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Journal Articles

Therapeutic Effects and Metabolic Rewiring upon Glutaminase Loss in T-ALL

Victoria da Silva-Diz, Maya Aleksandrova, Amartya Singh, Eric Chiles, Xiaoyang Su, Daniel Herranz
Journal: Blood
Blood (2023) 142 (Supplement 1): 1448.
https://doi.org/10.1182/blood-2023-190974
Published: 2023
Journal Articles

Forever young: Sphk2 in HSCs, when less is more

Victoria da Silva-Diz, Daniel Herranz
Journal: Blood
Blood (2022) 140 (15): 1658–1660.
https://doi.org/10.1182/blood.2022017932
Published: 2022
Journal Articles

Sirt1 Is a Novel Therapeutic Target in T-ALL

Olga Lancho, Amartya Singh, Victoria da Silva-Diz, Patricia Renck Nunes, Luca Tottone, Shirley Luo, Maya Aleksandrova, Xiaoyang Su, Hossein Khiabanian, Daniel Herranz
Journal: Blood
Blood (2021) 138 (Supplement 1): 2221.
https://doi.org/10.1182/blood-2021-153950
Published: 2021
Journal Articles

A novel and highly effective mitochondrial uncoupling drug in T-cell leukemia

Victoria da Silva-Diz, Bin Cao, Olga Lancho, Eric Chiles, Amer Alasadi, Maya Aleksandrova, Shirley Luo, Amartya Singh, Hanlin Tao, David Augeri, Sonia Minuzzo, Stefano Indraccolo, Hossein Khiabanian, Xiaoyang Su, Shengkan Jin, Daniel Herranz
Journal: Blood
Blood (2021) 138 (15): 1317–1330.
https://doi.org/10.1182/blood.2020008955
Published: 2021
Includes: Supplemental data
Journal Articles

Overcoming NOTCH1-Driven Chemoresistance in T-Cell Acute Lymphoblastic Leukemia Via Metabolic Intervention with Oxphos Inhibitor

Natalia Baran, PhDMD, Alessia Lodi, PhD, Yogesh Dhungana, PhD, Shannon RENEE Sweeney, PhD, Pandey Renu, PhD, Shelley Herbrich, PhD, Fieke W Hoff, BSc, Anna Skwarska, PhD, Mecit Kaplan, MS, Vinitha Mary Kuruvilla, MSc, Antonio Cavazos, MSc, Marc Warmoes, PhD, Shanti Rojas-Sutterlin, PhD, Andre Haman, PhD, Diogo Troggian Veiga, PhD, Ken Furudate, DDM, PhD, Helen Ma, MS, Karine Harutyunyan, PhD, Wentao Yang, Mihai Gagea, MDPhD, Di Du, PhD, May Daher, Luciana Melo Garcia, MD, Sujan Piya, PhD, Vivian Ruvolo, MS, Sriram Shanmugavelandy, Ningping Feng, PhD, Jason P Gay, MS, Ondrej Havranek, MDPhD, Jared Henderson, MS, Katarzyna Tomczak, PhD, Marcin Kaminski, PhD, Daniel Herranz, PharmD, Adolfo Ferrando, MD, PhD, Elias Jabbour, MD, Maria E Di Francesco, PhD, David T. Teachey, MD, Terzah M. Horton, MD PhD, Katayoun Rezvani, MD PhD, Jun J. Yang, PhD, Steven M. Kornblau, MD, Eric Davis, MD, Koichi Takahashi, MD PhD, Michael Andreeff, MD PhD, Joseph R Marszalek, PhD, Philip Lorenzi, PhD, Jiyang Yu, PhD, Stefano Tiziani, PhD, Trang Hoang, PhD, Marina Konopleva, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 18–20.
https://doi.org/10.1182/blood-2020-136801
Published: 2020
Journal Articles

Glutaminase Inhibition Overcomes Acquired Resistance to Mitochondrial Complex I in NOTCH1-Driven T-Cell Acute Lymphoblastic Leukemias (T-ALL) Via Block of Glutamine Driven Reductive Metabolism

