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Journal Articles

The Lysine-Specific Demethylase 1 (LSD1) Inhibitor Tranylcypromine (TCP) in Combination with ATRA Is Tolerable and Has Anti-Leukemic Activity in Adult Patients with Relapsed/Refractory AML and MDS

Justin M Watts, MD, Terrence J Bradley, MD, Amber Thomassen, MA, MSN, Yvonne Trang Dinh, BS, Dalissa Tejera, MSN, Kristen Englund, Sorab Boga, MPH, Randy Astaiza, BS, Charles J Chen, MPH, Malika Abdur-Rahman, BS, MSED, Marinescu Ion, CCRC, FMG, Aymee Perez, PhD, Masoumeh Tayari, PhD, Lluis Morey, PhD, Maria E. Figueroa, MD, Ramin Shiekhattar, PhD, Arthur Zelent, PhD, Ronan Swords, MD PhD

Blood (2018) 132 (Supplement 1): 2721.

https://doi.org/10.1182/blood-2018-99-115411

Published: 2018

Journal Articles

LSD1 Inhibitors Induce Fetal Hemoglobin in Primary Human Erythroid Cells

Cuong LE, PhD, Greggory Myers, Alawi Habara, MBBS, MSc, David H.K. Chui, MD, Martin H. Steinberg, MD, James Douglas Engel, PhD, Shuaiying Cui, PhD

Blood (2018) 132 (Supplement 1): 1066.

https://doi.org/10.1182/blood-2018-99-117675

Published: 2018

Journal Articles

In Vivo Effects of LSD1 Inhibition By Small Chemical Inhibitors in Sickle Cell Mice

Cuong Le, PhD, Greggory Myers, Alawi Habara, Natee Jearawiriyapaisarn, PhD, Mary Lee, PhD, David H.K. Chui, MD, Martin H. Steinberg, MD, James Engel, PhD, Shuaiying Cui, PhD

Blood (2017) 130 (Supplement 1): 968.

https://doi.org/10.1182/blood.V130.Suppl_1.968.968

Published: 2017

Journal Articles

LSD1 Inhibition Leads to Differentiation in Hoxa9/Meis1- but Not in MN1-Induced Acute Myeloid Leukemia

Jessica Barth, Anna-Maria Scheder, Sebastian Mohr, Johannes Schulz-Fincke, Martin Schmitt, PhD, Alexandra Walter, Milica Tosic, Eric Metzger, Gesine Bug, MD, Michael Lübbert, Manfred Jung, PhD, Hubert Serve, Roland Schüle, PhD, Tobias Berg, MD

Blood (2017) 130 (Supplement 1): 1246.

https://doi.org/10.1182/blood.V130.Suppl_1.1246.1246

Published: 2017

Journal Articles

The Novel Translocation t(4;15)(q31;q22) in AML Is Associated with a Proliferative Phenotype in the Presence of All-Trans Retinoic Acid (ATRA)

Justin M Watts, MD, Aymee Perez, PhD, Fernando Vargas, MD, Yao-Shan Fan, MD PhD, Alejandra Weisman, Ana Rodriguez, Omar Lopez, Francisco Vega, MD PhD, Ronan T Swords, MD PhD FRCPI, FRCPath, Arthur Zelent, PhD

Blood (2016) 128 (22): 1526.

https://doi.org/10.1182/blood.V128.22.1526.1526

Published: 2016

Journal Articles

LSD1 Inhibition Induces Differentiation and Reduces the Frequency of Leukemia-Initiating Cells in Hoxa9/Meis1-Induced Acute Myeloid Leukemia

Jessica Barth, Anna-Maria Scheder, Sebastian Mohr, Schulz-Fincke Johannes, Martin Schmitt, Alexandra Walter, Milica Tosic, Eric Metzger, Michael Lübbert, MD, Manfred Jung, PhD, Hubert Serve, MD, Roland Schüle, Tobias Berg, MD

Blood (2016) 128 (22): 3935.

https://doi.org/10.1182/blood.V128.22.3935.3935

Published: 2016

Journal Articles

Safety, Phamacokinetics (PK), Pharmacodynamics (PD) and Preliminary Activity in Acute Leukemia of Ory-1001, a First-in-Class Inhibitor of Lysine-Specific Histone Demethylase 1A (LSD1/KDM1A): Initial Results from a First-in-Human Phase 1 Study

Tim Somervaille, MD PhD, Olga Salamero, MD, Pau Montesinos, MD PhD, Christophe Willekens, MD, Jose Antonio Perez Simon, MD, Arnaud Pigneux, MD, Christian Recher, MD PhD, Rakesh Popat, Cesar Molinero, MD PhD, Christina Mascaro, PhD, Tamara Maes, PhD, Francesc Bosch, MD PhD

Blood (2016) 128 (22): 4060.

https://doi.org/10.1182/blood.V128.22.4060.4060

Published: 2016

Journal Articles

Novel Epigenetic Modulators That Promote Fetal Hemoglobin Production for the Prevention of Sickle Cell Disease Related Complications

