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Christina Trambas
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A single amino acid change, A91V, leads to conformational changes that can impair processing to the active form of perforin

Clinical Trials & Observations
Christina Trambas, Federico Gallo, Daniela Pende, Stefania Marcenaro, Lorenzo Moretta, Carmela De Fusco, Alessandra Santoro, Luigi Notarangelo, Maurizio Arico, Gillian M. Griffiths
Journal: Blood
Blood (2005) 106 (3): 932–937.
https://doi.org/10.1182/blood-2004-09-3713
Published: 2005