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Issue Archive

Volume 4, Issue 4
February 25 2020
Issue Cover

Table of Contents

POINT-COUNTERPOINT

Stem cell donors should be screened for CHIP
Amy E. DeZern,Lukasz P. Gondek
View Articletitled, Stem cell donors should be screened for CHIP
Stem cell donors should not be screened for clonal hematopoiesis
Christopher J. Gibson,R. Coleman Lindsley
View Articletitled, Stem cell donors should not be screened for clonal hematopoiesis

STIMULUS REPORT

Germline variants in predisposition genes in children with Down syndrome and acute lymphoblastic leukemia
Peleg Winer,Ivo S. Muskens,Kyle M. Walsh,Ajay Vora,Anthony V. Moorman,Joseph L. Wiemels,Irene Roberts,Anindita Roy,Adam J. de Smith
View Articletitled, Germline variants in predisposition genes in children with Down syndrome and acute lymphoblastic leukemia
Supplemental data

REVIEW ARTICLES

Anthracycline-related cardiotoxicity in older patients with acute myeloid leukemia: a Young SIOG review paper
Clinical Trials & Observations
Nina Rosa Neuendorff,Kah Poh Loh,Alice S. Mims,Konstantinos Christofyllakis,Wee-Kheng Soo,Bediha Bölükbasi,Carlos Oñoro-Algar,William G. Hundley,Heidi D. Klepin
View Articletitled, Anthracycline-related cardiotoxicity in older patients with acute myeloid leukemia: a Young SIOG review paper
A practical approach to evaluating postoperative thrombocytopenia
Clinical Trials & Observations
Leslie Skeith,Lisa Baumann Kreuziger,Mark A. Crowther,Theodore E. Warkentin
View Articletitled, A practical approach to evaluating postoperative thrombocytopenia

CLINICAL TRIALS AND OBSERVATIONS

A phase 1 study of azacitidine with high-dose cytarabine and mitoxantrone in high-risk acute myeloid leukemia
Clinical Trials & Observations
Kirk E. Cahill,Yasmin H. Karimi,Theodore G. Karrison,Nitin Jain,Margaret Green,Howard Weiner,Noreen Fulton,Sabah Kadri,Lucy A. Godley,Andrew S. Artz,Hongtao Liu,Michael J. Thirman,Michelle M. Le Beau,Megan E. McNerney,Jeremy Segal,Richard A. Larson,Wendy Stock,Olatoyosi Odenike
View Articletitled, A phase 1 study of azacitidine with high-dose cytarabine and mitoxantrone in high-risk acute myeloid leukemia
Supplemental data
Outpatient intensive induction chemotherapy for acute myeloid leukemia and high-risk myelodysplastic syndrome
Clinical Trials & Observations
Frances Linzee Mabrey,Kelda M. Gardner,Kathleen Shannon Dorcy,Andrea Perdue,Heather A. Smith,Alicyn M. Davis,Cody Hammer,Donelle Rizzuto,Sunny Jones,Kim Quach,Bart L. Scott,Paul C. Hendrie,Mary-Elizabeth M. Percival,Roland B. Walter,Frederick R. Appelbaum,Elihu H. Estey,Pamela S. Becker
View Articletitled, Outpatient intensive induction chemotherapy for acute myeloid leukemia and high-risk myelodysplastic syndrome
Supplemental data
Presentation of BK polyomavirus–associated hemorrhagic cystitis after allogeneic hematopoietic cell transplantation
Clinical Trials & Observations
Hannah Imlay,Hu Xie,Wendy M. Leisenring,Elizabeth R. Duke,Louise E. Kimball,Meei-Li Huang,Steven A. Pergam,Joshua A. Hill,Keith R. Jerome,Filippo Milano,W. Garrett Nichols,Phillip S. Pang,Hans H. Hirsch,Ajit P. Limaye,Michael Boeckh
View Articletitled, Presentation of BK polyomavirus–associated hemorrhagic cystitis after allogeneic hematopoietic cell transplantation
Supplemental data
Combination of dasatinib with chemotherapy in previously untreated core binding factor acute myeloid leukemia: CALGB 10801
Clinical Trials & Observations
Guido Marcucci,Susan Geyer,Kristina Laumann,Weiqiang Zhao,Donna Bucci,Geoffrey L. Uy,William Blum,Ann-Kathrin Eisfeld,Timothy S. Pardee,Eunice S. Wang,Wendy Stock,Jonathan E. Kolitz,Jessica Kohlschmidt,Krzysztof Mrózek,Clara D. Bloomfield,Richard M. Stone,Richard A. Larson
View Articletitled, Combination of dasatinib with chemotherapy in previously untreated core binding factor acute myeloid leukemia: CALGB 10801

