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Journal Articles

Combinatorial Administration of Pharmacological Inhibitors Targeting DNMT1 and KDM1A Produces Synergistic and Additive Increases in F Retiulocytes and γ-Globin Expression in Normal Baboons

Vinzon Ibanez, B.S., Kestis Vaitkus, Robert E. Molokie, MD, Yogenthiran Saunthararajah, MD, Donald Lavelle, PhD

Blood (2020) 136 (Supplement 1): 5.

https://doi.org/10.1182/blood-2020-136599

Published: 2020

Journal Articles

Effect of Nicotinamide, 1-Methylnicotinamide, and N'-Methylnicotinamide on Erythroid Colony Formation and γ-Globin Expression in Cultured Baboon CD34+ Cells

Donald Lavelle, PhD, Vinzon Ibanez, B.S., Kestis Vaitkus, Yogenthiran Saunthararajah, MD, Robert E. Molokie, MD

Blood (2020) 136 (Supplement 1): 4–5.

https://doi.org/10.1182/blood-2020-133974

Published: 2020

Journal Articles

Cathepsin B, a Negative Regulator of Autophagy, Identified As a Novel Therapeutic Drug Target in Sickle Cell Disease

Jagadeesh Ramasamy, PhD, Vinzon Ibanez, B.S., Kareem Al-Qadi, Helen Zhang, Jennifer Afranie-Sakyi, MD, Robert E. Molokie, MD, Donald Lavelle, PhD, Angela Rivers, MD

Blood (2020) 136 (Supplement 1): 32.

https://doi.org/10.1182/blood-2020-140119

Published: 2020

Journal Articles

The Impact of Selenium Deficiency on a Sickle Cell Disease Mouse Model

Ramasamy Jagadeeswaran, PhD, Hong Lenny, PhD, Helen Zhang, Jennifer Afranie-Sakyi, Robert E. Molokie, MD, Donald Lavelle, PhD, Alan Diamond, PhD, Angela Rivers, MD

Blood (2018) 132 (Supplement 1): 3645.

https://doi.org/10.1182/blood-2018-99-111833

Published: 2018

Journal Articles

The LSD1 Inhibitor RN-1 Increases γ-Globin Expression in Baboons By Targeting an Early Event Responsible for γ-Globin Repression

Kestis Vaitkus, Vinzon Ibanez, B.S., Maria Armila Ruiz, B.S., Ramasamy Jagadeeswaran, PhD, Yogenthiran Saunthararajah, MD, James Douglas Engel, PhD, Joseph DeSimone, PhD, Angela Rivers, MD, Donald Lavelle, PhD

Blood (2018) 132 (Supplement 1): 1054.

https://doi.org/10.1182/blood-2018-99-113539

Published: 2018

Journal Articles

Oral Administration of the LSD1 Inhibitor OG-S1335 Increases Fetal Hemoglobin in Humanized Transgenic Sickle Cell Disease Mice and in Baboons

Angela Rivers, MD PhD, Kestis Vaitkus, Ramasamy Jagadeeswaran, PhD MSc, Vinzon Ibanez, B.S., Maria Armila Ruiz, B.S., Filippo Ciceri, PhD, Fernando Cavalcanti, PhD, Robert E. Molokie, MD, Donald Lavelle, PhD

Blood (2017) 130 (Supplement 1): 356.

https://doi.org/10.1182/blood.V130.Suppl_1.356.356

Published: 2017

Journal Articles

The Abnormal Presence of Mitochondria in Circulating Red Blood Cells Cause an Increased Oxygen Consumption Rate, ROS Generation and Hemolysis in Patients with Sickle Cell Disease

Ramasamy Jagadeeswaran, PhD MSc, Hong Lenny, PhD, Benjamin Vazquez, BA, Joshua Muniz, BS, Aimee Schad, Shivi Jain, MD, Michel Gowhari, DO, Donald Lavelle, PhD, Alan Diamond, PhD, Robert E. Molokie, MD, Angela Rivers, MD PhD

Blood (2017) 130 (Supplement 1): 2237.

https://doi.org/10.1182/blood.V130.Suppl_1.2237.2237

Published: 2017

Journal Articles

Phase 1 Evaluation of Oral Tetrahydrouridine-Decitabine As Non-Cytotoxic Epigenetic Disease Modification for Sickle Cell Disease

Robert E Molokie, MD, Donald Lavelle, PhD, Michel Gowhari, DO, Michael Pacini, PharmD, Lani Krauz, Johara Hassan, MD, Vinzon Ibanez, Maria A Ruiz, Daisy Pacelli, Sherry Fada, Mitch A. Phelps, PhD, Santosh L. Saraf, MD, Lewis L. Hsu, MD PhD, Victor R. Gordeuk, MD, Joseph DeSimone, PhD, Yogenthiran Saunthararajah, MD

Blood (2016) 128 (22): 124.

