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Charlotte Pawlyn, MB BChir
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Journal Articles

Lenalidomide Is a Highly Effective Maintenance Therapy in Myeloma Patients of All Ages; Results of the Phase III Myeloma XI Study

Graham H Jackson, MD PhD, Faith E Davies, MD, Charlotte Pawlyn, MB BChir, David A Cairns, MSc, PhD, Alina Striha, MSc, Corinne Collett, Anna Waterhouse, John R Jones, MD, Bhuvan Kishore, MBBS, MRCP, FRCPath, Mamta Garg, MD, Cathy D Williams, Kamaraj Karunanithi, MBBS, MD, Jindriska Lindsay, MD, Matthew W Jenner, MD, Gordon Cook, MDPhD, Martin F Kaiser, MD, Mark T Drayson, MD PhD, Roger G Owen, MB BCh, MD, Nigel H Russell, MD, Walter M Gregory, PhD, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1143.
https://doi.org/10.1182/blood.V128.22.1143.1143
Published: 2016
Journal Articles

Primary IMiD Refractory Myeloma; Results from 3894 Patients Treated in the Phase III Myeloma XI Study

Charlotte Pawlyn, MB BChir, Faith E Davies, MD, Martin F Kaiser, MD, David A Cairns, MSc, PhD, Alina Striha, MSc, Corinne Collett, Anna Waterhouse, John R Jones, MD, Bhuvan Kishore, MBBS, MRCP, FRCPath, Mamta Garg, MD, Cathy D Williams, Kamaraj Karunanithi, MBBS, MD, Jindriska Lindsay, MD, Matthew W Jenner, MD, Gordon Cook, MD PhD, Mark T Drayson, MD PhD, Roger G Owen, MB BCh, MD, Nigel H Russell, MD, Walter M Gregory, PhD, Graham H Jackson, MD PhD, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1144.
https://doi.org/10.1182/blood.V128.22.1144.1144
Published: 2016
Journal Articles

Inhibition of the Epigenetic Modifier EZH2 Upregulates Cell Cycle Control Genes to Inhibit Myeloma Cell Growth and Overcome High-Risk Disease Features

Charlotte Pawlyn, MB BChir, Michael Bright, PhD, Amy Buros, PhD, Caleb K. Stein, MS, Zoe Walters, PhD, Lauren Aronson, PhD, Fabio Mirabella, PhD, Martin F Kaiser, MD, John R Jones, MD, Brian A Walker, PhD, Graham H Jackson, MD PhD, Paul Clarke, PhD, Leif Bergsagel, MD, Paul Workman, PhD, Marta Chesi, PhD, Gareth J Morgan, MD PhD, Faith E Davies, MD
Journal: Blood
Blood (2016) 128 (22): 3289.
https://doi.org/10.1182/blood.V128.22.3289.3289
Published: 2016
Journal Articles

Response Adapted Induction Treatment Improves Outcomes for Myeloma Patients; Results of the Phase III Myeloma XI Study

Graham H Jackson, MD PhD, Faith E Davies, MD, Charlotte Pawlyn, MB BChir, David A Cairns, MSc, PhD, Alina Striha, MSc, Corinne Collett, Anna Waterhouse, John R Jones, MD, Bhuvan Kishore, MBBS, MRCP, FRCPath, Mamta Garg, MD, Cathy D Williams, Kamaraj Karunanithi, MBBS, MD, Jindriska Lindsay, MD, Matthew W Jenner, MD, Gordon Cook, MDPhD, Martin F Kaiser, MD, Mark T Drayson, MD PhD, Roger G Owen, MB BCh, MD, Nigel H Russell, MD, Walter M Gregory, PhD, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2016) 128 (22): 244.
https://doi.org/10.1182/blood.V128.22.244.244
Published: 2016
Journal Articles

Impact of Minimal Residual Disease in Transplant Ineligible Myeloma Patients: Results from the UK NCRI Myeloma XI Trial

Ruth Mary de Tute, PhD FRCPath, Andy C Rawstron, BSc, PhD, David A Cairns, MSc, PhD, Charlotte Pawlyn, MB BChir, Faith E Davies, MD, Corinne Collett, Martin F Kaiser, John R Jones, MD, Anna Waterhouse, Alina Striha, MSc, Gordon Cook, MDPhD, Matthew W Jenner, MD, Nigel H Russell, MD, Mark T Drayson, MD PhD, Walter M Gregory, PhD, Graham H Jackson, MD PhD, Gareth J Morgan, MD PhD, Roger G Owen, MD
Journal: Blood
Blood (2016) 128 (22): 245.
https://doi.org/10.1182/blood.V128.22.245.245
Published: 2016
Journal Articles

DNA Methylation Profiling of Myeloma Trial Patients Reveals Specific Epigenetic Changes Associated with Outcome

