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Journal Articles

Concurrent GBT1118 & Losartan Treatment Improves Sickle Cell Nephropathy

Guohui Ren, Maria Armila Ruiz, Suman Setty, Victor R. Gordeuk, Santosh L. Saraf

Blood (2024) 144 (Supplement 1): 2484.

https://doi.org/10.1182/blood-2024-198807

Published: 2024

Journal Articles

Thrombomodulin Protects Against Cell-Free Hemoglobin Mediated Acute Kidney Injury in Sickle Cell Anemia

Guohui Ren, Jiwang Chen, Richard Minshall, Maricela Castellon, Maria Armila Ruiz, Victor R. Gordeuk, Santosh L. Saraf

Blood (2023) 142 (Supplement 1): 3853.

https://doi.org/10.1182/blood-2023-173668

Published: 2023

Journal Articles

Fruit and Vegetable Intake in Adults with Sickle Cell Disease

Syeda Akila Ally, Jin Han, Robert Molokie, Maria Armila Ruiz, Victor R. Gordeuk, James Lash, Santosh L. Saraf

Blood (2023) 142 (Supplement 1): 5301.

https://doi.org/10.1182/blood-2023-180756

Published: 2023

Journal Articles

A Pilot Study for the Kidney Effects of Voxelotor in Sickle Cell Anemia

Santosh L. Saraf, Lani Krauz, Robert Molokie, Franklin Njoku, Maria Armila Ruiz, Guadalupe Salas, Alana Aziz-Bradley, Jin Han, Victor R. Gordeuk

Blood (2023) 142 (Supplement 1): 5296.

https://doi.org/10.1182/blood-2023-178630

Published: 2023

Journal Articles

Defining and Predicting Rapid Egfr Decline in Sickle Cell Disease

Santosh L. Saraf, Jin Han, Maria Armila Ruiz, Andrew Srisuwananukorn, David Shuey, Faiz Ahmed Hussain, Franklin Njoku, Robert E. Molokie, Victor R. Gordeuk

Blood (2021) 138 (Supplement 1): 122.

https://doi.org/10.1182/blood-2021-147861

Published: 2021

Journal Articles

Improved Hemolytic Anemia with GBT1118 Is Reno-Protective in Transgenic Sickle Mice

Guohui Ren, Maria Armila Ruiz, Suman L Setty, Richard Minshall, James P. Lash, Victor R. Gordeuk, Santosh L. Saraf

Blood (2021) 138 (Supplement 1): 192.

https://doi.org/10.1182/blood-2021-145616

Published: 2021

Journal Articles

Haptoglobin 1-1 Isoform Predicts Higher Serum Haptoglobin Concentration and Lower Multiorgan Failure Risk in Sickle Cell Disease

Maria Armila Ruiz, David Shuey, Jin Han, Binal N. Shah, Richard Minshall, James P. Lash, Victor R. Gordeuk, Santosh L. Saraf

Blood (2021) 138 (Supplement 1): 3095.

https://doi.org/10.1182/blood-2021-149697

Published: 2021

Journal Articles

Clinical and Biomarker Predictors for Avascular Necrosis in Sickle Cell Disease

Michael Rabaza, Maria Armila Ruiz, Liana Posch, Faiz Ahmed Hussain, Franklin Njoku, Robert E. Molokie, Jin Han, Victor R. Gordeuk, Karen Xie, Santosh L. Saraf

Blood (2021) 138 (Supplement 1): 3091.

https://doi.org/10.1182/blood-2021-147829

Published: 2021

Journal Articles

Thrombomodulin and Endothelial Dysfunction in Sickle Cell Anemia

Maria Armila Ruiz, MS, Binal N. Shah, Jin Han, PharmD, PhD, Rasha Raslan, MD, Victor R Gordeuk, MD, Santosh L. Saraf, MD

Blood (2019) 134 (Supplement_1): 3558.

https://doi.org/10.1182/blood-2019-123862

Published: 2019

Journal Articles

The LSD1 Inhibitor RN-1 Increases γ-Globin Expression in Baboons By Targeting an Early Event Responsible for γ-Globin Repression

Kestis Vaitkus, Vinzon Ibanez, B.S., Maria Armila Ruiz, B.S., Ramasamy Jagadeeswaran, PhD, Yogenthiran Saunthararajah, MD, James Douglas Engel, PhD, Joseph DeSimone, PhD, Angela Rivers, MD, Donald Lavelle, PhD

