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Fadi Towfic, PhD
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Journal Articles

Clonal Somatic Mutations Are a Biomarker for Inferior Prognosis in Diffuse Large B-Cell Lymphoma

Nicholas J. Boddicker, PhD, Pinkal Desai, MDMPH, Mithun Vinod Shah, MD PhD, Vivekananda Sarangi, Matthew J. Maurer, MS, Elliot J. Cahn, Peter Martin, FRCPC, MD MS, Brian K. Link, MD, Thomas E. Witzig, MD, Andrew L. Feldman, MD, Grzegorz S. Nowakowski, MD, Thomas M. Habermann, MD, Susan L. Slager, PhD, C. Chris Huang, PhD, Fadi Towfic, PhD, Yan Asmann, PhD, Anita K Gandhi, PhD, Anne J. Novak, PhD, James R. Cerhan, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 26–27.
https://doi.org/10.1182/blood-2020-141726
Published: 2020
Journal Articles

Genetic and Transcript Changesin Cereblon in IMiD-Treated Myeloma Patients

Sarah Gooding, FRCPath,MRCP,MBBChir, Naser Ansari-Pour, PhD, Fadi Towfic, PhD, Maria Ortiz, Dan Rozelle, PhD, Victoria Zadorozhny, Michael Amatangelo, Erin Flynt, Kao-Tai Tsai, Paola Neri, MD PhD, Nizar Bahlis, MD, Paresh Vyas, MD PhD, Anjan Thakurta
Journal: Blood
Blood (2019) 134 (Supplement_1): 1793.
https://doi.org/10.1182/blood-2019-126828
Published: 2019
Journal Articles

Genomic Landscape Including Novel Mutational Drivers in Relapsed/Refractory Diffuse Large B Cell Lymphoma

Kerstin Wenzl, PhD, Maria Ortiz, Nicholas Stong, PhD, C. Chris Huang, PhD, Matthew J. Maurer, MS, Fadi Towfic, PhD, Patrick R. Hagner, PhD, Hamid Nikbakht, PhD, Matthew Stokes, PhD, Sneh Lata, PhD, Sitharthan Kamalakaran, PhD, Konstantinos Mavrommatis, PhD, Matthew Trotter, PhD, Rebecca L. King, MD, Brian K. Link, MD, Susan L. Slager, PhD, Yan Asmann, PhD, Myron Czuczman, Stephen M Ansell, MD PhD, Thomas M. Habermann, MD, James R. Cerhan, MD PhD, Grzegorz Nowakowski, MD, Anne J Novak, PhD, Anita K Gandhi
Journal: Blood
Blood (2019) 134 (Supplement_1): 919.
https://doi.org/10.1182/blood-2019-123694
Published: 2019
Journal Articles

Clustering of Transcriptomic Signatures in Newly Diagnosed Diffuse Large B-Cell Lymphoma Identifies Two High-Risk Subgroups Which Increase in Prevalence at Relapse

Maria Ortiz, Kerstin Wenzl, PhD, Matthew Stokes, PhD, C. Chris Huang, PhD, Matthew J. Maurer, MS, Fadi Towfic, PhD, Patrick R. Hagner, PhD, Alexander Ratushny, PhD, Mark McConnell, PhD, Samuel A Danziger, PhD, Nicholas Stong, PhD, Sneh Lata, PhD, Sitharthan Kamalakaran, PhD, Konstantimos Mavrommatis, PhD, Matthew Trotter, PhD, Rebecca L. King, MD, Brian K. Link, MD, Susan L. Slager, PhD, Yan Asmann, PhD, Myron Czuczman, Stephen M Ansell, MD PhD, James R. Cerhan, MD PhD, Grzegorz Nowakowski, MD, Thomas M. Habermann, MD, Anita K Gandhi, Anne J Novak, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 923.
https://doi.org/10.1182/blood-2019-122756
Published: 2019
Journal Articles

Large-Scale Analysis of Relapsed/Refractory Multiple Myeloma Genome Reveals Increased Prevalence of High-Risk Molecular Features and Oncogenic Drivers

Fadi Towfic, PhD, Naser Ansari-Pour, PhD, Maria Ortiz, Sarah Gooding, MD PhD, Dan Rozelle, PhD, Victoria Zadorozhny, Konstantinos Mavrommatis, PhD, Sneh Lata, PhD, Nicholas Stong, PhD, Sitharthan Kamalakaran, PhD, Kao-Tai Tsai, Erin Flynt, Anjan Thakurta
Journal: Blood
Blood (2019) 134 (Supplement_1): 365.
https://doi.org/10.1182/blood-2019-124939
Published: 2019
Journal Articles