https://doi.org/10.1182/blood.V128.22.124.124

Published: 2016

Journal Articles

Efficacy and Safety of Long-Term Treatment with the LSD1 Inhibitor RN-1 to Increase HbF in Normal, Non-Anemic Baboons

Kestis Vaitkus, Vinzon Ibanez, Robert E Molokie, MD, Angela Rivers, MD PhD, Joseph DeSimone, PhD, Donald Lavelle, PhD

Blood (2016) 128 (22): 324.

https://doi.org/10.1182/blood.V128.22.324.324

Published: 2016

Journal Articles

Mitophagy Induction Is a Potential Therapeutic Approach for Sickle Cell Disease

Ramasamy Jagadeeswaran, PhD, Benjamin Alejandro Vazquez, BS, Vinzon Ibanez, Maria A Ruiz, Robert E Molokie, MD, Joseph DeSimone, PhD, Donald Lavelle, PhD, Angela Rivers, MD PhD

Blood (2016) 128 (22): 267.

https://doi.org/10.1182/blood.V128.22.267.267

Published: 2016

Journal Articles

Investigation of Two Combination HbF Induction Regimens, RN-1 and Hydroxyurea Versus RN-1 and Decitabine, in a Humanized Sickle Cell Mouse Model

Ramasamy Jagadeeswaran, PhD, Yash Agarwal, Vinzon Ibanez, Maria Armila Ruiz, Kestis Vaitkus, Joseph DeSimone, PhD, Donald Lavelle, PhD, Angela Rivers, MD PhD

Blood (2015) 126 (23): 3386.

https://doi.org/10.1182/blood.V126.23.3386.3386

Published: 2015

Journal Articles

The LSD1 Inhibitor RN-1 Recapitulates the Fetal Pattern of Hemoglobin Synthesis in Anemic and Normal, Non-Anemic Baboons

Angela Rivers, MD PhD, Kestis Vaitkus, Vinzon Ibanez, Maria Armila Ruiz, Ramaswamy Jagadeeswaran, PhD, Joseph DeSimone, PhD, Donald Lavelle, PhD

Blood (2015) 126 (23): 642.

https://doi.org/10.1182/blood.V126.23.642.642

Published: 2015

Journal Articles

Combination with Thu to Address Pharmacologic Limitations of Decitabine, Interim PK/PD from a Phase 1/2 Clinical Trial of Oral Thu-Decitabine in Sickle Cell Disease

Donald Lavelle, PhD, Michel Gowhari, DO, Michael Pacini, PharmD, Lani Krauz, RN, Johara Hassan, MD, Vinzon Ibanez, Maria A. Ruiz, MSc, Daisy Pacelli, BSc, Chaher Alhandalous, MD, Mitch A. Phelps, PhD, Kathleen Fenner, BS,MS, Reda Z. Mahfouz, MDPhD, John Barnard, Lewis L. Hsu, MD PhD, Victor R. Gordeuk, MD, Joseph DeSimone, PhD, Yogen Saunthararajah, MD, Robert E. Molokie, MD

Blood (2014) 124 (21): 90.

https://doi.org/10.1182/blood.V124.21.90.90

Published: 2014

Journal Articles

The Tet Dioxygenase Co-Factor Ascorbic Acid Reduces DNA Methylation and Increases Expression of the γ-Globin Gene and Acts in a Combinatorial Manner with HbF-Inducing Drugs Targeting Repressive Epigenetic Modifications

Maria Armila Ruiz, B.S., Angela Rivers, MD PhD, Kestis Vaitkus, Vinzon Ibanez, Robert E. Molokie, MD, Joseph DeSimone, PhD, Donald Lavelle, PhD

Blood (2014) 124 (21): 334.

https://doi.org/10.1182/blood.V124.21.334.334

Published: 2014

Journal Articles

RN-1, a Potent and Selective LSD1 Inhibitor, Induces High Levels of Fetal Hemoglobin (HbF) in Anemic Baboons ( P. anubis )

Angela Rivers, MD PhD, Kestis Vaitkus, Maria Armila Ruiz, B.S., Vinzon Ibanez, Tatiana Kouznetsova, M.S., Joseph DeSimone, PhD, Donald Lavelle, PhD

Blood (2014) 124 (21): 336.

https://doi.org/10.1182/blood.V124.21.336.336

Published: 2014

Journal Articles

Expansion of Cord Blood Stem Cells Mediated by Epigenetic Mechanisms Remain Permissive to External Environmental Cues

Hiroto Araki, MD, PhD, Kazumi Yoshinaga, MS, Sudhakar Baluchamy, PhD, Benjamin Petro, BS, Donald Lavelle, PhD, Joseph DeSimone, PhD, Naoyuki Katayama, MD, PhD, Nadim Mahmud, MD, PhD

Blood (2008) 112 (11): 3868.

https://doi.org/10.1182/blood.V112.11.3868.3868

Published: 2008

Journal Articles

The G9A Histone Methyltransferase BIX-01294 Reactivates ε-Globin Expression and Blocks Erythroid Differentiation in Primary Baboon Erythroid Progenitor Cell Cultures

