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Journal Articles

Evaluation of Maternal Safety Following Prenatal Cell and Gene Therapy for Hemophilia a in a Large Animal Model Demonstrates Absence of Maternal Exposure to the Cells or Gene Products Infused into the Fetus

Quan DM Pham, Martin Rodriguez, BSc, Ritu M Ramamurthy, Sunil George, PhD, Jorge Figueroa, MD, Anthony Atala, MD, Christopher B Doering, PhD, H. Trent Spencer, PhD, Christopher D Porada, PhD, M. Graca Almeida-Porada, MD PhD

Blood (2020) 136 (Supplement 1): 32.

https://doi.org/10.1182/blood-2020-140883

Published: 2020

Journal Articles

Administration of Cells Engineered to Secrete Fviii-mcoET3 in Prenatal Sheep Recipients Results in Sustained Curative Fviii Plasma Levels for 3 Years after Birth, without Immune or Toxicity-Related Adverse Events

Martin Rodriguez, BSc, Brady Trevisan, Sunil George, PhD, Ritu M Ramamurthy, Andrew Rabah, Jordan E Shields, MS, Denise Schwahn, DVM, Jorge Figueroa, MD, Diane Meares, John Owen, MDMBA,FRCPC, Michael Gautreaux, PhD, D.ABHI, Anthony Atala, MD, Christopher B Doering, PhD, H. Trent Spencer, PhD, Christopher D Porada, PhD, M. Graca Almeida-Porada, MD PhD

Blood (2020) 136 (Supplement 1): 1–2.

https://doi.org/10.1182/blood-2020-140845

Published: 2020

Journal Articles

Delivery of Fviii-mcoET3 to Previously Untreated Sheep Using Human Placental Cells Enables Durable Elevation of Plasma FVIII Levels and Avoids Inhibitor Formation

Brady Trevisan, Martin Rodriguez, BSc, Sunil George, PhD, Shannon Lankford, Jordan E Shields, MS, Jorge Figueroa, MD, Diane Meares, John Owen, MDMBA,FRCPC, Anthony Atala, MD, Christopher B Doering, PhD, H. Trent Spencer, PhD, Christopher D Porada, PhD, M. Graca Almeida-Porada, MD PhD

Blood (2020) 136 (Supplement 1): 34.

https://doi.org/10.1182/blood-2020-140745

Published: 2020

Journal Articles

The 3.2 Angstrom Crystal Structure of a Bioengineered Factor VIII Construct Illustrates Two Conformations of the C2 Domain

Ian W Smith, MS, Anne d'Aquino, BS, Ernest T. Parker, Christopher B Doering, PhD, Paul C Spiegel, Jr., PhD

Blood (2018) 132 (Supplement 1): 21.

https://doi.org/10.1182/blood-2018-99-119083

Published: 2018

Journal Articles

Engineering CD5-Targeted Chimeric Antigen Receptors and Edited T Cells for the Treatment of T-Cell Leukemia

Lauren C Fleischer, Sunil S Raikar, MD, Robert Moot, B.S., Kristopher A Knight, B.S., Christopher B Doering, PhD, H. Trent Spencer, PhD

Blood (2017) 130 (Supplement 1): 1914.

https://doi.org/10.1182/blood.V130.Suppl_1.1914.1914

Published: 2017

Journal Articles

Prenatal Transplantation of Placental Cells Engineered to Express FVIII Leads to Corrective Plasma Levels of FVIII after Birth

M. Graca Almeida-Porada, MD PhD, Sunil George, PhD, Alshaima Morsi, MD, Nadia El-Akabawy, MD, Jorge Figueroa, Jordan E Shields, MS, Diane Meares, Andrew M. Farland, MD, Anthony Atala, MD, Christopher B Doering, PhD, H. Trent Spencer, PhD, Christopher D Porada, PhD

Blood (2017) 130 (Supplement 1): 361.

https://doi.org/10.1182/blood.V130.Suppl_1.361.361

Published: 2017

Journal Articles

Factor V Atlanta: A Novel Mutation in the F5 Gene Reveals Potential New Cis-Acting Elements Involved in Regulating FV-Short and TFPI Levels

Karen L Zimowski, MD, Michelle D. Ho, BS, Jordan E Shields, MS, Gabriela Denning, PhD, Teodolinda Petrillo, PhD, Navdeep Jhita, MD, Angel A Rivera, PhD, Miguel A Escobar, MD, Christine L Kempton, Christopher B Doering, PhD, Rodney M Camire, PhD

