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Journal Articles

Baseline Biomarkers of T-Cell Function Correlate with Clinical Responses to Odronextamab (REGN1979), and Loss of CD20 Target Antigen Expression Identified As a Mechanism of Treatment Resistance

Jurriaan Brouwer-Visser, PhD, Nathalie Fiaschi, PhD, Raquel P. Deering, PhD, Ankur Dhanik, PhD, Kamil J. Cygan, PhD, Wen Zhang, PhD, Se Jeong, MPH, Stephane Pourpe, MS, Lauren Boucher, Sara Hamon, PhD, Max S. Topp, MD, Rajat Bannerji, MDPhD, Johannes Duell, MD, Ranjana Advani, MD, Dina M. Flink, PhD, Aafia Chaudhry, MD MBA, MS, Andres Sirulnik, MD PhD, Andrew J. Murphy, PhD, David M. Weinreich, MD, George D. Yancopoulos, MD PhD, Gavin Thurston, PhD, Srikanth R. Ambati, MBBS, MD, Vladimir Jankovic, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 10–11.
https://doi.org/10.1182/blood-2020-137499
Published: 2020
Journal Articles

Clinical Activity of REGN1979, a Bispecific Human, Anti-CD20 x Anti-CD3 Antibody, in Patients with Relapsed/Refractory (R/R) B-Cell Non-Hodgkin Lymphoma (B-NHL)

Rajat Bannerji, MD PhD, John N. Allan, MD, Jon E. Arnason, MD, Jennifer R. Brown, MD PhD, Ranjana H Advani, MD, Jeffrey A. Barnes, MD PhD, Stephen M Ansell, MD PhD, Susan M. O'Brien, MD, Julio Chavez, Johannes Duell, MD, Kevin A. David, MD, Peter Martin, FRCPC, MD MS, Robin M. Joyce, MD, Robert Charnas, PhD, Srikanth R. Ambati, MBBS, MD, Lieve Adriaens, PharmD, Melanie Ufkin, PhD, Min Zhu, PhD, Jingjin Li, PhD, Peter Gasparini, MS, Anfal Ibrahim, BS, Vladimir Jankovic, MD, Nathalie Fiaschi, PhD, Olulanu Aina, PhD, Wen Zhang, PhD, Raquel P. Deering, PhD, Sara Hamon, PhD, Gavin Thurston, PhD, Andrew J. Murphy, PhD, David M. Weinreich, MD, George D. Yancopoulos, MD PhD, Israel Lowy, MD PhD, David Sternberg, MD PhD, Max S. Topp, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 762.
https://doi.org/10.1182/blood-2019-122451
Published: 2019
Journal Articles

Pharmacologic Blockade of Notch/Delta-like Ligand 4 Signaling Protects from Gastrointestinal Acute Graft-Versus-Host Disease in Non-Human Primates

Victor Tkachev, PhD, Frank Kuhnert, PhD, Scott N Furlan, MD, Hengqi Zheng, MD, Daniel J Hunt, Lucrezia Colonna, PhD, Judith M Carlson, BS, Agne Taraseviciute, MD PhD, Angela Panoskaltsis-Mortari, PhD, Virginia Hoglund, Kayla Betz, Alison Yu, PhD, Bruce R. Blazar, MD, Steve Carpenter, MD PhD, Olivier Harari, MD PhD, Gavin Thurston, PhD, Ivan Maillard, MD PhD, Leslie Kean, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2027.
https://doi.org/10.1182/blood-2018-99-110030
Published: 2018
Journal Articles

REGN5458, a Bispecific BCMAxCD3 T Cell Engaging Antibody, Demonstrates Robust In Vitro and In Vivo Anti-Tumor Efficacy in Multiple Myeloma Models, Comparable to That of BCMA CAR T Cells

David J Dilillo, PhD, Kara Olson, MS, Katja Mohrs, T. Craig Meagher, PhD, Kevin Bray, PhD, Olga Sineshchekova, Thomas Startz, Marc Retter, PhD, Stephen Godin, PhD, Frank Delfino, PhD, John Lin, PhD, Eric Smith, PhD, Olin Gavin Thurston, PhD, Jessica R. Kirshner, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1944.
https://doi.org/10.1182/blood-2018-99-112500
Published: 2018
Journal Articles

