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Journal Articles

A Niche Driven Mechanism Determines Response to ATRA and a Mutation-Independent Therapeutic Approach for MDS and AML

Ioanna Mosialou, Abdullah Mahmood Ali, Alvaro Cuesta-Dominguez, Rossella Labella, Voula Vgenopoulou, Brygida Bisikirska, Marta Galan-Diez, Anqi Wang, Jan Philipp Bewersdorf, Cui Liang, Mael Heiblig, Joseph G Jurcic, Ellin Berman, Raul Rabadan, Steven M. Kornblau, Guillermo Garcia-Manero, Azra Raza, Stavroula Kousteni

Blood (2024) 144 (Supplement 1): 5788.

https://doi.org/10.1182/blood-2024-212307

Published: 2024

Journal Articles

Methylation Biology of a Blood-Based MDS Risk Stratification Test

Alvin Shi, Abdullah Mahmood Ali, Gordon Cann, Rita Shaknovich, Oliver Venn, Azra Raza, Qinwen Liu

Blood (2023) 142 (Supplement 1): 4599.

https://doi.org/10.1182/blood-2023-180256

Published: 2023

Journal Articles

Serum Amyloid A1 (SAA1) Secreted By the Stromal Microenvironment Drives Malignant Clonal Proliferation in Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML)

Brian Chernak, Marta Galan-Diez, Abdullah Mahmood Ali, Alvaro Cuesta-Dominguez, Ziwei Chen, Thomas Koehnke, Ravindra Majeti, Martin Carroll, Azra Raza, Stavroula Kousteni

Blood (2023) 142 (Supplement 1): 4118.

https://doi.org/10.1182/blood-2023-174485

Published: 2023

Journal Articles

Casein Kinase 1 Delta Is a Novel Regulator of mRNA Translation and Druggable Target in Aggressive Lymphomas

Ipsita Pal, PhD, Sohani Das Sharma, PhD, Andre M. Grilo, PhD, Prabhjot S. Mundi, MD, Luigi Scotto, PhD, Abdullah Mahmood Ali, PhD, Luke E Berchowitz, PhD, Siddhartha Mukherjee, MD PhD, Owen O'Connor, MD PhD, Marko Jovanovic, PhD, Changchun Deng, MD PhD

Blood (2019) 134 (Supplement_1): 2864.

https://doi.org/10.1182/blood-2019-129528

Published: 2019

Journal Articles

Pharmacological Targeting of Osteoblast-Induced MDS and AML

Ioanna Mosialou, PhD, Marta Galan-Diez, PhD, Andrew Vandenberg, Abdullah Mahmood Ali, PhD, Azra Raza, MD, Stavroula Kousteni, PhD

Blood (2018) 132 (Supplement 1): 5235.

https://doi.org/10.1182/blood-2018-99-119985

Published: 2018

Journal Articles

Long Term Responses to Rigosertib in Lower-Risk Myelodysplastic Syndromes (MDS) Patients

Azra Raza, MD, Can Yalçın, Miray Cimist, Ryan Shelton, BS, Syed Fazl Ali Bilgrami, MD, Mark Lawrence Heaney, MD PhD, Abdullah Mahmood Ali, PhD

Blood (2017) 130 (Supplement 1): 5316.

https://doi.org/10.1182/blood.V130.Suppl_1.5316.5316

Published: 2017

Journal Articles

Rigosertib Oral in Transfusion Dependent Lower Risk Myelodysplastic Syndromes (LR-MDS): Optimization of Dose and Rate of Transfusion Independence (TI) or Transfusion Reduction (TR) in a Single-Arm Phase 2 Study

Azra Raza, MD, Aref Al-Kali, MD, Raoul Tibes, MD PhD, Gary Spitzer, MD, Manila Gaddh, MD, Benjamin Tycko, MD PhD, Sangmin Lee, MD, Naomi Galili, PhD, Abdullah Mahmood Ali, PhD, John G. Mears, MD, Siddhartha Mukherjee, MD PhD, Ryan Shelton, BS, Steven M. Fruchtman, MD, Michael E. Petrone, MD MPH, Patrick S. Zbyszewski, MBA, Mark Lawrence Heaney, MD PhD

Blood (2017) 130 (Supplement 1): 1689.

https://doi.org/10.1182/blood.V130.Suppl_1.1689.1689

Published: 2017

Journal Articles

TET2 Deficiency Led to Expansion of Dysfunctional Erythroid Progenitors

Xiaoli Qu, MS, Lixiang Chen, Yaomei Wang, Yumin Huang, John Hale, Wei Li, Huizhi Zhao, Shijie Zhang, Xinhua Guo, Abdullah Mahmood Ali, PhD, Azra Raza, MD, Mohandas Narla, DSc, Qiaozhen Kang, PhD, Xiuli An, MD PhD

Blood (2017) 130 (Supplement 1): 2202.

