Working groups of the European Leukemia Net (ELN) have published several important consensus guidelines. Acute lymphoblastic leukemia (ALL) has many different clinical and biological subgroups and the knowledge on disease biology and therapeutic options is increasing exponentially. The European Working Group for Adult ALL has therefore summarized the current state of the art and provided comprehensive consensus recommendations for diagnostic approaches, biologic and clinical characterization, prognostic factors and risk stratification as well as definitions of endpoints and outcomes. Aspects of treatment, management of subgroups and specific situations, aftercare and supportive care are covered in a separate publication. The present recommendation intends to provide guidance for the initial management of adult ALL patients and to define principles as a basis for future collaborative research. -
Skip Nav Destination
Review Article|
January 31, 2024
Diagnosis, Prognostic Factors and Assessment of ALL in Adults: 2023 ELN Recommendations from a European Expert Panel
Nicola Gökbuget,
Goethe-Universität, Frankfurt, Germany
* Corresponding Author; email: goekbuget@em.uni-frankfurt.de
Search for other works by this author on:
Nicolas Boissel,
Nicolas Boissel
Hopital Saint-Louis, AP-HP, Paris, France
Search for other works by this author on:
Sabina Chiaretti,
Sabina Chiaretti
Hematology, Department of Translational and Precision Medicine, Sapienza University, Rome, Italy
Search for other works by this author on:
Herve Dombret,
Herve Dombret
Université Paris Cité, Hôpital Saint-Louis, Assistance Publique - Hôpitaux de Paris (AP-HP), Paris, France
Search for other works by this author on:
Michael Doubek,
Michael Doubek
Department of Internal Medicine - Hematology and Oncology, University Hospital Brno & Faculty of Medicine, Masaryk University, Brno, Czech Republic
Search for other works by this author on:
Adele K Fielding,
Adele K Fielding
UCL Cancer Institute, London, United Kingdom
Search for other works by this author on:
Robin Foà,
Robin Foà
Hematology, Department of Translational and Precision Medicine, Sapienza University, Italy., Rome, Italy
Search for other works by this author on:
Sebastian Giebel,
Sebastian Giebel
Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch, Gliwice, Poland
Search for other works by this author on:
David I Marks,
David I Marks
University of Bristol, Bristol, United Kingdom
Search for other works by this author on:
Giovanni Martinelli,
Giovanni Martinelli
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy
Search for other works by this author on:
Oliver G Ottmann,
Oliver G Ottmann
Division of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, United Kingdom
Search for other works by this author on:
Anita W. Rijneveld,
Anita W. Rijneveld
Erasmus University Medical Center, Rotterdam, Netherlands
Search for other works by this author on:
Philippe Rousselot,
Philippe Rousselot
Centre Hospitalier de Versailles, Université Paris-Saclay, France
Search for other works by this author on:
Josep-Maria Ribera,
Josep-Maria Ribera
Institut Català d'Oncologia-Hospital Germans Trias i Pujol. Josep Carreras Research Institute. Badalona. Universitat Autònoma de Barcelona, Badalona, Spain
Search for other works by this author on:
Renato Bassan
Renato Bassan
Ospedale dell'Angelo, Mestre-Venezia, Mestre-Venezia, Italy
Search for other works by this author on:
Blood blood.2023020794.
Article history
Submitted:
July 11, 2023
Revision Received:
January 17, 2024
Accepted:
January 21, 2024
Citation
Nicola Gökbuget, Nicolas Boissel, Sabina Chiaretti, Herve Dombret, Michael Doubek, Adele K Fielding, Robin Foà, Sebastian Giebel, Dieter Hoelzer, Mathilde Hunault, David I Marks, Giovanni Martinelli, Oliver G Ottmann, Anita W. Rijneveld, Philippe Rousselot, Josep-Maria Ribera, Renato Bassan; Diagnosis, Prognostic Factors and Assessment of ALL in Adults: 2023 ELN Recommendations from a European Expert Panel. Blood 2024; blood.2023020794. doi: https://doi.org/10.1182/blood.2023020794
Download citation file:
Advertisement
Cited By
Advertisement
This feature is available to Subscribers Only
Sign In or Create an Account Close Modal