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Journal Articles

Forty Percent of MDS Patients Wish They Received Red Blood Cell Transfusions at Higher Hemoglobin Thresholds Than They Currently Are: A Multinational Transfusion Audit

Rena Buckstein, MD FRCPC, Rebecca Starkman, Yulia Lin, MD FRCPC, Simon J. Stanworth, MD, David Bowen, MD PhD, Lea Harrison, Sophie Wintrich, Jeannie Callum, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3092.
https://doi.org/10.1182/blood-2018-99-110560
Published: 2018
Journal Articles

Longitudinal Changes of Impairments in Health-Related Quality of Life in Lower-Risk MDS Patients: A European Leukemianet Study

Reinhard Stauder, MD MSc, Ge Yu, MSc., Karin A Koinig, PhD, Dominic Culligan, MD, Pierre Fenaux, MD PhD, Jaroslav Cermak, MD PhD, Argiris Symeonidis, MD PhD, Teresa Bernal, MD, Eva Hellström-Lindberg, MD PhD, Moshe Mittelman, MD, Saskia Langemeijer, MD PhD, Mette Skov Holm, MD PhD, Juliet Mills, MD, Agnès Guerci-Bresler, MD, Corine van Marrewijk, PhD, Hege Garelius, MD, Fabio Efficace, PhD, Alexandra Smith, PhD, David Bowen, MD PhD, Theo M de Witte, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3097.
https://doi.org/10.1182/blood-2018-99-112508
Published: 2018
Journal Articles

A Feasibility Randomized Trial of Red Cell Transfusion Thresholds in Myelodysplasia

Simon Stanworth, MD, Sally Killick, MD, Zoe McQuilten, MD, Marina Karakantza, MD, Heather Smethurst, RSCN RGN, Laura Pankhurst, M.Sc, Renate L Hodge, B.Sc, M.Sc, Valerie Hopkins, B.Sc, Helen Thomas, M.Sc, Alison J Deary, M.Sc, Rena Buckstein, MD FRCPC, Jeannie Callum, MD, Yulia Lin, MD FRCPC, David Bowen, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 527.
https://doi.org/10.1182/blood-2018-99-112949
Published: 2018
Journal Articles

Excess Mortality in Low-Risk MDS Can be Explained By MDS and AML Related Causes of Death

Krzysztof Madry, Ge Yu, MSc., Karol Lis, MD, Pierre Fenaux, MD PhD, David Bowen, MD PhD, Argiris Symeonidis, MD PhD, Moshe Mittelman, MD, Reinhard Stauder, MD MSc, Jaroslav Cermak, MD PhD, Guillermo Sanz, Eva Hellström-Lindberg, MD PhD, Luca Malcovati, MD, Saskia Langemeijer, MD PhD, Ulrich Germing, MD, Mette Skov Holm, MD PhD, Agnès Guerci-Bresler, MD, Dominic Culligan, MD, Laurence Sanhes, MD, Juliet Mills, MD, Ioannis Kotsianidis, MD PhD, Corine van Marrewijk, PhD, Simon Crouch, PhD BA, MA, MSc, Theo M de Witte, MD, Alexandra Smith, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4385.
https://doi.org/10.1182/blood-2018-99-115928
Published: 2018
Journal Articles

Elevated Labile Plasma Iron (LPI) Levels in Patients with Lower-Risk Myelodysplastic Syndromes (MDS) Are Associated with Decreased Quality of Life and Reduced Survival

Marlijn Hoeks, MD, Tim Bagguley, MS, Rian Roelofs, Msc, Louise De Swart, MD, David Bowen, MD PhD, Argiris Symeonidis, MD PhD, Corine van Marrewijk, PhD, Eva Hellström-Lindberg, MD PhD, Aurelia Tatic, MD, Saskia Langemeijer, MD PhD, Dominic J. Culligan, Marian Macheta, MD, Hege Garelius, MD, Michail Spanoudakis, MD, Sally Killick, MD, Panagiotis Panagiotidis, MD PhD, Oana Stanca Ciocan, MD, Juliet Mills, MD, Bryson Pottinger, Sam Ackroyd, MD, Claire Hall, MD, Jackie Droste, PhD, Alexandra Smith, PhD, Dorine W. Swinkels, MD PhD, Theo M de Witte, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4392.
https://doi.org/10.1182/blood-2018-99-118070
Published: 2018
Journal Articles

