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Journal Articles

The Unfolded Protein Response Causes Prothrombotic Transformation of Pancreatic Cancer Linking Tumor Progression with Cancer-Associated Thrombosis

Oluwatoyosi Muse, PhD, Rushad Patell, MD, Christian Peters, PhD, Sol Schulman, MD PhD, Emale Darzi, MS, Calvin Schuster, BA, Ling Huang, PhD, Shibani Mukherjee, PhD, Senthil Muthuswamy, PhD, Jeffrey I. Zwicker, MD, Robert C. Flaumenhaft, MD PhD

Blood (2019) 134 (Supplement_1): 632.

https://doi.org/10.1182/blood-2019-123544

Published: 2019

Journal Articles

Inducible Expression of Mutant ELANE Correlates with Disruption of Differentiation Program, but Not the Unfolded Protein Response

Bhavuk Garg, PhD, Hrishikesh M Mehta, PhD, Ralph Kamel, Marshall S. Horwitz, MD PhD, Seth J. Corey, MD

Blood (2019) 134 (Supplement_1): 103.

https://doi.org/10.1182/blood-2019-127409

Published: 2019

Journal Articles

Proteomic Profiling and Mechanistic Investigating of a Novel Anti-Cancer Small Molecule Inhibitor of Sec61

Yu Qian, PhD, Henry W.B. Johnson, PhD, Christopher J. Kirk, PhD, Eric Lowe, BS, Dustin McMinn, PhD, Beatriz Millare, BS, Tony Muchamuel, MS, Jinhai Wang, PhD

Blood (2019) 134 (Supplement_1): 2076.

https://doi.org/10.1182/blood-2019-125988

Published: 2019

Journal Articles

Combining De-Glycosylating Agents with CAR-T Cells for Targeting Solid Tumors and Reducing Toxicity

Beatrice Greco, MSc, Katia Paolella, Barbara Camisa, Valeria Malacarne, PhD, Laura Falcone, Andrea Graziani, PhD, Chiara Bonini, MD, Attilio Bondanza, MD, Monica Casucci, PhD

Blood (2018) 132 (Supplement 1): 4544.

https://doi.org/10.1182/blood-2018-99-116019

Published: 2018

Journal Articles

Arginine Depletion in Combination with Canavanine Supplementation Induces Massive Cell Death in Myeloma Cells By Interfering with Their Protein Metabolism and Bypassing Potential Rescue Mechanisms

Johannes Windschmitt, Björn Jacobi, MD, Yagmur Bülbül, Lilli Sester, Janine Tappe, Christof Hiebel, PhD, Christian Behl, PhD, Matthias Theobald, Markus Munder, MD

Blood (2018) 132 (Supplement 1): 3205.

https://doi.org/10.1182/blood-2018-99-113396

Published: 2018

Journal Articles

N-RasG12D-Mediated Dysregulation of IRE1alpha-Xbp1s Signaling Promotes Pre-Leukemic Hematopoietic Stem Cell Expansion

Lu Liu, PhD, Meiling Zhao, MS, Kevin B Yang, Xi Jin, PhD, Gina Ney, MD PhD, Juan Del Valle, BS, PhD, Takao Iwawaki, PhD, Qing Li, MD PhD

Blood (2016) 128 (22): 567.

https://doi.org/10.1182/blood.V128.22.567.567

Published: 2016

Journal Articles

Ribosome Profiling Uncovers Selective mRNA Translation Associated with eIF2 Phosphorylation in Erythrocyte Progenitors

Paolini Nahuel, MSc, Moore Kat, MSc, di Summa Franca, BSc, Fokkema Ivo, MSc, Jansen Sjoert, MSc, 't Hoen Peter-Bram, PhD, Marieke Von Lindern, PhD

Blood (2016) 128 (22): 1197.

https://doi.org/10.1182/blood.V128.22.1197.1197

Published: 2016

Journal Articles

Characterization of Missense Mutations in Factor VIII That Lead to Abnormal N-Linked Glycosylation

Wei Wei, MDPhD, Xiaofan Zhu, MD, Renchi Yang, MD PhD, Bin Zhang, PhD

Blood (2016) 128 (22): 3764.

https://doi.org/10.1182/blood.V128.22.3764.3764

Published: 2016

Journal Articles

Conditional Expression of Mutant ELANE Produces Unfolded Protein Response but Fails to Promote Cell Death or Differentiation Block: What Is the Mechanism for Severe Congenital Neutropenia?

