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Volume 1, Issue 18

August 8 2017

In this Issue

BLOOD ADVANCES TALK
STIMULUS REPORTS
LYMPHOID NEOPLASIA
MYELOID NEOPLASIA
PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS
THROMBOSIS AND HEMOSTASIS
TRANSFUSION MEDICINE
TRANSPLANTATION
ERRATUM

BLOOD ADVANCES TALK

How many mice? Design considerations for murine studies

Donna Neuberg

View Articletitled, How many mice? Design considerations for murine studies

Supplemental data

STIMULUS REPORTS

Overexpression of RUNX1 short isoform has an important role in the development of myelodysplastic/myeloproliferative neoplasms

Hiroko Sakurai,Yuka Harada,Yosuke Ogata,Yuki Kagiyama,Naoki Shingai,Noriko Doki,Kazuteru Ohashi,Toshio Kitamura,Norio Komatsu,Hironori Harada

View Articletitled, Overexpression of RUNX1 short isoform has an important role in the development of myelodysplastic/myeloproliferative neoplasms

Supplemental data

Activated protein C light chain provides an extended binding surface for its anticoagulant cofactor, protein S

José A. Fernández,Xiao Xu,Ranjeet K. Sinha,Laurent O. Mosnier,Michel F. Sanner,John H. Griffin

View Articletitled, Activated protein C light chain provides an extended binding surface for its anticoagulant cofactor, protein S

Supplemental data

LYMPHOID NEOPLASIA

High proportions of PD-1⁺ and PD-L1⁺ leukocytes in classical Hodgkin lymphoma microenvironment are associated with inferior outcome
Clinical Trials & Observations

Peter Hollander,Peter Kamper,Karin Ekstrom Smedby,Gunilla Enblad,Maja Ludvigsen,Julie Mortensen,Rose-Marie Amini,Stephen Hamilton-Dutoit,Francesco d’Amore,Daniel Molin,Ingrid Glimelius

View Articletitled, High proportions of PD-1+ and PD-L1+ leukocytes in classical Hodgkin lymphoma microenvironment are associated with inferior outcome

Supplemental data

MYELOID NEOPLASIA

ASXL1 and BIM germ line variants predict response and identify CML patients with the greatest risk of imatinib failure
Clinical Trials & Observations

Justine E. Marum,David T. Yeung,Leanne Purins,John Reynolds,Wendy T. Parker,Doris Stangl,Paul P. S. Wang,David J. Price,Jonathan Tuke,Andreas W. Schreiber,Hamish S. Scott,Timothy P. Hughes,Susan Branford

View Articletitled, ASXL1 and BIM germ line variants predict response and identify CML patients with the greatest risk of imatinib failure

Supplemental data

Paradoxical enhancement of leukemogenesis in acute myeloid leukemia with moderately attenuated RUNX1 expressions

Ken Morita,Shintaro Maeda,Kensho Suzuki,Hiroki Kiyose,Junichi Taniguchi,Pu Paul Liu,Hiroshi Sugiyama,Souichi Adachi,Yasuhiko Kamikubo

View Articletitled, Paradoxical enhancement of leukemogenesis in acute myeloid leukemia with moderately attenuated RUNX1 expressions

Supplemental data

Interleukin-6 levels predict event-free survival in pediatric AML and suggest a mechanism of chemotherapy resistance
Clinical Trials & Observations

Alexandra M. Stevens,Jennifer M. Miller,Jaime O. Munoz,Amos S. Gaikwad,Michele S. Redell

View Articletitled, Interleukin-6 levels predict event-free survival in pediatric AML and suggest a mechanism of chemotherapy resistance

Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Dynamic change of transcription pausing through modulating NELF protein stability regulates granulocytic differentiation

Xiuli Liu,Aishwarya A. Gogate,Melodi Tastemel,Venkat S. Malladi,Huiyu Yao,Kim Nguyen,Lily Jun-Shen Huang,Xiaoying Bai

View Articletitled, Dynamic change of transcription pausing through modulating NELF protein stability regulates granulocytic differentiation

Supplemental data

THROMBOSIS AND HEMOSTASIS

Deletion of the Arp2/3 complex in megakaryocytes leads to microthrombocytopenia in mice

David S. Paul,Caterina Casari,Congying Wu,Raymond Piatt,Swetha Pasala,Robert A. Campbell,Kathryn O. Poe,Dorsaf Ghalloussi,Robert H. Lee,Jeremy D. Rotty,Brian C. Cooley,Kellie R. Machlus,Joseph E. Italiano, Jr,Andrew S. Weyrich,James E. Bear,Wolfgang Bergmeier

View Articletitled, Deletion of the Arp2/3 complex in megakaryocytes leads to microthrombocytopenia in mice

Supplemental data

ICAM-1–targeted thrombomodulin mitigates tissue factor–driven inflammatory thrombosis in a human endothelialized microfluidic model

Colin F. Greineder,Ian H. Johnston,Carlos H. Villa,Kandace Gollomp,Charles T. Esmon,Douglas B. Cines,Mortimer Poncz,Vladimir R. Muzykantov

View Articletitled, ICAM-1–targeted thrombomodulin mitigates tissue factor–driven inflammatory thrombosis in a human endothelialized microfluidic model