Emerging Clinical Activity of REGN1979, an Anti-CD20 x Anti-CD3 Bispecific Antibody, in Patients with Relapsed/Refractory Follicular Lymphoma (FL), Diffuse Large B-Cell Lymphoma (DLBCL), and Other B-Cell Non-Hodgkin Lymphoma (B-NHL) Subtypes

Rajat Bannerji, MDPhD, Jon E. Arnason, MD, Ranjana Advani, MD, Jennifer R. Brown, MD PhD, John N. Allan, MD, Stephen M. Ansell, MD PhD, Jeffrey Barnes, MD PhD, Susan M. O'Brien, MD, Julio C. Chavez, MD, Johannes Duell, MD, Israel Lowy, MD PhD, Robert Charnas, PhD, David Sternberg, MD PhD, Srikanth Ambati, MBBS, MD, Lieve Adriaens, PharmD, Melanie Ufkin, PhD, Xiaoyu Yan, PhD, Jingjin Li, PhD, Mark Navarro, BA, Peter Gasparini, MS, Vladimir Jankovic, MD, Nathalie Fiaschi, PhD, Wen Zhang, PhD, Sara Hamon, PhD, Gavin Thurston, PhD, Max S. Topp
Journal: Blood
Blood (2018) 132 (Supplement 1): 1690.
https://doi.org/10.1182/blood-2018-99-113328
Published: 2018
Journal Articles

CD20xCD3 Bispecific Fully Human Antibody Induces Potent Anti-Tumor Activity Against CD20-Expressing Tumors in Immune Competent Mice Humanized for CD20 and CD3

Bindu Varghese, PhD, Jayanthi Menon, Luis Rodriguez, Kara Olson, Pamela Krueger, Tammy Huang, PhD, Eric Smith, PhD, Gavin Thurston, PhD, Jessica R. Kirshner, PhD
Journal: Blood
Blood (2015) 126 (23): 818.
https://doi.org/10.1182/blood.V126.23.818.818
Published: 2015
Journal Articles

A Novel CD20xCD3 Bispecific Fully Human Antibody Induces Potent Anti-Tumor Effects Against B Cell Lymphoma in Mice

Bindu Varghese, PhD, Jayanthi Menon, Luis Rodriguez, Lauric Haber, Kara Olson, Paurene Duramad, PhD, Adelekan Oyejide, Eric Smith, PhD, Gavin Thurston, PhD, Jessica Kirshner, PhD
Journal: Blood
Blood (2014) 124 (21): 4501.
https://doi.org/10.1182/blood.V124.21.4501.4501
Published: 2014
Journal Articles

VEGF-mediated cross-talk within the neonatal murine thymus

Andrew R. Cuddihy, Shundi Ge, Judy Zhu, Julie Jang, Ann Chidgey, Gavin Thurston, Richard Boyd, Gay M. Crooks
Journal: Blood
Blood (2009) 113 (12): 2723–2731.
https://doi.org/10.1182/blood-2008-06-162040
Published: 2009
Includes: Multimedia, Supplemental data
Journal Articles

Angiopoietin-1 promotes lymphatic sprouting and hyperplasia

Tuomas Tammela, Anne Saaristo, Marja Lohela, Tohru Morisada, Jenny Tornberg, Camilla Norrmén, Yuichi Oike, Katri Pajusola, Gavin Thurston, Toshio Suda, Seppo Yla-Herttuala, Kari Alitalo
Journal: Blood
Blood (2005) 105 (12): 4642–4648.
https://doi.org/10.1182/blood-2004-08-3327
Published: 2005
Journal Articles

The Tie-2 ligand Angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies

Ulrike Fiedler, Marion Scharpfenecker, Stefanie Koidl, Anja Hegen, Verena Grunow, Jarno M. Schmidt, Wilhelm Kriz, Gavin Thurston, Hellmut G. Augustin
Journal: Blood
Blood (2004) 103 (11): 4150–4156.
https://doi.org/10.1182/blood-2003-10-3685
Published: 2004