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Journal Articles

Alternative AAV gene therapy for hemophilia A using expression of Bi8, a novel single-chain FVIII-mimetic antibody

Vincent Muczynski, Olivier D. Christophe, Lewis Tanner, Charlotte Vayssiere, Alice Guérin, Caterina Casari, Jenny McIntosh, Doyoung Lee, Gavin Ling, Satyen Gohil, Peter J. Lenting, Edward G. D. Tuddenham, Amit C. Nathwani

Blood (2025) 146 (26): 3175–3187.

https://doi.org/10.1182/blood.2024027709

Published: 2025

Includes: Supplemental data

Journal Articles

Domain and residue mapping of autoantibodies to β 2 GPI reveals differences among antiphospholipid syndrome phenotypes

Suresh Kumar, Deepesh Vaid, Paola Lonati, Arianna Da Via, Marta Tonello, Pier Luigi Meroni, Vittorio Pengo, Nicola Pozzi

Blood (2025) 146 (26): 3234–3245.

https://doi.org/10.1182/blood.2025029488

Published: 2025

Includes: Supplemental data

Journal Articles

Estrogen upregulates lactoferrin to induce hypercoagulability for hemostatic protection during pregnancy

Ruomei Cheng, Xiaopeng Tang, Xiaoshan Huang, Xudong Dong, Yifan Chen, Jinai Gao, Long Bai, II, Dawit Adisu Tadese, Quxi Zhao, Meiquan Li, Deyuan Su, Qiumin Lu, Ziyi Wang, Ren Lai

Blood blood.2025030270.

https://doi.org/10.1182/blood.2025030270

Published: 2025

Includes: Supplemental data

Journal Articles

Layilin inhibits integrin activation, and its loss results in platelet hyperactivation via Rac1 in inflammatory bowel disease

Rebecca A. Mellema, Kimberly A. Queisser, Abigail Ajanel, Nansy Albtoush, Lydia Smith-Sanchez, Matthew T. Rondina, Julie Will, John F. Valentine, Aaron C. Petrey

Blood (2025) 146 (24): 2979–2992.

https://doi.org/10.1182/blood.2025028477

Published: 2025

Includes: Supplemental data

Journal Articles

Interplay of procoagulatory and neutrophil-derived anticoagulatory proteins in C1q-NET–driven blood coagulation

Minnah Thomas, Davor Frleta, KehDih Lai, John O’Brien, Aditi K. Patel, Yuanqi Zhao, Keith A. Kobylarz, Naxin Tu, Gabor Halasz, Chunguang Guo, Lynn E. Macdonald, Lori G. Morton, Dan Chalothorn, Kishor B. Devalaraja-Narashimha

Blood (2025) 146 (24): 2993–3002.

https://doi.org/10.1182/blood.2024027161

Published: 2025

Includes: Multimedia, Supplemental data

Journal Articles

Cryo-EM structure of the tissue factor/factor VIIa complex with a factor X mimetic reveals a novel allosteric mechanism

Josepha C. Sedzro, Amanda L. Photenhauer, Fabienne Birkle, Katarina Meze, Alex Mortenson, Cade Duckworth, Po-Chao Wen, Sarah Kearns, Michael A. Cianfrocco, Emad Tajkhorshid, Melanie D. Ohi, James H. Morrissey

Blood (2025) 146 (23): 2833–2842.

https://doi.org/10.1182/blood.2025029430

Published: 2025

Includes: Multimedia, Supplemental data

Journal Articles

FLI1 -related thrombocytopenia: piecing together the story

Richard C. Godby, Dong Chen

Blood (2025) 146 (22): 2728.

https://doi.org/10.1182/blood.2025030799

Published: 2025

Journal Articles

Multisite Validation of a Venous Thrombosis Risk Model in Critically Ill Children Through the CHAT Consortium

Julie Jaffray, Brian R Branchford, Maua Mosha Alleyne, Ernest Amankwah, E. Vincent S. Faustino, Neil A Zakai, Anthony A. Sochet, Amy Stillings, Emily Krava, Guy Young, Neil A Goldenberg