Virryan Banzon, M.S., Vinzon Ibanez, M.S., Kestis Vaitkus, Tatiana Kousnetzova, MS, Joseph Desimone, PhD, Donald Lavelle, PhD

Blood (2008) 112 (11): 129.

https://doi.org/10.1182/blood.V112.11.129.129

Published: 2008

Journal Articles

The Role of DNA Damage/Stress Response Pathways in the Mechanism of Action of Decitabine

Vinzon Ibanez, M.S., Virryan Banzon, M.S., Tatiana Kousnetzova, MS, Kestis Vaitkus, Kenneth Peterson, PhD, Joseph DeSimone, PhD, Donald Lavelle, PhD

Blood (2008) 112 (11): 490.

https://doi.org/10.1182/blood.V112.11.490.490

Published: 2008

Journal Articles

DNA Methylation and Globin Gene Expression.

Yogenthiran Saunthararajah, Donald Lavelle, PhD

Blood (2008) 112 (11): sci-19.

https://doi.org/10.1182/blood.V112.11.sci-19.sci-19

Published: 2008

Journal Articles

Expression of γ-Globin Is Reactivated by a Novel Mechanism in Baboon CD34+ Erythroid Progenitor Cell Cultures.

Donald Lavelle, PhD, Janet Chin, M.D., Mahipal Singh, Ph.D., Kestis Vaitkus, B.S., Virryan Banzon, M.S., Tatiana Kousnetzova, M.S., Maria Hankewych, B.S., Joseph DeSimone, Ph.D.

Blood (2007) 110 (11): 1768.

https://doi.org/10.1182/blood.V110.11.1768.1768

Published: 2007

NARROW

Combinatorial Administration of Pharmacological Inhibitors Targeting DNMT1 and KDM1A Produces Synergistic and Additive Increases in F Retiulocytes and γ-Globin Expression in Normal Baboons

Effect of Nicotinamide, 1-Methylnicotinamide, and N'-Methylnicotinamide on Erythroid Colony Formation and γ-Globin Expression in Cultured Baboon CD34+ Cells

Cathepsin B, a Negative Regulator of Autophagy, Identified As a Novel Therapeutic Drug Target in Sickle Cell Disease

The Impact of Selenium Deficiency on a Sickle Cell Disease Mouse Model

The LSD1 Inhibitor RN-1 Increases γ-Globin Expression in Baboons By Targeting an Early Event Responsible for γ-Globin Repression

Oral Administration of the LSD1 Inhibitor OG-S1335 Increases Fetal Hemoglobin in Humanized Transgenic Sickle Cell Disease Mice and in Baboons

The Abnormal Presence of Mitochondria in Circulating Red Blood Cells Cause an Increased Oxygen Consumption Rate, ROS Generation and Hemolysis in Patients with Sickle Cell Disease

Phase 1 Evaluation of Oral Tetrahydrouridine-Decitabine As Non-Cytotoxic Epigenetic Disease Modification for Sickle Cell Disease

Efficacy and Safety of Long-Term Treatment with the LSD1 Inhibitor RN-1 to Increase HbF in Normal, Non-Anemic Baboons

Mitophagy Induction Is a Potential Therapeutic Approach for Sickle Cell Disease

Investigation of Two Combination HbF Induction Regimens, RN-1 and Hydroxyurea Versus RN-1 and Decitabine, in a Humanized Sickle Cell Mouse Model

The LSD1 Inhibitor RN-1 Recapitulates the Fetal Pattern of Hemoglobin Synthesis in Anemic and Normal, Non-Anemic Baboons

Combination with Thu to Address Pharmacologic Limitations of Decitabine, Interim PK/PD from a Phase 1/2 Clinical Trial of Oral Thu-Decitabine in Sickle Cell Disease

The Tet Dioxygenase Co-Factor Ascorbic Acid Reduces DNA Methylation and Increases Expression of the γ-Globin Gene and Acts in a Combinatorial Manner with HbF-Inducing Drugs Targeting Repressive Epigenetic Modifications

RN-1, a Potent and Selective LSD1 Inhibitor, Induces High Levels of Fetal Hemoglobin (HbF) in Anemic Baboons ( P. anubis )

Expansion of Cord Blood Stem Cells Mediated by Epigenetic Mechanisms Remain Permissive to External Environmental Cues

The G9A Histone Methyltransferase BIX-01294 Reactivates ε-Globin Expression and Blocks Erythroid Differentiation in Primary Baboon Erythroid Progenitor Cell Cultures

The Role of DNA Damage/Stress Response Pathways in the Mechanism of Action of Decitabine

DNA Methylation and Globin Gene Expression.

Expression of γ-Globin Is Reactivated by a Novel Mechanism in Baboon CD34+ Erythroid Progenitor Cell Cultures.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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