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TO THE EDITOR:
The cyclic adenosine monophosphate response element-binding protein (CREBBP) gene is located on chromosome 16p13 and encodes a histone acetyltransferase having the same name that is involved in transcriptional regulation and cell cycle control.1,2 The translocation t(8;16)(p11;p13)[KAT6A::CREBBP] results in the disruption of CREBBP as well as its fusion to KAT6A, another gene important in transcription control. This fusion is sufficient for leukemogenesis and leads to a rare but well described type of acute myeloid leukemia (AML) with consistent biologic characteristics and a distinct gene expression profile.3-8 Although generally associated with inferior outcomes among adults, including a recent adjustment made by the European LeukemiaNet toward the adverse-risk group, there are variable reports regarding the prognostic significance of this fusion among pediatric patients.4,7,9 This prognostic variability is partially...
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.© 2023 by The American Society of Hematology
2023
© 2023 by The American Society of Hematology
2023
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