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Journal Articles

PHF6 - Somatic Mutations and Their Role in Pathophysiology of MDS and AML

Bartlomiej Przychodzen, MSc, Xiaorong Gu, PhD, Dewen You, PhD, Cassandra M. Hirsch, Michael J. Clemente, Aaron D. Viny, MD MS, Ross L. Levine, MD, Torsten Haferlach, Manja Maggendorfer, Mikkael A. Sekeres, MD MS, Hetty E. Carraway, MD MBA, Aziz Nazha, MD, Francis Enane, Jaroslaw P. Maciejewski, MD PhD

Blood (2015) 126 (23): 1259.

https://doi.org/10.1182/blood.V126.23.1259.1259

Published: 2015

Journal Articles

Activation of the Unfolded Protein Response with the First-in-Class P97 Inhibitor CB-5083 Induces Stable Disease Regression and Overcomes Ara-C Resistance in AML

Steffan T. Nawrocki, PhD, Yingchun Han, MD, Ronan LE Moigne, PhD, Valeria Visconte, PhD, Bartlomiej Przychodzen, MSc, Mark Rolfe, PhD, Stevan Djakovic, PhD, Daniel Anderson, David Wustrow, PhD, Han-Jie Zhou, Steve Wong, PhD, Anjali Advani, MD, Hetty E. Carraway, MD MBA, Jaroslaw P. Maciejewski, MD PhD, Mikkael A. Sekeres, MD MS, Kevin R. Kelly, MD PhD, Jennifer S. Carew, PhD

Blood (2015) 126 (23): 1350.

https://doi.org/10.1182/blood.V126.23.1350.1350

Published: 2015

Journal Articles

Whole-Exome Sequencing Identifies Germline IDH2 and IDH3 mutations That Predispose to Myeloid Neoplasms

Remco Molenaar, M.Sc., Srinivasa Reddy Sanikommu, MD, Bhumika J. Patel, Bartlomiej Przychodzen, MSc, Cornelis J van Noorden, PhD, Tomas Radivoyevitch, PhD, Hideki Makishima, MD PhD, Hetty E. Carraway, MD MBA, Jaroslaw P. Maciejewski, MD PhD

Blood (2015) 126 (23): 1405.

https://doi.org/10.1182/blood.V126.23.1405.1405

Published: 2015

Journal Articles

Outcome of Newly Diagnosed Acute Myeloid Leukemia (AML) Refractory to 1 or 2 Cycles of Induction Chemotherapy

Ahmad Zarzour, MD, Aziz Nazha, MD, Matt Kalaycio, MD, Bhumika J. Patel, Aaron T. Gerds, MD MS, Michael J. Clemente, Cassandra M Hirsch, Jennifer S. Carew, PhD, Anjali S. Advani, MD, Srinivasa R. Sanikommu, MBBS, Bartlomiej Przychodzen, MSc, Hetty E. Carraway, MD MBA, Sudipto Mukherjee, MD PhD, Jaroslaw P. Maciejewski, MD PhD, Mikkael A. Sekeres, MD MS

Blood (2015) 126 (23): 1319.

https://doi.org/10.1182/blood.V126.23.1319.1319

Published: 2015

Journal Articles

Characterization of the Mutational Spectrum in Young Patients with Myelodysplastic Syndrome

Cassandra M Hirsch, Bartlomiej Przychodzen, MSc, Tomas Radivoyevitch, PhD, Sean Hobson, Bhumika J. Patel, Swapna Thota, MD, Michael J. Clemente, Hetty E. Carraway, MD MBA, Mikkael A Sekeres, MD MS, Jaroslaw P. Maciejewski, MD PhD

Blood (2015) 126 (23): 5218.

https://doi.org/10.1182/blood.V126.23.5218.5218

Published: 2015

Journal Articles

Novel Findings for the Role of Microenvironment and Heat Shock Proteins (HSP) in B -Cell Recptor (BCR) Activation, Disease Progression and Transformation of Follicular Non-Hodgkin Lymphoma (FL): Gene Expression Profiling (GEP) and Immuno-Histochemical (IH) Studies Reveal New Pathways for Potential Targeted Therapies

Saad M B Rassam, MD FRCP, FRCPath, John Schofield, FRCPath, Farooq Malik, PhD, Azim M Mohamedali, PhD, Bartlomiej Przychodzen, MSc, Gabrielle Elstein, Ghulam J Mufti, FRCP, FRCPath

