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Issue Archive

Volume 2, Issue 19
October 9 2018
Issue Cover

Table of Contents

CLINICAL TRIALS AND OBSERVATIONS

Coagulation parameters during the course of severe postpartum hemorrhage: a nationwide retrospective cohort study
Clinical Trials & Observations
Ada Gillissen,Thomas van den Akker,Camila Caram-Deelder,Dacia D. C. A. Henriquez,Kitty W. M. Bloemenkamp,Moniek P. M. de Maat,Jos J. M. van Roosmalen,Joost J. Zwart,Jeroen Eikenboom,Johanna G. van der Bom,on behalf of the TeMpOH-1 Study Group
View Articletitled, Coagulation parameters during the course of severe postpartum hemorrhage: a nationwide retrospective cohort study
Supplemental data
Successful hematopoietic stem cell mobilization and apheresis collection using plerixafor alone in sickle cell patients
Clinical Trials & Observations
Erica B. Esrick,John P. Manis,Heather Daley,Cristina Baricordi,Hélène Trébéden-Negre,Francis J. Pierciey,Myriam Armant,Sarah Nikiforow,Matthew M. Heeney,Wendy B. London,Luca Biasco,Mohammed Asmal,David A. Williams,Alessandra Biffi
View Articletitled, Successful hematopoietic stem cell mobilization and apheresis collection using plerixafor alone in sickle cell patients
Supplemental data

Professional illustration by Patrick Lane, ScEYEnce Studios.

Daratumumab in life-threatening autoimmune hemolytic anemia following hematopoietic stem cell transplantation
Clinical Trials & Observations
Catharina Schuetz,Manfred Hoenig,Despina Moshous,Christof Weinstock,Martin Castelle,Matthieu Bendavid,Kristin Shimano,Vanessa Tolbert,Ansgar S. Schulz,Christopher C. Dvorak
View Articletitled, Daratumumab in life-threatening autoimmune hemolytic anemia following hematopoietic stem cell transplantation

HEMATOPOIESIS AND STEM CELLS

ASXL1 impairs osteoclast formation by epigenetic regulation of NFATc1
Nidhi Rohatgi,Wei Zou,Patrick L. Collins,Jonathan R. Brestoff,Timothy H. Chen,Yousef Abu-Amer,Steven L. Teitelbaum
View Articletitled, ASXL1 impairs osteoclast formation by epigenetic regulation of NFATc1
Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

NK cell development in a human stem cell niche: KIR expression occurs independently of the presence of HLA class I ligands
Xiaoyi Zhao,Sandra Weinhold,Jens Brands,Maryam Hejazi,Özer Degistirici,Gesine Kögler,Roland Meisel,Markus Uhrberg
View Articletitled, NK cell development in a human stem cell niche: KIR expression occurs independently of the presence of HLA class I ligands
Supplemental data
Accelerated, but not conventional, radiotherapy of murine B-cell lymphoma induces potent T cell–mediated remissions
Suparna Dutt,Michelle B. Atallah,Yoshitaka Minamida,Alexander Filatenkov,Kent P. Jensen,Bettina P. Iliopoulou,Rasa Tamosiuniene,Jeffrey Waters,Edgar G. Engleman,Samuel Strober
View Articletitled, Accelerated, but not conventional, radiotherapy of murine B-cell lymphoma induces potent T cell–mediated remissions
Supplemental data

LYMPHOID NEOPLASIA

An inhibitor of proteasome β2 sites sensitizes myeloma cells to immunoproteasome inhibitors
Sondra Downey-Kopyscinski,Ellen W. Daily,Marc Gautier,Ananta Bhatt,Bogdan I. Florea,Constantine S. Mitsiades,Paul G. Richardson,Christoph Driessen,Herman S. Overkleeft,Alexei F. Kisselev
View Articletitled, An inhibitor of proteasome β2 sites sensitizes myeloma cells to immunoproteasome inhibitors
Supplemental data
Inhibition of MEK and ATR is effective in a B-cell acute lymphoblastic leukemia model driven by Mll-Af4 and activated Ras
S. Haihua Chu,Evelyn J. Song,Jonathan R. Chabon,Janna Minehart,Chloe N. Matovina,Jessica L. Makofske,Elizabeth S. Frank,Kenneth Ross,Richard P. Koche,Zhaohui Feng,Haiming Xu,Andrei Krivtsov,Andre Nussenzweig,Scott A. Armstrong
View Articletitled, Inhibition of MEK and ATR is effective in a B-cell acute lymphoblastic leukemia model driven by <em>Mll-Af4</em> and activated <em>Ras</em>
Supplemental data
Proteomic profiling identifies outcome-predictive markers in patients with peripheral T-cell lymphoma, not otherwise specified
Clinical Trials & Observations
Maja Ludvigsen,Martin Bjerregård Pedersen,Kristina Lystlund Lauridsen,Tim Svenstrup Poulsen,Stephen Jacques Hamilton-Dutoit,Søren Besenbacher,Knud Bendix,Michael Boe Møller,Peter Nørgaard,Francesco d’Amore,Bent Honoré
View Articletitled, Proteomic profiling identifies outcome-predictive markers in patients with peripheral T-cell lymphoma, not otherwise specified
Supplemental data
Combined inhibition of receptor tyrosine and p21-activated kinases as a therapeutic strategy in childhood ALL
Clinical Trials & Observations
Ina-Katrin Siekmann,Kevin Dierck,Sebastian Prall,Marianne Klokow,Julia Strauss,Sophia Buhs,Antonina Wrzeszcz,Michael Bockmayr,Florian Beck,Magdalena Trochimiuk,Kristina Gottschling,Victoria Martens,Melissa Khosh-Naucke,Helwe Gerull,Jürgen Müller,Lena Behrmann,Martin Blohm,René P. Zahedi,Irmela Jeremias,Albert Sickmann,Peter Nollau,Martin A. Horstmann
View Articletitled, Combined inhibition of receptor tyrosine and p21-activated kinases as a therapeutic strategy in childhood ALL
Supplemental data

