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Journal Articles

Targeting Nicotinamide Adenine Dinucleotide (NAD) Glycohydrase Activity of CD38 Exerts Anti-Myeloma Effect Accompanying Intracellular NAD Elevation

Saki Kushima, Takayuki Sasano, Masao Matsuoka, MD PhD, Hiroyuki Hata, MD PhD, Yawara Kawano, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1810.
https://doi.org/10.1182/blood-2019-123624
Published: 2019
Journal Articles

Integrated Systems Level Examination of Proteasome Inhibitor Stress Recovery in Myeloma Cells Reveals Druggable Vulnerabilities Linked to Multiple Metabolic Processes

Paula Saavedra-Garcia, PhD, Hibah A Al-Sadah, MSc, Lucy Penfold, PhD, Xiaobei Xiong, MRes, Elena Lopez-Jimenez, PhD, Katarzyna Parzych, PhD, Valentina S Caputo, Kevin Blighe, PhD, Martin F. Kaiser, Paolo Piazza, PhD, Vesela Encheva, PhD, Ambrosius P Snijders, PhD, Hector C Keun, DPhil, Diego Oyarzun, PhD, Denise Thiel, MSc, Zijing Liu, PhD, Mauricio Barahona, PhD, Holger W Auner, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1818.
https://doi.org/10.1182/blood-2019-121549
Published: 2019
Journal Articles

Hexokinase-2 Regulates Hypoxia-Inducible Autophagy, Leading to Enhance Anti-Apoptotic Capability of Refractory Multiple Myeloma

Sho Ikeda, MD PhD, Fumito Abe, MD PhD, Matsuda Yuka, Akihiro Kitadate, MD PhD, Takahiro Kobayashi, MD PhD, Naoto Takahashi, MD PhD, Hiroyuki Tagawa, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1787.
https://doi.org/10.1182/blood-2019-123360
Published: 2019
Journal Articles

T Cell Activation By OKT3 Is a Function of the Percent Monocytes in PBMC of Healthy Donors and MDS Patients

Alison Tarke, Valentina Ferrari, BA, Hannah Fields, Luca Ferrari, Franco Ferrari, PhD, Tiffany N Tanaka, MD, Rafael Bejar, MD PhD, Antonella Vitiello, Dr. Pharm., Thomas A Lane, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4870.
https://doi.org/10.1182/blood-2019-131474
Published: 2019
Journal Articles

Fas Mutations in Non-Hodgkin's Lymphoma (NHL): Implications for Disease Progression and Therapeutic Resistance

Ryan N Rys, BSc, BA, Maanasa Venkataraman, MSc, Jibin Zeng, MSc, Koren Kathleen Mann, PhD, Nathalie Johnson, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1520.
https://doi.org/10.1182/blood-2019-130602
Published: 2019
Journal Articles

Detection of Measurable Residual Disease (MRD) in Peripheral Blood: First Report of a Novel Microfluidic Platform in Patients with Acute Myeloid Leukemia (AML)

Matthew C Foster, MD, Yuri Fedoriw, MD, Will Pulley, BA, Joshua Zeidner, MD, Catherine C. Coombs, MD, Emily Mirkin, Maryam Zomorrodi, Rachel Toughiri, PhD, Alena Bartakova, MD, Craig Carson, PhD, Rolf Muller, PhD, Paul M. Armistead, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1417.
https://doi.org/10.1182/blood-2019-127434
Published: 2019
Journal Articles

FLT3-ITD Enhances Proliferation and Survival of AML Cells through Activation of RSK1 to Upregulate the mTORC1/eIF4F Pathway Cooperatively with PIM or PI3K and to Inhibit Bad and Bim

Ayako Nogami, MD PhD BPharm, Daisuke Watanabe, MD, Keigo Okada, MD, PhD, Hiroki Akiyama, MD, PhD, Yoshihiro Umezawa, MD, PhD, Toshikage Nagao, MD, PhD, Shuji Tohda, MD, PhD, Osamu Miura, MD, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1425.
https://doi.org/10.1182/blood-2019-123183
Published: 2019
Journal Articles