Blood (2015) 126 (23): 3897.

https://doi.org/10.1182/blood.V126.23.3897.3897

Published: 2015

Journal Articles

Prognostic Impact of Molecular Mutations in AML at First Relapse

Anjali S. Advani, MD, Paul Elson, PhD, Valeria Visconte, PhD, Jennifer S. Carew, PhD, Jaime Fensterl, Bartlomiej Przychodzen, MSc, Mikkael A. Sekeres, MD MS, Cassandra M Hirsch, Alek Nielsen, John Desamito, Hetty E. Carraway, MD MBA, Aaron T. Gerds, MD MS, Betty K. Hamilton, MD, Sudipto Mukherjee, MD PhD, Ronald M. Sobecks, MD, Matt Kalaycio, MD, Yogen Saunthararajah, MD, Jaroslaw P. Maciejewski, MD PhD

Blood (2015) 126 (23): 3825.

https://doi.org/10.1182/blood.V126.23.3825.3825

Published: 2015

Journal Articles

Ex Vivo Experiments Show That IDH1/2-Mutant Inhibitors Can be Safely Used As Adjuvants to Regular Chemotherapy in IDH1/2 -Mutated Acute Myeloid Leukemia

Remco Molenaar, M.Sc., Bhumika J. Patel, Mohammed Khurshed, MD, Bartlomiej Przychodzen, MSc, Srinivasa Reddy Sanikommu, MD, Hetty E. Carraway, MD MBA, Tomas Radivoyevitch, PhD, Hideki Makishima, MD PhD, Cornelis J van Noorden, PhD, Jaroslaw P. Maciejewski, MD PhD

Blood (2015) 126 (23): 3788.

https://doi.org/10.1182/blood.V126.23.3788.3788

Published: 2015

Journal Articles

Impact of Eltrombopag on Expansion of Clones with Somatic Mutations in Refractory Aplastic Anemia

Bhumika J. Patel, Bartlomiej Przychodzen, MSc, Michael J. Clemente, Cassandra M. Hirsch, Tomas Radivoyevitch, PhD, Swapna Thota, MD, Aziz Nazha, MD, Hetty E. Carraway, MD MBA, Mikkael A. Sekeres, MD MS, Jaroslaw P. Maciejewski, MD PhD

Blood (2015) 126 (23): 300.

https://doi.org/10.1182/blood.V126.23.300.300

Published: 2015

Journal Articles

The Complexity of Interpreting Genomic Data in Patients with Primary and Secondary Acute Myeloid Leukemia (AML)

Aziz Nazha, MD, Ahmad Zarzour, MD, Tomas Radivoyevitch, PhD, Hetty E. Carraway, MD MBA, Jennifer S. Carew, PhD, Cassandra M Hirsch, Kassy E Kneen, Bartlomiej Przychodzen, MSc, Bhumika J. Patel, Michael Clemente, MS, Srinivasa R. Sanikommu, MBBS, Matt Kalaycio, MD, Jaroslaw P. Maciejewski, MD PhD, Mikkael A. Sekeres, MD MS

Blood (2015) 126 (23): 86.

https://doi.org/10.1182/blood.V126.23.86.86

Published: 2015

Journal Articles

Prognostic Impact of Molecular Mutations in Acute Myeloid Leukemia (AML) and Myelodysplastic Syndromes (MDS) on Allogeneic Hematopoietic Cell Transplant (HCT) Outcomes: Adverse Impact of TET2 Mutations

Betty K. Hamilton, MD, Navneet S. Majhail, MD MS, Cassandra M Hirsch, Bartlomiej Przychodzen, MSc, Lisa A. Rybicki, MS, Marcos De Lima, MD, Matt Kalaycio, MD, Brian J. Bolwell, MD, Aaron T. Gerds, MD MS, Ronald Sobecks, MD, Rabi Hanna, MD, Mikkael A. Sekeres, MD MS, Jaroslaw P. Maciejewski, MD PhD

Blood (2015) 126 (23): 740.

https://doi.org/10.1182/blood.V126.23.740.740

Published: 2015

Journal Articles

Downregulation of BAP1 in Chronic Myelomonocytic Leukemia: Correlated with a Post-Translational Reduction of BRCA1 Levels and Independent of Promoter Methylation

