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Journal Articles

Molecular Detection of Minimal Residual Disease Precedes Morphological Relapse and Could be Used to Identify Relapse in Pediatric and Young Adult B-Cell Acute Lymphoblastic Leukemia Patients Treated with Tisagenlecleucel

Blood (2018) 132 (Supplement 1): 1551.

https://doi.org/10.1182/blood-2018-99-115460

Published: 2018

Journal Articles

Immunomodulatory Effects of HDACi in Combination with Checkpoint Blockade and Lenalidomide in the Immunosuppressive Multiple Myeloma Bone Marrow Microenvironment

Greg D Whitehill, BS, Alicia Chivers, MS, Bryan Danielson, PhD, Julien SR Tessier, MS, Gabriela Hernandez Duran, Gabrielle L Bender, BS, Douglas W. Sborov, MD MSc, Craig C Hofmeister, MDMPH, James Bradner, MD, Teru Hideshima, MD PhD, Kenneth C Anderson, MD, Gullu Gorgun, PhD

Blood (2017) 130 (Supplement 1): 4422.

https://doi.org/10.1182/blood.V130.Suppl_1.4422.4422

Published: 2017

Journal Articles

The KDM3A-KLF2-IRF4 Axis Maintains Myeloma Cell Survival

Hiroto Ohguchi, MD PhD, Teru Hideshima, MDPhD, Manoj Bhasin, PhD, Gullu Gorgun, PhD, Loredana Santo, MD, Michele Cea, MD, Naoya Mimura, MD PhD, Rikio Suzuki, MDPhD, Yu-Tzu Tai, PhD, Ruben D. Carrasco, MD PhD, Noopur S. Raje, MD, Paul G. Richardson, MD, Hideo Harigae, MD PhD, Takaomi Sanda, MD PhD, Kenneth C. Anderson, MD

Blood (2015) 126 (23): 3633.

https://doi.org/10.1182/blood.V126.23.3633.3633

Published: 2015

Journal Articles

Proteasome Inhibitors Sensitize Myeloma Cells to T Cell-Mediated Killing

Niels W.C.J. van de Donk, MD, PhD, Henk M. Lokhorst, MD, Maarten Emmelot, Tineke Aarts-Riemens, Douglas W. McMillin, PhD, Gullu Gorgun, PhD, Steffen Klippel, PhD, Eugen Dhimolea, PhD, Jana Jakubikova, PhD, Catriona A. Hayes, MD, Panisinee Lawasut, MD, Jake E Delmore, Nikhil C. Munshi, MD, Paul G. Richardson, MD, Kenneth C. Anderson, MD, Constantine S. Mitsiades, MD, PhD, Tuna Mutis, MD PhD

Blood (2011) 118 (21): 1838.

https://doi.org/10.1182/blood.V118.21.1838.1838

Published: 2011

Journal Articles

Dual Inhibition of Canonical and Non-Canonical NF-KB Pathway Demonstrates Significant Anti-Tumor Activities in Multiple Myeloma (MM)

Claire Fabre, MD, PhD, Naoya Mimura, MD, PhD, Kathryn Bobb, MS, Gullu Gorgun, PhD, Diana D. Cirstea, MD, Yiguo Hu, PhD, Jiro Minami, MD, PhD, Hiroto Ohguchi, MD, PhD, Jie Zhang, PhD, Jeffrey Meshulam, BS, Constantine S. Mitsiades, MD, PhD, Paul G. Richardson, MD, Teru Hideshima, MD, PhD, Kenneth C. Anderson, MD

Blood (2011) 118 (21): 2902.

https://doi.org/10.1182/blood.V118.21.2902.2902

Published: 2011

Journal Articles

DEPTOR Is a Regulator of Response to mTOR Kinase Inhibitors in Multiple Myeloma

Diana Cirstea, MD, Teru Hideshima, MD, PhD, Loredana Santo, MD, Homare Eda, MD, PhD, Miriam Canavese, PhD, Tyler A. Scullen, BA, Anuj K. Mahindra, MD, Gullu Gorgun, PhD, Yiguo Hu, MD, PhD, Naoya Mimura, MD, PhD, Claire Fabre, MD, PhD, Jiro Minami, MD, PhD, Hiroto Ohguchi, MD, PhD, Kenneth C. Anderson, MD, Sylvie M Guichard, PharmD, PhD, Noopur S. Raje, MD

Blood (2011) 118 (21): 2916.