Blood blood.2025029841.

https://doi.org/10.1182/blood.2025029841

Published: 2025

Includes: Supplemental data

Journal Articles

Platelet defects in patients and mice with Ehlers-Danlos syndrome

Mariia Kumskova, Gagan D Flora, Manasa K. Nayak, Ivan Budnik, Aditi Jain, Rakesh B. Patel, Abhishek B Jha, Madankumar Ghatge, Neelam Chauhan, James V. Michael, Steven E. McKenzie, Anjali Sharathkumar, Janice M Staber, Steven R Lentz, Anil Chauhan

Blood blood.2025029912.

https://doi.org/10.1182/blood.2025029912

Published: 2025

Includes: Supplemental data

Journal Articles

A bispecific nanobody for the treatment of von Willebrand disease type 1

Ivan Peyron, Caterina Casari, Geneviève McCluskey, Vincent Licari, Emilie Bocquet, Claire Auditeau, Mélanie Y. Daniel, Stéphanie Roullet, Sophie Susen, Olivier D. Christophe, Peter J. Lenting, Cécile V. Denis

Blood (2025) 146 (21): 2597–2607.

https://doi.org/10.1182/blood.2025029401

Published: 2025

Includes: Supplemental data

Journal Articles

Targeting FXR in hepatocytes: a promising approach to enhance fibrinolysis and reduce deep vein thrombosis risk

Bolin Li, Heze Fan, Hao Wu, Yiqiong Zhang, Ning Ding, Peining Liu, Qi Wang, Miaomiao Cao, Zixuan Meng, Xinxin Feng, Xiaozhen Zhuo, Wei Wu, Ying Xiong, Kai Deng, Ting Li, Junhui Liu, Yue Wu

Blood (2025) 146 (20): 2464–2478.

https://doi.org/10.1182/blood.2024027772

Published: 2025

Includes: Supplemental data

Journal Articles

Molecular determinants of thrombosis recurrence risk across venous thromboembolism subtypes

Blood (2025) 146 (19): 2357–2369.

https://doi.org/10.1182/blood.2024027879

Published: 2025

Includes: Supplemental data

Journal Articles

Factor IXa and factor X influence factor VIIIa stability and inactivation mechanisms in vitro and in vivo

Johnathan J. Morris, Nicole A. Parsons, Amelia R. Wilhelm, Robert J. Davidson, Lauren K. Olenick, Connor T. Watson, Andrew Vanden Heuvel, Lindsey A. George

Blood (2025) 146 (18): 2259–2271.

https://doi.org/10.1182/blood.2024027705

Published: 2025

Includes: Supplemental data

Journal Articles

A 3.3-Å cryo-EM structure of an engineered high-affinity human prothrombinase complex

Fatma Işık Üstok, Alexandre Faille, James A. Huntington

Blood blood.2025031527.

https://doi.org/10.1182/blood.2025031527

Published: 2025

Includes: Supplemental data

Journal Articles

Chilling controversy: cold-stored platelets for prophylactic transfusions

Moritz Stolla, Andrew P. Cap, Phillip C. Spinella

Blood (2025) 146 (17): 2023–2028.

https://doi.org/10.1182/blood.2025029252

Published: 2025

Journal Articles

Therapeutic base editing to generate a gain-of-function F9 variant for hemophilia B

Nemekhbayar Baatartsogt, Yuji Kashiwakura, Takafumi Hiramoto, Rina Ito, Rikako Sato, Yasumitsu Nagao, Hina Naruoka, Haruka Takata, Morisada Hayakawa, Khishigjargal Batjargal, Tomoki Togashi, Atsushi Hoshino, Taro Shimizu, Yusuke Sato, Tatsuhiro Ishida, Osamu Nureki, Tsukasa Ohmori

Blood blood.2024027870.