David C Johnson, PhD, Dil B Begum, Sidra Ellis, Amy L Sherborne, Amy Price, Charlotte Smith, Fabio Mirabella, PhD, Karen Menezes, Scott Kimber, John R Jones, MD, Charlotte Pawlyn, MB BChir, Matthew W Jenner, MD, Richard S Houlston, MD PhD FRCP, Gordon Cook, Nigel H. Russell, V, MD, Alina Striha, MSc, Corinne Collett, Anna Waterhouse, Walter M Gregory, PhD, David A Cairns, MSc, PhD, Mark T Drayson, MD PhD, Roger G Owen, MD PhD, Faith E Davies, MD, Gareth J Morgan, MD PhD, Graham H Jackson, MD PhD, Martin F Kaiser, MD
Journal: Blood
Blood (2016) 128 (22): 804.
https://doi.org/10.1182/blood.V128.22.804.804
Published: 2016
Journal Articles

The Impact of Maintenance Lenalidomide on the Mutational Status of the Myeloma Clone at Relapse in the NCRI Myeloma XI Trial for Newly Diagnosed Multiple Myeloma Patients (NDMM)

John R Jones, MD, Niels Weinhold, PhD, Shweta S. Chavan, PhD, Charlotte Pawlyn, MB BChir, Lorenzo Melchor, PhD, David A Cairns, MSc, PhD, Dil B Begum, Charlotte Smith, Sidra Ellis, Amy Price, Amy L Sherborne, Brian A Walker, PhD, Christopher P Wardell, PhD, Gordon Cook, MD PhD, Matthew W Jenner, MD, Nigel H Russell, MD, Mark T Drayson, MD PhD, Roger G Owen, MD PhD, Faith E Davies, MD, Martin F Kaiser, MD, Graham H Jackson, MD PhD, Walter M Gregory, PhD, Mel Greaves, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2016) 128 (22): 4412.
https://doi.org/10.1182/blood.V128.22.4412.4412
Published: 2016
Journal Articles

The Mutational and Signaling Landscape of Multiple Myeloma Varies Dependent upon Translocation Cyclin D (TC) Subgroup

Caleb K. Stein, MS, Charlotte Pawlyn, MB BChir, Shweta S. Chavan, PhD, Niels Weinhold, PhD, Brian A Walker, PhD, Adam Rosenthal, Ola Landgren, MD, PhD, Peter Leif Bergsagel, MD PhD, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2016) 128 (22): 4441.
https://doi.org/10.1182/blood.V128.22.4441.4441
Published: 2016
Journal Articles

Identifying Ultra-High Risk Myeloma By Integrated Molecular Genetic and Gene Expression Profiling

Amy L Sherborne, Dil B Begum, Amy Price, David C Johnson, PhD, Sidra Ellis, Charlotte Smith, Fabio Mirabella, PhD, Karen Menezes, Scott Kimber, John R Jones, MD, Charlotte Pawlyn, MB BChir, Richard S Houlston, MD PhD FRCP, Nigel H. Russell, V, MD, Matthew W Jenner, MD, Gordon Cook, Alina Striha, MSc, Corinne Collett, Anna Waterhouse, Walter M Gregory, PhD, David A Cairns, MSc, PhD, Mark T Drayson, MD PhD, Roger G Owen, MD PhD, Faith E Davies, MD, Gareth J Morgan, MD PhD, Graham H Jackson, MD PhD, Martin F Kaiser, MD
Journal: Blood
Blood (2016) 128 (22): 4407.
https://doi.org/10.1182/blood.V128.22.4407.4407
Published: 2016
Journal Articles

Spatiotemporal Analysis of Intraclonal Heterogeneity in Multiple Myeloma: Unravelling the Impact of Treatment and the Propagating Capacity of Subclones Using Whole Exome Sequencing

Lorenzo Melchor, PhD, John R Jones, MD, Oleg Lenive, Erich Allen Peterson, PhD BS, MS, Annamaria Brioli, MD PhD, Alex Murison, PhD, Christopher P Wardell, PhD, Martin F Kaiser, Paula Proszek, Eileen Mary Boyle, MD PhD, Dil B Begum, Charlotte Pawlyn, MB BChir, David C Johnson, PhD, Inmaculada Rapado, David A Cairns, Walter M Gregory, Roger G Owen, Graham H Jackson, MD PhD, Mark T Drayson, MD PhD, Faith E Davies, MD, Joaquín Martínez-López, MD PhD, Richard S Houlston, MDPhDFRCP, Mel Greaves, FRS, Brian A Walker, PhD, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2015) 126 (23): 371.
https://doi.org/10.1182/blood.V126.23.371.371
Published: 2015
Journal Articles

Quadruplet Vs Sequential Triplet Induction Therapy Approaches to Maximise Response for Newly Diagnosed, Transplant Eligible, Myeloma Patients