GENE THERAPY

High level of fetal-globin reactivation by designed transcriptional activator-like effector
Jun Zhan,Maria Johnson Irudayam,Yukio Nakamura,Ryo Kurita,Arthur W. Nienhuis
View Articletitled, High level of fetal-globin reactivation by designed transcriptional activator-like effector
Supplemental data

HEALTH SERVICES AND OUTCOMES

Impact of gender and caregiving responsibilities on academic success in hematology
Allison A. King,Sara K. Vesely,Emily Vettese,Sadie Cook,Adam Cuker,Wendy Stock,Morgan Homer,Josel Fritz,Lillian Sung
View Articletitled, Impact of gender and caregiving responsibilities on academic success in hematology
Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Patient-reported long-term quality of life after tisagenlecleucel in relapsed/refractory diffuse large B-cell lymphoma
Clinical Trials & Observations
Richard T. Maziarz,Edmund K. Waller,Ulrich Jaeger,Isabelle Fleury,Joseph McGuirk,Harald Holte,Samantha Jaglowski,Stephen J. Schuster,Michael R. Bishop,Jason R. Westin,Stephan Mielke,Takanori Teshima,Veronika Bachanova,Stephen R. Foley,Peter Borchmann,Gilles A. Salles,Jie Zhang,Ranjan Tiwari,Lida B. Pacaud,Qiufei Ma,Constantine S. Tam
View Articletitled, Patient-reported long-term quality of life after tisagenlecleucel in relapsed/refractory diffuse large B-cell lymphoma
Supplemental data
Comparing CAR T-cell toxicity grading systems: application of the ASTCT grading system and implications for management
Clinical Trials & Observations
Martina Pennisi,Tania Jain,Bianca D. Santomasso,Elena Mead,Kitsada Wudhikarn,Mari Lynne Silverberg,Yakup Batlevi,Roni Shouval,Sean M. Devlin,Connie Batlevi,Renier J. Brentjens,Parastoo B. Dahi,Claudia Diamonte,Sergio Giralt,Elizabeth F. Halton,Molly Maloy,Maria Lia Palomba,Miriam Sanchez-Escamilla,Craig S. Sauter,Michael Scordo,Gunjan Shah,Jae H. Park,Miguel-Angel Perales
View Articletitled, Comparing CAR T-cell toxicity grading systems: application of the ASTCT grading system and implications for management

MYELOID NEOPLASIA

A 4-gene leukemic stem cell score can independently predict the prognosis of myelodysplastic syndrome patients
Clinical Trials & Observations
Yu-Hung Wang,Chien-Chin Lin,Chi-Yuan Yao,Chia-Lang Hsu,Hsin-An Hou,Cheng-Hong Tsai,Wen-Chien Chou,Hwei-Fang Tien
View Articletitled, A 4-gene leukemic stem cell score can independently predict the prognosis of myelodysplastic syndrome patients
Supplemental data
High-risk LCH in infants is serially transplantable in a xenograft model but responds durably to targeted therapy
Lynn H. Lee,Christa Krupski,Jason Clark,Mark Wunderlich,Robert B. Lorsbach,Michael S. Grimley,Matthew Burwinkel,Adam Nelson,Ashish R. Kumar
View Articletitled, High-risk LCH in infants is serially transplantable in a xenograft model but responds durably to targeted therapy
Supplemental data

PLATELETS AND THROMBOPOIESIS

IκB kinase 2 is not essential for platelet activation
Manuel Salzmann,Sonja Bleichert,Bernhard Moser,Marion Mussbacher,Mildred Haase,Bastian Hoesel,Waltraud C. Schrottmaier,Julia B. Kral-Pointner,Makoto Itakura,Katy Schmidt,Alice Assinger,Johannes A. Schmid
View Articletitled, IκB kinase 2 is not essential for platelet activation
Supplemental data

