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Issue Archive

Volume 2, Issue 8
April 24 2018
Issue Cover

Table of Contents

EXCEPTIONAL CASE REPORT

Can somatic GATA2 mutation mimic germ line GATA2 mutation?
Clinical Trials & Observations
Mallika Sekhar,Rachael Pocock,David Lowe,Christopher Mitchell,Teresa Marafioti,Rachel Dickinson,Matthew Collin,Marc Lipman
View Articletitled, Can somatic GATA2 mutation mimic germ line GATA2 mutation?
Supplemental data

STIMULUS REPORT

Ectopic Lck expression in CLL demarcates intratumoral subpopulations with aberrant B-cell receptor signaling
Efthymia Theofani,Spyridon Alexis,Paul Costeas,Christos Andriopoulos,Georgia Feleskoura,Panagiotis Zikos,Anthi Aktypi,Alexandros Spyridonidis,Konstantina Nika
View Articletitled, Ectopic Lck expression in CLL demarcates intratumoral subpopulations with aberrant B-cell receptor signaling
Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

Patterns of care and outcomes in adolescent and young adult acute lymphoblastic leukemia: a population-based study
Clinical Trials & Observations
Lori Muffly,Elysia Alvarez,Daphne Lichtensztajn,Renata Abrahão,Scarlett Lin Gomez,Theresa Keegan
View Articletitled, Patterns of care and outcomes in adolescent and young adult acute lymphoblastic leukemia: a population-based study
Supplemental data

HEMATOPOIESIS AND STEM CELLS

M1 and M2 macrophages differentially regulate hematopoietic stem cell self-renewal and ex vivo expansion
Yi Luo,Lijian Shao,Jianhui Chang,Wei Feng,Y. Lucy Liu,Michele H. Cottler-Fox,Peter D. Emanuel,Martin Hauer-Jensen,Irwin D. Bernstein,Lingbo Liu,Xing Chen,Jianfeng Zhou,Peter J. Murray,Daohong Zhou
View Articletitled, M1 and M2 macrophages differentially regulate hematopoietic stem cell self-renewal and ex vivo expansion
Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Zinc finger–IRF composite elements bound by Ikaros/IRF4 complexes function as gene repression in plasma cell
Kyoko Ochiai,Haruka Kondo,Yasunobu Okamura,Hiroki Shima,Yuko Kurokochi,Kazumi Kimura,Ryo Funayama,Takeshi Nagashima,Keiko Nakayama,Katsuyuki Yui,Kengo Kinoshita,Kazuhiko Igarashi
View Articletitled, Zinc finger–IRF composite elements bound by Ikaros/IRF4 complexes function as gene repression in plasma cell
Supplemental data

LYMPHOID NEOPLASIA

Pilot trial of ibrutinib in patients with relapsed or refractory T-cell lymphoma
Clinical Trials & Observations
Anita Kumar,Santosha Vardhana,Alison J. Moskowitz,Pierluigi Porcu,Ahmet Dogan,Jason A. Dubovsky,Matthew J. Matasar,Zhigang Zhang,Anas Younes,Steven M. Horwitz
View Articletitled, Pilot trial of ibrutinib in patients with relapsed or refractory T-cell lymphoma
Supplemental data