Charlotte Pawlyn, MB BChir, Faith E Davies, MD, David A Cairns, Corinne Collett, Anna Chalmers, Alina Striha, John R Jones, MD, Mamta Garg, MD, David Allotey, MD, Kamaraj Karunanithi, MBBS, MD, Donald Milligan, MD MBChB, Martin F Kaiser, MD, Matthew W Jenner, MD, Gordon Cook, MD PhD, Nigel H. Russell, MD, Mark T Drayson, MD PhD, Roger G Owen, MD, Walter M Gregory, Graham H Jackson, MD, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2015) 126 (23): 189.
https://doi.org/10.1182/blood.V126.23.189.189
Published: 2015
Journal Articles

Identifying Targets for Therapy in High Risk t(4;14) Myeloma Using Multi-Level Molecular and Phenotypic Analysis of Isogenic MMSET and MMSET Knock out Cell Lines

Charlotte Pawlyn, MB BChir, Tim Chambers, Veronica Macleod, Daniel Sappington, Amy Buros, PhD, Caleb K. Stein, MS, Martin F Kaiser, MD, Rosemary Burke, Swen Hoelder, Gunnar Boysen, Ricky D Edmondson, PhD, Gareth J Morgan, MD PhD, Faith E Davies, MD
Journal: Blood
Blood (2015) 126 (23): 1792.
https://doi.org/10.1182/blood.V126.23.1792.1792
Published: 2015
Journal Articles

WB-DWI MRI Scanning Outperforms FDG PET-CT for the Assessment of Myeloma Disease Burden

Charlotte Pawlyn, MB BChir, Martin F Kaiser, MD, Lucy Fowkes, MD, John R Jones, MD, Faith E Davies, MD, Gareth J Morgan, MD PhD, David Collins, BA, MInstP, Bhupinder Sharma, MD, Angela Riddell, MD, Christina Messiou, MD
Journal: Blood
Blood (2015) 126 (23): 1758.
https://doi.org/10.1182/blood.V126.23.1758.1758
Published: 2015
Journal Articles

Myeloma XI Trial for Newly Diagnosed Multiple Myeloma (NDMM); A Report of Second Primary Malignancy (SPM) Rates and the Importance of Review of Reported Cases

John R Jones, MD, David A Cairns, Rachel Sigsworth, Corinne Collett, Charlotte Pawlyn, MB BChir, Alina Striha, Lorenzo Melchor, PhD, Martin F Kaiser, MD, Mark T Drayson, MD PhD, Faith E Davies, MD, Walter M Gregory, Kevin Boyd, MD, Roger G Owen, Graham H Jackson, MD, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2015) 126 (23): 1847.
https://doi.org/10.1182/blood.V126.23.1847.1847
Published: 2015
Journal Articles

Velcade, Vorinostat and Dexamethasone (V 2 D) in Relapsed Myeloma: Results of the Phase 2 Muk Four Trial

Matthew W Jenner, MD, Avie-Lee Tillotson, Sarah R Brown, Louise M Flanagan, Debbie Sherratt, Charlotte Pawlyn, MB BChir, Cathy Williams, Faith E Davies, MD
Journal: Blood
Blood (2015) 126 (23): 1852.
https://doi.org/10.1182/blood.V126.23.1852.1852
Published: 2015
Journal Articles

Specific Identification of High Risk Disease Using Molecular Profiling By Mymap (Myeloma MLPA and translocation PCR) of 1,036 Cases

Martin F Kaiser, MD, Eileen Mary Boyle, MD PhD, Brian A Walker, PhD, Dil B Begum, Paula Proszek, David C Johnson, PhD, Charlotte Pawlyn, MB BChir, John R Jones, MD, Suvi Savola, PhD, Roger G Owen, Mark T Drayson, MD PhD, David A Cairns, Gordon Cook, MD PhD, Walter M Gregory, Richard S Houlston, MDPhDFRCP, Faith E Davies, MD, Graham H Jackson, MD, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2015) 126 (23): 2981.
https://doi.org/10.1182/blood.V126.23.2981.2981
Published: 2015
Journal Articles

Molecular Subgroups of Hyperdiploidy and Their Prognostic Relevance - an Analysis of 1,036 Myeloma Trial Patients

Martin F Kaiser, MD, Eileen Mary Boyle, MD PhD, Brian A Walker, PhD, Dil B Begum, Paula Proszek, David C Johnson, PhD, Charlotte Pawlyn, MB BChir, John R Jones, MD, Suvi Savola, PhD, Roger G Owen, Mark T Drayson, MD PhD, David A Cairns, Gordon Cook, MD PhD, Walter M Gregory, Richard S Houlston, MDPhDFRCP, Faith E Davies, MD, Graham H Jackson, MD, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2015) 126 (23): 2983.
https://doi.org/10.1182/blood.V126.23.2983.2983
Published: 2015