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Journal Articles

Novel Thermostable Inhibitor of Contact Activation Tica Effectively Blocks Contact Activation in Low Tissue Factor Thrombin Generation

Tom Van De Berg, MD, Dennis P.L. Suylen, M.G.L. Christella D. Thomassen, Rene van Oerle, Henri M.H. Spronk, PhD, Rafael Apitz, PhD, H. Coenraad Hemker, MD PhD, Tilman M. Hackeng, PhD

Blood (2019) 134 (Supplement_1): 1146.

https://doi.org/10.1182/blood-2019-130875

Published: 2019

Journal Articles

Development of a Neural Network to Predict Thrombosis in the Antiphospholipid Syndrome with an Accuracy of 87%

Romy Kremers, PhD, Stéphane Zuily, MD PhD, Philip De Groot, PhD, Coenraad Hemker, MD PhD, Denis Wahl, MD PhD, Bas De Laat, MD, PhD

Blood (2018) 132 (Supplement 1): 3796.

https://doi.org/10.1182/blood-2018-99-115834

Published: 2018

Journal Articles

Applying Neural Networking Identifies Antiphospholipid Syndrome Patients with an Accuracy of 98.7%

Romy Kremers, PhD, Stéphane Zuily, MDPhD, Hilde Kelchtermans, PhD, Philip G. de Groot, PhD, Tessa Peters, Saartje Bloemen, PhD, Coenraad Hemker, MD PhD, Denis Wahl, MD PhD, Bas De Laat, MD PhD

Blood (2017) 130 (Supplement 1): 460.

https://doi.org/10.1182/blood.V130.Suppl_1.460.460

Published: 2017

Journal Articles

Fixed Doses of Anticoagulants Cause Wide Variation of Thrombin Generation

Coenraad Hemker, MD PhD, Saartje Bloemen, PhD, Romy Kremers, PhD, Hilde Kelchtermans, PhD, Bas De Laat, MD PhD

Blood (2016) 128 (22): 5012.

https://doi.org/10.1182/blood.V128.22.5012.5012

Published: 2016

Journal Articles

Elevated Fibrinogen Levels in Patients Treated with Vitamin K Antagonists Attenuate the Inactivation of Thrombin

Romy Kremers, PhD, Saartje Bloemen, PhD, Hilde Kelchtermans, PhD, Tessa Peters, Rob Wagenvoord, PhD, Bas De Laat, MD PhD, Coenraad Hemker, MD PhD

Blood (2016) 128 (22): 3837.

https://doi.org/10.1182/blood.V128.22.3837.3837

Published: 2016

Journal Articles

Rebalanced Thrombin Generation in Liver Cirrhosis Calls for Tailored Transfusion Protocols

Romy Kremers, MSc, Marie-Claire Kleinegris, MD, Hugo ten Cate, MD PhD, Bas De Laat, MD PhD, Rob Wagenvoord, PhD, Coenraad Hemker, MD PhD

Blood (2015) 126 (23): 3523.

https://doi.org/10.1182/blood.V126.23.3523.3523

Published: 2015

Journal Articles

Restoration of Procoagulant Factor Levels after Cardiac Surgery Causes Thrombin Generation to Rise to Thrombotic Levels

Romy Kremers, MSc, Yvonne Bosch, MSc, Saartje Bloemen, PhD, Bas De Laat, MD PhD, Rob Wagenvoord, PhD, Raed Al Dieri, PhDPharmD, Coenraad Hemker, MD PhD

Blood (2015) 126 (23): 1143.

https://doi.org/10.1182/blood.V126.23.1143.1143

Published: 2015

Journal Articles

Thrombin generation: biochemical possibilities and clinical reality

H. Coenraad Hemker

Blood (2015) 126 (3): 288–289.

https://doi.org/10.1182/blood-2015-05-643403

Published: 2015

Journal Articles

Characterization of an autosomal dominant bleeding disorder caused by a thrombomodulin mutation

Yesim Dargaud, Jean Yves Scoazec, Simone J. H. Wielders, Christine Trzeciak, Tilman M. Hackeng, Claude Négrier, H. Coenraad Hemker, Theo Lindhout, Elisabetta Castoldi

Blood (2015) 125 (9): 1497–1501.

https://doi.org/10.1182/blood-2014-10-604553

Published: 2015

Journal Articles

Thrombin Generation in Zebrafish

Evelien Schurgers, PhD, Martijn Moorlag, Hilde Kelchtermans, PhD, Coenraad Hemker, PhD, Bas De Laat, PhD

Blood (2014) 124 (21): 4218.

https://doi.org/10.1182/blood.V124.21.4218.4218

Published: 2014

Journal Articles

Simultaneous Measurement of Thrombin Generation and Fibrin Formation in Whole Blood Applying Continuous Flow Is Predictive for the Amount of Blood Loss during/after Cardiothoracic Surgery