MYELOID NEOPLASIA

A next-generation sequencing–based assay for minimal residual disease assessment in AML patients with FLT3-ITD mutations
Clinical Trials & Observations
Mark J. Levis,Alexander E. Perl,Jessica K. Altman,Christopher D. Gocke,Erkut Bahceci,Jason Hill,Chaofeng Liu,Zhiyi Xie,Andrew R. Carson,Valerie McClain,Timothy T. Stenzel,Jeffrey E. Miller
View Articletitled, A next-generation sequencing–based assay for minimal residual disease assessment in AML patients with <em>FLT3</em>-ITD mutations
Supplemental data
MLL leukemia induction by t(9;11) chromosomal translocation in human hematopoietic stem cells using genome editing
Corina Schneidawind,Johan Jeong,Dominik Schneidawind,In-Suk Kim,Jesús Duque-Afonso,Stephen Hon Kit Wong,Masayuki Iwasaki,Erin H. Breese,James L. Zehnder,Matthew Porteus,Michael L. Cleary
View Articletitled, <em>MLL</em> leukemia induction by t(9;11) chromosomal translocation in human hematopoietic stem cells using genome editing
Supplemental data
A CD123-targeting antibody-drug conjugate, IMGN632, designed to eradicate AML while sparing normal bone marrow cells
Yelena Kovtun,Gregory E. Jones,Sharlene Adams,Lauren Harvey,Charlene A. Audette,Alan Wilhelm,Chen Bai,Lingyun Rui,Rassol Laleau,Fenghua Liu,Olga Ab,Yulius Setiady,Nicholas C. Yoder,Victor S. Goldmacher,Ravi V. J. Chari,Jan Pinkas,Thomas Chittenden
View Articletitled, A CD123-targeting antibody-drug conjugate, IMGN632, designed to eradicate AML while sparing normal bone marrow cells
Supplemental data
Hypomethylating agents in relapsed and refractory AML: outcomes and their predictors in a large international patient cohort
Clinical Trials & Observations
Maximilian Stahl,Michelle DeVeaux,Pau Montesinos,Raphael Itzykson,Ellen K. Ritchie,Mikkael A. Sekeres,John D. Barnard,Nikolai A. Podoltsev,Andrew M. Brunner,Rami S. Komrokji,Vijaya R. Bhatt,Aref Al-Kali,Thomas Cluzeau,Valeria Santini,Amir T. Fathi,Gail J. Roboz,Pierre Fenaux,Mark R. Litzow,Sarah Perreault,Tae Kon Kim,Thomas Prebet,Norbert Vey,Vivek Verma,Ulrich Germing,Juan Miguel Bergua,Josefina Serrano,Steven D. Gore,Amer M. Zeidan
View Articletitled, Hypomethylating agents in relapsed and refractory AML: outcomes and their predictors in a large international patient cohort
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Red pulp macrophages in the human spleen are a distinct cell population with a unique expression of Fc-γ receptors
Sietse Q. Nagelkerke,Christine W. Bruggeman,Joke M. M. den Haan,Erik P. J. Mul,Timo K. van den Berg,Robin van Bruggen,Taco W. Kuijpers
View Articletitled, Red pulp macrophages in the human spleen are a distinct cell population with a unique expression of Fc-γ receptors
Supplemental data

TRANSPLANTATION

Delayed immune reconstitution after allogeneic transplantation increases the risks of mortality and chronic GVHD
Nelli Bejanyan,Claudio G. Brunstein,Qing Cao,Aleksandr Lazaryan,Xianghua Luo,Julie Curtsinger,Rohtesh S. Mehta,Erica Warlick,Sarah A. Cooley,Bruce R. Blazar,Jeffrey S. Miller,Daniel Weisdorf,John E. Wagner,Michael R. Verneris
View Articletitled, Delayed immune reconstitution after allogeneic transplantation increases the risks of mortality and chronic GVHD
Supplemental data
Outcomes of Medicare-age eligible NHL patients receiving RIC allogeneic transplantation: a CIBMTR analysis
Clinical Trials & Observations
Nirav N. Shah,Kwang Woo Ahn,Carlos Litovich,Timothy S. Fenske,Sairah Ahmed,Minoo Battiwalla,Nelli Bejanyan,Parastoo B. Dahi,Javier Bolaños-Meade,Andy I. Chen,Stefan O. Ciurea,Veronika Bachanova,Zachariah DeFilipp,Narendranath Epperla,Nosha Farhadfar,Alex F. Herrera,Bradley M. Haverkos,Leona Holmberg,Nasheed M. Hossain,Mohamed A. Kharfan-Dabaja,Vaishalee P. Kenkre,Hillard M. Lazarus,Hemant S. Murthy,Taiga Nishihori,Andrew R. Rezvani,Anita D’Souza,Bipin N. Savani,Matthew L. Ulrickson,Edmund K. Waller,Anna Sureda,Sonali M. Smith,Mehdi Hamadani
View Articletitled, Outcomes of Medicare-age eligible NHL patients receiving RIC allogeneic transplantation: a CIBMTR analysis
Supplemental data

COMMENTARY

Approaching the crisis in medical research funding: an important role for nonprofit organizations and medical societies
Janis L. Abkowitz,Robert Hromas
View Articletitled, Approaching the crisis in medical research funding: an important role for nonprofit organizations and medical societies
All Issues

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Nivolumab plus brentuximab vedotin for relapsed/refractory peripheral T-cell lymphoma and cutaneous T-cell lymphoma
Phillips NS, Mulrooney DA, Williams AM, et al. Neurocognitive impairment associated with chronic morbidity in long-term survivors of Hodgkin Lymphoma. Blood Adv. 2023;7(23):7270-7278.
A multicenter study of venetoclax-based treatment for patients with Richter transformation of chronic lymphocytic leukemia
Race and ethnicity reporting and representation in hemophilia clinical trials
Immune status and selection of patients for immunotherapy in myeloma: a proposal

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