Ana María Hurtado, Gines Luengo-Gil, Laura Palomo, MSc, Eva Lumbreras, Eva Caparrós, Tzu Hua Chen-Liang, Bartlomiej Przychodzen, MSc, Maria Luz Amigo, María Díez-Campelo, MD PhD, Lurdes Zamora, PhD, Francisco José Ortuño, Raul Teruel Montoya, PhD, Jaroslaw P. Maciejewski, MD PhD, Consuelo Del Cañizo, MD PhD, Francesc Sole, PhD, Francisca Ferrer-Marin, Andres Jerez

Blood (2015) 126 (23): 1648.

https://doi.org/10.1182/blood.V126.23.1648.1648

Published: 2015

Journal Articles

Myelodysplastic Syndrome (MDS)-Determining Clonal Events at Presentation of Aplastic Anemia (AA)

Eiju Negoro, MD PhD, Naoko Hosono, MDPhD, Wenyi Shen, MD, Tetsuichi Yoshizato, MD, Bhumika J. Patel, Cassandra Hirsh, BSc, Bartlomiej Przychodzen, MSc, Michael J. Clemente, Reda Z. Mahfouz, MDPhD, Aleksandra Wodnar-Filipowicz, PhD, Hideki Makishima, MD PhD, Seishi Ogawa, MD PhD, Mikkael A. Sekeres, MD MS, Jaroslaw P. Maciejewski, MD PhD

Blood (2015) 126 (23): 1652.

https://doi.org/10.1182/blood.V126.23.1652.1652

Published: 2015

Journal Articles

Clonal Mutational Landscape of Childhood Myelodysplastic Syndromes

Blood (2015) 126 (23): 1662.

https://doi.org/10.1182/blood.V126.23.1662.1662

Published: 2015

Journal Articles

Molecular Predictors of Response in Patients with Myeloid Neoplasms Treated with Lenalidomide

Eiju Negoro, MD PhD, Chantana Polprasert, MD, Tomas Radivoyevitch, PhD, Vera Adema, Naoko Hosono, MDPhD, Hideki Makishima, MD PhD, Bartlomiej Przychodzen, MSc, Mikkael A. Sekeres, MD MS, Valeria Santini, MD, Kathy McGaw, Alan F. List, MD, Francesc Sole, PhD, Jaroslaw P. Maciejewski, MD PhD

Blood (2015) 126 (23): 2853.

https://doi.org/10.1182/blood.V126.23.2853.2853

Published: 2015

Journal Articles

TET 2 Alterations in Myeloid Malignancies, Impact on Clinical Characteristics, Outcome, and Disease Predisposition

Aziz Nazha, MD, Manja Meggendorfer, PhD, Niroshan Nadarajah, M.Sc., Kassy E Kneen, Tomas Radivoyevitch, PhD, Bartlomiej Przychodzen, MSc, Hideki Makishima, MD PhD, Bhumika J. Patel, Srinivasa R. Sanikommu, MBBS, Sean Hobson, Mridul Mukherji, PhD, Mikkael A. Sekeres, MD MS, Torsten Haferlach, Jaroslaw P. Maciejewski, MD PhD

Blood (2015) 126 (23): 1645.

https://doi.org/10.1182/blood.V126.23.1645.1645

Published: 2015

Journal Articles

The Revised International Prognostic Scoring System "Molecular" (IPSS-Rm), a Validated and Dynamic Model in Treated Patients with Myelodysplastic Syndromes (MDS)

Aziz Nazha, MD, Mayur Subhash Narkhede, MD, Tomas Radivoyevitch, PhD, Matt Kalaycio, MD, Bhumika J. Patel, Aaron T. Gerds, MD MS, Sudipto Mukherjee, MD PhD, Michael Clemente, MS, Cassandra M Hirsch, Anjali S. Advani, MD, Bartlomiej Przychodzen, MSc, Hetty E. Carraway, MD MBA, Jaroslaw P. Maciejewski, MD PhD, Mikkael A. Sekeres, MD MS

Blood (2015) 126 (23): 607.

https://doi.org/10.1182/blood.V126.23.607.607

Published: 2015

Journal Articles

Network-Based Analysis of Exome Sequencing Mutations Identifies Molecular Subtypes of Myelodysplastic Syndromes