Blood (2017) 130 (Supplement 1): 366.

https://doi.org/10.1182/blood.V130.Suppl_1.366.366

Published: 2017

Journal Articles

Targeting T-Cell Malignancies with Chimeric Antigen Receptors Using Two Structurally Different Antigen Binding Domains Against CD5

Sunil S Raikar, MD, Lauren C Fleischer, Robert Moot, B.S., Na Yoon Paik, B.S., Kristopher Knight, B.S., Christopher B Doering, PhD, H. Trent Spencer, PhD

Blood (2017) 130 (Supplement 1): 4462.

https://doi.org/10.1182/blood.V130.Suppl_1.4462.4462

Published: 2017

Journal Articles

Ancestral Sequence Reconstruction of Von Willebrand Factor Reveals Highly Conserved Structure/Function

Philip M Zakas, PhD, Caelan Radford, Christine Brown, Courtney Dwyer, RLAT, Christopher B Doering, PhD, Eric A Gaucher, PhD, David Lillicrap, MD FRCPC

Blood (2017) 130 (Supplement 1): 240.

https://doi.org/10.1182/blood.V130.Suppl_1.240.240

Published: 2017

Journal Articles

The Impact of Anti-Factor VIII A1 and A3 Domain Antibodies in the Immune Reponse to Factor VIII in Patients with Hemophilia a

Jasmine C Ito, Courtney Cox, MSc, W. Hunter Baldwin, BS, Christopher B Doering, PhD, Shannon L. Meeks, MD

Blood (2017) 130 (Supplement 1): 2373.

https://doi.org/10.1182/blood.V130.Suppl_1.2373.2373

Published: 2017

Journal Articles

Characterization of Factor VIII Immune Complexes By Analytical Ultracentrifugation

Pete Lollar, MD, Ernest T. Parker, John F. Healey, Christopher B. Doering, PhD

Blood (2016) 128 (22): 3787.

https://doi.org/10.1182/blood.V128.22.3787.3787

Published: 2016

Journal Articles

Bioengineering Coagulation Factor VIII through Ancestral Protein Reconstruction

Philip Zakas, BS, Kristopher Knight, Ernest T Parker, BA, H. Trent Spencer, PhD, Eric Gaucher, PhD, Christopher B Doering, PhD

Blood (2015) 126 (23): 123.

https://doi.org/10.1182/blood.V126.23.123.123

Published: 2015

Journal Articles

Expansion and Bioengineering of Peripheral Blood-Derived Anti-Cancer Gd T Cells in Serum Free Media

Kathryn S Sutton, MD BS, Anindya Dasgupta, PhD, David McCarty, Christopher B Doering, PhD, H. Trent Spencer, PhD

Blood (2015) 126 (23): 5553.

https://doi.org/10.1182/blood.V126.23.5553.5553

Published: 2015

Journal Articles

Expanding the Ligand Binding Repertoire of Chimeric Antigen Receptors Using Lamprey Variable Lymphocyte Receptors

Robert Moot, BS, Sunil Raikar, MD, Lauren C Fleischer, BS, David McCarty, Melissa Querrey, Christopher B Doering, PhD, H. Trent Spencer, PhD

Blood (2015) 126 (23): 3244.

https://doi.org/10.1182/blood.V126.23.3244.3244

Published: 2015

Journal Articles

Preclinical Development and Validation of a Hematopoietic Stem Cell-Based Lentivector Treatment for Hemophilia a

Christopher B Doering, PhD, Gabriela Denning, PhD, Jordan E Shields, MS, William Swaney, Lilith Reeves, Punam Malik, MD, H. Trent Spencer, PhD

Blood (2015) 126 (23): 4421.

https://doi.org/10.1182/blood.V126.23.4421.4421

Published: 2015

Journal Articles

Improving Lentiviral Transduction Efficiency with Microfluidic Systems

Reginald Tran, BS, David R Myers, PhD, Jordan E Shields, MS, Byungwook Ahn, PhD, Yongzhi Qiu, PhD, Caroline Hansen, BS, Yumiko Sakurai, MSc, Robert Moot, BS, H. Trent Spencer, PhD, Christopher B Doering, PhD, Wilbur A Lam, MD PhD

Blood (2015) 126 (23): 4415.

https://doi.org/10.1182/blood.V126.23.4415.4415

Published: 2015

Journal Articles

Reduced Antigenicity Of Ovine Factor VIII In Human Hemophilia A Inhibitor Plasmas