Rebecca M. Cafiero, MD, Steven Holshouser, Craig Kutz, Julie Kanter, MD, Patrick Woster, PhD

Blood (2015) 126 (23): 973.

https://doi.org/10.1182/blood.V126.23.973.973

Published: 2015

Journal Articles

Activity of RN-1, an LSD-1 Inhibitor, on Fetal Globin Expression in Sickle Mice and Sickle Erythroid Progenitors

Shuaiying Cui, PhD, Jose Sangerman, PhD, Seyed Mehdi Nouraie, MD, PhD, Yan Dai, PhD, Oluwakemi Owoyemi, MD MPH, Robert E. Taylor, MD PhD, Susan P. Perrine, MD

Blood (2015) 126 (23): 961.

https://doi.org/10.1182/blood.V126.23.961.961

Published: 2015

Journal Articles

RN-1, a Potent and Selective LSD1 Inhibitor, Induces High Levels of Fetal Hemoglobin (HbF) in Anemic Baboons ( P. anubis )

Angela Rivers, MD PhD, Kestis Vaitkus, Maria Armila Ruiz, B.S., Vinzon Ibanez, Tatiana Kouznetsova, M.S., Joseph DeSimone, PhD, Donald Lavelle, PhD

Blood (2014) 124 (21): 336.

https://doi.org/10.1182/blood.V124.21.336.336

Published: 2014

Journal Articles

Comparing Strategies to Reactivate Fetal Globin Expression for the Treatment of Beta-Globinopathies

Laura Breda, PhD, Jeremy W. Rupon, MD PhD, Irene Motta, MD, Wulan Deng, Gerd A. Blobel, MD PhD, Stefano Rivella, PhD

Blood (2014) 124 (21): 333.

https://doi.org/10.1182/blood.V124.21.333.333

Published: 2014

Journal Articles

The Tet Dioxygenase Co-Factor Ascorbic Acid Reduces DNA Methylation and Increases Expression of the γ-Globin Gene and Acts in a Combinatorial Manner with HbF-Inducing Drugs Targeting Repressive Epigenetic Modifications

Maria Armila Ruiz, B.S., Angela Rivers, MD PhD, Kestis Vaitkus, Vinzon Ibanez, Robert E. Molokie, MD, Joseph DeSimone, PhD, Donald Lavelle, PhD

Blood (2014) 124 (21): 334.

https://doi.org/10.1182/blood.V124.21.334.334

Published: 2014

Journal Articles

Pharmacological Inhibitors of LSD1 Promote Differentiation of Myeloid Leukemia Cells through a Mechanism Independent of Histone Demethylation

James T Lynch, PhD, Gary J Spencer, PhD, William J Harris, PhD, Alba Maiques-Díaz, PhD, Filippo Ciceri, PhD, Xu Huang, PhD, Tim C P Somervaille, PhD FRCP, FRCPath

Blood (2014) 124 (21): 267.

https://doi.org/10.1182/blood.V124.21.267.267

Published: 2014

Journal Articles

MLL-AF9 Positive Acute Myeloid Leukemia Cells Are Sensitive To All-Trans Retinoic Acid

Kenichi Sakamoto, MD, Toshihiko Imamura, MD, Mio Yano, MD, Hideki Yoshida, MD, Atsushi Fujiki, MD, Yoshifumi Hirashima, MD, Hajime Hosoi, MD

Blood (2013) 122 (21): 3827.

https://doi.org/10.1182/blood.V122.21.3827.3827

Published: 2013

Journal Articles

LSD1 Influences Both Histone and DNA Methylation During Terminal Erythroid Maturation

Michael Getman, MS, Jeffrey Malik, PhD, James Palis, M.D., Laurie A Steiner, MD

Blood (2013) 122 (21): 3671.

https://doi.org/10.1182/blood.V122.21.3671.3671

Published: 2013

Journal Articles

RN-1, a New and Potent Lsd-1 Inhibitor, Increases γ-Globin Expression In a Humanized Sickle Cell Mouse Model

Angela Rivers, MD, PhD, Maria Armila Ruiz, BS, Kestis Vaitkus, Tatiana Kouznetsova, M.S., Joseph DeSimone, PhD, Donald Lavelle, Ph.D.