Aziz Nazha, MD, Bartlomiej Przychodzen, MSc, Hideki Makishima, MD PhD, Hetty E. Carraway, MD MBA, Bhumika J. Patel, Cassandra M Hirsch, Michael Clemente, MS, Srinivasa R. Sanikommu, MBBS, Aaron T. Gerds, MD MS, Jennifer S. Carew, PhD, Satoru Miyano, MD PhD, Matt Kalaycio, MD, Seishi Ogawa, MD PhD, Jaroslaw P. Maciejewski, MD PhD, Mikkael A. Sekeres, MD MS

Blood (2015) 126 (23): 611.

https://doi.org/10.1182/blood.V126.23.611.611

Published: 2015

Journal Articles

Impact of STAT3 Mutations on Clinical Features and Treatment Outcomes in Large Granular Lymphocyte Leukemia

Srinivasa Reddy Sanikommu, MD, Michael Clemente, MS, Peter Chomczynski, Swapna Thota, MD, Bhumika J. Patel, Aziz Nazha, MD, Bartlomiej Przychodzen, MSc, Jaroslaw P Maciejewski, MD PhD FACP

Blood (2015) 126 (23): 2216.

https://doi.org/10.1182/blood.V126.23.2216.2216

Published: 2015

Journal Articles

Determinants of Phenotypic Commitment and Clonal Progression--Conclusions from the Study of Clonal Architecture in CMML

Bhumika J. Patel, Bartlomiej Przychodzen, MSc, Michael J. Clemente, Cassandra M. Hirsch, Tomas Radivoyevitch, PhD, Swapna Thota, MD, Thomas LaFramboise, PhD, Hirotoshi Sakaguchi, MD PhD, Seiji Kojima, MD PhD, Hetty E. Carraway, MD MBA, Mikkael A. Sekeres, MD MS, Seishi Ogawa, MD PhD, Hideki Makishima, MD PhD, Jaroslaw P. Maciejewski, MD PhD

Blood (2015) 126 (23): 2848.

https://doi.org/10.1182/blood.V126.23.2848.2848

Published: 2015

NARROW

PHF6 - Somatic Mutations and Their Role in Pathophysiology of MDS and AML

Activation of the Unfolded Protein Response with the First-in-Class P97 Inhibitor CB-5083 Induces Stable Disease Regression and Overcomes Ara-C Resistance in AML

Whole-Exome Sequencing Identifies Germline IDH2 and IDH3 mutations That Predispose to Myeloid Neoplasms

Outcome of Newly Diagnosed Acute Myeloid Leukemia (AML) Refractory to 1 or 2 Cycles of Induction Chemotherapy

Characterization of the Mutational Spectrum in Young Patients with Myelodysplastic Syndrome

Prognostic Impact of Molecular Mutations in AML at First Relapse

Ex Vivo Experiments Show That IDH1/2-Mutant Inhibitors Can be Safely Used As Adjuvants to Regular Chemotherapy in IDH1/2 -Mutated Acute Myeloid Leukemia

Impact of Eltrombopag on Expansion of Clones with Somatic Mutations in Refractory Aplastic Anemia

The Complexity of Interpreting Genomic Data in Patients with Primary and Secondary Acute Myeloid Leukemia (AML)

Prognostic Impact of Molecular Mutations in Acute Myeloid Leukemia (AML) and Myelodysplastic Syndromes (MDS) on Allogeneic Hematopoietic Cell Transplant (HCT) Outcomes: Adverse Impact of TET2 Mutations

Downregulation of BAP1 in Chronic Myelomonocytic Leukemia: Correlated with a Post-Translational Reduction of BRCA1 Levels and Independent of Promoter Methylation

Myelodysplastic Syndrome (MDS)-Determining Clonal Events at Presentation of Aplastic Anemia (AA)

Clonal Mutational Landscape of Childhood Myelodysplastic Syndromes

Molecular Predictors of Response in Patients with Myeloid Neoplasms Treated with Lenalidomide

TET 2 Alterations in Myeloid Malignancies, Impact on Clinical Characteristics, Outcome, and Disease Predisposition

The Revised International Prognostic Scoring System "Molecular" (IPSS-Rm), a Validated and Dynamic Model in Treated Patients with Myelodysplastic Syndromes (MDS)

Network-Based Analysis of Exome Sequencing Mutations Identifies Molecular Subtypes of Myelodysplastic Syndromes

Impact of STAT3 Mutations on Clinical Features and Treatment Outcomes in Large Granular Lymphocyte Leukemia

Determinants of Phenotypic Commitment and Clonal Progression--Conclusions from the Study of Clonal Architecture in CMML

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American Society of Hematology

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American Society of Hematology

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