https://doi.org/10.1182/blood.V118.21.2916.2916

Published: 2011

Journal Articles

Immunomodulatory Effects of Histone Deacetylase 6 Inhibition in Suppressor Immune Cells in Multiple Myeloma

Gullu Gorgun, PhD, Teru Hideshima, MD, PhD, Noopur S. Raje, MD, Naoya Mimura, MD, PhD, James E. Bradner, MD, Diana Cirstea, MD, Loredana Santo, MD, Yu-Tzu Tai, PhD, Michael Sellitto, Yiguo Hu, PhD, Claire Fabre, MD, PhD, Hiroto Ohguchi, MD, PhD, Jiro Minami, MD, PhD, Paul G. Richardson, MD, Nikhil C. Munshi, MD, Kenneth C. Anderson, MD

Blood (2011) 118 (21): 128.

https://doi.org/10.1182/blood.V118.21.128.128

Published: 2011

Journal Articles

Blockade of XBP1 Splicing by Inhibition of IRE1α Is a Promising Therapeutic Option in Multiple Myeloma

Blood (2011) 118 (21): 133.

https://doi.org/10.1182/blood.V118.21.133.133

Published: 2011

Journal Articles

AT9283, a Small Molecule Multi-Targeted Kinase Inhibitor with Potent Activity Against Aurora Kinase and STAT3 In Combination with Lenalidomide Results In Synergistic Anti-Myeloma Activity

Loredana Santo, MD, Teru Hideshima, MD, PhD, Diana Cirstea, MD, Madhavi L Bandi, PhD, Erik A Nelson, PhD, Hiroshi Ikeda, MD, Sonia Vallet, MD, Samantha Pozzi, MD, Kishan Patel, Gullu Gorgun, PhD, Naoya Mimura, MD, Claire Fabre, MD, Yiguo Hu, PhD, Dharminder Chauhan, PhD, Matthew S Squires, PhD, Nikhil C. Munshi, MD, Kenneth C. Anderson, MD, Noopur Raje, MD

Blood (2010) 116 (21): 2994.

https://doi.org/10.1182/blood.V116.21.2994.2994

Published: 2010

Journal Articles

Inhibition of Histone Deacetylase 6 Effects on Interaction of Tumor and Immune Cells In Multiple Myeloma

Gullu Gorgun, PhD, Teru Hideshima, MD, PhD, Naoya Mimura, MD, PhD, Diana Cirstea, M.D., Loredana Santo, MD, Yiguo Hu, MD, PhD, Claire Fabre, MD, Noopur Raje, MD, Nikhil C. Munshi, MD, Paul G Richardson, MD, Kenneth C. Anderson, MD

Blood (2010) 116 (21): 2996.

https://doi.org/10.1182/blood.V116.21.2996.2996

Published: 2010

Journal Articles

Bcl6 as a Novel Therapeutic Target in Multiple Myeloma (MM).

Teru Hideshima, M.D., Ph.D., Constantine S. Mitsiades, MD, PhD, Hiroshi Ikeda, MD, PhD, Dharminder Chauhan, PhD, Noopur Raje, M.D., Gullu Gorgun, PhD, Mariateresa Fulciniti, PhD, Diana Cirstea, MD, Giulia Perron, MD, Loredana Santo, M.D., Ayaka Hideshima, Klaus Podar, MD, MSc, PhD, Nikhil C. Munshi, MD, Paul Richardson, M.D., Ph.D., Daniel R. Carrasco, MD, PhD, Kenneth C. Anderson, MD

Blood (2009) 114 (22): 295.

https://doi.org/10.1182/blood.V114.22.295.295

Published: 2009

Journal Articles

A NOVEL Aurora A Kinase INHIBITOR MLN8237 Induces Cytotoxicity and CELL Cycle Arrest IN MULTIPLE MYELOMA.

Gullu Gorgun, PhD, Elisabetta Calabrese, MD, Teru Hideshima, MD, PhD, Jeffrey Ecsedy, PhD, Giada Bianchi, MD, Mala Mani, PhD, Madhavi Bandi, Hiroshi Ikeda, MD, PhD, Giulia Perrone, MD, Yiguo Hu, MD, PhD, Yu-Tzu Tai, PhD, Mei Zheng, Diana Cristea, MD, Loredana Santo, MD, Daniel R. Carrasco, MD, PhD, Nikhil Munshi, MD, Paul Richardson, MD, Kenneth C. Anderson, MD

Blood (2009) 114 (22): 3830.

https://doi.org/10.1182/blood.V114.22.3830.3830

Published: 2009

Journal Articles

AT9283, a Small Molecule Multi-Targeted Kinase Inhibitor Induces Antimyeloma Activity Via Potent Aurora Kinase and STAT3 Inhibition.

