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Journal Articles

Myeloma Cells Addicted to Glutamine for Biomass Production Are Sensitive to Lenalidomide

Sinto Chirackal, PhD, Esteban Braggio, PhD, Rahman Atiqur, PhD, Gregory J Ahmann, BS, Yuan Xiao Zhu, PhD, A. Keith Stewart, MB, ChB, Marta Chesi, PhD, P. Leif Bergsagel, MD, Rafael Fonseca, MD

Blood (2019) 134 (Supplement_1): 4410.

https://doi.org/10.1182/blood-2019-124967

Published: 2019

Journal Articles

Inhibition of Autophagy with 3-Methyladenine Potentiates Bortezomib-Induced Apoptosis of Myeloma Cell Via up Regulation of Mitochondrial Reactive Oxygen Species

Yeung-Chul Mun, Jee Young Ahn, Eun Sun Yoo, Kyoung Eun Lee, Eunmi Nam, Soon Nam Lee, Hyun Ae Woo, Sue Goo Rhee, Chu Myong Seong

Blood (2018) 132 (Supplement 1): 4472.

https://doi.org/10.1182/blood-2018-99-117727

Published: 2018

Journal Articles

Cereblon and Redox in Plasma Cells

Florian Bassermann, MD PhD

Blood (2017) 130 (Supplement 1): SCI-9.

https://doi.org/10.1182/blood.V130.Suppl_1.SCI-9.SCI-9

Published: 2017

Journal Articles

4-Hydroxy-2-Nonenal (HNE), a Product of Lipid Peroxidation, Induces Tissue Factor Decryption By Two Independent Mechanisms

Shabbir Ansari, Usha R Pendurthi, PhD, L. Vijaya Mohan Rao, PhD

Blood (2016) 128 (22): 1382.

https://doi.org/10.1182/blood.V128.22.1382.1382

Published: 2016

Journal Articles

Anti-ß2GPI Antibodies Induce Oxidative and Nitrative Stress in Endothelial Cells through Activation of Discrete Nox Isoforms and eNOS Uncoupling

Ravi Kumar Alluri, PhD, Meifang Wu, MD, Suman Kundu, MS, MBA, Keith R. McCrae, MD

Blood (2016) 128 (22): 720.

https://doi.org/10.1182/blood.V128.22.720.720

Published: 2016

Journal Articles

Lenalidomide Inhibits Thioredoxin Reductase (TrxR) in Multiple Myeloma (MM) Cells but Direct Inhibition of Trxr and Thioredoxin (Trx) Can Bypass Requirement of Cereblon (CRBN)

Sinto Sebastian Chirackal, PhD, Esteban Braggio, PhD, Yuan Xiao Zhu, PhD, Chang-Xin Shi, PhD, Scott Van Wier, Gregory Ahmann, Veronica Gonzalez-Calle, MD, Marta Chesi, PhD, Leif Bergsagel, MD, Keith Stewart, M.B., Ch.B., Rafael Fonseca, MD

Blood (2016) 128 (22): 4482.

https://doi.org/10.1182/blood.V128.22.4482.4482

Published: 2016

Journal Articles

Tissue Factor Decryption By Oxidative Stress-Induced Lipid Peroxidation: Potential Mechanisms

Shabbir Ansari, Usha R Pendurthi, PhD, L. Vijaya Mohan Rao, PhD

Blood (2015) 126 (23): 125.

https://doi.org/10.1182/blood.V126.23.125.125

Published: 2015

Journal Articles

NADPH Oxidase Activation and Endothelial Nitric Oxide Synthase Uncoupling Contribute to Endothelial Dysfunction in Antiphospholipid Syndrome

Meifang Wu, MD, Suman Kundu, MS, MBA, Keith R. McCrae, MD

Blood (2015) 126 (23): 4639.

https://doi.org/10.1182/blood.V126.23.4639.4639

Published: 2015

Journal Articles

SK053, an Inhibitor of Enzymes Involved in Allosteric Disulfide Bonds Formation, Targets Expression of Histone Genes and Induces Differentiation of Human AML Cell

Justyna Chlebowska, M.Sc., Pawel Gaj, PhD, Piotr Stawinski, M.Sc., Michal Lazniewski, M.Sc., Malgorzata Firczuk, PhD, Karolina Furs, Radoslaw Sadowski, Szymon Klossowski, M.Sc., Ryszard Ostaszewski, PhD, Jakub Golab, MD PhD, Krzysztof Giannopoulos, MD PhD, Rafal Ploski, MD, PhD, Dominika Nowis, MD, PhD

Blood (2014) 124 (21): 3503.

https://doi.org/10.1182/blood.V124.21.3503.3503

Published: 2014

Journal Articles

SK053 An Inhibitor Of Enzymes Involved In Allosteric Disulfide Bonds Formation Induces Differentiation Of Human AML Cells

Justyna Chlebowska, M.Sc., Malgorzata Firczuk, Ph.D., Karolina Furs, Angelika Muchowicz, Ph.D., Radoslaw Sadowski, Adam D. Staruch, M.D., Szymon Klossowski, M.Sc., Ryszard Ostaszewski, Ph.D., Anna Paulina Dabrowska-Iwanicka, M.D., Ph.D., Jakub Golab, M.D., Ph.D., Dominika Nowis, M.D., Ph.D.

