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Journal Articles

Interim Results of the Real-Life Study Evaluating the Efficacy and Safety of Ponatinib "Topase" Reveals Induction of Early Molecular Responses in Patients with TKI-Resistant or Intolerant CML

Agnès Guerci, MD PhD, Emilie Cayssials, MD, Philippe Rousselot, MD PhD, Francoise Huguet, MD, Valerie Coiteux, MD, Marc G. Berger, MD PhD, Gabriel Etienne, MD PhD, Ali G Turhan, MD PhD

Blood (2019) 134 (Supplement_1): 5908.

https://doi.org/10.1182/blood-2019-122769

Published: 2019

Journal Articles

NUP98-HOXA9 -Initiates Molecular and Biologic Features of Disease Progression in a Humanized Model of CML

Ivan Sloma, PharmD, PhD, Philip Beer, PhD FRCPath, MRCP, Christophe Desterke, PhD, Elizabeth Bulaeva, Misha Bilenky, Michelle Moksa, Kamini Raghuram, Cedric Brimacombe, Karen Lambie, Ali G Turhan, MD PhD, Orianne Wagner-Ballon, MD PhD, Philippe Gaulard, MD PhD, R. Keith Humphries, MD PhD, Martin Hirst, PhD BS, Connie J. Eaves, PhD

Blood (2019) 134 (Supplement_1): 4139.

https://doi.org/10.1182/blood-2019-127839

Published: 2019

Journal Articles

The Embryonic Program Activated during Blast Crisis of Chronic Myelogenous Leukemia (CML) Implicates a TCF7L2 and MYC Cooperative Chromatin Binding and Represents a Druggable Target

Christophe Desterke, PhD, Sarah Pagliaro, Pharm D, Patricia Hugues, Annelise Bennaceur-Griscelli, MD PhD, Ali G Turhan, MD PhD

Blood (2019) 134 (Supplement_1): 1632.

https://doi.org/10.1182/blood-2019-124796

Published: 2019

Journal Articles

DIS3 Mutation in RUNX1-Mutated AML1 Confers a Highly Dismal Prognosis in AML By Repressing Sister Chromatid Cohesion

Christophe Desterke, PhD, Annelise Bennaceur-Griscelli, MD PhD, Ali G Turhan, MD PhD

Blood (2019) 134 (Supplement_1): 1454.

https://doi.org/10.1182/blood-2019-123352

Published: 2019

Journal Articles

Revisiting Early Stages of Chronic Myeloid Leukemia (CML): Evidence That Leukemic Progenitors Appear First in Peripheral Blood during Molecular Recurrence

Ali G Turhan, MD PhD, Patricia Hugues, Nathalie Sorel, Christophe Desterke, Annelise Bennaceur-Griscelli, MD PhD, Jean-Claude Chomel, PharmD PhD

Blood (2018) 132 (Supplement 1): 5425.

https://doi.org/10.1182/blood-2018-99-110676

Published: 2018

Journal Articles

Single Cell Transcriptome in Chronic Myeloid Leukemia (CML): Pseudotime Analysis Reveals a Rare Population with Embryonic Stem Cell Features and Druggable Intricated Transitional Stem Cell States

Sarah Pagliaro, Pharm D, Christophe Desterke, Herve Acloque, PhD, Annelise Bennaceur-Griscelli, MD PhD, Ali G Turhan, MD PhD

Blood (2018) 132 (Supplement 1): 934.

https://doi.org/10.1182/blood-2018-99-110679

Published: 2018

Journal Articles

A Novel Metabolic Transcriptome Identified in Myelodysplastic Syndromes (MDS) Correlates with OMS Classification and Poor Prognosis

Christophe Desterke, Estelle Balducci, Xavier Fund, Claire Borie, Annelise Bennaceur-Griscelli, MD PhD, Ali G Turhan, MD PhD

Blood (2018) 132 (Supplement 1): 5495.

https://doi.org/10.1182/blood-2018-99-110678

Published: 2018

Journal Articles

Micro-RNA Profiling Reveals the Key Role of miR-206 in the Hematopoietic Potential of Human Embryonic and Induced Pluripotent Stem Cells

