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Journal Articles

Immune Landscapes Predict Chemotherapy Resistance and Anti-Leukemic Activity of Flotetuzumab, an Investigational CD123×CD3 Bispecific Dart® Molecule, in Patients with Relapsed/Refractory Acute Myeloid Leukemia

Blood (2019) 134 (Supplement_1): 460.

https://doi.org/10.1182/blood-2019-121870

Published: 2019

Journal Articles

Adaptive Immune Gene Signatures Correlate with Response to Flotetuzumab, a CD123 × CD3 Bispecific Dart ® Molecule, in Patients with Relapsed/Refractory Acute Myeloid Leukemia

Sergio Rutella, MD PhD FRCPath, Sarah E. Church, PhD, Jayakumar Vadakekolathu, PhD, Elena Viboch, MSc, Amy H Sullivan, BSc, Tressa Hood, MSc, Sarah E. Warren, PhD, Alessandra Cesano, MD PhD, Ross La Motte-Mohs, PhD, John Muth, MS, Helene Lelièvre, PhD PharmD, Bob Lowenberg, MD, John F. DiPersio, MD PhD, Jan K Davidson-Moncada, MD PhD

Blood (2018) 132 (Supplement 1): 444.

https://doi.org/10.1182/blood-2018-99-111539

Published: 2018

Journal Articles

Phase 1 Cohort Expansion of Flotetuzumab, a CD123×CD3 Bispecific Dart ® Protein in Patients with Relapsed/Refractory Acute Myeloid Leukemia (AML)

Blood (2018) 132 (Supplement 1): 764.

https://doi.org/10.1182/blood-2018-99-117085

Published: 2018

Journal Articles

Immune Gene Expression Profiling in Children and Adults with Acute Myeloid Leukemia Identifies Distinct Phenotypic Patterns

Jayakumar Vadakekolathu, PhD, Tasleema Patel, BSc, Stephen Reeder, BSc, Heidi Schaarschmidt, BSc, Marc Schmitz, MD, Martin Bornhäuser, MD, Sarah E. Warren, PhD, Tressa Hood, MS, Patrick Danaher, PhD, Alessandra Cesano, Joseph M. Beechem, PhD, A. Graham Pockley, PhD, Sarah K Tasian, MD, Sergio Rutella, MDPhDFRCPath

Blood (2017) 130 (Supplement 1): 3942.

https://doi.org/10.1182/blood.V130.Suppl_1.3942.3942

Published: 2017

Journal Articles

Molecular Definition of Activated B Cell-like (ABC) DLBCL Identifies Patients Who May Benefit from Front-Line Intensive R-HDS Chemotherapy with ASCT

Federica Melle, Giovanna Motta, Marco Fabbri, Valentina Tabanelli, MD, Angelica Calleri, PhD, Riccardo Bruna, Enrico Derenzini, MD PhD, Chiara Corsini, Corrado Tarella, MD Prof, Alessandro M. Gianni, MDProf, Alessandro Rambaldi, MD Prof, Alessandra Cesano, Stefano A. Pileri

Blood (2017) 130 (Supplement 1): 3998.

https://doi.org/10.1182/blood.V130.Suppl_1.3998.3998

Published: 2017

Journal Articles

Analytical Validation of the nCounter ® -based Lymphoma Subtyping Test (LST) for Cell-of-Origin (COO) Identification in Formalin-Fixed Paraffin-Embedded (FFPE) Diffuse Large B-Cell Lymphoma (DLBCL) Specimens

Ning Chen, Shannon Dennis, Patrick Danaher, Brett Wallden, Tressa Hood, Xing Ren, Mingdong Liu, Naeem Dowidar, Amy Sullivan, Taryn Haffner, Alessandra Cesano, Sean Ferree, James Storhoff

Blood (2016) 128 (22): 2933.

https://doi.org/10.1182/blood.V128.22.2933.2933

Published: 2016

Journal Articles

Functional Pathway Analysis Of JAK2 Mutated and Wild Type Myeloproliferative Neoplasms As a Tool For Patient Stratification and Therapeutic Selection

Matt Westfall, Ph.D., Rachael E. Hawtin, Ph.D., Diane Longo, Ph.D., Michelle Cholankeril, MD, Reena K. Vora, MD, Michelle Atallah, Alessandra Cesano, M.D., Ph.D., Steven L Allen, MD, Scott Z. Fields, MD