MDS Diagnosis: Many Patients May Not Require Bone Marrow Examination

Howard S. Oster, MD PhD, Simon Crouch, MSc, PhD, Alexandra Smith, PhD, Ge Yu, MSc, Bander Abu Shrkihe, MD, Shoham Baruch, Albert Kolomansky, MD, Jonathan Ben-Ezra, MD, Shachar Naor, MD, Pierre Fenaux, MD PhD, Argiris Symeonidis, MD PhD, Reinhard Stauder, MD MSc, Jaroslav Cermak, MD PhD, Guillermo Sanz, Eva Hellström-Lindberg, MD PhD, Luca Malcovati, MD, Saskia Langemeijer, MD PhD, Ulrich Germing, MD, Mette Skov Holm, MD PhD, Krzysztof Madry, Agnes Guerci-Bresler, MD, Dominic Culligan, MD, Laurence Sanhes, MD, Juliet Mills, MD, Ioannis Kotsianidis, PhD, Corine van Marrewijk, PhD, David Bowen, MD PhD, Theo de Witte, MD PhD, Moshe Mittelman, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4357.
https://doi.org/10.1182/blood-2018-99-111838
Published: 2018
Journal Articles

The Medalist Trial: Results of a Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Luspatercept to Treat Anemia in Patients with Very Low-, Low-, or Intermediate-Risk Myelodysplastic Syndromes (MDS) with Ring Sideroblasts (RS) Who Require Red Blood Cell (RBC) Transfusions

Pierre Fenaux, MD PhD, Uwe Platzbecker, Ghulam J. Mufti, Guillermo Garcia-Manero, MD, Rena Buckstein, MD FRCPC, Valeria Santini, María Díez-Campelo, Carlo Finelli, MD, Mario Cazzola, Osman Ilhan, MD, Mikkael A. Sekeres, MD MS, José F. Falantes, Beatriz Arrizabalaga, MD PhD, Flavia Salvi, Valentina Giai, Paresh Vyas, David Bowen, MD PhD, Dominik Selleslag, MD, Amy E. DeZern, MD, Joseph G. Jurcic, MD, Ulrich Germing, MD, Katharina S. Götze, MD, Bruno Quesnel, Odile Beyne-Rauzy, Thomas Cluzeau, MD PhD, Maria Teresa Voso, Dominiek Mazure, Edo Vellenga, Peter L Greenberg, MD, Eva Hellström-Lindberg, MD PhD, Amer M. Zeidan, MBBS, MHS, Abderrahmane Laadem, MD, Aziz Benzohra, Jennie Zhang, Anita Rampersad, Peter G. Linde, Matthew L. Sherman, Rami S. Komrokji, MD, Alan F. List, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1.
https://doi.org/10.1182/blood-2018-99-110805
Published: 2018
Journal Articles

Deriving Core Patient-Reported Outcomes in Patients with Myelodysplastic Syndromes — a Delphi Survey from the European-MDS Registry

Igor Stojkov, MSc, Annette Conrads-Frank, PhD, Ursula Rochau, MD PhD, Karin A Koinig, PhD, Helena Borba, PhD, Marjan Arvandi, PhD, Pierre Fenaux, MD PhD, Argiris Symeonidis, MD PhD, David Bowen, MD PhD, Moshe Mittelman, MD, Corine van Marrewijk, PhD, Theo de Witte, MD PhD, Fabio Efficace, PhD, Uwe Siebert, MD PhD, Reinhard Stauder, MD MSc
Journal: Blood
Blood (2018) 132 (Supplement 1): 2295.
https://doi.org/10.1182/blood-2018-99-112063
Published: 2018
Journal Articles

Results of a Phase 2 Trial of the Monocyte-Targeted Histone Deacetylase Inhibitor Tefinostat (CHR-2845) in Chronic Myelomonocytic Leukemia (CMML) — the UK Monocle Study

Steven Knapper, DM, Michael Dennis, MD, MRCP, FRCPath, Mark W Drummond, PhDMD, Robert K. Hills, MA, DPhil, MSc, Richard James Dillon, MA, PhD MRCP, FRCPath, Christopher Pocock, MD PhD, Dominic J. Culligan, Paresh Vyas, Daniel Wiseman, MB, ChB, Joanna Zabkiewicz, PhD, Marie Hodges, PhD MSc, Catherine Cargo, MB, FRCPath, Jan Taylor, PhD MSc, BSc, Laura Upton, Melissa Wright, David Bowen, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1818.
https://doi.org/10.1182/blood-2018-99-110356
Published: 2018
Journal Articles

