Abstract
Approximately 10–15% of patients with CLL report a family history (FH) of CLL or a related lymphoproliferative disorder. Whether the biologic features of CLL that occurs within families differ from those that occur sporadically is unknown. A recent study addressing this question has reported that mutated IgVH is significantly more common among familial than sporadic CLL, 68% vs 47%, although the distribution of VH genes used was similar (
Blood
111
:5691
, 2008
Disclosures: No relevant conflicts of interest to declare.
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2008, The American Society of Hematology
2008