Blood (2013) 122 (21): 5263.

https://doi.org/10.1182/blood.V122.21.5263.5263

Published: 2013

Journal Articles

Single Cell Network Profiling (SCNP) of Early-Stage Chronic Lymphocytic Leukemia (CLL): Association with p53, IGHV Mutational Status and Time to First Treatment (TTFT)

Jason Ptacek, PhD, Erik Evensen, Rachael E. Hawtin, Ph.D., Greg Friedland, Jodi R. Ware, PharmD, James Cordeiro, Nadia Peragine, Ph.D, Alessandra Cesano, M.D., Ph.D., Robin Foà, MD, Anna Guarini, PhD

Blood (2012) 120 (21): 1783.

https://doi.org/10.1182/blood.V120.21.1783.1783

Published: 2012

Journal Articles

Single Cell Network Profiling (SCNP) Identifies Altered Signaling Between Patient Risk Groups in B-Cell Chronic Lymphocytic Leukemia (B-CLL).

Jason Ptacek, PhD, Erik Evensen, Ph.D., Greg Friedland, James Cordeiro, Jodi R. Ware, PharmD, Charles C. Chu, PhD, Rajendra N Damle, PhD, Lu Zhang, MS, Nicholas Chiorazzi, MD, Alessandra Cesano, M.D., Ph.D., Rachael E. Hawtin, Ph.D.

Blood (2012) 120 (21): 2876.

https://doi.org/10.1182/blood.V120.21.2876.2876

Published: 2012

Journal Articles

Azacitidine (AZA) and Decitabine (DAC) Show Differential Effects On DNA Methyltransferase (DNMT) Levels in Patients with High Risk (HR) Myelodysplastic Syndrome (MDS)

Aileen Cohen, M.D., Ph.D., Ying-Wen Huang, MS, Rachael E. Hawtin, Ph.D., Jodi R. Ware, PharmD, Alessandra Cesano, M.D., Ph.D., Steven M. Kornblau, MD, PhD

Blood (2012) 120 (21): 4906.

https://doi.org/10.1182/blood.V120.21.4906.4906

Published: 2012

Journal Articles

Single-Cell Network Profiling (SCNP)-Based Classifier to Predict Response to Induction Therapy in Elderly Patients with Acute Myeloid Leukemia (AML): Validation in Two Independent Sample Sets From ECOG and SWOG Trials.

Alessandra Cesano, M.D., Ph.D., Cheryl L Willman, MD, Kenneth J. Kopecky, PhD, Urte Gayko, Ph.D., Santosh Putta, Ph.D., Brent Louie, Ph.D., Matt Westfall, Ph.D., Norman Purvis, Ph.D., David Spellmeyer, PhD, Carol Marimpietri, James Hackett, Ph.D., Jing Shi, Elisabeth Paietta, PhD, Martin S. Tallman, MD, Larry D Cripe, MD, Susan K. Atwater, MD, Frederick R. Appelbaum, MD, Jerald P. Radich, MD

Blood (2012) 120 (21): 2489.

https://doi.org/10.1182/blood.V120.21.2489.2489

Published: 2012

Journal Articles

Single Cell Network Profiling (SCNP) Reveals Age-and Disease-Based Heterogeneity in Healthy Individuals and in Patients with Low Risk (LR) Myelodysplastic Syndrome (MDS)

Aileen Cleary Cohen, MD, PhD, Ying-Wen Huang, MS, Alessandra Cesano, M.D., Ph.D., Rachael E. Hawtin, Ph.D., Jodi R. Ware, PharmD, Bishmaraj Arulrajah, B.S., Steven M. Kornblau, MD

Blood (2011) 118 (21): 2788.

https://doi.org/10.1182/blood.V118.21.2788.2788

Published: 2011

Journal Articles

BCR Responsiveness is Associated with Time to First Treatment (TTFT) in B-Cell Chronic Lymphocytic Leukemia (B-CLL): Results From a Single Cell Network Profiling (SCNP) Verification Study

Alessandra Cesano, M.D., Ph.D., Erik Evensen, Ph.D., Jason Ptacek, PhD, James Cordeiro, Rachael E. Hawtin, Ph.D., Jodi R. Ware, PharmD, Ilaria Nichele, Maria Teresa Scupoli, Ph.D.

