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Volume 1, Issue 14
June 13 2017
Issue Cover

Table of Contents

BLOOD ADVANCES TALK

The direct oral anticoagulants: can we finally stop using rat poison?
Mark Crowther
View Articletitled, The direct oral anticoagulants: can we finally stop using rat poison?
Supplemental data

EXCEPTIONAL CASE REPORTS

Multifocal brain involvement in a patient with hairy cell leukemia successfully treated with rituximab and cladribine
Clinical Trials & Observations
Anamarija M. Perry,Kant Matsuda,Vikram Wadhwa,Donna Hewitt,Muhamad Almiski,James B. Johnston,Versha Banerji
View Articletitled, Multifocal brain involvement in a patient with hairy cell leukemia successfully treated with rituximab and cladribine
Effects of hemin and hemodialysis in a patient with acute intermittent porphyria and renal failure
Clinical Trials & Observations
Shirin Attarian,Chunli Yu,Karl E. Anderson,Ellen W. Friedman
View Articletitled, Effects of hemin and hemodialysis in a patient with acute intermittent porphyria and renal failure

STIMULUS REPORTS

Chromatin dynamics during the differentiation of long-term hematopoietic stem cells to multipotent progenitors
Xiang Yu,Chao Wu,Dheeraj Bhavanasi,Hong Wang,Brian D. Gregory,Jian Huang
View Articletitled, Chromatin dynamics during the differentiation of long-term hematopoietic stem cells to multipotent progenitors
Supplemental data
Therapy-related myelofibrosis does not appear to exist
Clinical Trials & Observations
Lucia Masarova,Gabriele Todisco,Taghi Manshouri,Kate J. Newberry,Jorge E. Cortes,Hagop M. Kantarjian,Zeev Estrov,Srdan Verstovsek
View Articletitled, Therapy-related myelofibrosis does not appear to exist

REVIEW ARTICLE

Osteonecrosis in children and adolescents with acute lymphoblastic leukemia: a therapeutic challenge
Michaela Kuhlen,Marina Kunstreich,Kathinka Krull,Roland Meisel,Arndt Borkhardt
View Articletitled, Osteonecrosis in children and adolescents with acute lymphoblastic leukemia: a therapeutic challenge

IMMUNOBIOLOGY

Novel GM-CSF signals via IFN-γR/IRF-1 and AKT/mTOR license monocytes for suppressor function
Eliana Ribechini,James A. Hutchinson,Sabine Hergovits,Marion Heuer,Jörg Lucas,Ulrike Schleicher,Ana-Laura Jordán Garrote,Sarah J. Potter,Paloma Riquelme,Heike Brackmann,Nora Müller,Hartmann Raifer,Ingolf Berberich,Magdalena Huber,Andreas Beilhack,Michael Lohoff,Christian Bogdan,Matthias Eyrich,Heike M. Hermanns,Edward K. Geissler,Manfred B. Lutz
View Articletitled, Novel GM-CSF signals via IFN-γR/IRF-1 and AKT/mTOR license monocytes for suppressor function
Supplemental data

LYMPHOID NEOPLASIA

Microenvironmental agonists generate de novo phenotypic resistance to combined ibrutinib plus venetoclax in CLL and MCL
Kallesh D. Jayappa,Craig A. Portell,Vicki L. Gordon,Brian J. Capaldo,Stefan Bekiranov,Mark J. Axelrod,L. Kyle Brett,Julia D. Wulfkuhle,Rosa I. Gallagher,Emanuel F. Petricoin,Timothy P. Bender,Michael E. Williams,Michael J. Weber
View Articletitled, Microenvironmental agonists generate de novo phenotypic resistance to combined ibrutinib plus venetoclax in CLL and MCL
Supplemental data

