3R Induced Leukemia

Sara Rohrabaugh, PhD, Meenu Kesarwani, PhD, Zachary Kincaid, BS, Erika Huber, H. Leighton Grimes, PhD, Mohammad Azam, PhD
Journal: Blood
Blood (2016) 128 (22): 632.
https://doi.org/10.1182/blood.V128.22.632.632
Published: 2016
Journal Articles

Regulation of Hematopoietic Stem and Progenitor Cell Differentiation By Mirn23a/b Micrornas

Jeffrey Kurkewich, BS, Justin Hansen, Nathan Klopfenstein, Helen Zhang, Christian Wood, Austin Boucher, David E. Muench, MEng, H. Leighton Grimes, PhD, Richard Dahl, PhD
Journal: Blood
Blood (2016) 128 (22): 3880.
https://doi.org/10.1182/blood.V128.22.3880.3880
Published: 2016
Journal Articles

Long-Lasting Dysregulation of the Hematopoietic Stem Cell Compartment in Obesity

Jung-Mi Lee, PhD, Bryan Goddard, Ashwini S. Hinge, PhD, Bruce J. Aronow, PhD, Nathan Salomonis, PhD, Marie-Dominique Filippi, PhD, H. Leighton Grimes, PhD, Jose A Cancelas, MD PhD, Damien Reynaud, PhD
Journal: Blood
Blood (2015) 126 (23): 245.
https://doi.org/10.1182/blood.V126.23.245.245
Published: 2015
Journal Articles

Upregulation of Vav3 Is Required for Leukemogenesis By BCR-ABL through Polycomb Repression Complex Dependent De-Repression of the Cdkn2a Locus

Megha Desai, PhD, Kyung-Hee Chang, PhD, E. David Muench, BS, Anjelika Gasilina, Ashley Wellendorf, Xose R Bustelo, H. Leighton Grimes, PhD, Nicolas Nassar, PhD, Jose A Cancelas, MD PhD
Journal: Blood
Blood (2015) 126 (23): 3661.
https://doi.org/10.1182/blood.V126.23.3661.3661
Published: 2015
Journal Articles

Transcriptional Control of HSC Fitness

David E. Muench, MEng, Chinavenmeni S. Velu, PhD, Andre Olsson, PhD, Sara E. Meyer, PhD, H. Leighton Grimes, PhD
Journal: Blood
Blood (2015) 126 (23): 1161.
https://doi.org/10.1182/blood.V126.23.1161.1161
Published: 2015
Journal Articles

Single Cell RNA seq for Analysis of Cell Fate Decisions

H. Leighton Grimes, PhD, Singh Harinder, PhD, Andre Olsson, PhD, Nathan Salomonis, PhD, Bruce J. Aronow, PhD, Viren Chaudhry, PhD
Journal: Blood
Blood (2015) 126 (23): SCI-20.
https://doi.org/10.1182/blood.V126.23.SCI-20.SCI-20
Published: 2015
Journal Articles

Balancing Proliferation, Differentiation, and Survival: Powerful Genetic and RNAi Technologies Reveal Essential microRNA Signaling for Leukemic Progenitor Cell Fitness

Sara E. Meyer, PhD, Emily Orr, Andrew M. Rogers, MS,MD, John G Doench, PhD, Bruce J. Aronow, PhD, Ashish Lal, PhD, Edwina McGlinn, PhD, H. Leighton Grimes, PhD
Journal: Blood
Blood (2015) 126 (23): 441.
https://doi.org/10.1182/blood.V126.23.441.441
Published: 2015
Journal Articles

Identification of the Origin of Eosinophils

Andre Olsson, PhD, Nathan Salomonis, PhD, Harinder Singh, H. Leighton Grimes, PhD
Journal: Blood
Blood (2015) 126 (23): 886.
https://doi.org/10.1182/blood.V126.23.886.886
Published: 2015
Journal Articles

Systemic Inflammation Recruits Ccr7 + Dendritric-Biased Granulocyte-Macrophage Progenitors to Lymphatic Circulation in a Non-Canonical Traf6-Dependent Manner

Juana Serrano-Lopez, PhD, Josefina Serrano, Cuiping Zhang, MD PhD, Ashley Wellendorf, Jing Fang, MDPhD, Joaquin Sanchez-Garcia, H. Leighton Grimes, PhD, Daniel T Starczynowski, PhD, Jose A Cancelas, MD PhD
Journal: Blood
Blood (2015) 126 (23): 785.
https://doi.org/10.1182/blood.V126.23.785.785
Published: 2015