Experts from the European Leukemia Net (ELN) working group for adult acute lymphoblastic leukemia have identified an unmet need for guidance regarding management of adult ALL from diagnosis to aftercare. The group has previously summarized their recommendations regarding diagnostic approaches, prognostic factors and assessment of ALL (cross-reference). The current recommendation summarizes clinical management. It covers treatment approaches including the use of new immunotherapies, application of MRD for treatment decisions, management of specific subgroups and challenging treatment situations as well as late effects and supportive care. The recommendation provides guidance for physicians caring for adult ALL patients which has to be complemented by regional expertise preferably provided by national academic study groups. -
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Review Article|
February 2, 2024
Management of ALL in Adults: 2023 ELN Recommendations from a European Expert Panel
Nicola Gökbuget,
Goethe-Universität, Frankfurt, Germany
* Corresponding Author; email: goekbuget@em.uni-frankfurt.de
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Nicolas Boissel,
Nicolas Boissel
Hopital Saint-Louis, AP-HP, Paris, France
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Sabina Chiaretti,
Sabina Chiaretti
Hematology, Department of Translational and Precision Medicine, Sapienza University, Rome, Italy
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Herve Dombret,
Herve Dombret
Université Paris Cité, Hôpital Saint-Louis, Assistance Publique - Hôpitaux de Paris (AP-HP), Paris, France
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Michael Doubek,
Michael Doubek
Department of Internal Medicine - Hematology and Oncology, University Hospital Brno & Faculty of Medicine, Masaryk University, Brno, Czech Republic
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Adele K Fielding,
Adele K Fielding
UCL Cancer Institute, London, United Kingdom
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Robin Foà,
Robin Foà
Hematology, Sapienza University of Rome, Rome, Italy
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Sebastian Giebel,
Sebastian Giebel
Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch, Gliwice, Poland
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Dieter Hoelzer,
Dieter Hoelzer
em. University of Frankfurt, Frankfurt, Germany
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David I Marks,
David I Marks
University of Bristol, Bristol, United Kingdom
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Giovanni Martinelli,
Giovanni Martinelli
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy
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Anita W. Rijneveld,
Anita W. Rijneveld
Erasmus University Medical Center, Rotterdam, Netherlands
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Philippe Rousselot,
Philippe Rousselot
Centre Hospitalier de Versailles, University Versailles Paris-Saclay, Le Chesnay Rocquencourt, France
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Josep-Maria Ribera,
Josep-Maria Ribera
Institut Català d'Oncologia-Hospital Germans Trias i Pujol. Josep Carreras Research Institute. Badalona. Universitat Autònoma de Barcelona, Badalona, Spain
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Renato Bassan
Renato Bassan
Ospedale dell'Angelo, Mestre-Venezia, Mestre-Venezia, Italy
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Blood blood.2023023568.
Article history
Submitted:
December 19, 2023
Revision Received:
January 19, 2024
Accepted:
January 21, 2024
Citation
Nicola Gökbuget, Nicolas Boissel, Sabina Chiaretti, Herve Dombret, Michael Doubek, Adele K Fielding, Robin Foà, Sebastian Giebel, Dieter Hoelzer, Mathilde Hunault, David I Marks, Giovanni Martinelli, Oliver Ottmann, Anita W. Rijneveld, Philippe Rousselot, Josep-Maria Ribera, Renato Bassan; Management of ALL in Adults: 2023 ELN Recommendations from a European Expert Panel. Blood 2024; blood.2023023568. doi: https://doi.org/10.1182/blood.2023023568
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