Blood (2011) 118 (21): 2834.

https://doi.org/10.1182/blood.V118.21.2834.2834

Published: 2011

Journal Articles

Single Cell Network Profiling (SCNP) Functionally Characterizes FLT3 Pathway Deregulation in Non-M3 Acute Myeloid Leukemia (AML) and Provides Prognostic Value Independent From Mutational Status

Alessandra Cesano, M.D., Ph.D., Santosh Putta, Ph.D., Kavita Mathi, MD, David B. Rosen, PhD, Urte Gayko, Ph.D., Rachael E. Hawtin, Ph.D., Larry D Cripe, MD, Zhuoxin Sun, PhD, Martin S. Tallman, MD, Elisabeth Paietta, Ph.D.

Blood (2011) 118 (21): 2512.

https://doi.org/10.1182/blood.V118.21.2512.2512

Published: 2011

Journal Articles

Single Cell Network Profiling (SCNP) Reveals Race-Associated Differences in B Cell Receptor Signaling Pathway Activation

Diane Longo, Ph.D., Brent Louie, Ph.D., Kavita Mathi, MD, Zoltan Pos, PhD, Ena Wang, M.D., Rachael E. Hawtin, Ph.D., Francesco Marincola, M.D., Alessandra Cesano, M.D., Ph.D.

Blood (2011) 118 (21): 1125.

https://doi.org/10.1182/blood.V118.21.1125.1125

Published: 2011

Journal Articles

Impact of Time From Blood Draw to Peripheral Blood Mononuclear Cell (PBMC) Processing and Cryopreservation on Functional Pathway Activity As Measured by Single Cell Network Profiling (SCNP) Assays

Diane Longo, Ph.D., Brent Louie, Ph.D., Erik Evensen, Ph.D., Rachael E. Hawtin, Ph.D., Alessandra Cesano, M.D., Ph.D.

Blood (2011) 118 (21): 4922.

https://doi.org/10.1182/blood.V118.21.4922.4922

Published: 2011

Journal Articles

Single Cell Network Profiling (SCNP) Signatures Predict Response to Induction Therapy and Relapse Risk In Pediatric Patients with Acute Myeloid Leukemia: Children's Oncology Group (COG) Study POG-9421

Norman J. Lacayo, MD, Aileen Cohen, Ph.D., M.D., Matt Westfall, Ph.D., Alan Lackey, MS, Xiaohua (Robert) Xin, Ph.D., M.D., Urte Gayko, Ph.D., Santosh Putta, Ph.D., Soheil Meshinchi, MD, PhD, Susana C. Raimondi, PhD, Todd A. Alonzo, PhD, Robert J. Arceci, MD, PhD, Yaddanapudi Ravindranath, MD, Gary Van Houten Dahl, MD, Alessandra Cesano, MD

Blood (2010) 116 (21): 954.

https://doi.org/10.1182/blood.V116.21.954.954

Published: 2010

Journal Articles

Single Cell Network Profiling (SCNP) of IFN-α Signaling Pathways In Peripheral Blood Mononuclear Cells From Healthy Donors: Implications for Disease Characterization, Treatment Selection, and Drug Discovery

Diane Longo, PhD, Erik Evensen, PhD, Wendy J. Fantl, PhD, Zoltan Pos, PhD, Francesco Marincola, MD, Alessandra Cesano, MD

Blood (2010) 116 (21): 4867.

https://doi.org/10.1182/blood.V116.21.4867.4867

Published: 2010

Journal Articles

Single Cell Network Profiling (SCNP) Assay Reveals B Cell Receptor Signaling Heterogeneity In the Context of ZAP-70 Expression In Patients with Chronic Lymphocytic Leukemia (CLL)

Keith Shults, Ph.D., Eric Evensen, Ph.D., Maria Teresa Scupoli, Ph.D., Roberta Zanotti, MD, Xiaohua (Robert) Xin, Ph.D., M.D., Alessandra Cesano, Ph.D., MD

Blood (2010) 116 (21): 3586.

https://doi.org/10.1182/blood.V116.21.3586.3586

Published: 2010

Journal Articles

Sample Cryopreservation Does Not Affect Functional Read Outs In SCNP Assays: Implications for Biomarker Development