THROMBOSIS AND HEMOSTASIS

The efficacy and safety of direct oral anticoagulants in noncirrhotic portal vein thrombosis
Clinical Trials & Observations
Leonard Naymagon,Douglas Tremblay,Nicole Zubizarreta,Erin Moshier,Kevin Troy,Thomas Schiano,John Mascarenhas
View Articletitled, The efficacy and safety of direct oral anticoagulants in noncirrhotic portal vein thrombosis
A phase 2 PK/PD study of andexanet alfa for reversal of rivaroxaban and edoxaban anticoagulation in healthy volunteers
Clinical Trials & Observations
Genmin Lu,Pamela B. Conley,Janet M. Leeds,Mark J. Karbarz,Gallia G. Levy,Vandana S. Mathur,Janice Castillo,Mark Crowther,John T. Curnutte
View Articletitled, A phase 2 PK/PD study of andexanet alfa for reversal of rivaroxaban and edoxaban anticoagulation in healthy volunteers
Supplemental data

TRANSPLANTATION

Phosphorylated ERK1/2 in CD4 T cells is associated with acute GVHD in allogeneic hematopoietic stem cell transplantation
Clinical Trials & Observations
Hidekazu Itamura,Takero Shindo,Satoshi Yoshioka,Takayuki Ishikawa,Shinya Kimura
View Articletitled, Phosphorylated ERK1/2 in CD4 T cells is associated with acute GVHD in allogeneic hematopoietic stem cell transplantation
Supplemental data
Weighty choices: selecting optimal G-CSF doses for stem cell mobilization to optimize yield
Nosha Farhadfar,Jack W. Hsu,Brent R. Logan,Jennifer A. Sees,Pintip Chitphakdithai,Michele W. Sugrue,Hisham Abdel-Azim,Paolo N. Anderlini,Christopher Bredeson,Saurabh Chhabra,Miguel Angel Diaz,Siddhartha Ganguly,Peiman Hematti,Rammurti T. Kamble,Kimberly A. Kasow,Hillard M. Lazarus,Debra Kelly Lynch,Hemant S. Murthy,Richard F. Olsson,Mona Papari,Donna Przepiorka,Bipin N. Savani,Raquel Schears,Sachiko Seo,Melhem M. Solh,Thomas Spitzer,Jean A. Yared,Michael A. Pulsipher,Nirali N. Shah,Galen E. Switzer,Dennis L. Confer,Bronwen E. Shaw,John R. Wingard
View Articletitled, Weighty choices: selecting optimal G-CSF doses for stem cell mobilization to optimize yield
Supplemental data
KIR B donors improve the outcome for AML patients given reduced intensity conditioning and unrelated donor transplantation
Clinical Trials & Observations
Daniel Weisdorf,Sarah Cooley,Tao Wang,Elizabeth Trachtenberg,Cynthia Vierra-Green,Stephen Spellman,Jennifer A. Sees,Ashley Spahn,Jenny Vogel,Todd A. Fehniger,Ann E. Woolfrey,Steven M. Devine,Maureen Ross,Edmund K. Waller,Ronald M. Sobecks,Joseph McGuirk,Betul Oran,Sherif S. Farag,Tsiporah Shore,Koen Van Besien,Steven G. E. Marsh,Lisbeth A. Guethlein,Peter Parham,Jeffrey S. Miller
View Articletitled, <em>KIR B</em> donors improve the outcome for AML patients given reduced intensity conditioning and unrelated donor transplantation
Supplemental data

COMMENTARY

Guidance on changing therapy choice in myelofibrosis
Clinical Trials & Observations
Donal P. McLornan,Claire N. Harrison
View Articletitled, Guidance on changing therapy choice in myelofibrosis
All Issues

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Subsequent malignant neoplasms in patients previously treated with anti-CD19 CAR T-cell therapy
Phillips NS, Mulrooney DA, Williams AM, et al. Neurocognitive impairment associated with chronic morbidity in long-term survivors of Hodgkin Lymphoma. Blood Adv. 2023;7(23):7270-7278.
Unleashed monocytic engagement in Sézary syndrome during the combination of anti-CCR4 antibody with type I interferon
A multicenter study of venetoclax-based treatment for patients with Richter transformation of chronic lymphocytic leukemia
Race and ethnicity reporting and representation in hemophilia clinical trials

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