Gene Expression and Genomic Markers Identify a Subpopulation of Poor Prognosis t(4;14) Patients in Newly Diagnosed Multiple Myeloma

Maria Ortiz, Fadi Towfic, PhD, Erin Flynt, Nicholas Stong, PhD, Sneh Lata, PhD, Dharanya Sampath, Dan Rozelle, PhD, Matthew Trotter, PhD, Jill Corre, PharmD, PhD, Hervé Avet-Loiseau, MD PhD, Anjan Thakurta
Journal: Blood
Blood (2019) 134 (Supplement_1): 366.
https://doi.org/10.1182/blood-2019-128907
Published: 2019
Journal Articles

Interactome of Aiolos/Ikaros in Diffuse Large B-Cell Lymphoma (DLBCL) Reveals Novel Combination of Cereblon Modulators (CELMoD) and Histone Deacetylase (HDAC) Inhibitors

Patrick R. Hagner, PhD, Hsiling Chiu, MS, Vivek S. Chopra, PhD, Martino S. Colombo, PhD, Nisha Patel, PhD, Maria Ortiz, Remco S. Loos, PhD, Fadi Towfic, PhD, Michelle Waldman, MS, Anita K Gandhi
Journal: Blood
Blood (2019) 134 (Supplement_1): 306.
https://doi.org/10.1182/blood-2019-126681
Published: 2019
Journal Articles

Crowdsourced High-Risk Classifiers for Multiple Myeloma Patients Commonly Identify PHF19 As a Robust Progression Biomarker

Michael J Mason, PhD, Carolina D. Schinke, MD, Christine Eng, PhD, Fadi Towfic, PhD, Fred Gruber, PhD, Brian S. White, Yi Cui, PhD, Bailiang Li, PhD, Thomas Yu, BS, William S. Dalton, PhDMD, Hartmut Goldschmidt, MD, Herve Avet-Loiseau, MD PhD, Mehmet Samur, PhD, Maria Ortiz, Matthew Trotter, PhD, Boris Hayete, PhD, Andrew Dervan, Erin Flynt, Hongyue Dai, PhD, Douglas Bassett, PhD, Pieter Sonneveld, Kenneth H. Shain, MD PhD, Nikhil C. Munshi, MD, Daniel Auclair, Dirk Hose, MD, Gareth Morgan, MDPhDFRCP, Jonathan Göke, PhD, Brian A Walker, PhD, Anjan Thakurta, Justin Guinney, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4370.
https://doi.org/10.1182/blood-2019-127362
Published: 2019
Journal Articles

Profiling the Immune Tumor Microenvironment of Newly Diagnosed Diffuse Large B Cell Lymphoma Identifies Three Major Immune Infiltration Patterns

C. Chris Huang, PhD, Yumi Nakayama, PhD, Matthew Stokes, PhD, Fadi Towfic, PhD, chung-Wein Lee, Yan Ren, Mathieu Marella, PhD, Maria Wang, Patrick R. Hagner, PhD, Suzana Couto, Kathryn Newhall, Anita K Gandhi
Journal: Blood
Blood (2019) 134 (Supplement_1): 2797.
https://doi.org/10.1182/blood-2019-123691
Published: 2019
Journal Articles

Eliciting Anti-Tumor T Cell Immunity in Chronic Lymphocytic Leukemia (CLL) with PD-L1/PD-1 Blockade Is Enhanced By Avadomide Immunotherapy through the Triggering of Immunogenic Interferon Signaling

Nikolaos Ioannou, PhD MSc, BSc, Patrick R. Hagner, PhD, Fadi Towfic, PhD, Anita K. Gandhi, PhD, Kostas Stamatopoulos, MD PhD, Piers E.M. Patten, BSc, MRCP, MRCPath, PhD, Anna Vardi, MD PhD, Alan G. Ramsay, BSc,MSc,PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 237.
https://doi.org/10.1182/blood-2018-99-111605
Published: 2018
Journal Articles

Single Cell Analysis of Acquired Pomalidomide-Resistance in Multiple Myeloma Cell Lines Reveals Distinct Subclonal Cereblon Mutations and Gene Expression Heterogeneity