Loredana Santo, M.D., Teru Hideshima, MD., Ph.D., Erik A. Nelson, Ph.D, Diana Cirstea, MD, Madhavi Bandi, Ph.D, Hiroshi Ikeda, MD, PhD, Gullu Gorgun, PhD, Sonia Vallet, MD., Samantha Pozzi, MD, Giulia Perrone, MD, Kishan Patel, Yiguo Hu, Ph.D, Matthew S Squires, Murray Yule, Elisabetta Calabrese, MD., Dharminder Chauhan, Ph.D, Nikhil C. Munshi, Kenneth C. Anderson, MD, Noopur Raje, MD.

Blood (2009) 114 (22): 3833.

https://doi.org/10.1182/blood.V114.22.3833.3833

Published: 2009

Journal Articles

Immunomodulatory EFFECTS of Lenalidomide and Pomalidomide ON INTERACTION of TUMOR and BONE MARROW Accessory CELLS IN MULTIPLE MYELOMA.

Gullu Gorgun, PhD, Elisabetta Calabrese, MD, Teru Hideshima, MD, PhD, Giulia Perrone, MD, Giada Bianchi, MD, Hiroshi Ikeda, MD, PhD, Mala Mani, PhD, Yiguo Hu, MD, PhD, Diana Cristea, MD, Loredana Santo, MD, Yu-Tzu Tai, PhD, Nikhil Munshi, MD, Paul Richardson, MD, Kenneth C. Anderson, MD

Blood (2009) 114 (22): 950.

https://doi.org/10.1182/blood.V114.22.950.950

Published: 2009

Journal Articles

Overcoming p53 Loss with a Multi-Targeted Small Molecule Inhibitor in Multiple Myeloma.

Diana Cirstea, MD, Teru Hideshima, MD, PhD, Loredana Santo, MD, Sonia Vallet, MD, Samantha Pozzi, MD, Kishan Patel, Hiroshi Ikeda, MD, PhD, Hannes Loferer, PhD, Giulia Perrone, MD, Gullu Gorgun, PhD, Yiguo Hu, MD, PhD, Nikhil C. Munshi, MD, Kenneth C. Anderson, MD, Noopur Raje, MD

Blood (2009) 114 (22): 4915.

https://doi.org/10.1182/blood.V114.22.4915.4915

Published: 2009

Journal Articles

Panobinostat Inhibits JAK2/STAT3 Pathway in Multiple Myeloma.

Giulia Perrone, MD, Elisabetta Calabrese, MD., Teru Hideshima, M.D., Ph.D., Gullu Gorgun, PhD,, Ikeda Hiroshi, Diana Cristea, Loredana Santo, Hu Yiguo, Kenneth C. Anderson, MD

Blood (2009) 114 (22): 2849.

https://doi.org/10.1182/blood.V114.22.2849.2849

Published: 2009

Journal Articles

A Novel Aurora-a Kinase Inhibitor MLN8237 Induces Cytotoxicity and Cell Cycle Arrest in Experimental Multiple Myeloma Models.

Gullu Gorgun, PhD, Elisabetta Calabrese, MD, Mala Mani, PhD, Teru Hideshima, M.D., Ph.D., Hiroshi Ikeda, MD, PhD, Giulia Perrone, MD, Loredana Santo, MD, Diana Cirstea, MD, Simona Blotta, Paul G. Richardson, MD, Jeffrey Ecsedy, Kenneth C. Anderson, MD

Blood (2008) 112 (11): 1719.

https://doi.org/10.1182/blood.V112.11.1719.1719

Published: 2008

Journal Articles

Immunomodulatory Effects of Lenalidomide and Bortezomib on Bone Marrow Stroma Cell and CD4 T Cell Interaction in Multiple Myeloma.