Alessandra Cesano, MD, Jason R Gotlib, MD, MS, Norman J. Lacayo, MD, Santosh Putta, Ph.D., Alan Lackey, MS, Urte Gayko, Ph.D., Steven M. Kornblau, MD

Blood (2010) 116 (21): 4843.

https://doi.org/10.1182/blood.V116.21.4843.4843

Published: 2010

NARROW

Immune Landscapes Predict Chemotherapy Resistance and Anti-Leukemic Activity of Flotetuzumab, an Investigational CD123×CD3 Bispecific Dart® Molecule, in Patients with Relapsed/Refractory Acute Myeloid Leukemia

Adaptive Immune Gene Signatures Correlate with Response to Flotetuzumab, a CD123 × CD3 Bispecific Dart ® Molecule, in Patients with Relapsed/Refractory Acute Myeloid Leukemia

Phase 1 Cohort Expansion of Flotetuzumab, a CD123×CD3 Bispecific Dart ® Protein in Patients with Relapsed/Refractory Acute Myeloid Leukemia (AML)

Immune Gene Expression Profiling in Children and Adults with Acute Myeloid Leukemia Identifies Distinct Phenotypic Patterns

Molecular Definition of Activated B Cell-like (ABC) DLBCL Identifies Patients Who May Benefit from Front-Line Intensive R-HDS Chemotherapy with ASCT

Analytical Validation of the nCounter ® -based Lymphoma Subtyping Test (LST) for Cell-of-Origin (COO) Identification in Formalin-Fixed Paraffin-Embedded (FFPE) Diffuse Large B-Cell Lymphoma (DLBCL) Specimens

Functional Pathway Analysis Of JAK2 Mutated and Wild Type Myeloproliferative Neoplasms As a Tool For Patient Stratification and Therapeutic Selection

Single Cell Network Profiling (SCNP) of Early-Stage Chronic Lymphocytic Leukemia (CLL): Association with p53, IGHV Mutational Status and Time to First Treatment (TTFT)

Single Cell Network Profiling (SCNP) Identifies Altered Signaling Between Patient Risk Groups in B-Cell Chronic Lymphocytic Leukemia (B-CLL).

Azacitidine (AZA) and Decitabine (DAC) Show Differential Effects On DNA Methyltransferase (DNMT) Levels in Patients with High Risk (HR) Myelodysplastic Syndrome (MDS)

Single-Cell Network Profiling (SCNP)-Based Classifier to Predict Response to Induction Therapy in Elderly Patients with Acute Myeloid Leukemia (AML): Validation in Two Independent Sample Sets From ECOG and SWOG Trials.

Single Cell Network Profiling (SCNP) Reveals Age-and Disease-Based Heterogeneity in Healthy Individuals and in Patients with Low Risk (LR) Myelodysplastic Syndrome (MDS)

BCR Responsiveness is Associated with Time to First Treatment (TTFT) in B-Cell Chronic Lymphocytic Leukemia (B-CLL): Results From a Single Cell Network Profiling (SCNP) Verification Study

Single Cell Network Profiling (SCNP) Functionally Characterizes FLT3 Pathway Deregulation in Non-M3 Acute Myeloid Leukemia (AML) and Provides Prognostic Value Independent From Mutational Status

Single Cell Network Profiling (SCNP) Reveals Race-Associated Differences in B Cell Receptor Signaling Pathway Activation

Impact of Time From Blood Draw to Peripheral Blood Mononuclear Cell (PBMC) Processing and Cryopreservation on Functional Pathway Activity As Measured by Single Cell Network Profiling (SCNP) Assays

Single Cell Network Profiling (SCNP) Signatures Predict Response to Induction Therapy and Relapse Risk In Pediatric Patients with Acute Myeloid Leukemia: Children's Oncology Group (COG) Study POG-9421

Single Cell Network Profiling (SCNP) of IFN-α Signaling Pathways In Peripheral Blood Mononuclear Cells From Healthy Donors: Implications for Disease Characterization, Treatment Selection, and Drug Discovery

Single Cell Network Profiling (SCNP) Assay Reveals B Cell Receptor Signaling Heterogeneity In the Context of ZAP-70 Expression In Patients with Chronic Lymphocytic Leukemia (CLL)

Sample Cryopreservation Does Not Affect Functional Read Outs In SCNP Assays: Implications for Biomarker Development

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American Society of Hematology

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