Blood (2018) 132 (Supplement 1): 1054.

https://doi.org/10.1182/blood-2018-99-113539

Published: 2018

Journal Articles

Oral Administration of the LSD1 Inhibitor OG-S1335 Increases Fetal Hemoglobin in Humanized Transgenic Sickle Cell Disease Mice and in Baboons

Angela Rivers, MD PhD, Kestis Vaitkus, Ramasamy Jagadeeswaran, PhD MSc, Vinzon Ibanez, B.S., Maria Armila Ruiz, B.S., Filippo Ciceri, PhD, Fernando Cavalcanti, PhD, Robert E. Molokie, MD, Donald Lavelle, PhD

Blood (2017) 130 (Supplement 1): 356.

https://doi.org/10.1182/blood.V130.Suppl_1.356.356

Published: 2017

Journal Articles

Investigation of Two Combination HbF Induction Regimens, RN-1 and Hydroxyurea Versus RN-1 and Decitabine, in a Humanized Sickle Cell Mouse Model

Ramasamy Jagadeeswaran, PhD, Yash Agarwal, Vinzon Ibanez, Maria Armila Ruiz, Kestis Vaitkus, Joseph DeSimone, PhD, Donald Lavelle, PhD, Angela Rivers, MD PhD

Blood (2015) 126 (23): 3386.

https://doi.org/10.1182/blood.V126.23.3386.3386

Published: 2015

Journal Articles

The LSD1 Inhibitor RN-1 Recapitulates the Fetal Pattern of Hemoglobin Synthesis in Anemic and Normal, Non-Anemic Baboons

Angela Rivers, MD PhD, Kestis Vaitkus, Vinzon Ibanez, Maria Armila Ruiz, Ramaswamy Jagadeeswaran, PhD, Joseph DeSimone, PhD, Donald Lavelle, PhD

Blood (2015) 126 (23): 642.

https://doi.org/10.1182/blood.V126.23.642.642

Published: 2015

Journal Articles

RN-1, a Potent and Selective LSD1 Inhibitor, Induces High Levels of Fetal Hemoglobin (HbF) in Anemic Baboons ( P. anubis )

Angela Rivers, MD PhD, Kestis Vaitkus, Maria Armila Ruiz, B.S., Vinzon Ibanez, Tatiana Kouznetsova, M.S., Joseph DeSimone, PhD, Donald Lavelle, PhD

Blood (2014) 124 (21): 336.

https://doi.org/10.1182/blood.V124.21.336.336

Published: 2014

Journal Articles

The Tet Dioxygenase Co-Factor Ascorbic Acid Reduces DNA Methylation and Increases Expression of the γ-Globin Gene and Acts in a Combinatorial Manner with HbF-Inducing Drugs Targeting Repressive Epigenetic Modifications

Maria Armila Ruiz, B.S., Angela Rivers, MD PhD, Kestis Vaitkus, Vinzon Ibanez, Robert E. Molokie, MD, Joseph DeSimone, PhD, Donald Lavelle, PhD

Blood (2014) 124 (21): 334.

https://doi.org/10.1182/blood.V124.21.334.334

Published: 2014

Journal Articles

Elevated Levels Of γ-Globin Gene Promoter 5-Hydroxymethylcytosine are Associated With Increased DNA Hypomethylation and HbF Expression

Maria Armila Ruiz, BS, Angela Rivers, MD, PhD, Kestis Vaitkus, Tatiana Kouznetsova, M.S., Nadim Mahmud, MD, PhD, Joseph DeSimone, PhD, Donald Lavelle, PH.D.

Blood (2013) 122 (21): 438.

https://doi.org/10.1182/blood.V122.21.438.438

Published: 2013

Journal Articles

RN-1, a New and Potent Lsd-1 Inhibitor, Increases γ-Globin Expression In a Humanized Sickle Cell Mouse Model

Angela Rivers, MD, PhD, Maria Armila Ruiz, BS, Kestis Vaitkus, Tatiana Kouznetsova, M.S., Joseph DeSimone, PhD, Donald Lavelle, Ph.D.