Blood (2013) 122 (21): 4215.

https://doi.org/10.1182/blood.V122.21.4215.4215

Published: 2013

Journal Articles

Development Of Second Generation Thiol Isomerase Inhibitors To Prevent Thrombus Formation

Daniel R Kennedy, Ph.D., Partha P Nag, Ph.D., Christine N. Galinski, Pharm.D. Candidate, Sheryl Bowley, Ph.D., Roelof H. Bekendam, Ph.D., James R. Dilks, Alissa A Scalise, Pharm.D. Candidate, Lotte van Hessem, Ph.D., Jun Pu, Ph.D., Tatiana Pilyugina, Sivaraman Dandapani, Ph.D., Benito Munoz, Ph.D., Robert Flaumenhaft, M.D. Ph.D

Blood (2013) 122 (21): 926.

https://doi.org/10.1182/blood.V122.21.926.926

Published: 2013

Journal Articles

The Rheumatoid Arthritis Drug Auranofin Has Significant in Vitro Activity in MCL and DLCL and Is Synergistic with a Glutathione Depleting Agent

Jolanta Skalska, PhD, Michelle M. Kiebala, PhD, Shannon P. Hilchey, PhD, Yun Dai, MD, PhD, Steven Grant, MD, Paul S. Brookes, PhD, Derick R. Peterson, PhD, Sanjay B. Maggirwar, PhD, Steven H. Bernstein, MD

Blood (2012) 120 (21): 1658.

https://doi.org/10.1182/blood.V120.21.1658.1658

Published: 2012

Journal Articles

Thrombosis and Inflammation Are Coupled by a Common Thioredoxin Reductase Pathway Downstream of the P2×7 Receptor.

Andrea S Rothmeier, Ph.D., Christian Furlan-Freguia, Ph.D., Brian G. Petrich, PhD, Patrizia Marchese, PhD, Zaverio M. Ruggeri, MD, PhD, Mark H. Ginsberg, M.D., Wolfram Ruf, MD

Blood (2012) 120 (21): 2218.

https://doi.org/10.1182/blood.V120.21.2218.2218

Published: 2012

Journal Articles

Selective Damage to Antioxidant Gene Promoters in FA Cells

Wei Du, MD, PhD, Reena Rani, Jared Sipple, Jonathan Schick, Qishen Pang, PhD

Blood (2011) 118 (21): 2413.

https://doi.org/10.1182/blood.V118.21.2413.2413

Published: 2011

Journal Articles

Protein Disulfide Isomerase Inhibitors: A New Class of Antithrombotic Agents

Reema Jasuja, Ph.D., Freda H. Passam, MD, PhD, Daniel R Kennedy, Ph.D., Sarah H Kim, Lotte van Hessem, Lin Lin, PhD, Sucharit S Joshi, MD, James R. Dilks, Bruce Furie, MD, Barbara C. Furie, PhD, Robert C. Flaumenhaft, MD, PhD

Blood (2011) 118 (21): 369.

https://doi.org/10.1182/blood.V118.21.369.369

Published: 2011

Journal Articles

Treatment with Auranofin Induces Oxidative and Lethal Endoplasmic Reticulum (ER) Stress Exerting Single Agent Activity Against Primary CLL Cells

Rekha Rao, PhD, Kami Maddocks, MD, Amy J. Johnson, PhD, Lata Chauhan, PhD, Suman Kambhampati, MD, Siddhartha Ganguly, MD, Ruben Reyes, MD, Omar S. Aljitawi, MD, Kevin Schorno, MBA, Kendra Ford, MSN, RN, CCRC, Eileen Dickman, PhD, MBA, John C. Byrd, MD, Kapil N. Bhalla, MD

Blood (2011) 118 (21): 929.

https://doi.org/10.1182/blood.V118.21.929.929

Published: 2011

Journal Articles

ATM Mutant Lymphoid Tumour Cells Exhibit Impaired Activation of the Redox-Sensitive Nrf2-ARE Detoxification Pathway and Are Differentially Sensitive to Nrf2-Activating Compounds

Victoria J Weston, PhD, Angelo Agathanggelou, PhD, Paul AH Moss, MD, PhD, Pamela R. Kearns, BSc, MBBCh, MRCP, PhD, A. Malcolm R Taylor, PhD, Tatjana Stankovic, MD, PhD

Blood (2010) 116 (21): 49.

https://doi.org/10.1182/blood.V116.21.49.49

Published: 2010

Journal Articles

Compound Deficiency of Nrf2 and Selenoproteins in Hematopoietic Cells Leads to Severe Defects in Erythroid and Lymphoid Lineage Development.