https://doi.org/10.1182/blood.V130.Suppl_1.2202.2202

Published: 2017

Journal Articles

Longitudinal Transcriptome Analysis of Myelodysplatic Syndrome Progression to Acute Myeloid Leukemia: Implications for Prognosis

Etienne De Clara, PhD, Abdullah Mahmood Ali, PhD, Jehanzeb Kayani, Christopher Szeto, PhD, Justin Golovato, Andrew Sedgewick, PhD, Joseph G. Jurcic, MD, Steve Benz, PhD, Shahrooz Rabizadeh, PhD, Azra Raza, MD

Blood (2017) 130 (Supplement 1): 3961.

https://doi.org/10.1182/blood.V130.Suppl_1.3961.3961

Published: 2017

Journal Articles

Emergence of a Novel Clinical Entity within Myelodysplastic Syndromes Marked By Absence of Quantifiable Terminal Erythroid Differentiation, More Profound Anemia and Significantly Worse Survival across All Prognostic Risk Categories

Abdullah Mahmood Ali, PhD, Yumin Huang, Ronald F Pinheiro, MD, Fumin Xue, PhD, Jingping Hu, PhD, Nicholas Iverson, BS, Daniela Hoehn, MDPhD, Diego Coutinho, BS, Joseph Lane, MD, Christopher D. Hillyer, MD, Naomi Galili, PhD, Joseph G. Jurcic, MD, Mohandas Narla, DSc, Xiuli An, MD PhD, Azra Raza, MD

Blood (2017) 130 (Supplement 1): 4244.

https://doi.org/10.1182/blood.V130.Suppl_1.4244.4244

Published: 2017

Journal Articles

Umbralisib/TGR-1202 As a Novel Dual PI3K/CK1 Inhibitor Has a Unique Therapeutic Role in Silencing Oncogenes in Aggressive Lymphomas

Ipsita Pal, PhD, Yu Ri Kim, MD, Luigi Scotto, PhD, Mark R Lipstein, PhD, Abdullah Mahmood Ali, PhD, Siddhartha Mukherjee, MD PhD, Susan E. Bates, MDPhD, Owen A. O'Connor, MD, PhD, Changchun Deng, MD PhD

Blood (2017) 130 (Supplement 1): 2809.

https://doi.org/10.1182/blood.V130.Suppl_1.2809.2809

Published: 2017

Journal Articles

Unique Gene Expressional Profile Associated with Lack of Quantifiable Terminal Erythroid Differentiation in Myelodysplastic Syndrome Patients

Abdullah Mahmood Ali, PhD, Yumin Huang, Diego Coutinho, BS, Brian Chernak, BA, Etienne De Clara, PhD, Daniela Hoehn, MDPhD, Joseph G. Jurcic, MD, Mohandas Narla, DSc, Xiuli An, MD PhD, Azra Raza, MD

Blood (2017) 130 (Supplement 1): 2952.

https://doi.org/10.1182/blood.V130.Suppl_1.2952.2952

Published: 2017

Journal Articles

Killer Immunoglobulin-like Receptors (KIR) in Low-Risk Myelodysplastic Syndrome: Genotyping and Gene Expression Evaluation

Diego Coutinho, BS, Abdullah Mahmood Ali, PhD, Antonio Gualberto, PhD MD, Catherine Scholz, PharmD, Karen Bracken, MHS, Joseph G. Jurcic, MD, Azra Raza, MD

Blood (2017) 130 (Supplement 1): 1677.

https://doi.org/10.1182/blood.V130.Suppl_1.1677.1677

Published: 2017

Journal Articles

A Genomic Predictive Signature for Rigosertib in Lower Risk MDS Derived By Integrating Clinical Response, Mechanism of Action Data and Simulation

Steven M. Fruchtman, MD, Abdullah Mahmood Ali, PhD, Michael E. Petrone, MD MPH, Patrick Simon Zbyszewski, MBA, Benjamin Hoffman, PhD, Shireen Vali, PhD, Neeraj Kumar Singh, Shahabuddin Usmani, Himanshu Grover, Taher Abbasi, Azra Raza, MD

Blood (2016) 128 (22): 5535.

https://doi.org/10.1182/blood.V128.22.5535.5535

Published: 2016

Journal Articles

Loss of TET2 Function in Myelodysplastic Syndrome Results in Intragenic Hypermethylation and Alterations in mRNA Splicing

Allegra M Lord, Kendell Clement, Rebekka K. Schneider, MD, McConkey Marie, PhD, Michelle C. Chen, Ross L. Levine, MD, Ann Mullally, MD, Naomi Galili, PhD, Abdullah Mahmood Ali, PhD, Azra Raza, MD, Rafael Bejar, MD PhD, Alexander Meissner, PhD, Benjamin L. Ebert, MDPhD

Blood (2014) 124 (21): 775.

https://doi.org/10.1182/blood.V124.21.775.775

Published: 2014

Journal Articles

Molecular Genetic Analysis of Myelodysplastic Syndromes (MDS) Patients with Ring Sideroblasts (RS); Independent Confirmation of Association of SF3B1 Mutations with Better Prognosis

