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Chunsheng Chen, PhD
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Journal Articles

A Novel, Highly Potent and Selective PDE9 Inhibitor for the Treatment of Sickle Cell Disease

James G McArthur, PhD, Thiago Maciel, PhD, Chunsheng Chen, PhD, Aurelie Fricot, Dione Kobayashi, PhD, Julia Nguyen, BS, Phong Nguyen, Anna Parachova, PhD, Fuad Abdulla, Gregory M. Vercellotti, MD, Niels Svenstrup, PhD, John D Belcher, PhD
Journal: Blood
Blood (2016) 128 (22): 268.
https://doi.org/10.1182/blood.V128.22.268.268
Published: 2016
Journal Articles

Haptoglobin and Hemopexin Infusion Efficiently Activates the Nrf2/HO-1 Axis and Inhibits Inflammation and Vaso-Occlusion in Murine Sickle Cell Disease

John D Belcher, PhD, Chunsheng Chen, PhD, Julia Nguyen, BS, Fuad Abdulla, DVM, Phong Nguyen, BS, Hao Nguyen, Ping Zhang, PhD, Nathan Brinkman, Gregory M Vercellotti, MD
Journal: Blood
Blood (2016) 128 (22): 2477.
https://doi.org/10.1182/blood.V128.22.2477.2477
Published: 2016
Journal Articles

Complement Activation in a Murine Model of Sickle Cell Disease: Inhibition of Vaso-Occlusion By Blocking C5 Activation

Terry Robert Schaid, Jr., BA, Julia Nguyen, BS, Chunsheng Chen, PhD, Fuad Abdulla, DVM, Trevor Killeen, Hao Nguyen, Joseph Edmund, MBBS, Margaret A Lindorfer, PhD, Ronald P Taylor, PhD, Agustin P Dalmasso, MD, John D Belcher, PhD, Gregory M Vercellotti, MD
Journal: Blood
Blood (2016) 128 (22): 158.
https://doi.org/10.1182/blood.V128.22.158.158
Published: 2016
Journal Articles

Hemopexin Gene Therapy Inhibits Inflammation and Vaso-Occlusion in Transgenic Sickle Cell Mice

Gregory M Vercellotti, Ping Zhang, PhD, Chunsheng Chen, PhD, Julia Nguyen, BS, Fuad Abdulla, DVM, Phong Nguyen, BS, Carlos Nowotny, Aman Irfanullah, Ann Smith, PhD, Clifford J. Steer, MD, John D. Belcher, PhD
Journal: Blood
Blood (2015) 126 (23): 412.
https://doi.org/10.1182/blood.V126.23.412.412
Published: 2015
Journal Articles

H-Ferritin Ferroxidase Activity Induces Cytoprotective Pathways and Inhibits Microvascular Stasis in Transgenic Sickle Mice

Gregory M Vercellotti, MD, Chunsheng Chen, PhD, Carol M Bruzzone, MS, Heather A. Bechtel, MD, Julia Ngyuen, BS, Robert P Hebbel, MD, Clifford J Steer, MD, John D Belcher, PhD
Journal: Blood
Blood (2012) 120 (21): 378.
https://doi.org/10.1182/blood.V120.21.378.378
Published: 2012
Journal Articles

MP4CO, a Pegylated Hemoglobin Saturated with Carbon Monoxide, Inhibits Microvascular Stasis in Transgenic Sickle Mice Through Heme Oxygenase-1.

John D Belcher, PhD, Chunsheng Chen, PhD, Mark Young, PhD, Kenneth Burhop, PhD, Gregory M Vercellotti, MD
Journal: Blood
Blood (2012) 120 (21): 2112.
https://doi.org/10.1182/blood.V120.21.2112.2112
Published: 2012
Journal Articles

Prevention of Venular Stasis, Circulatory Collapse and Mortality in Transgenic Sickle Mice Administered MP4CO, a Pegylated Hemoglobin Saturated with Carbon Monoxide

John D Belcher, PhD, Chunsheng Chen, PhD, Mark Young, PhD, Phuc Tran, Gregory M Vercellotti, MD
Journal: Blood
Blood (2011) 118 (21): 850.
https://doi.org/10.1182/blood.V118.21.850.850
Published: 2011
Journal Articles

Plasma Hemoglobin and Heme Trigger Weibel Palade Body Exocytosis and Vaso-Occlusion in Transgenic Sickle Mice

John D Belcher, PhD, Julia Nguyen, Chunsheng Chen, PhD, Ann Smith, PhD, Abdu I Alayash, PhD, DSc, Sethu L Nair, PhD, Arif Somani, MD, Robert P Hebbel, MD, Gregory M Vercellotti, MD
Journal: Blood
Blood (2011) 118 (21): 896.
https://doi.org/10.1182/blood.V118.21.896.896
Published: 2011
Journal Articles

Carbon Monoxide Decreases Leukocytosis in Murine Sickle Cell Disease Models Via Decreased Granulopoiesis.

Joan D Beckman, BS, Julie V. Vineyard, BS, Chunsheng Chen, PhD, Julia Ngyuen, BS, Michael O Nwaneri, M.D., Paul Marker, BS, John D. Belcher, Ph.D., Gregory M. Vercellotti, MD
Journal: Blood
Blood (2008) 112 (11): 1433.
https://doi.org/10.1182/blood.V112.11.1433.1433
Published: 2008
Journal Articles

Microenvironment-Induced Endothelial Heterogeneity Stimulates Retinal Neovascularization in Sickle Mice.

Kalpna Gupta, PhD, Chunsheng Chen, PhD, Gerard A. Lutty, MD, Robert P. Hebbel, MD
Journal: Blood
Blood (2006) 108 (11): 1198.
https://doi.org/10.1182/blood.V108.11.1198.1198
Published: 2006