Natalia Baran, PhDMD, Alessia Lodi, PhD, Shannon Renee Sweeney, PhD, Vinitha Mary Kuruvilla, MSc, Antonio Cavazos, Daniel Herranz, PharmD, Anna Skwarska, PhD, Marc Warmoes, PhD, Eric Davis, MD, Karine Harutyunyan, PhD, Ningping Feng, PhD, Jason P Gay, MS, Marcin Kaminski, PhD, Sergej Konoplev, Elias Jabbour, MD, Adolfo A. Ferrando, MD PhD, Maria E Di Francesco, PhD, Philip Lorenzi, Joseph R Marszalek, PhD, Stefano Tiziani, PhD, Marina Y Konopleva, MD PhD, Pandey Renu, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 806.
https://doi.org/10.1182/blood-2019-128930
Published: 2019
Journal Articles

Mitochondrial Complex I Inhibitor Iacs-010759 Reverses the NOTCH1-Driven Metabolic Reprogramming in T-ALL Via Blockade of Oxidative Phosphorylation: Synergy with Chemotherapy and Glutaminase Inhibition

Natalia Baran, PhDMD, Alessia Lodi, PhD, Shannon Renee Sweeney, MS, Pandey Renu, PhD, Vinitha Mary Kuruvilla, Antonio Cavazos, MSc, Daniel Herranz, PharmD, Anna Skwarska, PhD, Marc Warmoes, PhD, R. Eric Davis, MD, Karine Harutyunyan, PhD, Ningping Feng, PhD, Jason P Gay, MS, Sergej Naumovich Konoplev, MD PhD, Marcin Kaminski, PhD, Jeffrey J Kovacs, PhD, Di Du, PhD, Elias J. Jabbour, MD, Adolfo A. Ferrando, MD PhD, Maria E Di Francesco, PhD, Philip L Lorenzi, PhD, Joseph R Marszalek, PhD, Stefano Tiziani, PhD, Marina Y. Konopleva, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4020.
https://doi.org/10.1182/blood-2018-99-117310
Published: 2018
Journal Articles

Suppression of GATA3 Binding Drives Selective Abrogation of NOTCH1-MYC Enhancer Activity By Nucleosome Invasion in Thymocyte Development and Leukemia

Laura Belver, PhD, Alexander Y Yang, Daniel Herranz, PharmD, Aidan Quinn, Francesco G Brundu, PhD, Pablo Perez-Duran, PhD, Silvia Alvarez, PhD, Devya Gurung, Pedro P Rocha, PhD, Ramya Raviram, PhD, Marissa Rashkovan, PhD, Raul Rabadan, PhD, Adolfo A. Ferrando, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 545.
https://doi.org/10.1182/blood-2018-99-119423
Published: 2018
Journal Articles

Synergistic Targeting of Protein Translation and Inhibition of NOTCH Signaling in T-ALL

Marta Sanchez-Martin, PhD, Alberto Ambesi-Impiombato, MDPhD, Luyao Xu, Yue Qin, Daniel Herranz, PhD, Mukesh Bansal, PhD, Tiziana Girardi, Kim De Keersmaecker, Andrea Califano, PhD, Adolfo A. Ferrando, MD PhD
Journal: Blood
Blood (2015) 126 (23): 3719.
https://doi.org/10.1182/blood.V126.23.3719.3719
Published: 2015
Journal Articles

­­­­­­N-Me, a Long Range T-Cell Specific Oncogenic Enhancer in T-ALL

Daniel Herranz, PhD, Alberto Ambesi-Impiombato, MD PhD, Teresa Palomero, PhD, Stephanie A. Schnell, Laura Belver, PhD, Agnieszka A. Wendorff, PhD, Luyao Xu, Mireia Castillo-Martin, MD, David Llobet-Navas, PhD, Carlos Cordon-Cardo, MD PhD, Emmanuelle Clappier, Jean Soulier, MD PhD, Adolfo A. Ferrando, MD PhD
Journal: Blood
Blood (2014) 124 (21): 487.
https://doi.org/10.1182/blood.V124.21.487.487
Published: 2014
Journal Articles

An Oncogenic Metabolic Switch Mediates Resistance to NOTCH1 Inhibition in T-ALL

Daniel Herranz, PhD, Valeria Tosello, PhD, Alberto Ambesi-Impiombato, MD, PhD, Mireia Castillo, MD, Carlos Cordon-Cardo, MD, PhD, Adolfo A. Ferrando, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 285.
https://doi.org/10.1182/blood.V120.21.285.285
Published: 2012