Hrishikesh M Mehta, PhD, Arighno Das, BA, Ralph Kamel, MD, Marshall Horwitz, MD PhD, Seth Corey, MD MPH

Blood (2016) 128 (22): 3899.

https://doi.org/10.1182/blood.V128.22.3899.3899

Published: 2016

Journal Articles

C-Jun Regulates ER Stress Signaling to Promote Chemotherapy Resistance in Acute Myeloid Leukemia

Chun Zhou, PhD, Daniela Di Marcantonio, PhD, Esteban Martinez, Nehal Solanki-Patel, Suraj Peri, PhD, Claudia Scholl, Stefan Fröhling, David L. Wiest, PhD, Stephen Matthew Sykes, PhD

Blood (2015) 126 (23): 2464.

https://doi.org/10.1182/blood.V126.23.2464.2464

Published: 2015

Journal Articles

Crispr Sgrnas Genome-Wide Screen Identifies the Proteasome Regulatory Subunit PSMC6 As a Bortezomib Resistance Gene in Human Multiple Myeloma Cells

Chang-Xin Shi, PhD, Klaus M Kortum, MD, Yuan Xiao Zhu, PhD, Patrick Jedlowski, Esteban Braggio, PhD, Laura Ann Bruins, Patrick G. Votruba, M.S., Moulun Luo, PhD, Robert A. Stewart, Jonathan M. Ahmann, A. Keith Stewart

Blood (2015) 126 (23): 450.

https://doi.org/10.1182/blood.V126.23.450.450

Published: 2015

Journal Articles

A Novel Radiosensitivity Phenotype in Shwachman-Diamond Syndrome Is Mediated By ER Stress Response

Nimrat Chatterjee, PhD, Christopher Lee Williams, B.S., Saleh Bhar, MD, Alison A Bertuch, MD PhD

Blood (2015) 126 (23): 3618.

https://doi.org/10.1182/blood.V126.23.3618.3618

Published: 2015

Journal Articles

Characterization of a PERK Kinase Inhibitor with Anti-Myeloma Activity

Tina Bagratuni, Nefeli Mavrianou, Efstathios Kastritis, MD, Christine Liakos, Evangelos Terpos, MD, Meletios A. Dimopoulos

Blood (2015) 126 (23): 4188.

https://doi.org/10.1182/blood.V126.23.4188.4188

Published: 2015

Journal Articles

Clotting Factor VIII Overexpression Shows Signs of ER Stress but Does Not Cause Toxicity upon Gene Transfer

Irene Zolotukhin, MS, Brett Palaschak, BA, David M Markusic, PhD, Roland Herzog, PhD

Blood (2015) 126 (23): 3238.

https://doi.org/10.1182/blood.V126.23.3238.3238

Published: 2015

Journal Articles

ONC201 Induces p53-Independent Apoptosis and Cell Cycle Arrest in Hematological Malignancies and Leukemic Stem/Progenitor Cells By Inducing ER Stress and mTOR Inhibition

Jo Ishizawa, MD PhD, Kensuke Kojima, MD PhD, Dhruv Chachad, MS, Peter P. Ruvolo, PhD, Vivian R Ruvolo, MA, Rodrigo Jacamo, PhD, Archana Dilip, MS, Hong Mu, MD PhD, Zhihong Zeng, MD, Polina Matre, PhD, Joshua E. Allen, PhD, Sattva S Neelapu, MD, Timothy J. McDonnell, MD PhD, Roberto N. Miranda, MD, Larry W. Kwak, MD PhD, Hagop M. Kantarjian, MD, Marina Konopleva, MD PhD, R Eric Davis, MD, Michael Andreeff, MD PhD

Blood (2014) 124 (21): 3122.

https://doi.org/10.1182/blood.V124.21.3122.3122

Published: 2014

Journal Articles

Novel Deletion Mutants in the Juxtamembrane Domain of Fms-like Tyrosine Kinase 3 (FLT3) Induce Transformation By Release from Autoinhibition in AML

Nicolas Chatain, PhD, Janine Rossa, Giulia Rossetti, PhD, Rodrigo Casasnovas Perera, PhD, Paolo Carloni, PhD, Torsten Haferlach, MD, Tim H. Brümmendorf, MD, Susanne Schnittger, PhD, Steffen Koschmieder, MD

Blood (2014) 124 (21): 885.

https://doi.org/10.1182/blood.V124.21.885.885

Published: 2014

Journal Articles

BCR-ABL+ Bp-ALL Exhibits Heightened Sensitivity to Simultaneous Induction of Energy and ER Stress Via Downregulation of Mcl-1 Expression

Guy J. Leclerc, PhD, Joanna DeSalvo, B.Sc., Gilles M. Leclerc, PhD, Theodore J. Lampidis, PhD, Julio C. Barredo, MD

Blood (2014) 124 (21): 916.

https://doi.org/10.1182/blood.V124.21.916.916

Published: 2014

Journal Articles

Toll-Like Receptor Activation Promotes Multiple Myeloma Cell Growth and Survival By Suppression Of Endoplasmic Reticulum Stress Factor CHOP