Selective Targeting BET Family Bdii Bromodomain with Abbv-744 and BCL-2 with Venetoclax (ABT-199) Is Synergistic in Primary Acute Myeloid Leukemia Models

Tianyu Cai, PhD, Vinitha Mary Kuruvilla, MSc, Xiaoyu Lin, Tamar Uziel, PhD, Xin Lu, Lu Zhang, Xiaoli Huang, Qi Zhang, PhD, Antonio Cavazos, Lina Han, PhD, Yu Shen, Marina Y Konopleva, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1369.
https://doi.org/10.1182/blood-2019-128618
Published: 2019
Journal Articles

CLL-Derived Exosomes Function As Trojan Horses That Induce SMAD6-Dependent Apoptosis of Normal B-Cells

Orit Uziel, PhD, Zinab Sarsur- Amer, Einat Beery, Pia Raanani, MD, Uri Rozovski, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1734.
https://doi.org/10.1182/blood-2019-129873
Published: 2019
Journal Articles

CG-806, a First-in-Class Pan-FLT3/Pan-BTK Inhibitor, Exhibits Broad Signaling Inhibition in Chronic Lymphocytic Leukemia Cells

Ekaterina Kim, MS, Hongying Zhang, MD PhD, Mariela Sivina, Alicia Vaca, PhD, Philip A. Thompson, MBBS, Nitin Jain, MD, Alessandra Ferrajoli, MD, Zeev E. Estrov, MD, Michael J Keating, MBBS, William G. Wierda, MD PhD, William G Rice, PhD, Michael Andreeff, MD PhD, Jan A. Burger, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3051.
https://doi.org/10.1182/blood-2019-124473
Published: 2019
Journal Articles

The Dual PI3K-δ/γ Inhibitor Duvelisib in Combination with the Bcl-2 Inhibitor Venetoclax Shows Promising Responses in Richter Syndrome-PDX Models

Andrea Iannello, PhD, Francesca Arruga, PhD, Nicoletta Vitale, PhD, Elisa Marchi, Richard R. Furman, MD, John N. Allan, MD, Silvia Coma, PhD, Jonathan A. Pachter, PhD, Silvia Deaglio, MD PhD, Tiziana Vaisitti, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2862.
https://doi.org/10.1182/blood-2019-125754
Published: 2019
Journal Articles

Transcriptional and Spatial Heterogeneity of Mouse Megakaryocytes at Single-Cell Resolution

Shu Sun, BS, Chen Jin, PhD, Yueying Li, MD, Jia Si, Yueli Cui, Matthew T. Rondina, MD, Fuchou Tang, PhD, Qian-fei Wang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 275.
https://doi.org/10.1182/blood-2019-129471
Published: 2019
Journal Articles

Impact of Tisagenlecleucel Chimeric Antigen Receptor (CAR)-T Cell Therapy Product Attributes on Clinical Outcomes in Adults with Relapsed or Refractory Diffuse Large B-Cell Lymphoma (r/r DLBCL)

Veronika Bachanova, MD PhD, Constantine S. Tam, MBBS, MD, Peter Borchmann, MD, Ulrich Jaeger, MD, Joseph P. McGuirk, DO, Harald Holte, MD PhD, Edmund K. Waller, PhDMD, Samantha Jaglowski, MDMPH, Michael R. Bishop, MD, Charalambos Andreadis, MD MSCE, Stephen Ronan Foley, MD FRCPC, Jason R. Westin, MD, Isabelle Fleury, MD, P Joy Ho, MBBS(Syd) DPhil(Oxon) FRACP FRCPA FFSc(RCPA), Stephan Mielke, MD, Takanori Teshima, MD, Gilles Salles, MD PhD, Stephen J Schuster, MD, Richard T. Maziarz, MD, Koen Van Besien, MD PhD, Koji Izutsu, MD PhD, Marie Jose Kersten, MD PhD, John M. Magenau, MD, Nina D. Wagner-Johnston, MD, Koji Kato, MD PhD, Paolo Corradini, Jufen Chu, PhD, Irina Gershgorin, PhD, Therese Choquette, PhD, Lida Bubuteishvili Pacaud, MD, Margit Jeschke, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 242.
https://doi.org/10.1182/blood-2019-128302
Published: 2019
Journal Articles

