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Journal Articles

Inducible MyD88/CD40 (iMC) Enhances Proliferation and Survival of Tumor-Specific TCR-Modified T Cells and Improves Anti-Tumor Efficacy in Myeloma

Tsvetelina Pentcheva-Hoang, PhD, David Torres, Tania Rodriguez, PhD, Ana Korngold, PhD, An Lu, Jeannette Crisostomo, Annemarie Moseley, MD PhD, Lorenz Jahn, Mirjam H.M. Heemskerk, PhD, Kevin M Slawin, MD, David M Spencer, PhD, Aaron E Foster, PhD

Blood (2016) 128 (22): 4550.

https://doi.org/10.1182/blood.V128.22.4550.4550

Published: 2016

Journal Articles

T-Cell Depleted HLA-Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation (haplo-HSCT) Followed By Donor Lymphocyte Infusion with T Cells Transduced with the Inducible Caspase 9 (iC9) Suicide Gene in Children with Hematological Malignancies

Barbarella Lucarelli, MD, Alice Bertaina, MD PhD, Pietro Merli, MD, Concetta Quintarelli, PhD, Daniela Pende, MD, Michela Falco, PhD, Maria Giuseppina Cefalo, MD, Giuseppina Li Pira, PhD, Ignazio Caruana, PhD, Letizia Pomponia Brescia, MD, Luisa Strocchio, MD, Giuseppe Maria Milano, MD, Valentina Bertaina, PhD, Matilde Sinibaldi, PhD, Mattia Algeri, MD, Lorenzo Moretta, MD, Joanna Stanson, Annemarie Moseley, MD PhD, Franco Locatelli, MD

Blood (2016) 128 (22): 4683.

https://doi.org/10.1182/blood.V128.22.4683.4683

Published: 2016

Journal Articles

Clinical Outcome and Immune Recovery after Adoptive Infusion of BPX-501 Cells (donor T cells transduced with iC9 suicide gene) in Children with Hemoglobinopathies and Diamond-Blackfan Anemia Given α/β T-Cell Depleted HLA-Haploidentical Stem Cell Transplantation (HSCT)

Alice Bertaina, MDPhD, Pietro Merli, MD, Daria Pagliara, MD, Giuseppina Li Pira, PhD, Biagio De Angelis, PhD, Letizia Pomponia Brescia, MD, Luisa Strocchio, MD, Francesca Del Bufalo, MD, Mauro Montanari, MD, Barbarella Lucarelli, MD, Mattia Algeri, MD, Martha French, PhD, Annemarie Moseley, MDPhD, Franco Locatelli, MD

Blood (2016) 128 (22): 2286.

https://doi.org/10.1182/blood.V128.22.2286.2286

Published: 2016

Journal Articles

Outcome of Children with Primary Immune-Deficiencies (PIDs) Enrolled in a Phase I-II Trial Based on the Infusion of BPX-501 Donor T Cells Genetically Modified with a Novel Suicide Gene (inducible Caspase 9, iC9) after T-Cell Depleted HLA-Haploidentical Allogeneic Stem Cell Transplantation (haplo-HSCT)

Neena Kapoor, MD, Alice Bertaina, MD PhD, Pietro Merli, MD, Swati Naik, MD, Waseem Qasim, MBBS PhD, Mary Slatter, MD, Reem Elfeky, MD, Barbarella Lucarelli, MD, Monika Smogorzewska, PhD, Giuseppina Li Pira, PhD, Valentina Bertaina, PhD, Annemarie Moseley, MD PhD, Franco Locatelli, MD

Blood (2016) 128 (22): 72.

https://doi.org/10.1182/blood.V128.22.72.72

Published: 2016

Journal Articles

Inducible MyD88/CD40 Enhances Proliferation and Survival of PRAME-Specific TCR-Engineered T Cells and Increases Anti-Tumor Effects in Myeloma

Tsvetalina Hoang, PhD, Aaron Foster, PhD, Jeannette Crisostomo, An Lu, Annemarie Moseley, MDPhD, Mirjam H.M. Heemskerk, PhD, Kevin M Slawin, MD, David M Spencer, PhD

Blood (2015) 126 (23): 1886.

https://doi.org/10.1182/blood.V126.23.1886.1886

Published: 2015

Journal Articles

Clinical Outcome after Adoptive Infusion of BPX-501 Cells (donor T cells transduced with iC9 suicide gene) in Children Given Alpha/Beta T-Cell Depleted HLA-Haploidentical Hematopoietic Stem Cell Transplantation (haplo-HSCT): Preliminary Results of a Phase I-II Trial

Franco Locatelli, Prof, MD PhD, Pietro Merli, MD, Giuseppina Li Pira, PhD, Valentina Bertaina, PhD, Barbarella Lucarelli, MD, Letizia Pomponia Brescia, MD, Mauro Montanari, MD, Daniela Pende, MD, Michela Falco, PhD, Daria Pagliara, MD, Maria Giuseppina Cefalo, MD, Alessandro Moretta, MD, Concetta Quintarelli, PhD, Brigitte Strahm, MD, Waseem Qasim, MBBS PhD, Mary Slatter, Lorenzo Moretta, MD, Annemarie Moseley, MDPhD, Alice Bertaina, MDPhD

Blood (2015) 126 (23): 1931.

