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Mgta-456, an Aryl Hydrocarbon Receptor (AHR) Antagonist Based Expansion of CD34+ Hematopoietic Stem Cells (HSC), Permits Selection of Better HLA Matched Cord Blood Units (CBUs) and Promotes Faster Neutrophil Recovery and Uniform Engraftment with Potentially Less Acute Graft-Vs-Host Disease (GVHD)

Heather Stefanski, MD PhD, Claudio G Brunstein, MD PhD, David H. McKenna, MD, Darin Sumstad, MLS, Jeffrey S. Miller, MD, Bruce R. Blazar, MD, Todd E. DeFor, MS, Anthony E. Boitano, PhD, Michael P. Cooke, PhD, Glen D. Raffel, MD PhD, John C. Davis, Jr., MD MPH, MS, John E. Wagner, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 804.
https://doi.org/10.1182/blood-2019-122329
Published: 2019
Journal Articles

Mgta-456 Contains Large Numbers of Expanded Cord Blood (CB) CD34+CD90+ Hematopoietic Stem Cells (HSC) Which Confer All Engraftment Activity and Correlate with Accelerated Neutrophil Recovery after Myeloablative Conditioning in Patients with Hematologic Malignancy

Anthony E. Boitano, PhD, Michael P. Cooke, PhD, Kevin A. Goncalves, PhD, Darin Sumstad, MLS, John E. Wagner, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2083.
https://doi.org/10.1182/blood-2018-99-114988
Published: 2018
Journal Articles

Clinical Translation of Pluripotent Cell-Derived Off-the-Shelf Natural Killer Cell Cancer Immunotherapy

Frank Cichocki, Ryan Bjordahl, PhD, Svetlana Gaidarova, Paul Rogers, Raedun Clarke, PhD, Brian Groff, Stacey Moreno, Ramzey Abujarour, PhD, Megan Robinson, Greg Bonello, PhD, Tom Lee, PhD, Weijie Lan, PhD, Betsy Rezner, BS, Stewart Abbot, Darin Sumstad, MLS, Bruce Blazar, MD, Daniel Shoemaker, PhD, Scott Wolchko, Dan Kaufman, MD, David H. McKenna, MD, Bahram Valamehr, PhD, Sarah Cooley, MD, Jeffrey S. Miller, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 656.
https://doi.org/10.1182/blood.V130.Suppl_1.656.656
Published: 2017
Journal Articles

Phase 2 Trials with Mgta-456, Single Cord Blood Units (CBU) Expanded with an Aryl Hydrocarbon Receptor (AHR) Antagonist, Demonstrate Uniform Engraftment and Rapid Hematopoietic Recovery in Patients Following Myeloablative or Non-Myeloablative Conditioning

John E. Wagner, MD, Claudio G Brunstein, MD PhD, Todd E. DeFor, MS, Anthony E. Boitano, PhD, David McKenna, MD, Darin Sumstad, MLS, Bastiano Sanna, Conrad Bleul, Michael P Cooke, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 662.
https://doi.org/10.1182/blood.V130.Suppl_1.662.662
Published: 2017
Journal Articles

Umbilical cord blood–derived T regulatory cells to prevent GVHD: kinetics, toxicity profile, and clinical effect

Claudio G. Brunstein, Jeffrey S. Miller, David H. McKenna, Keli L. Hippen, Todd E. DeFor, Darin Sumstad, Julie Curtsinger, Michael R. Verneris, Margaret L. MacMillan, Bruce L. Levine, James L. Riley, Carl H. June, Chap Le, Daniel J. Weisdorf, Philip B. McGlave, Bruce R. Blazar, John E. Wagner
Journal: Blood
Blood (2016) 127 (8): 1044–1051.
https://doi.org/10.1182/blood-2015-06-653667
Published: 2016
Includes: Supplemental data
Journal Articles

StemRegenin-1 (SR1) Expansion Culture Abrogates the Engraftment Barrier Associated with Umbilical Cord Blood Transplantation (UCBT)

John E Wagner, MD, Claudio Brunstein, MD, David McKenna, MD, Darin Sumstad, MT(ASCP), Suzanne Maahs, Mary Laughlin, MD, Michael S. Perry, DVM,PhD, Anthony E. Boitano, PhD, Michael P. Cooke, PhD, Conrad C. Bleul, MD
Journal: Blood
Blood (2014) 124 (21): 728.
https://doi.org/10.1182/blood.V124.21.728.728
Published: 2014
Journal Articles

Safety and Exploratory Efficacy Of Ex Vivo Expanded Umbilical Cord Blood (UCB) Hematopoietic Stem and Progenitor Cells (HSPC) Using Cytokines and Stem-Regenin 1 (SR1): Interim Results Of a Phase 1/2 Dose Escalation Clinical Study

John E. Wagner, MD, Claudio G Brunstein, MD, David McKenna, MD, Darin Sumstad, MT(ASCP), Suzanne Maahs, Anthony E. Boitano, PhD, Michael P. Cooke, PhD, Conrad C. Bleul, MD
Journal: Blood
Blood (2013) 122 (21): 698.
https://doi.org/10.1182/blood.V122.21.698.698
Published: 2013
Journal Articles

The Influence of Bleeding on Trigger Changes for Platelet Transfusion in Chemotherapy-Induced Thrombocytopenic Patients

Benjamin Rioux-Masse, MD, FRCPC, Vincent Laroche, MD, FRCPC, Robert J. Bowman, MD, Bruce R. Lindgren, MS, Claudia S. Cohn, MD, PhD, Shelley M. Pulkrabek, MT(ASCP), CCRC, Terri Carr, RN, BSN, Darin Sumstad, MT(ASCP), Jeffrey McCullough, MD
Journal: Blood
Blood (2011) 118 (21): 1260.
https://doi.org/10.1182/blood.V118.21.1260.1260
Published: 2011
Journal Articles

Adoptive Transfer of Umbilical Cord Blood (UCB)-Derived Regulatory T Cells (Tregs) to Recipients of Nonmyeloablative Unrelated Double UCB Transplantation.

Claudio Brunstein, Keli L. Hippen, David H. McKenna, Qing Cao, Julie Curtsinger, Darin Sumstad, Bruce L. Levine, PhD, James L. Riley, Carl H. June, MD, Jeffrey S. Miller, Bruce R. Blazar, John E. Wagner
Journal: Blood
Blood (2009) 114 (22): 513.
https://doi.org/10.1182/blood.V114.22.513.513
Published: 2009