Elevated Labile Plasma Iron Levels (LPI) and Increased Oxidative Stress Are Associated with Red Blood Cell Transfusions in Patients with Lower-Risk Myelodysplastic Syndromes (MDS) Subtitle: from the European Leukemianet MDS Registry

Marlijn Hoeks, MD, Saskia Langemeijer, MD PhD, Louise De Swart, MD, Tim Bagguley, Corine van Marrewijk, PhD, David Bowen, MD PhD, Jaroslav Cermak, Eva Hellstrom-Lindberg, MD PhD, Aurelia Tatic, MD, Argiris Symeonidis, Marian G.J. Van Kraaij, MD PhD, Panagiotis Panagiotidis, Hege Garelius, MD, Dominic J Culligan, Marta Krejci, MD PhD, Jackie Droste, PhD, Alexandra Smith, PhD, Dorine W. Swinkels, MD PhD, Theo de Witte, MD PhD
Journal: Blood
Blood (2016) 128 (22): 4327.
https://doi.org/10.1182/blood.V128.22.4327.4327
Published: 2016
Journal Articles

Impact of Treatment with Iron Chelators in Lower-Risk MDS Patients Participating in the European Leukemianet MDS (EUMDS) Registry

Saskia Langemeijer, MD PhD, Louise De Swart, MD, Ge Yu, MSc., Alex Smith, Simon Crouch, PhD, Tom Johnston, PhD, Pierre Fenaux, MD PhD, Argiris Symeonidis, Jaroslav Cermak, Eva Hellstrom-Lindberg, MD PhD, Guillermo Sanz, MD, Reinhard Stauder, MD, Luca Malcovati, MD, Ulrich Germing, Mette Skov Holm, Moshe Mittelman, MD, Krzysztof Madry, MD PhD, Aurelia Tatic, MD, Antonio Almeida, MD PhD, Aleksandar Savic, Sophie Park, MD PhD, Odile Beyne-Rauzy, MD, Raphaël Itzykson, MD PhD, Corine van Marrewijk, PhD, David Bowen, MD PhD, Theo de Witte, MD PhD
Journal: Blood
Blood (2016) 128 (22): 3186.
https://doi.org/10.1182/blood.V128.22.3186.3186
Published: 2016
Journal Articles

Age and Gender-Related Pretreatment Quality of Life Profiles in Patients with Higher-Risk Myelodysplastic Syndromes. Establishing Benchmark Data from an International Study

Fabio Efficace, PhD, Gianluca Gaidano, MD PhD, Massimo Breccia, MD, Pasquale Niscola, MD, Francesco Cottone, Luana Fianchi, Maria Teresa Voso, Giovanni Caocci, Francesco Buccisano, Emanuele Angelucci, MD, Valeria Santini, MD, Reinhard Stauder, MD MSc, Uwe Platzbecker, MD, Alessandra Ricco, MD, Nicola Di Renzo, David Bowen, MD PhD, Franco Mandelli, MD
Journal: Blood
Blood (2015) 126 (23): 2099.
https://doi.org/10.1182/blood.V126.23.2099.2099
Published: 2015
Journal Articles

Somatic Mutations in MDS Patients Are Associated with Clinical Features and Predict Prognosis Independent of the IPSS-R: Analysis of Combined Datasets from the International Working Group for Prognosis in MDS-Molecular Committee

Rafael Bejar, MDPhD, Elli Papaemmanuil, PhD, Torsten Haferlach, Guillermo Garcia-Manero, MD, Jaroslaw P. Maciejewski, MD PhD, Mikkael A. Sekeres, MD MS, Matthew J. Walter, MD, Timothy A. Graubert, MD, Mario Cazzola, MD, Luca Malcovati, MD, Seishi Ogawa, MD PhD, Pierre Fenaux, MD PhD, Eva Hellstrom-Lindberg, MD PhD, Wolfgang Kern, MD, Jacqueline Boultwood, PhD, Andrea Pellagatti, PhD, David Bowen, MD PhD, Sudhir Tauro, PhD, Michael J Groves, PhD, Paresh Vyas, MD PhD, Lynn Quek, MD, Aziz Nazha, MD, Felicitas Thol, MD, Michael Heuser, MD, Lee-Yung Shih, MD, Eric Padron, MD, David Sallman, MD, Rami S. Komrokji, MD, Alan F. List, MD, Valeria Santini, MD, Michaela Fontenay, MD PhD, Peter J Campbell, MD PhD, Heinz Tüchler, Kristen Stevenson, MS, Donna S Neuberg, ScD, Peter Greenberg, MD, Benjamin L Ebert, MD PhD
Journal: Blood
Blood (2015) 126 (23): 907.
https://doi.org/10.1182/blood.V126.23.907.907
Published: 2015
Journal Articles