https://doi.org/10.1182/blood.2024027870

Published: 2025

Includes: Supplemental data

Journal Articles

A novel cause of type 1 von Willebrand disease: impaired exocytosis of Weibel-Palade bodies due to biallelic MADD variants

Sophie Hordijk, Stijn A. Groten, Petra E. Bürgisser, Sebastiaan N. J. Laan, Georg Christoph Korenke, Tomáš Honzík, Diane Beysen, Frank W. G. Leebeek, Paul A. Skehel, Maartje van den Biggelaar, Tom Carter, Ruben Bierings

Blood (2025) 146 (17): 2133–2144.

https://doi.org/10.1182/blood.2024027935

Published: 2025

Includes: Supplemental data

Journal Articles

The interleukin-33 receptor (ST2) is a novel therapeutic target to attenuate the progression of hemophilic arthropathy

Blood (2025) 146 (16): 1979–1990.

https://doi.org/10.1182/blood.2024027578

Published: 2025

Includes: Supplemental data

Journal Articles

F8 gene variants influence the response to desmopressin in hemophilia A carriers

Benoît Guillet, Roseline d’Oiron, Marc Trossaert, Bénédicte Wibaut, Brigitte Pan-Petesch, Birgit Frotscher, Fabienne Volot, Laurent Ardillon, Stéphanie Désage, Céline Falaise, Christine Biron-Andréani, Vincent Cussac, Brigitte Tardy, Yoann Huguenin, Hervé Chambost, Sophie Bayart, Sabine-Marie Castet, Xavier Delavenne

Blood (2025) 146 (16): 1991–2004.

https://doi.org/10.1182/blood.2025029829

Published: 2025

Includes: Supplemental data

Journal Articles

Human missense variants in F3 impair the initiation of blood coagulation

Shabbir A Ansari, Marisa A. Brake, Nishtha Pathak, James T. Flaumenhaft, Jacob Ludington, Natasha Panwar, Ernest Turro, Sol Schulman

Blood blood.2025029571.

https://doi.org/10.1182/blood.2025029571

Published: 2025

Includes: Supplemental data

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Alternative AAV gene therapy for hemophilia A using expression of Bi8, a novel single-chain FVIII-mimetic antibody

Domain and residue mapping of autoantibodies to β 2 GPI reveals differences among antiphospholipid syndrome phenotypes

Estrogen upregulates lactoferrin to induce hypercoagulability for hemostatic protection during pregnancy

Layilin inhibits integrin activation, and its loss results in platelet hyperactivation via Rac1 in inflammatory bowel disease

Interplay of procoagulatory and neutrophil-derived anticoagulatory proteins in C1q-NET–driven blood coagulation

Cryo-EM structure of the tissue factor/factor VIIa complex with a factor X mimetic reveals a novel allosteric mechanism

FLI1 -related thrombocytopenia: piecing together the story

Multisite Validation of a Venous Thrombosis Risk Model in Critically Ill Children Through the CHAT Consortium

Platelet defects in patients and mice with Ehlers-Danlos syndrome

A bispecific nanobody for the treatment of von Willebrand disease type 1

Targeting FXR in hepatocytes: a promising approach to enhance fibrinolysis and reduce deep vein thrombosis risk

Molecular determinants of thrombosis recurrence risk across venous thromboembolism subtypes

Factor IXa and factor X influence factor VIIIa stability and inactivation mechanisms in vitro and in vivo

A 3.3-Å cryo-EM structure of an engineered high-affinity human prothrombinase complex

Chilling controversy: cold-stored platelets for prophylactic transfusions

Therapeutic base editing to generate a gain-of-function F9 variant for hemophilia B

A novel cause of type 1 von Willebrand disease: impaired exocytosis of Weibel-Palade bodies due to biallelic MADD variants

The interleukin-33 receptor (ST2) is a novel therapeutic target to attenuate the progression of hemophilic arthropathy

F8 gene variants influence the response to desmopressin in hemophilia A carriers

Human missense variants in F3 impair the initiation of blood coagulation

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