Yukie Kawatani, Takafumi Suzuki, Ritsuko Shimizu, Vincent Kelly, Masayuki Yamamoto, MD, PhD

Blood (2009) 114 (22): 1993.

https://doi.org/10.1182/blood.V114.22.1993.1993

Published: 2009

Journal Articles

The Selenoprotein Thioredoxin Reductase 1 Is Crucial for B-1 Cell but Dispensable for B-2 Cell Development.

Pankaj Kumar Mandal, Ursula Zimber-Strobl, Georg W. Bornkamm, Armin Gerbitz, MD, Marcus Conrad

Blood (2009) 114 (22): 3691.

https://doi.org/10.1182/blood.V114.22.3691.3691

Published: 2009

Journal Articles

Thioredoxin Interacting Protein (TXNIP) Correlates with Production of Reactive Oxygen Species (ROS) and Underlines Differences in Stress Response Gene Profile in Patients with Chronic Lymphocytic Leukemia (CLL).

Nebu V. Koshy, MD, Ellen Friday, PhD, Francesco Turturro, MD

Blood (2009) 114 (22): 4375.

https://doi.org/10.1182/blood.V114.22.4375.4375

Published: 2009

NARROW

Myeloma Cells Addicted to Glutamine for Biomass Production Are Sensitive to Lenalidomide

Inhibition of Autophagy with 3-Methyladenine Potentiates Bortezomib-Induced Apoptosis of Myeloma Cell Via up Regulation of Mitochondrial Reactive Oxygen Species

Cereblon and Redox in Plasma Cells

4-Hydroxy-2-Nonenal (HNE), a Product of Lipid Peroxidation, Induces Tissue Factor Decryption By Two Independent Mechanisms

Anti-ß2GPI Antibodies Induce Oxidative and Nitrative Stress in Endothelial Cells through Activation of Discrete Nox Isoforms and eNOS Uncoupling

Lenalidomide Inhibits Thioredoxin Reductase (TrxR) in Multiple Myeloma (MM) Cells but Direct Inhibition of Trxr and Thioredoxin (Trx) Can Bypass Requirement of Cereblon (CRBN)

Tissue Factor Decryption By Oxidative Stress-Induced Lipid Peroxidation: Potential Mechanisms

NADPH Oxidase Activation and Endothelial Nitric Oxide Synthase Uncoupling Contribute to Endothelial Dysfunction in Antiphospholipid Syndrome

SK053, an Inhibitor of Enzymes Involved in Allosteric Disulfide Bonds Formation, Targets Expression of Histone Genes and Induces Differentiation of Human AML Cell

SK053 An Inhibitor Of Enzymes Involved In Allosteric Disulfide Bonds Formation Induces Differentiation Of Human AML Cells

Development Of Second Generation Thiol Isomerase Inhibitors To Prevent Thrombus Formation

The Rheumatoid Arthritis Drug Auranofin Has Significant in Vitro Activity in MCL and DLCL and Is Synergistic with a Glutathione Depleting Agent

Thrombosis and Inflammation Are Coupled by a Common Thioredoxin Reductase Pathway Downstream of the P2×7 Receptor.

Selective Damage to Antioxidant Gene Promoters in FA Cells

Protein Disulfide Isomerase Inhibitors: A New Class of Antithrombotic Agents

Treatment with Auranofin Induces Oxidative and Lethal Endoplasmic Reticulum (ER) Stress Exerting Single Agent Activity Against Primary CLL Cells

ATM Mutant Lymphoid Tumour Cells Exhibit Impaired Activation of the Redox-Sensitive Nrf2-ARE Detoxification Pathway and Are Differentially Sensitive to Nrf2-Activating Compounds

Compound Deficiency of Nrf2 and Selenoproteins in Hematopoietic Cells Leads to Severe Defects in Erythroid and Lymphoid Lineage Development.

The Selenoprotein Thioredoxin Reductase 1 Is Crucial for B-1 Cell but Dispensable for B-2 Cell Development.

Thioredoxin Interacting Protein (TXNIP) Correlates with Production of Reactive Oxygen Species (ROS) and Underlines Differences in Stress Response Gene Profile in Patients with Chronic Lymphocytic Leukemia (CLL).

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American Society of Hematology

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ASH Publications

American Society of Hematology

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