Prognostic Impact of Transfusions Intensity on Survival and Development of Thrombocytopenia in Newly Diagnosed Lower-Risk MDS Patients Participating in the European Leukemianet EU-MDS Registry

Louise De Swart, MD, Tom Johnston, PhD, Alexandra Smith, Pierre Fenaux, MD PhD, Argiris Symeonidis, MD PhD, Jaroslav Cermak, MD PhD, Eva Hellström-Lindberg, MD PhD, Guillermo Sanz, MD PhD, Reinhard Stauder, MD MSc, Luca Malcovati, MD, Ulrich Germing, MD, Gerwin Huls, MD PhD, Mette Skov Holm, Moshe Mittelman, MD, Krzysztof Madry, Aurelia Tatic, MD, Antonio Medina Almeida, Aleksandar Savic, Sophie Park, MD PhD, Odile Beyne-Rauzy, MD PhD, Raphaël Itzykson, MD PhD, Corine van Marrewijk, David Bowen, MD PhD, Theo de Witte, MD PhD
Journal: Blood
Blood (2015) 126 (23): 1677.
https://doi.org/10.1182/blood.V126.23.1677.1677
Published: 2015
Journal Articles

Labile Plasma Iron (LPI) Is a Clinical Indicator of Overt Iron Overload in Patients with Lower-Risk Myelodysplastic Syndromes (MDS) from the European Leukemianet MDS Registry

Louise De Swart, MD, Chloé Reiniers, Tim Bagguley, David Bowen, MD PhD, Jaroslav Cermak, MD PhD, Eva Hellström-Lindberg, MD PhD, Aurelia Tatic, MD, Argiris Symeonidis, MD PhD, Gerwin Huls, MD PhD, Panagiotis Panagiotidis, Hege Garelius, MD, Dominic Culligan, Marta Krejci, Corine van Marrewijk, Jackie Droste, PhD, Alexandra Smith, Dorine W. Swinkels, MD PhD, Theo de Witte, MD PhD
Journal: Blood
Blood (2015) 126 (23): 2865.
https://doi.org/10.1182/blood.V126.23.2865.2865
Published: 2015
Journal Articles

TP53 Mutation Status Divides MDS Patients with Complex Karyotypes into Distinct Prognostic Risk Groups: Analysis of Combined Datasets from the International Working Group for MDS-Molecular Prognosis Committee

Rafael Bejar, MDPhD, Elli Papaemmanuil, PhD, Torsten Haferlach, MD, Guillermo Garcia-Manero, MD, Jaroslaw P. Maciejewski, MD PhD, Mikkael A. Sekeres, MD MS, Matthew J. Walter, MD, Timothy A. Graubert, MD, Mario Cazzola, MD, Luca Malcovati, MD, Peter J Campbell, PhD, Seishi Ogawa, MD PhD, Jacqueline Boultwood, PhD, David Bowen, MD PhD, Sudhir Tauro, PhD, Michael J Groves, PhD, Michaela Fontenay, MDPhD, Lee-Yung Shih, MD, Heinz Tüchler, Kristen E. Stevenson, MS, Donna Neuberg, ScD, Peter L. Greenberg, MD PhD, Benjamin L. Ebert, MDPhD
Journal: Blood
Blood (2014) 124 (21): 532.
https://doi.org/10.1182/blood.V124.21.532.532
Published: 2014
Journal Articles

Hepcidin and GDF15 Levels during the First 2 Years Follow-up in Patients with Low and Int-1 Risk Myelodysplastic Syndromes (MDS) from the European Leukemianet MDS Registry

Louise De Swart, MD, Chloé Reiniers, Tim Bagguley, Corine van Marrewijk, PhD, David Bowen, MD PhD, Jaroslav Cermak, MD PhD As. Prof., Eva Hellström-Lindberg, MD PhD, Aurelia Tatic, MD, Argiris Symeonidis, MD PhD, Gerwin A Huls, MD PhD, Alex Smith, Theo de Witte, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3267.
https://doi.org/10.1182/blood.V124.21.3267.3267
Published: 2014
Journal Articles