Blood (2013) 122 (21): 561.

https://doi.org/10.1182/blood.V122.21.561.561

Published: 2013

Journal Articles

Combinatorial Effect of Pharmacological Inhibitors of Lsd-1 and DNMT on γ-Globin Synthesis in Cultured Baboon Bone Marrow Erythroid Progenitors

Donald Lavelle, Ph.D., Kestis Vaitkus, Maria Armila Ruiz, B.S., Angela Rivers, MD, PhD, James D. Engel, PhD, Joseph DeSimone, PhD

Blood (2012) 120 (21): 249.

https://doi.org/10.1182/blood.V120.21.249.249

Published: 2012

Journal Articles

Dynamic Regulation of 5-Hydroxymethylcytosine At the γ-Globin Promoter During Erythroid Differentiation

Maria Armila Ruiz, B.S., Kestis Vaitkus, Aparna Vasanthakumar, PhD, Angela Rivers, MD, PhD, Tatiana Kouznetsova, M.S., Joseph DeSimone, PhD, Lucy A. Godley, MD, PhD, Donald Lavelle, Ph.D.

Blood (2012) 120 (21): 824.

https://doi.org/10.1182/blood.V120.21.824.824

Published: 2012

Journal Articles

Quantitative Analysis of Tissue and Developmental Stage-Specific Differences in DNA Methylation throughout the β-Globin Gene Locus by DNA MassARRAY,

Maria Armila Ruiz, B.S., Kestutis Vaitkus, B.S., Tatiana Kouznetsova, B.S., Joseph DeSimone, PhD, Yogen Saunthararajah, MD, Donald Lavelle, Ph.D.

Blood (2011) 118 (21): 3196.

https://doi.org/10.1182/blood.V118.21.3196.3196

Published: 2011

NARROW

Concurrent GBT1118 & Losartan Treatment Improves Sickle Cell Nephropathy

Thrombomodulin Protects Against Cell-Free Hemoglobin Mediated Acute Kidney Injury in Sickle Cell Anemia

Fruit and Vegetable Intake in Adults with Sickle Cell Disease

A Pilot Study for the Kidney Effects of Voxelotor in Sickle Cell Anemia

Defining and Predicting Rapid Egfr Decline in Sickle Cell Disease

Improved Hemolytic Anemia with GBT1118 Is Reno-Protective in Transgenic Sickle Mice

Haptoglobin 1-1 Isoform Predicts Higher Serum Haptoglobin Concentration and Lower Multiorgan Failure Risk in Sickle Cell Disease

Clinical and Biomarker Predictors for Avascular Necrosis in Sickle Cell Disease

Thrombomodulin and Endothelial Dysfunction in Sickle Cell Anemia

The LSD1 Inhibitor RN-1 Increases γ-Globin Expression in Baboons By Targeting an Early Event Responsible for γ-Globin Repression

Oral Administration of the LSD1 Inhibitor OG-S1335 Increases Fetal Hemoglobin in Humanized Transgenic Sickle Cell Disease Mice and in Baboons

Investigation of Two Combination HbF Induction Regimens, RN-1 and Hydroxyurea Versus RN-1 and Decitabine, in a Humanized Sickle Cell Mouse Model

The LSD1 Inhibitor RN-1 Recapitulates the Fetal Pattern of Hemoglobin Synthesis in Anemic and Normal, Non-Anemic Baboons

RN-1, a Potent and Selective LSD1 Inhibitor, Induces High Levels of Fetal Hemoglobin (HbF) in Anemic Baboons ( P. anubis )

The Tet Dioxygenase Co-Factor Ascorbic Acid Reduces DNA Methylation and Increases Expression of the γ-Globin Gene and Acts in a Combinatorial Manner with HbF-Inducing Drugs Targeting Repressive Epigenetic Modifications

Elevated Levels Of γ-Globin Gene Promoter 5-Hydroxymethylcytosine are Associated With Increased DNA Hypomethylation and HbF Expression

RN-1, a New and Potent Lsd-1 Inhibitor, Increases γ-Globin Expression In a Humanized Sickle Cell Mouse Model

Combinatorial Effect of Pharmacological Inhibitors of Lsd-1 and DNMT on γ-Globin Synthesis in Cultured Baboon Bone Marrow Erythroid Progenitors

Dynamic Regulation of 5-Hydroxymethylcytosine At the γ-Globin Promoter During Erythroid Differentiation

Quantitative Analysis of Tissue and Developmental Stage-Specific Differences in DNA Methylation throughout the β-Globin Gene Locus by DNA MassARRAY,

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American Society of Hematology

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American Society of Hematology

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