Stephane Flamant, Jean-Claude Chomel, PharmD PhD, Christophe Desterke, Olivier Feraud, Emilie Gobbo, Maria Teresa Mitjavila-Garcia, Adlen Foudi, Frank Griscelli, Ali G Turhan, MD PhD, Annelise Bennaceur-Griscelli, MD PhD

Blood (2018) 132 (Supplement 1): 1275.

https://doi.org/10.1182/blood-2018-99-110729

Published: 2018

Journal Articles

The Cell Surface NADH Oxidase ENOX2 Is Highly Expressed in Chronic Myeloid Leukemia (CML): a Redox Protein As a Secreted Surrogate Biomarker and Druggable Target

Seda Baykal, Maud Voldoire, MD, Christophe Desterke, Nathalie Sorel, Hyacinthe Atchroue Johnson Ansah, Agnes Guerci-Bresler, MD, Jean-Claude Chomel, PharmD PhD, Annelise Bennaceur-Griscelli, MD PhD, Ali G Turhan, MD, PhD

Blood (2016) 128 (22): 3059.

https://doi.org/10.1182/blood.V128.22.3059.3059

Published: 2016

Journal Articles

ETS1 Expression Is Upregulated in Chronic Myeloid Leukemia (CML) and the ETS1 Transcriptional Program Correlates with Disease Progression Towards Blast Crisis

Christophe Desterke, PhD, Maud Voldoire, MD, Nathalie Sorel, Marie Laure Bonnet, Sarah Pagliaro, PharmD, Annelise Bennaceur-Griscelli, MD PhD, Emilie Cayssials, MD, Jean-Claude Chomel, PharmD PhD, Ali G Turhan, MD, PhD

Blood (2016) 128 (22): 442.

https://doi.org/10.1182/blood.V128.22.442.442

Published: 2016

Journal Articles

Blast Crisis in a Dish: Generation of a Blast Crisis Model in Chronic Myeloid Leukemia (CML) Using Patient-Specific Induced Pluripotent Stem Cells ( iPSC)

Gladys Telliam, Christophe Desterke, PhD, Olivier Féraud, PhD, Frank Griscelli, PharmD, PhD, Noufissa Oudrhiri, Micheline Fontaine Arnoux, Radhia Najar, PhD, Herve Acloque, PhD, Annelise Bennaceur-Griscelli, MD PhD, Ali G Turhan, MD, PhD

Blood (2016) 128 (22): 933.

https://doi.org/10.1182/blood.V128.22.933.933

Published: 2016

Journal Articles

Aryl Hydrocarbon Receptor (AhR) Pathway Directly Controls Hematopoietic Proliferation in Chronic Myeloid Leukemia (CML) and Its Inhibition Allows Massive Expansion of Leukemic Progenitors and Stem Cells

Melanie Gentil, MD, Patricia Hugues, Gladys Telliam, Ivan Sloma, PharmD,PhD, Seda Baykal, Jerome Artus, PhD, Agnes Guerci, MD, Hyacinthe Johnson Ansa, Adlen Foudi, PhD, Annelise Bennaceur-Griscelli, MD PhD, Ali G Turhan, MD PhD

Blood (2015) 126 (23): 4013.

https://doi.org/10.1182/blood.V126.23.4013.4013

Published: 2015

Journal Articles

A Bio-Integrative Approach Identifies an Inflammatory Signature in Chronic Myeloid Leukemia (CML) Stem Cells That Is Highly Perturbed in CML Blast Crisis and Involves REL transcription Factor

Christophe Desterke, PhD, Ludovic Marie-Sainte, Amine Sbitti, PhD, Ali Naama, Annelise Bennaceur-Griscelli, MD PhD, Ali G Turhan, MD PhD, Ivan Sloma, PharmD,PhD

Blood (2015) 126 (23): 4017.

https://doi.org/10.1182/blood.V126.23.4017.4017

Published: 2015

Journal Articles

Inecalcitol, a Novel Adjuvant Therapy Inhibiting Chronic Myeloid Leukemia (CML) Stem Cells, Activates a Macrophage Differentiation Pathway in Leukemic Progenitors