Tina Bagratuni, Efstathios Kastritis, Christine Liacos, Evangelos Eleutherakis-Papaiakovou, Nikolaos Kanellias, Evangelos Terpos, Meletios A. Dimopoulos, MD

Blood (2013) 122 (21): 3112.

https://doi.org/10.1182/blood.V122.21.3112.3112

Published: 2013

Journal Articles

The NEDD8 Conjugation Pathway Inhibitor MLN4924 Activates AMPK and Induces The ER Stress/UPR-Mediated Cell Death Pathway In Acute Lymphoblastic Leukemia

Gilles M. Leclerc, Ph.D., Shuhua Zheng, B.Sc., Ronan T. Swords, MD, PhD, FRCPI, FRCPath, Guy J. Leclerc, Ph.D., Julio C. Barredo, M.D.

Blood (2013) 122 (21): 1285.

https://doi.org/10.1182/blood.V122.21.1285.1285

Published: 2013

Journal Articles

Bim-Targeting Therapy Circumvents Adaptive Bortezomib-Resistance In Myeloma Through a Novel Cross-Link Between Autophagy and Apoptosis

Shuang Chen, MD/PhD, Yun Dai, MD, PhD, Yu Zhang, PhD, Liang Zhou, MD/PhD, Hui Lin, MD, Xin-Yan Pei, Robert Z. Orlowski, M.D., Ph.D., Steven Grant, MD

Blood (2013) 122 (21): 601.

https://doi.org/10.1182/blood.V122.21.601.601

Published: 2013

NARROW

The Unfolded Protein Response Causes Prothrombotic Transformation of Pancreatic Cancer Linking Tumor Progression with Cancer-Associated Thrombosis

Inducible Expression of Mutant ELANE Correlates with Disruption of Differentiation Program, but Not the Unfolded Protein Response

Proteomic Profiling and Mechanistic Investigating of a Novel Anti-Cancer Small Molecule Inhibitor of Sec61

Combining De-Glycosylating Agents with CAR-T Cells for Targeting Solid Tumors and Reducing Toxicity

Arginine Depletion in Combination with Canavanine Supplementation Induces Massive Cell Death in Myeloma Cells By Interfering with Their Protein Metabolism and Bypassing Potential Rescue Mechanisms

N-RasG12D-Mediated Dysregulation of IRE1alpha-Xbp1s Signaling Promotes Pre-Leukemic Hematopoietic Stem Cell Expansion

Ribosome Profiling Uncovers Selective mRNA Translation Associated with eIF2 Phosphorylation in Erythrocyte Progenitors

Characterization of Missense Mutations in Factor VIII That Lead to Abnormal N-Linked Glycosylation

Conditional Expression of Mutant ELANE Produces Unfolded Protein Response but Fails to Promote Cell Death or Differentiation Block: What Is the Mechanism for Severe Congenital Neutropenia?

C-Jun Regulates ER Stress Signaling to Promote Chemotherapy Resistance in Acute Myeloid Leukemia

Crispr Sgrnas Genome-Wide Screen Identifies the Proteasome Regulatory Subunit PSMC6 As a Bortezomib Resistance Gene in Human Multiple Myeloma Cells

A Novel Radiosensitivity Phenotype in Shwachman-Diamond Syndrome Is Mediated By ER Stress Response

Characterization of a PERK Kinase Inhibitor with Anti-Myeloma Activity

Clotting Factor VIII Overexpression Shows Signs of ER Stress but Does Not Cause Toxicity upon Gene Transfer

ONC201 Induces p53-Independent Apoptosis and Cell Cycle Arrest in Hematological Malignancies and Leukemic Stem/Progenitor Cells By Inducing ER Stress and mTOR Inhibition

Novel Deletion Mutants in the Juxtamembrane Domain of Fms-like Tyrosine Kinase 3 (FLT3) Induce Transformation By Release from Autoinhibition in AML

BCR-ABL+ Bp-ALL Exhibits Heightened Sensitivity to Simultaneous Induction of Energy and ER Stress Via Downregulation of Mcl-1 Expression

Toll-Like Receptor Activation Promotes Multiple Myeloma Cell Growth and Survival By Suppression Of Endoplasmic Reticulum Stress Factor CHOP

The NEDD8 Conjugation Pathway Inhibitor MLN4924 Activates AMPK and Induces The ER Stress/UPR-Mediated Cell Death Pathway In Acute Lymphoblastic Leukemia

Bim-Targeting Therapy Circumvents Adaptive Bortezomib-Resistance In Myeloma Through a Novel Cross-Link Between Autophagy and Apoptosis

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American Society of Hematology

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ASH Publications

American Society of Hematology

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