MYELOID NEOPLASIA

Identification of IRF8 as a potent tumor suppressor in murine acute promyelocytic leukemia
Coline Gaillard,Sangeetha Surianarayanan,Trevor Bentley,Matthew R. Warr,Briana Fitch,Huimin Geng,Emmanuelle Passegué,Hugues de Thé,Scott C. Kogan
View Articletitled, Identification of IRF8 as a potent tumor suppressor in murine acute promyelocytic leukemia
Supplemental data
KDM6B overexpression activates innate immune signaling and impairs hematopoiesis in mice
Yue Wei,Hong Zheng,Naran Bao,Shan Jiang,Carlos E. Bueso-Ramos,Joseph Khoury,Caleb Class,Yue Lu,Kevin Lin,Hui Yang,Irene Ganan-Gomez,Daniel T. Starczynowski,Kim-Anh Do,Simona Colla,Guillermo Garcia-Manero
View Articletitled, KDM6B overexpression activates innate immune signaling and impairs hematopoiesis in mice
Supplemental data
Cell-lineage level–targeted sequencing to identify acute myeloid leukemia with myelodysplasia-related changes
Kazuaki Yokoyama,Eigo Shimizu,Nozomi Yokoyama,Sousuke Nakamura,Rika Kasajima,Miho Ogawa,Tomomi Takei,Mika Ito,Asako Kobayashi,Rui Yamaguchi,Seiya Imoto,Satoru Miyano,Arinobu Tojo
View Articletitled, Cell-lineage level–targeted sequencing to identify acute myeloid leukemia with myelodysplasia-related changes
Supplemental data

THROMBOSIS AND HEMOSTASIS

Humanized GPIbα–von Willebrand factor interaction in the mouse
Sachiko Kanaji,Jennifer N. Orje,Taisuke Kanaji,Yuichi Kamikubo,Yosuke Morodomi,Yunfeng Chen,Alessandro Zarpellon,Jerome Eberhardt,Stefano Forli,Scot A. Fahs,Rashmi Sood,Sandra L. Haberichter,Robert R. Montgomery,Zaverio M. Ruggeri
View Articletitled, Humanized GPIbα–von Willebrand factor interaction in the mouse
Supplemental data

TRANSFUSION MEDICINE

Eculizumab in cold agglutinin disease (DECADE): an open-label, prospective, bicentric, nonrandomized phase 2 trial
Clinical Trials & Observations
Alexander Röth,Martin Bommer,Andreas Hüttmann,Dörte Herich-Terhürne,Nils Kuklik,Jan Rekowski,Veronika Lenz,Hubert Schrezenmeier,Ulrich Dührsen
View Articletitled, Eculizumab in cold agglutinin disease (DECADE): an open-label, prospective, bicentric, nonrandomized phase 2 trial

TRANSPLANTATION

Chromosome Y–encoded antigens associate with acute graft-versus-host disease in sex-mismatched stem cell transplant
Clinical Trials & Observations
Wei Wang,Hu Huang,Michael Halagan,Cynthia Vierra-Green,Michael Heuer,Jason E. Brelsford,Michael Haagenson,Richard H. Scheuermann,Amalio Telenti,William Biggs,Nathaniel M. Pearson,Julia Udell,Stephen Spellman,Martin Maiers,Caleb J. Kennedy
View Articletitled, Chromosome Y–encoded antigens associate with acute graft-versus-host disease in sex-mismatched stem cell transplant
Supplemental data

COMMENTARY

The ASH Agenda for Hematology Research: a roadmap for advancing scientific discovery and cures for hematologic diseases
Charles G. Mullighan
View Articletitled, The ASH Agenda for Hematology Research: a roadmap for advancing scientific discovery and cures for hematologic diseases
  • Cover Image

    Cover Image

    issue cover

    COVER FIGURE
    Mice were generated with conditional deletion of ASXL1 in myeloid cells. This image shows mouse femur histology with staining for tartrate-resistant acid phosphatase (red reaction product) activity to highlight the marked increase in osteoclasts in these mice. See the article by Rohatgi et al.

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Röth A, Broome CM, Barcellini W, et al. Long-term sutimlimab improves quality of life for patients with cold agglutinin disease: CARDINAL 2-year follow-up. Blood Adv. 2023;7(19):5890-5897.
Proteomic profiling for biomarker discovery in heparin-induced thrombocytopenia
Hemolysis events in the phase 3 PEGASUS study of pegcetacoplan in patients with paroxysmal nocturnal hemoglobinuria
Development of combination therapies with BTK inhibitors and dasatinib to treat CNS-infiltrating E2A-PBX1+/preBCR+ ALL
Organ involvement in adults with BPDCN is associated with sun exposure history, TET2 and RAS mutations, and survival

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