Christophe Desterke, PhD, Hyacinthe Johnson-Ansa, MD, Patricia Hugues, Jean Francois Dufour-Lamartinie, MD, Remi Delansorne, PhD, Agnes Guerci, MD, Annelise BENNACEUR Griscelli, MD PhD, Ali G Turhan, MD PhD

Blood (2015) 126 (23): 4020.

https://doi.org/10.1182/blood.V126.23.4020.4020

Published: 2015

Journal Articles

Infrared Microspectroscopy Allows Direct Identification of Leukemic Cells Expressing T315I-Mutated BCR-ABL Via a Unique Spectral Signature

Christophe Sandt, Olivier Feraud, Marie Laure Bonnet, Rania Khedhir, Marie Claude Meunier, Paul Dumas, Annelise Bennaceur-Griscelli, MD PhD, Ali G Turhan, MD PhD

Blood (2014) 124 (21): 4510.

https://doi.org/10.1182/blood.V124.21.4510.4510

Published: 2014

Journal Articles

A Novel DNA Repair Chip Assay Allows Rapid Identification of DNA Repair Abnormalities Induced By BCR-ABL

Ali G Turhan, MD PhD, Fanny Sarrazy, Marie Laure Bonnet, Angelina Bertrand, Marie Claude Meunier, Djamel Aggoune, Jean-Claude Chomel, PharmD, PhD, Olivier Feraud, Sylvain Caillat, Annelise Bennaceur-Griscelli, MD PhD, Sylvie Sauvaigo, PhD

Blood (2014) 124 (21): 4536.

https://doi.org/10.1182/blood.V124.21.4536.4536

Published: 2014

Journal Articles

T315I-Mutated BCR-ABL Induces a Distinct and Specific Molecular Signature With High Expression Of Zinc Finger (ZNF) Transcription Factors

Christophe Desterke, PhD, Djamel Aggoune, Marie Laure Bonnet, Nais Prade, Jean-Claude Chomel, PharmD, PhD, Eric Delabesse, MD, PhD, Ali G Turhan, MD, PhD

Blood (2013) 122 (21): 4899.

https://doi.org/10.1182/blood.V122.21.4899.4899

Published: 2013

Journal Articles

Superoxide Dismutase 2 (Sod2) Expression Is Highly Decreased In Chronic Myeloid Leukemia (CML): Contribution To Genetic Instability In Bcr-Abl-Expressing Leukemic Cells

Sandrine Girerd, Lucie Tosca, PharmD, PhD, Olivier Herault, MD, PhD, Christine Vignon, PhD, Denis Biard, PhD, Fatima Dkhissi, PhD, Clémentine Bouneau, Djamel Aggoune, Angelina Bertrand, Marie Laure Bonnet, Nathalie Sorel, PhD, Gerard Tachdjian, MD, PhD, François Guilhot, MD, Joelle Guilhot, PhD, Jean-Claude Chomel, PharmD, PhD, Ali G Turhan, MD, PhD

Blood (2013) 122 (21): 3980.

https://doi.org/10.1182/blood.V122.21.3980.3980

Published: 2013

Journal Articles

Vitamin D3 Analog Inecalcitol Synergizes Vith Imatinib To Inhibit Selectively The Growth Of Chronic Myeloid Leukemia (CML) Progenitors and Stem Cells

Ali G Turhan, MD, PhD, Marie Laure Bonnet, Bouneau Clementine, Remi Delansorne, PhD, Jean-François Dufour-Lamartinie, MD, Agnès Guerci-Bresler, MD, Hyacinthe A. Johnson-Ansah, MD, Annelise Bennaceur-Griscelli, MD, PhD

Blood (2013) 122 (21): 3981.

https://doi.org/10.1182/blood.V122.21.3981.3981

Published: 2013

Journal Articles

Severe Acquired Bleeding Tendency Secondary To An Anti-Thrombin Antibody In a Patient With Monoclonal Gammapathy Of Unknown Significance: Direct In Vivo evidence