Supplemental data

TRANSFUSION MEDICINE

Whole-exome sequencing for RH genotyping and alloimmunization risk in children with sickle cell anemia

Stella T. Chou,Jonathan M. Flanagan,Sunitha Vege,Naomi L. C. Luban,R. Clark Brown,Russell E. Ware,Connie M. Westhoff

View Articletitled, Whole-exome sequencing for RH genotyping and alloimmunization risk in children with sickle cell anemia

Supplemental data

TRANSPLANTATION

Clinical profile, biological markers, and comorbidity index as predictors of transplant-related mortality after allo-HSCT
Clinical Trials & Observations

Aliénor Xhaard,Renato Cunha,Marc Busson,Marie Robin,Nathalie Dhedin,Tereza Coman,Aurélie Cabannes-Hamy,Flore Sicre de Fontbrune,David Michonneau,Gérard Socié,Rodrigo T. Calado,Régis Peffault de Latour

View Articletitled, Clinical profile, biological markers, and comorbidity index as predictors of transplant-related mortality after allo-HSCT

ERRATUM

Reina-Castillón J, Pujol R, López-Sánchez M, et al. Detectable clonal mosaicism in blood as a biomarker of cancer risk in Fanconi anemia. Blood Adv. 2017;1(5):319-329.

View Articletitled, Reina-Castillón J, Pujol R, López-Sánchez M, et al. Detectable clonal mosaicism in blood as a biomarker of cancer risk in Fanconi anemia. Blood Adv. 2017;1(5):319-329.

Cover Image

Cover Image

COVER FIGURE
Aberrant release of platelets into bone marrow of mice lacking Arp2/3 function in the megakaryocytic lineage. Whole-mount staining of femur bone marrow is shown. Green staining indicates platelets and megakaryocytes, red staining indicates endothelial cells, and blue staining indicates nuclei. See the article by Paul et al.
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Table of Contents

BLOOD ADVANCES TALK

How many mice? Design considerations for murine studies

STIMULUS REPORTS

Overexpression of RUNX1 short isoform has an important role in the development of myelodysplastic/myeloproliferative neoplasms

Activated protein C light chain provides an extended binding surface for its anticoagulant cofactor, protein S

LYMPHOID NEOPLASIA

High proportions of PD-1⁺ and PD-L1⁺ leukocytes in classical Hodgkin lymphoma microenvironment are associated with inferior outcome
Clinical Trials & Observations

MYELOID NEOPLASIA

ASXL1 and BIM germ line variants predict response and identify CML patients with the greatest risk of imatinib failure
Clinical Trials & Observations

Paradoxical enhancement of leukemogenesis in acute myeloid leukemia with moderately attenuated RUNX1 expressions

Interleukin-6 levels predict event-free survival in pediatric AML and suggest a mechanism of chemotherapy resistance
Clinical Trials & Observations

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Dynamic change of transcription pausing through modulating NELF protein stability regulates granulocytic differentiation

THROMBOSIS AND HEMOSTASIS

Deletion of the Arp2/3 complex in megakaryocytes leads to microthrombocytopenia in mice

ICAM-1–targeted thrombomodulin mitigates tissue factor–driven inflammatory thrombosis in a human endothelialized microfluidic model

TRANSFUSION MEDICINE

Whole-exome sequencing for RH genotyping and alloimmunization risk in children with sickle cell anemia

TRANSPLANTATION

Clinical profile, biological markers, and comorbidity index as predictors of transplant-related mortality after allo-HSCT
Clinical Trials & Observations

ERRATUM

Reina-Castillón J, Pujol R, López-Sánchez M, et al. Detectable clonal mosaicism in blood as a biomarker of cancer risk in Fanconi anemia. Blood Adv. 2017;1(5):319-329.

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Table of Contents

BLOOD ADVANCES TALK

STIMULUS REPORTS

LYMPHOID NEOPLASIA

High proportions of PD-1+ and PD-L1+ leukocytes in classical Hodgkin lymphoma microenvironment are associated with inferior outcome Clinical Trials & Observations

MYELOID NEOPLASIA

ASXL1 and BIM germ line variants predict response and identify CML patients with the greatest risk of imatinib failure Clinical Trials & Observations

Interleukin-6 levels predict event-free survival in pediatric AML and suggest a mechanism of chemotherapy resistance Clinical Trials & Observations

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

THROMBOSIS AND HEMOSTASIS

TRANSFUSION MEDICINE

TRANSPLANTATION

Clinical profile, biological markers, and comorbidity index as predictors of transplant-related mortality after allo-HSCT Clinical Trials & Observations

ERRATUM

Cover Image

Email alerts

ASH Publications

American Society of Hematology

This Feature Is Available To Subscribers Only

High proportions of PD-1⁺ and PD-L1⁺ leukocytes in classical Hodgkin lymphoma microenvironment are associated with inferior outcome
Clinical Trials & Observations

ASXL1 and BIM germ line variants predict response and identify CML patients with the greatest risk of imatinib failure
Clinical Trials & Observations

Interleukin-6 levels predict event-free survival in pediatric AML and suggest a mechanism of chemotherapy resistance
Clinical Trials & Observations

Clinical profile, biological markers, and comorbidity index as predictors of transplant-related mortality after allo-HSCT
Clinical Trials & Observations