Abdullah Mahmood Ali, PhD, Nicholas Iverson, Alexander Penson, PhD, Allison Scott, Tabish Riaz, Raul Rabadan, PhD, Siddhartha Mukherjee, MD PhD, Azra Raza, MD

Blood (2014) 124 (21): 3237.

https://doi.org/10.1182/blood.V124.21.3237.3237

Published: 2014

Journal Articles

FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathway

Abdullah Mahmood Ali, Arun Pradhan, Thiyam Ramsingh Singh, Changhu Du, Jie Li, Kebola Wahengbam, Elke Grassman, Arleen D. Auerbach, Qishen Pang, Amom Ruhikanta Meetei

Blood (2012) 119 (14): 3285–3294.

https://doi.org/10.1182/blood-2011-10-385963

Published: 2012

Includes: Supplemental data

Journal Articles

Impaired FANCD2 monoubiquitination and hypersensitivity to camptothecin uniquely characterize Fanconi anemia complementation group M

Thiyam Ramsing Singh, Sietske T. Bakker, Sheba Agarwal, Michael Jansen, Elke Grassman, Barbara C. Godthelp, Abdullah Mahmood Ali, Chang-hu Du, Martin A. Rooimans, Qiang Fan, Kebola Wahengbam, Jurgen Steltenpool, Paul R. Andreassen, David A. Williams, Hans Joenje, Johan P. de Winter, Amom Ruhikanta Meetei

Blood (2009) 114 (1): 174–180.

https://doi.org/10.1182/blood-2009-02-207811

Published: 2009

Includes: Supplemental data

Journal Articles

Ectopic HOXB4 overcomes the inhibitory effect of tumor necrosis factor-α on Fanconi anemia hematopoietic stem and progenitor cells

Michael D. Milsom, Bernhard Schiedlmeier, Jeff Bailey, Mi-Ok Kim, Dandan Li, Michael Jansen, Abdullah Mahmood Ali, Michelle Kirby, Christopher Baum, Leslie J. Fairbairn, David A. Williams

Blood (2009) 113 (21): 5111–5120.

https://doi.org/10.1182/blood-2008-09-180224

Published: 2009

Includes: Supplemental data

NARROW

A Niche Driven Mechanism Determines Response to ATRA and a Mutation-Independent Therapeutic Approach for MDS and AML

Methylation Biology of a Blood-Based MDS Risk Stratification Test

Serum Amyloid A1 (SAA1) Secreted By the Stromal Microenvironment Drives Malignant Clonal Proliferation in Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML)

Casein Kinase 1 Delta Is a Novel Regulator of mRNA Translation and Druggable Target in Aggressive Lymphomas

Pharmacological Targeting of Osteoblast-Induced MDS and AML

Long Term Responses to Rigosertib in Lower-Risk Myelodysplastic Syndromes (MDS) Patients

Rigosertib Oral in Transfusion Dependent Lower Risk Myelodysplastic Syndromes (LR-MDS): Optimization of Dose and Rate of Transfusion Independence (TI) or Transfusion Reduction (TR) in a Single-Arm Phase 2 Study

TET2 Deficiency Led to Expansion of Dysfunctional Erythroid Progenitors

Longitudinal Transcriptome Analysis of Myelodysplatic Syndrome Progression to Acute Myeloid Leukemia: Implications for Prognosis

Emergence of a Novel Clinical Entity within Myelodysplastic Syndromes Marked By Absence of Quantifiable Terminal Erythroid Differentiation, More Profound Anemia and Significantly Worse Survival across All Prognostic Risk Categories

Umbralisib/TGR-1202 As a Novel Dual PI3K/CK1 Inhibitor Has a Unique Therapeutic Role in Silencing Oncogenes in Aggressive Lymphomas

Unique Gene Expressional Profile Associated with Lack of Quantifiable Terminal Erythroid Differentiation in Myelodysplastic Syndrome Patients

Killer Immunoglobulin-like Receptors (KIR) in Low-Risk Myelodysplastic Syndrome: Genotyping and Gene Expression Evaluation

A Genomic Predictive Signature for Rigosertib in Lower Risk MDS Derived By Integrating Clinical Response, Mechanism of Action Data and Simulation

Loss of TET2 Function in Myelodysplastic Syndrome Results in Intragenic Hypermethylation and Alterations in mRNA Splicing

Molecular Genetic Analysis of Myelodysplastic Syndromes (MDS) Patients with Ring Sideroblasts (RS); Independent Confirmation of Association of SF3B1 Mutations with Better Prognosis

FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathway

Impaired FANCD2 monoubiquitination and hypersensitivity to camptothecin uniquely characterize Fanconi anemia complementation group M

Ectopic HOXB4 overcomes the inhibitory effect of tumor necrosis factor-α on Fanconi anemia hematopoietic stem and progenitor cells

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American Society of Hematology

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American Society of Hematology

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