Sarah Gooding, Chad C. Bjorklund, Michael Amatangelo, Yan Ren, Mathieu Marella, Suzana Couto, Christopher Park, Sneh Lata, Reshma Nibhani, Fadi Towfic, PhD, Udo Oppermann, Karthik Ramasamy, William E. Pierceall, Paresh Vyas, Anjan Thakurta, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2648.
https://doi.org/10.1182/blood-2018-99-112644
Published: 2018
Journal Articles

Avadomide (CC-122) Alters T Cell Repertoire and Enhances Infiltration of Lymphocytes into Tumor Microenvironment in DLBCL Patients

Patrick R. Hagner, PhD, Fadi Towfic, PhD, Frank Schmitz, MD PhD, Xuehai Wang, PhD, Andrew P. Weng, MD, Michael Pourdehnad, MD, Anita K. Gandhi, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4211.
https://doi.org/10.1182/blood-2018-99-114481
Published: 2018
Journal Articles

A High-Risk Multiple Myeloma Group Identified By Integrative Multi-Omics Segmentation of Newly Diagnosed Patients

Maria Ortiz, Fadi Towfic, PhD, Mehmet Kemal Samur, PhD, Erin Flynt, In Sock Jang, PhD, Kai Wang, PhD, Cody Ashby, PhD, Brian A Walker, PhD, Matthew Trotter, PhD, Gareth Morgan, MD, Nikhil Munshi, MD, Anjan Thakurta, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3165.
https://doi.org/10.1182/blood-2018-99-117114
Published: 2018
Journal Articles

Discovery of an Immune-Driven Gene Expression Signature That Predicts for Clinical Benefit to CC-122 in Relapsed or Refractory Diffuse Large B-Cell Lymphoma (R/R DLBCL)

Alberto Risueño, PhD, Patrick R. Hagner, PhD, Celia Fontanillo, PhD, Amira Djebbari, DSc, Joel S. Parker, PhD, Clifton P. Drew, PhD, Fadi Towfic, PhD, Michael Pourdehnad, MD, Anita K. Gandhi, PhD, Matthew Trotter, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2830.
https://doi.org/10.1182/blood.V130.Suppl_1.2830.2830
Published: 2017
Journal Articles

Crowdsourcing a High-Risk Classifier for Multiple Myeloma Patients

Andrew P Dervan, Michael Mason, PhD, Fadi Towfic, PhD, Michael Amatangelo, PhD, Daniel Auclair, PhD, Douglas Bassett, PhD, Hongyue Dai, PhD, William S. Dalton, PhDMD, Samuel Danziger, PhD, Erin Flynt, PhD, Hartmut Goldschmidt, MD, Justin Guinney, PhD, Dirk Hose, MD, Konstantimos Mavrommatis, PhD, Gareth J. Morgan, MD PhD, Nikhil Munshi, MD, Alexander Ratushny, PhD, Dan Rozelle, PhD, Mehmet Kemal Samur, PhD, Frank Schmitz, MD PhD, Kenneth H Shain, MD PhD, Matthew Trotter, PhD, Brian A Walker, PhD, Brian S. White, PhD, Thomas Yu, BS, Anjan Thakurta, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 265.
https://doi.org/10.1182/blood.V130.Suppl_1.265.265
Published: 2017
Journal Articles

Identification of Novel Oncogenes and Tumor Suppressor Genes in Newly Diagnosed Multiple Myeloma

Brian A Walker, PhD, Christopher P. Wardell, PhD, Konstantimos Mavrommatis, PhD, Cody Cody Ashby, PhD, Michael Bauer, PhD, Mehmet Kemal Samur, PhD, Fadi Towfic, PhD, Maria Ortiz, Erin Flynt, PhD, Matthew Trotter, PhD, Anjan Thakurta, PhD, Nikhil Munshi, MD, Gareth J. Morgan, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 60.
https://doi.org/10.1182/blood.V130.Suppl_1.60.60
Published: 2017
Journal Articles

FOXM1 Is Associated with Development of Therapeutic Resistance in Multiple Myeloma

Michael Amatangelo, PhD, Maria Ortiz, Paola Neri, MD, Fadi Towfic, PhD, Chad Bjorklund, Jian Kang, Erica Sternberg, Nizar J. Bahlis, MD, Matthew Trotter, PhD, Anjan Thakurta, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1261.
https://doi.org/10.1182/blood.V130.Suppl_1.1261.1261
Published: 2017