Valerie Proulle, MD, PhD, Celine Desconclois, PD, Cecile Lavenu-Bombled, MD, PhD, Cecile Goujard, MD, PhD, Anish V Sharda, MBBS, MPH, Ali G Turhan, MD, PhD

Blood (2013) 122 (21): 1111.

https://doi.org/10.1182/blood.V122.21.1111.1111

Published: 2013

NARROW

Interim Results of the Real-Life Study Evaluating the Efficacy and Safety of Ponatinib "Topase" Reveals Induction of Early Molecular Responses in Patients with TKI-Resistant or Intolerant CML

NUP98-HOXA9 -Initiates Molecular and Biologic Features of Disease Progression in a Humanized Model of CML

The Embryonic Program Activated during Blast Crisis of Chronic Myelogenous Leukemia (CML) Implicates a TCF7L2 and MYC Cooperative Chromatin Binding and Represents a Druggable Target

DIS3 Mutation in RUNX1-Mutated AML1 Confers a Highly Dismal Prognosis in AML By Repressing Sister Chromatid Cohesion

Revisiting Early Stages of Chronic Myeloid Leukemia (CML): Evidence That Leukemic Progenitors Appear First in Peripheral Blood during Molecular Recurrence

Single Cell Transcriptome in Chronic Myeloid Leukemia (CML): Pseudotime Analysis Reveals a Rare Population with Embryonic Stem Cell Features and Druggable Intricated Transitional Stem Cell States

A Novel Metabolic Transcriptome Identified in Myelodysplastic Syndromes (MDS) Correlates with OMS Classification and Poor Prognosis

Micro-RNA Profiling Reveals the Key Role of miR-206 in the Hematopoietic Potential of Human Embryonic and Induced Pluripotent Stem Cells

The Cell Surface NADH Oxidase ENOX2 Is Highly Expressed in Chronic Myeloid Leukemia (CML): a Redox Protein As a Secreted Surrogate Biomarker and Druggable Target

ETS1 Expression Is Upregulated in Chronic Myeloid Leukemia (CML) and the ETS1 Transcriptional Program Correlates with Disease Progression Towards Blast Crisis

Blast Crisis in a Dish: Generation of a Blast Crisis Model in Chronic Myeloid Leukemia (CML) Using Patient-Specific Induced Pluripotent Stem Cells ( iPSC)

Aryl Hydrocarbon Receptor (AhR) Pathway Directly Controls Hematopoietic Proliferation in Chronic Myeloid Leukemia (CML) and Its Inhibition Allows Massive Expansion of Leukemic Progenitors and Stem Cells

A Bio-Integrative Approach Identifies an Inflammatory Signature in Chronic Myeloid Leukemia (CML) Stem Cells That Is Highly Perturbed in CML Blast Crisis and Involves REL transcription Factor

Inecalcitol, a Novel Adjuvant Therapy Inhibiting Chronic Myeloid Leukemia (CML) Stem Cells, Activates a Macrophage Differentiation Pathway in Leukemic Progenitors

Infrared Microspectroscopy Allows Direct Identification of Leukemic Cells Expressing T315I-Mutated BCR-ABL Via a Unique Spectral Signature

A Novel DNA Repair Chip Assay Allows Rapid Identification of DNA Repair Abnormalities Induced By BCR-ABL

T315I-Mutated BCR-ABL Induces a Distinct and Specific Molecular Signature With High Expression Of Zinc Finger (ZNF) Transcription Factors

Superoxide Dismutase 2 (Sod2) Expression Is Highly Decreased In Chronic Myeloid Leukemia (CML): Contribution To Genetic Instability In Bcr-Abl-Expressing Leukemic Cells

Vitamin D3 Analog Inecalcitol Synergizes Vith Imatinib To Inhibit Selectively The Growth Of Chronic Myeloid Leukemia (CML) Progenitors and Stem Cells

Severe Acquired Bleeding Tendency Secondary To An Anti-Thrombin Antibody In a Patient With Monoclonal Gammapathy Of Unknown Significance: Direct In Vivo evidence

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American Society of Hematology

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American Society of Hematology

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