Leonie Pelkmans, Anne Bouwhuis, Evelien Schurgers, PhD, Theo Lindhout, PhD, Dana Huskens, PhD, Coenraad Hemker, PhD, Marcus Lancé, MD, Bas De Laat, PhD, Hilde Kelchtermans, PhD

Blood (2014) 124 (21): 2813.

https://doi.org/10.1182/blood.V124.21.2813.2813

Published: 2014

Journal Articles

Thrombin-Dependent Incorporation of Von Willebrand Factor into a Fibrin Network

Adam Miszta, PhD, Leonie Pelkmans, Theo Lindhout, PhD, Philip De Groot, Coenraad Hemker, PhD, Johan Heemskerk, PhD, Hilde Kelchtermans, PhD, Bas De Laat, PhD

Blood (2014) 124 (21): 101.

https://doi.org/10.1182/blood.V124.21.101.101

Published: 2014

Journal Articles

Nonanticoagulant heparin prevents histone-mediated cytotoxicity in vitro and improves survival in sepsis

Karin C. A. A. Wildhagen, Pablo García de Frutos, Chris P. Reutelingsperger, Roy Schrijver, Cristina Aresté, Almudena Ortega-Gómez, Niko M. Deckers, H. Coenraad Hemker, Oliver Soehnlein, Gerry A. F. Nicolaes

Blood (2014) 123 (7): 1098–1101.

https://doi.org/10.1182/blood-2013-07-514984

Published: 2014

Includes: Supplemental data

Journal Articles

Mechanism Of Peak Protraction In Thrombin Generation After Administration Of Direct Factor Xa Inhibitors

Saartje Bloemen, Bas De Laat, PhD, H. Coenraad Hemker, Raed Al Dieri, PhD

Blood (2013) 122 (21): 1141.

https://doi.org/10.1182/blood.V122.21.1141.1141

Published: 2013

Journal Articles

Thrombin Generation Measurement In Whole Blood As a Control For Vitamin K Antagonist Treatment - Effect Of Thrombomodulin

Saartje Bloemen, Marieke de Laat, Arina ten Cate-Hoek, Hugo ten Cate, Bas De Laat, PhD, H. Coenraad Hemker, PhD, Raed Al Dieri, PhD

Blood (2013) 122 (21): 3646.

https://doi.org/10.1182/blood.V122.21.3646.3646

Published: 2013

Journal Articles

α2Macroglobulin Fails To Compensate For Decreased Thrombin Decay In Severe Antithrombin Deficiency In Liver Cirrhosis Patients

Romy Kremers, Marie-Claire Kleinegris, Bas De Laat, PhD, Rob Wagenvoord, PhD, Coenraad Hemker, PhD

Blood (2013) 122 (21): 3576.

https://doi.org/10.1182/blood.V122.21.3576.3576

Published: 2013

Journal Articles

Fibrinogen Attentuates Thrombin Decay In a Concentration-Dependent Manner

Romy Kremers, Rob Wagenvoord, PhD, Coenraad Hemker, PhD

Blood (2013) 122 (21): 2346.

https://doi.org/10.1182/blood.V122.21.2346.2346

Published: 2013

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Novel Thermostable Inhibitor of Contact Activation Tica Effectively Blocks Contact Activation in Low Tissue Factor Thrombin Generation

Development of a Neural Network to Predict Thrombosis in the Antiphospholipid Syndrome with an Accuracy of 87%

Applying Neural Networking Identifies Antiphospholipid Syndrome Patients with an Accuracy of 98.7%

Fixed Doses of Anticoagulants Cause Wide Variation of Thrombin Generation

Elevated Fibrinogen Levels in Patients Treated with Vitamin K Antagonists Attenuate the Inactivation of Thrombin

Rebalanced Thrombin Generation in Liver Cirrhosis Calls for Tailored Transfusion Protocols

Restoration of Procoagulant Factor Levels after Cardiac Surgery Causes Thrombin Generation to Rise to Thrombotic Levels

Thrombin generation: biochemical possibilities and clinical reality

Characterization of an autosomal dominant bleeding disorder caused by a thrombomodulin mutation

Thrombin Generation in Zebrafish

Simultaneous Measurement of Thrombin Generation and Fibrin Formation in Whole Blood Applying Continuous Flow Is Predictive for the Amount of Blood Loss during/after Cardiothoracic Surgery

Thrombin-Dependent Incorporation of Von Willebrand Factor into a Fibrin Network

Nonanticoagulant heparin prevents histone-mediated cytotoxicity in vitro and improves survival in sepsis

Mechanism Of Peak Protraction In Thrombin Generation After Administration Of Direct Factor Xa Inhibitors

Thrombin Generation Measurement In Whole Blood As a Control For Vitamin K Antagonist Treatment - Effect Of Thrombomodulin

α2Macroglobulin Fails To Compensate For Decreased Thrombin Decay In Severe Antithrombin Deficiency In Liver Cirrhosis Patients

Fibrinogen Attentuates Thrombin Decay In a Concentration-Dependent Manner

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