Inhibiting Mitochondria Function By Bcl-2 Inhibitor Venetoclax and Complex I Inhibitor Iacs-010759 Eliminate Leukemia Cells in Pre-Clinical AML Models

Qi Zhang, PhD, Alessia Lodi, PhD, Shannon Renee Sweeney, PhD, Lina Han, PhD, Tianyu Cai, PhD, Vinitha Mary Kuruvilla, MSc, Antonio Cavazos, Helen Ma, MS, Yoko Tabe, MD PhD, Joseph R Marszalek, PhD, Stefano Tiziani, PhD, Marina Y Konopleva, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3927.
https://doi.org/10.1182/blood-2019-124494
Published: 2019
Journal Articles

Meds433, a New Dihydroorotate Dehydrogenase Inhibitor, Induces Apoptosis and Differentiation in Acute Myeloid Leukemia

Valentina Gaidano, MD, Paola Circosta, PhD, Alessandro Cignetti, MD PhD, Mohammad Houshmand, Nicoletta Vitale, PhD, Stefano Sainas, PhD, Agnese Pippione, PhD, Manuela Marraudino, PhD, Brigitta Bonaldo, MD, Marta Giorgis, PhD, Donatella Boschi, PhD, Marco Lucio Lolli, PhD, Giuseppe Saglio, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3942.
https://doi.org/10.1182/blood-2019-128085
Published: 2019
Journal Articles

Inhibition of BMP-Smad Pathway Reduces Leukemic Stemness in Pediatric AML

Xin Long, PhD, Chris Man, PhD, Padmini Narayanan, PhD, Elizabeth Seashore, MD, Michele Redell, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3731.
https://doi.org/10.1182/blood-2019-129074
Published: 2019
Journal Articles

BCR-ABL and Src Family Kinases Induce YAP Tyrosine Phosphorylation Resulting in Survivin and Cyclin D1 Expression in Chronic Myeloid Leukemia Cells

Toshiyuki Hori, MD PhD, Kenta Moriyama, MS
Journal: Blood
Blood (2019) 134 (Supplement_1): 5366.
https://doi.org/10.1182/blood-2019-124643
Published: 2019
Journal Articles

PEDF Can Rescue the Inhibition of Injured Endothelial Cells on Hematopoietic Stem Cell Expansion Ex Vivo

Lingyu Zeng, MD,PhD, Wenyi Lu, Lan Ding, Wen Ju, Jianlin Qiao, PhD, Kailin Xu, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5008.
https://doi.org/10.1182/blood-2019-127978
Published: 2019
Journal Articles

Cxcr4 low FLT3/ITD + Cells Exhibit Enhanced Resistance to the FLT3 Inhibitor Quizartinib Compared to Cxcr4 high FLT3/ITD + Cells By Elevating Runx1 Expression

Seiji Fukuda, MD PhD, Chie Onishi, MD PhD, Takeshi Taketani, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2558.
https://doi.org/10.1182/blood-2019-129513
Published: 2019
Journal Articles

Comprehensive Cell Specific Transcriptome Profiling of a Pediatric Hodgkin Lymphoma Cohort

Jennifer Agrusa, MD, Elmoataz A Abdel Fattah, MBBCh, Howard Lin, BS, Rikhia Chakraborty, PhD, Brooks Scull, MS, Harshal Abhyankar, MS, Nmazuo Wudo Ozuah, MBBS, Olive S. Eckstein, MD, Terzah M Horton, MD PhD, Kala Kamdar, MD, Kenneth L. McClain, MD PhD, Chris Tsz-Kwong Man, PhD, Carl E. Allen, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2773.
https://doi.org/10.1182/blood-2019-125982
Published: 2019