MYELOID NEOPLASIA

Engraftment of chronic myelomonocytic leukemia cells in immunocompromised mice supports disease dependency on cytokines
Yanyan Zhang,Liang He,Dorothée Selimoglu-Buet,Chloe Jego,Margot Morabito,Christophe Willekens,M'boyba Khadija Diop,Patrick Gonin,Valérie Lapierre,Nathalie Droin,Eric Solary,Fawzia Louache
View Articletitled, Engraftment of chronic myelomonocytic leukemia cells in immunocompromised mice supports disease dependency on cytokines
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Gene correction of HAX1 reversed Kostmann disease phenotype in patient-specific induced pluripotent stem cells
Erik Pittermann,Nico Lachmann,Glenn MacLean,Stephan Emmrich,Mania Ackermann,Gudrun Göhring,Brigitte Schlegelberger,Karl Welte,Axel Schambach,Dirk Heckl,Stuart H. Orkin,Tobias Cantz,Jan-Henning Klusmann
View Articletitled, Gene correction of <em>HAX1</em> reversed Kostmann disease phenotype in patient-specific induced pluripotent stem cells
Supplemental data

PLATELETS AND THROMBOPOIESIS

In-depth PtdIns(3,4,5)P3 signalosome analysis identifies DAPP1 as a negative regulator of GPVI-driven platelet function
Tom N. Durrant,James L. Hutchinson,Kate J. Heesom,Karen E. Anderson,Len R. Stephens,Phillip T. Hawkins,Aaron J. Marshall,Samantha F. Moore,Ingeborg Hers
View Articletitled, In-depth PtdIns(3,4,5)P<sub>3</sub> signalosome analysis identifies DAPP1 as a negative regulator of GPVI-driven platelet function
Supplemental data

TRANSFUSION MEDICINE

Retrospective analysis of capillary hemoglobin recovery in nearly 1 200 000 blood donor returns
Pia Niittymäki,Mikko Arvas,Antti Larjo,Pirkko Mattila,Jarkko Ihalainen,Martti Syrjälä,Johanna Castrén,Jukka Partanen
View Articletitled, Retrospective analysis of capillary hemoglobin recovery in nearly 1 200 000 blood donor returns
Supplemental data
Human and murine splenic neutrophils are potent phagocytes of IgG-opsonized red blood cells
Sanne M. Meinderts,Per-Arne Oldenborg,Boukje M. Beuger,Thomas R. L. Klei,Johanna Johansson,Taco W. Kuijpers,Takashi Matozaki,Elise J. Huisman,Masja de Haas,Timo K. van den Berg,Robin van Bruggen
View Articletitled, Human and murine splenic neutrophils are potent phagocytes of IgG-opsonized red blood cells
Supplemental data
A population-based longitudinal study on the implication of demographic changes on blood donation and transfusion demand
Clinical Trials & Observations
Andreas Greinacher,Kerstin Weitmann,Linda Schönborn,Ulf Alpen,Doris Gloger,Wolfgang Stangenberg,Kerstin Stüpmann,Nico Greger,Volker Kiefel,Wolfgang Hoffmann
View Articletitled, A population-based longitudinal study on the implication of demographic changes on blood donation and transfusion demand
Supplemental data

COMMENTARY

JAK2 V617F hematopoietic clones are present several years prior to MPN diagnosis and follow different expansion kinetics
Thomas McKerrell,Naomi Park,Jianxiang Chi,Grace Collord,Thaidy Moreno,Hannes Ponstingl,Joao Dias,Petroula Gerasimou,Kiki Melanthiou,Chrystalla Prokopiou,Marios Antoniades,Ignacio Varela,Paul A. Costeas,George S. Vassiliou
View Articletitled, <em>JAK2</em> V617F hematopoietic clones are present several years prior to MPN diagnosis and follow different expansion kinetics
Supplemental data
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Röth A, Broome CM, Barcellini W, et al. Long-term sutimlimab improves quality of life for patients with cold agglutinin disease: CARDINAL 2-year follow-up. Blood Adv. 2023;7(19):5890-5897.
Proteomic profiling for biomarker discovery in heparin-induced thrombocytopenia
Hemolysis events in the phase 3 PEGASUS study of pegcetacoplan in patients with paroxysmal nocturnal hemoglobinuria
Development of combination therapies with BTK inhibitors and dasatinib to treat CNS-infiltrating E2A-PBX1+/preBCR+ ALL
Organ involvement in adults with BPDCN is associated with sun exposure history, TET2 and RAS mutations, and survival

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