https://doi.org/10.1182/blood.V126.23.1931.1931

Published: 2015

Journal Articles

Immune Reconstitution after Adoptive Infusion of BPX501 Cells (donor T cells transduced with iC9 suicide gene) in Children Given Alpha/Beta T-Cell Depleted HLA-Haploidentical Hematopoietic Stem Cell Transplantation (haplo-HSCT): Preliminary Phenotypic and Functional Results of a Phase I-II Trial

Pietro Merli, MD, Giuseppina Li Pira, PhD, Valentina Bertaina, PhD, Matilde Sinibaldi, PhD, Barbarella Lucarelli, MD, Letizia Pomponia Brescia, MD, Giuseppe Palumbo, MD, Giuseppe Maria Milano, MD, Maria Teresa Romano, MD, Valentina Cirillo, PhD, Luisa Strocchio, MD, Irma Airoldi, PhD, Luciana Vinti, MD, Concetta Quintarelli, PhD, Lorenzo Moretta, MD, Annemarie Moseley, MDPhD, Alice Bertaina, MDPhD, Franco Locatelli, Prof, MD PhD

Blood (2015) 126 (23): 3093.

https://doi.org/10.1182/blood.V126.23.3093.3093

Published: 2015

Journal Articles

BPX-501 Cells (donor T cells transduced with iC9 suicide gene) Are Able to Clear Life-Threatening Viral Infections in Children with Primary Immune Deficiencies Given Alpha/Beta T-Cell Depleted HLA-Haploidentical Hematopoietic Stem Cell Transplantation (haplo-HSCT)

Barbarella Lucarelli, MD, Pietro Merli, MD, Alice Bertaina, MDPhD, Matilde Sinibaldi, PhD, Stefania Gaspari, MD, Luisa Strocchio, MD, Angela Pitisci, PhD, Giuseppina Li Pira, PhD, Giuseppe Maria Milano, MD, Annemarie Moseley, MDPhD, Concetta Quintarelli, PhD, Franco Locatelli, Prof, MD PhD

Blood (2015) 126 (23): 4299.

https://doi.org/10.1182/blood.V126.23.4299.4299

Published: 2015

Journal Articles

Removal Of Alpha/Beta+ T Cells and Of CD19+ B Cells From The Graft Translates Into Rapid Engraftment, Absence Of Visceral Graft-Versus-Host Disease and Low Transplant-Related Mortality In Children With Acute Leukemia Given HLA-Haploidentical Hematopoietic Stem Cell Transplantation

Blood (2013) 122 (21): 157.

https://doi.org/10.1182/blood.V122.21.157.157

Published: 2013

Journal Articles

Efficacy of the “MarrowMiner” a Novel, Minimally Invasive Bone Marrow Harvesting Device in a Large Animal Model.

Daniel Kraft, MD, Lin Song, PhD, Annemarie Moseley, MD, PhD, Mike Crocker, Marc Long, PhD, Vartan Ghazarossian, PhD

Blood (2007) 110 (11): 1217.

https://doi.org/10.1182/blood.V110.11.1217.1217

Published: 2007

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Inducible MyD88/CD40 (iMC) Enhances Proliferation and Survival of Tumor-Specific TCR-Modified T Cells and Improves Anti-Tumor Efficacy in Myeloma

T-Cell Depleted HLA-Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation (haplo-HSCT) Followed By Donor Lymphocyte Infusion with T Cells Transduced with the Inducible Caspase 9 (iC9) Suicide Gene in Children with Hematological Malignancies

Clinical Outcome and Immune Recovery after Adoptive Infusion of BPX-501 Cells (donor T cells transduced with iC9 suicide gene) in Children with Hemoglobinopathies and Diamond-Blackfan Anemia Given α/β T-Cell Depleted HLA-Haploidentical Stem Cell Transplantation (HSCT)

Inducible MyD88/CD40 Enhances Proliferation and Survival of PRAME-Specific TCR-Engineered T Cells and Increases Anti-Tumor Effects in Myeloma

Clinical Outcome after Adoptive Infusion of BPX-501 Cells (donor T cells transduced with iC9 suicide gene) in Children Given Alpha/Beta T-Cell Depleted HLA-Haploidentical Hematopoietic Stem Cell Transplantation (haplo-HSCT): Preliminary Results of a Phase I-II Trial

Immune Reconstitution after Adoptive Infusion of BPX501 Cells (donor T cells transduced with iC9 suicide gene) in Children Given Alpha/Beta T-Cell Depleted HLA-Haploidentical Hematopoietic Stem Cell Transplantation (haplo-HSCT): Preliminary Phenotypic and Functional Results of a Phase I-II Trial

BPX-501 Cells (donor T cells transduced with iC9 suicide gene) Are Able to Clear Life-Threatening Viral Infections in Children with Primary Immune Deficiencies Given Alpha/Beta T-Cell Depleted HLA-Haploidentical Hematopoietic Stem Cell Transplantation (haplo-HSCT)

Removal Of Alpha/Beta+ T Cells and Of CD19+ B Cells From The Graft Translates Into Rapid Engraftment, Absence Of Visceral Graft-Versus-Host Disease and Low Transplant-Related Mortality In Children With Acute Leukemia Given HLA-Haploidentical Hematopoietic Stem Cell Transplantation

Efficacy of the “MarrowMiner” a Novel, Minimally Invasive Bone Marrow Harvesting Device in a Large Animal Model.

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