Gullu Gorgun, PhD, Elisabetta Calabrese, MD, Teru Hideshima, Hiroshi Ikeda, Giulia Perrone, Loredana Santo, Diana Cirstea, Paul G Richardson, Kenneth C Anderson

Blood (2008) 112 (11): 1690.

https://doi.org/10.1182/blood.V112.11.1690.1690

Published: 2008

Journal Articles

A Mouse Model for Immunotherapeutic Reversal of Leukemia-Induced T Cell Dysfunction

Alan G. Ramsay, PhD, Gullu Gorgun, PhD, Tobias A.W. Holderried, David Zahrieh, MS, Fenglong Liu, PhD, John Quackenbush, PhD, Carlo M. Croce, MD, John G. Gribben, MD, DSc

Blood (2008) 112 (11): 30.

https://doi.org/10.1182/blood.V112.11.30.30

Published: 2008

Journal Articles

AT7519, a Novel Small Molecule Multi-Cyclin Dependent Kinase Inhibitor, Induces Apoptosis in Multiple Myeloma VIA GSK3β

Loredana Santo, MD, Sonia Vallet, M.D., Teru Hideshima, M.D., Ph.D., Diana Cirstea, MD, Samantha Pozzi, MD, Nileshwari Vaghela, Hiroshi Ikeda, MD, PhD, Yutaka Okawa, MD, Gullu Gorgun, PhD, Giulia Perrone, MD, Elisabetta Calabrese, MD, Matthew S Squires, Marco Ladetto, MD, Nikhil C. Munshi, MD, Mario Boccadoro, Kenneth C. Anderson, MD, Noopur Raje, MD

Blood (2008) 112 (11): 251.

https://doi.org/10.1182/blood.V112.11.251.251

Published: 2008

NARROW

Molecular Detection of Minimal Residual Disease Precedes Morphological Relapse and Could be Used to Identify Relapse in Pediatric and Young Adult B-Cell Acute Lymphoblastic Leukemia Patients Treated with Tisagenlecleucel

Immunomodulatory Effects of HDACi in Combination with Checkpoint Blockade and Lenalidomide in the Immunosuppressive Multiple Myeloma Bone Marrow Microenvironment

The KDM3A-KLF2-IRF4 Axis Maintains Myeloma Cell Survival

Proteasome Inhibitors Sensitize Myeloma Cells to T Cell-Mediated Killing

Dual Inhibition of Canonical and Non-Canonical NF-KB Pathway Demonstrates Significant Anti-Tumor Activities in Multiple Myeloma (MM)

DEPTOR Is a Regulator of Response to mTOR Kinase Inhibitors in Multiple Myeloma

Immunomodulatory Effects of Histone Deacetylase 6 Inhibition in Suppressor Immune Cells in Multiple Myeloma

Blockade of XBP1 Splicing by Inhibition of IRE1α Is a Promising Therapeutic Option in Multiple Myeloma

AT9283, a Small Molecule Multi-Targeted Kinase Inhibitor with Potent Activity Against Aurora Kinase and STAT3 In Combination with Lenalidomide Results In Synergistic Anti-Myeloma Activity

Inhibition of Histone Deacetylase 6 Effects on Interaction of Tumor and Immune Cells In Multiple Myeloma

Bcl6 as a Novel Therapeutic Target in Multiple Myeloma (MM).

A NOVEL Aurora A Kinase INHIBITOR MLN8237 Induces Cytotoxicity and CELL Cycle Arrest IN MULTIPLE MYELOMA.

AT9283, a Small Molecule Multi-Targeted Kinase Inhibitor Induces Antimyeloma Activity Via Potent Aurora Kinase and STAT3 Inhibition.

Immunomodulatory EFFECTS of Lenalidomide and Pomalidomide ON INTERACTION of TUMOR and BONE MARROW Accessory CELLS IN MULTIPLE MYELOMA.

Overcoming p53 Loss with a Multi-Targeted Small Molecule Inhibitor in Multiple Myeloma.

Panobinostat Inhibits JAK2/STAT3 Pathway in Multiple Myeloma.

A Novel Aurora-a Kinase Inhibitor MLN8237 Induces Cytotoxicity and Cell Cycle Arrest in Experimental Multiple Myeloma Models.

Immunomodulatory Effects of Lenalidomide and Bortezomib on Bone Marrow Stroma Cell and CD4 T Cell Interaction in Multiple Myeloma.

A Mouse Model for Immunotherapeutic Reversal of Leukemia-Induced T Cell Dysfunction

AT7519, a Novel Small Molecule Multi-Cyclin Dependent Kinase Inhibitor, Induces Apoptosis in Multiple Myeloma VIA GSK3β

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American Society of Hematology

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American Society of Hematology

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