The Genomic Landscape of Myeloproliferative Neoplasms: Somatic Calr Mutations in the Majority of JAK2-Wildtype Patients

Jyoti Nangalia, MBBChir FRCPath, Charles Massie, PhD, E Joanna Baxter, PhD, Francesca L Nice, MRes, Gunes Gundem, PhD, David Wedge, PhD, Edward Avezov, PhD, Juan Li, PhD, Karoline Kollmann, PhD, David G. Kent, PhD, Athar Aziz, PhD, Anna L Godfrey, BMBCh FRCPath, Jonathan Hinton, MSc, Inigo Martincorena, PhD, Peter Van Loo, PhD, Amy V Jones, PhD, Paola Guglielmelli, PhD MD, Patrick Tarpey, PhD, Heather P Harding, PhD, John D Fitzpatrick, BA, Calum T Goudie, BA, Christina A Ortmann, MD, Stephen J Loughran, PhD, Keiran Raine, MSc, David Jones, MSc, Adam Butler, MSc, Jon W Teague, MSc, Sarah O'Meara, Stuart McLaren, Michele Bianchi, Yvonne Silber, MSc, Danai Dimitropolou, BSc, David Bloxham, MSc FRCPath, Laura J Mudie, BSc, Mark Maddison, BSc, Ben Robinson, BSc, Clodagh Keohane, MD, Cathy MacLean, MSc, Kate Hill, BM BS, Kim H. Orchard, MBBS, PhD, FRCP, FRCPath, Sudhir Tauro, PhD, Ming-Qing Du, MB, PhD, Mel Greaves, PhD, FRS, David Bowen, MD, PhD, Brian Huntly, MBChB FRCPath PhD, Claire N Harrison, DM, FRCP, FRCPath, Nicholas C.P. Cross, PhD, FRCPath, David Ron, MD, Alessandro M Vannucchi, MD, Elli Papaemmanuil, PhD, Peter J. Campbell, PhD, Anthony R Green, FRCPath FMedSci
Journal: Blood
Blood (2013) 122 (21): LBA-2.
https://doi.org/10.1182/blood.V122.21.LBA-2.LBA-2
Published: 2013
Journal Articles

Outcomes In RBC Transfusion-Dependent Patients (Pts) With Low-/Intermediate (Int)-1-Risk Myelodysplastic Syndromes (MDS) With Isolated Deletion 5q Treated With Lenalidomide (LEN): A Subset Analysis From The MDS-004 Study

Aristoteles Giagounidis, MD, PhD, Ghulam J. Mufti, MD, PhD, Moshe Mittelman, MD, Guillermo Sanz, MD, PhD, Uwe Platzbecker, MD, PhD, Petra Muus, MD, PhD, Dominik Selleslag, MD, Odile Beyne-Rauzy, MD, PhD, Peter te Boekhorst, MD, PhD, Consuelo del Cañizo, MD, PhD, Agnès Guerci-Bresler, MD, PhD, Michael Lübbert, MD, PhD, Bruno Quesnel, MD, PhD, Arnold Ganser, MD, David Bowen, MD, PhD, Brigitte Schlegelberger, MD, PhD, Tommy Fu, Bouchra Benettaib, MD, Eva Hellström-Lindberg, MD, PhD, Pierre Fenaux, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 2753.
https://doi.org/10.1182/blood.V122.21.2753.2753
Published: 2013
Journal Articles

Validation Of The Revised International Prognostic Scoring System (IPSS-R) In 1000 Newly Diagnosed MDS Patients With Low- and Intermediate-1 Risk MDS In The European Leukemianet MDS (EUMDS) Registry

Louise de Swart, Alex Smith, Tom Johnston, Detlef Haase, MD, Jackie Droste, Pierre Fenaux, Argiris Symeonidis, MD, PhD, Guillermo Sanz, MD, PhD, Eva Hellström-Lindberg, Jaroslav Cermak, Ass. Prof., PhD, Ulrich Germing, MD, Reinhard Stauder, MD, MSc, Otilia Georgescu, Marius MacKenzie, Luca Malcovati, MD, Mette Skov Holm, Antonio Medina Almeida, Krzysztof Madry, Borhane Slama, Agnès Guerci-Bresler, MD, PhD, Laurence Sanhes, MD, Odile Beyne-Rauzy, Elisa Luño, MD, David Bowen, MD, PhD, Theo de Witte
Journal: Blood
Blood (2013) 122 (21): 2770.
https://doi.org/10.1182/blood.V122.21.2770.2770
Published: 2013