Blood (2013) 122 (21): 561.

https://doi.org/10.1182/blood.V122.21.561.561

Published: 2013

Journal Articles

Fetal Hemoglobin Expression Is Differentially Affected by Inhibition of the Proposed Dred Complex Constituents, LSD1 and DNMT1

Tara L Arvedson, PhD, Lynn Tran, Sandra L Ross, MA, Sean Yoder, Alexandra Hertz, Kari Hale, John Eschelbach, Tom Dineen, Ph.D., Stephanie Matyas, Cynthia Hartley, Kurt Morgenstern, Ph.D., Dwight Winters, Park Cindy, Graham Molineux, Ph.D., Angela Coxon, PhD

Blood (2012) 120 (21): 3263.

https://doi.org/10.1182/blood.V120.21.3263.3263

Published: 2012

Journal Articles

Inhibition of LSD1 Influences Multiple Mechanisms of Epigenetic Gene Regulation During Terminal Erythroid Maturation

Michael Getman, MS, Samantha J England, PhD, James Palis, MD, Laurie A Steiner, MD

Blood (2012) 120 (21): 3442.

https://doi.org/10.1182/blood.V120.21.3442.3442

Published: 2012

Journal Articles

Pre-Clinical Efficacy of Combined Therapy with LSD1 Antagonist SP-2509 and Pan-Histone Deacetylase Inhibitor Against AML Blast Progenitor Cells

Warren Fiskus, Ph.D., Sunil Sharma, M.D., Sunil Abhyankar, MD, Joseph McGuirk, DO, David J. Bearss, PhD, Kapil Bhalla, MD

Blood (2012) 120 (21): 868.

https://doi.org/10.1182/blood.V120.21.868.868

Published: 2012

Journal Articles

LSD1 Inhibitor Activates Retinoic Acid Pathway in MLL Fusion Positive Acute Myeloid Leukemia

Mio Yano, MD, Toshihiko Imamura, MD, Kenichi Sakamoto, MD, Hideki Yoshida, MD, Atsushi Fujiki, MD, Yoshifumi Hirashima, MD, Hiroyuki Ishida, MD, Hajime Hosoi, MD

Blood (2012) 120 (21): 1345.

https://doi.org/10.1182/blood.V120.21.1345.1345

Published: 2012

NARROW

The Lysine-Specific Demethylase 1 (LSD1) Inhibitor Tranylcypromine (TCP) in Combination with ATRA Is Tolerable and Has Anti-Leukemic Activity in Adult Patients with Relapsed/Refractory AML and MDS

LSD1 Inhibitors Induce Fetal Hemoglobin in Primary Human Erythroid Cells

In Vivo Effects of LSD1 Inhibition By Small Chemical Inhibitors in Sickle Cell Mice

LSD1 Inhibition Leads to Differentiation in Hoxa9/Meis1- but Not in MN1-Induced Acute Myeloid Leukemia

The Novel Translocation t(4;15)(q31;q22) in AML Is Associated with a Proliferative Phenotype in the Presence of All-Trans Retinoic Acid (ATRA)

LSD1 Inhibition Induces Differentiation and Reduces the Frequency of Leukemia-Initiating Cells in Hoxa9/Meis1-Induced Acute Myeloid Leukemia

Safety, Phamacokinetics (PK), Pharmacodynamics (PD) and Preliminary Activity in Acute Leukemia of Ory-1001, a First-in-Class Inhibitor of Lysine-Specific Histone Demethylase 1A (LSD1/KDM1A): Initial Results from a First-in-Human Phase 1 Study

Novel Epigenetic Modulators That Promote Fetal Hemoglobin Production for the Prevention of Sickle Cell Disease Related Complications

Activity of RN-1, an LSD-1 Inhibitor, on Fetal Globin Expression in Sickle Mice and Sickle Erythroid Progenitors

RN-1, a Potent and Selective LSD1 Inhibitor, Induces High Levels of Fetal Hemoglobin (HbF) in Anemic Baboons ( P. anubis )

Comparing Strategies to Reactivate Fetal Globin Expression for the Treatment of Beta-Globinopathies

The Tet Dioxygenase Co-Factor Ascorbic Acid Reduces DNA Methylation and Increases Expression of the γ-Globin Gene and Acts in a Combinatorial Manner with HbF-Inducing Drugs Targeting Repressive Epigenetic Modifications

Pharmacological Inhibitors of LSD1 Promote Differentiation of Myeloid Leukemia Cells through a Mechanism Independent of Histone Demethylation

MLL-AF9 Positive Acute Myeloid Leukemia Cells Are Sensitive To All-Trans Retinoic Acid

LSD1 Influences Both Histone and DNA Methylation During Terminal Erythroid Maturation

RN-1, a New and Potent Lsd-1 Inhibitor, Increases γ-Globin Expression In a Humanized Sickle Cell Mouse Model

Fetal Hemoglobin Expression Is Differentially Affected by Inhibition of the Proposed Dred Complex Constituents, LSD1 and DNMT1

Inhibition of LSD1 Influences Multiple Mechanisms of Epigenetic Gene Regulation During Terminal Erythroid Maturation

Pre-Clinical Efficacy of Combined Therapy with LSD1 Antagonist SP-2509 and Pan-Histone Deacetylase Inhibitor Against AML Blast Progenitor Cells

LSD1 Inhibitor Activates Retinoic Acid Pathway in MLL Fusion Positive Acute Myeloid Leukemia

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American Society of Hematology

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ASH Publications

American Society of Hematology

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