Kristine Vanijcharoenkarn, Philip M Zakas, Rebecca Markovitz, B.A., Shannon L. Meeks, MD, Christopher B Doering, PhD

Blood (2013) 122 (21): 2355.

https://doi.org/10.1182/blood.V122.21.2355.2355

Published: 2013

Journal Articles

Bioengineered Coagulation Factor VIII Enables Long-Term Correction Of Murine Hemophilia A Following Liver-Directed Adeno-Associated Viral Vector Delivery

Harrison C. Brown, BBA, Jordan E Shields, Shangzhen Zhou, MD, J. Fraser Wright, PhD, H. Trent Spencer, PhD, Christopher B Doering, PhD

Blood (2013) 122 (21): 4210.

https://doi.org/10.1182/blood.V122.21.4210.4210

Published: 2013

Journal Articles

B-Cell Epitopes Within The A2 and C2 Domains Of Coagulant Factor VIII Refined By Orthologous Protein Antigenicity

Philip M Zakas, Kristine Vanijcharoenkarn, Rebecca Markovitz, B.A., Shannon L. Meeks, MD, Christopher B Doering, PhD

Blood (2013) 122 (21): 1101.

https://doi.org/10.1182/blood.V122.21.1101.1101

Published: 2013

Journal Articles

Reduced Antigenicity of Recombinant Ovine Factor VIII in Hemophilia A Inhibitor Patient Plasmas

Philip M Zakas, Shannon L. Meeks, MD, Christopher B Doering, PhD

Blood (2012) 120 (21): 1124.

https://doi.org/10.1182/blood.V120.21.1124.1124

Published: 2012

NARROW

Evaluation of Maternal Safety Following Prenatal Cell and Gene Therapy for Hemophilia a in a Large Animal Model Demonstrates Absence of Maternal Exposure to the Cells or Gene Products Infused into the Fetus

Administration of Cells Engineered to Secrete Fviii-mcoET3 in Prenatal Sheep Recipients Results in Sustained Curative Fviii Plasma Levels for 3 Years after Birth, without Immune or Toxicity-Related Adverse Events

Delivery of Fviii-mcoET3 to Previously Untreated Sheep Using Human Placental Cells Enables Durable Elevation of Plasma FVIII Levels and Avoids Inhibitor Formation

The 3.2 Angstrom Crystal Structure of a Bioengineered Factor VIII Construct Illustrates Two Conformations of the C2 Domain

Engineering CD5-Targeted Chimeric Antigen Receptors and Edited T Cells for the Treatment of T-Cell Leukemia

Prenatal Transplantation of Placental Cells Engineered to Express FVIII Leads to Corrective Plasma Levels of FVIII after Birth

Factor V Atlanta: A Novel Mutation in the F5 Gene Reveals Potential New Cis-Acting Elements Involved in Regulating FV-Short and TFPI Levels

Targeting T-Cell Malignancies with Chimeric Antigen Receptors Using Two Structurally Different Antigen Binding Domains Against CD5

Ancestral Sequence Reconstruction of Von Willebrand Factor Reveals Highly Conserved Structure/Function

The Impact of Anti-Factor VIII A1 and A3 Domain Antibodies in the Immune Reponse to Factor VIII in Patients with Hemophilia a

Characterization of Factor VIII Immune Complexes By Analytical Ultracentrifugation

Bioengineering Coagulation Factor VIII through Ancestral Protein Reconstruction

Expansion and Bioengineering of Peripheral Blood-Derived Anti-Cancer Gd T Cells in Serum Free Media

Expanding the Ligand Binding Repertoire of Chimeric Antigen Receptors Using Lamprey Variable Lymphocyte Receptors

Preclinical Development and Validation of a Hematopoietic Stem Cell-Based Lentivector Treatment for Hemophilia a

Improving Lentiviral Transduction Efficiency with Microfluidic Systems

Reduced Antigenicity Of Ovine Factor VIII In Human Hemophilia A Inhibitor Plasmas

Bioengineered Coagulation Factor VIII Enables Long-Term Correction Of Murine Hemophilia A Following Liver-Directed Adeno-Associated Viral Vector Delivery

B-Cell Epitopes Within The A2 and C2 Domains Of Coagulant Factor VIII Refined By Orthologous Protein Antigenicity

Reduced Antigenicity of Recombinant Ovine Factor VIII in Hemophilia A Inhibitor Patient Plasmas

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American Society of Hematology

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American Society of Hematology

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