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Journal Articles

High-Dose Cytarabine Is Indispensable for the Survival of Children with Myeloid Leukemia of Down Syndrome Despite Negative Minimal Residual Disease Post-Induction

Johann K. Hitzler, MD, Jason Berman, MD, Robert B. Gerbing, Amy Beckman, Betsy A Hirsch, PhD, Susana C. Raimondi, PhD, Todd E Druley, MD PhD, Michael R. Loken, PhD, Lisa Eidenschink Brodersen, PhD, Karen Chisholm, Shelton A. Viola, MD, Jeffrey W. Taub, MD, Alan S Gamis, MD MPH, Todd A. Alonzo, PhD, E. Anders Kolb, MD

Blood (2019) 134 (Supplement_1): 118.

https://doi.org/10.1182/blood-2019-126723

Published: 2019

Journal Articles

Combination Thioguanine and Decitabine Is Highly Active in Patients with Advanced Myeloid Malignancies: A Single Institution Experience

Kara Cicero, MD MPH, Mark L Heaney, Todd L. Rosenblat, MD MS, Nicole Lamanna, MD, Joseph G. Jurcic, MD, Mark G. Frattini, MD PhD, Daniel J. Lee, MD

Blood (2019) 134 (Supplement_1): 3899.

https://doi.org/10.1182/blood-2019-130203

Published: 2019

Journal Articles

Pediatric-Inspired Regimens Are Associated with Better Outcomes When Compared with Hypercvad in Hispanic Adolescents and Young Adults with Acute Lymphoblastic Leukemia

Roberta Demichelis, MD, Karla Adriana Espinosa, MD MSc, Juan Rangel-Patiño, MD, Emmanuel Almanza, MD, Ana Cooke, MD

Blood (2019) 134 (Supplement_1): 3877.

https://doi.org/10.1182/blood-2019-125370

Published: 2019

Journal Articles

A Retrospective Review of Mercaptopurine Metabolism Reveals High Rate of Patients with Suboptimal Metabolites Successfully Corrected with Allopurinol

Lauren Marie Vasta, MD, Richard C Zanetti, MD, Dina S. Parekh, MD, Anne B. Warwick, MD MPH, Kenneth Lieuw, MD PhD

Blood (2019) 134 (Supplement_1): 3878.

https://doi.org/10.1182/blood-2019-126184

Published: 2019

Journal Articles

Using Pharmacogenomics Testing to Optimize Care in Children with Acute Hematologic Malignancies

Trisha Kissoon, MD MBA

Blood (2019) 134 (Supplement_1): 5062.

https://doi.org/10.1182/blood-2019-129511

Published: 2019

Journal Articles

A Modified CALGB-10403 in Hispanic Adolescent and Young Adults with Philadelphia -Negative Acute Lymphoblastic Leukemia: Promising Results Despite a High-Rate of Metabolic and Hepatic Toxicities

Juan Rangel-Patiño, MD, Alvaro Cabrero Garcia, Carolina Balderas-Delgado, MD, Lauro Fabian Amador, MD, Yvette Neme Yunes, Ana Cooke, MD, Adriana Rosas, Roberta Demichelis, MD

Blood (2019) 134 (Supplement_1): 1352.

https://doi.org/10.1182/blood-2019-126108

Published: 2019

Journal Articles

Loss of KDM6A Confers Drug Resistance in Acute Myeloid Leukemia

Sophie M. Stief, M.Sc., Anna-Li Hanneforth, Raphael Mattes, Sabrina Weser, M.Sc., Binje Vick, PhD, Michael D. Bartoschek, M.Sc., Helena Domínguez Moreno, M.Sc., Wen-Hsin Liu, PhD, Bianka Ksienzyk, Maja Rothenberg-Thurley, PhD, Hilmar Quentmeier, PhD, Wolfgang Hiddemann, Klaus H. Metzeler, MD, Gunnar Schotta, PhD, Sebastian Bultmann, PhD, Irmela Jeremias, MD PhD, Heinrich Leonhardt, PhD, Karsten Spiekermann, MD

Blood (2018) 132 (Supplement 1): 3935.

https://doi.org/10.1182/blood-2018-99-114959

Published: 2018

Journal Articles

Outcome of Infants Younger Than 1 Year with Acute Lymphoblastic Leukemia Treated with the Interfant-06 Protocol; Results from an International Randomised Study

Blood (2018) 132 (Supplement 1): 655.

https://doi.org/10.1182/blood-2018-99-112854

Published: 2018

Journal Articles

Outcome of Patients with Acute Myeloid Leukemia (AML) Undergoing Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) Beyond First Complete Remission (CR1)

Georg Evers, MD, Dietrich W. Beelen, Jan Braess, MD, Cristina Sauerland, Hans-Jochem Kolb, MD, Albrecht Reichle, MD, Ernst Holler, MD, Rainer Schwerdtfeger, MD, Renate Arnold, MD, Christoph Scheid, MD, Utz Krug, MD, Carsten Müller-Tidow, MD, Christoph Schliemann, MD, Jan-Henrik Mikesch, MD, Georg Lenz, Bernhard J. Wörmann, MD, Wolfgang Hiddemann, Wolfgang E. Berdel, MD, Matthias Stelljes, MD

Blood (2018) 132 (Supplement 1): 4649.

https://doi.org/10.1182/blood-2018-99-116964

Published: 2018

Journal Articles

A Network Meta-Analysis of Clinical Trials Assessing Induction Chemotherapy in Newly Diagnosed Acute Myeloid Leukemia Among Young Adults

Nour Tlimat, MD, Salman Muddassir, Saad Ullah Malik, Warda Faridi, MD, Qurat Ul Ain Riaz Sipra, MBBS, MD, Faiz Anwer, MD

Blood (2018) 132 (Supplement 1): 1432.

https://doi.org/10.1182/blood-2018-99-119646

Published: 2018

Journal Articles

Treatment of Elderly and Unfit AML Patients with Prolonged Administration of Low Dose Cytarabine and Thioguanine Achieves High Complete Remission Rates in an Outpatient Setting

Christopher K Arthur, Anthony Jeffrey, Molly Forbes, Eva Yip, Vicki Katsioulas, William S. Stevenson, MBBS, PhD

Blood (2018) 132 (Supplement 1): 3998.

https://doi.org/10.1182/blood-2018-99-118027

Published: 2018

Journal Articles

SETD2 alterations impair DNA damage recognition and lead to resistance to chemotherapy in leukemia

Brenton G. Mar, S. Haihua Chu, Josephine D. Kahn, Andrei V. Krivtsov, Richard Koche, Cecilia A. Castellano, Jacob L. Kotlier, Rebecca L. Zon, Marie E. McConkey, Jonathan Chabon, Ryan Chappell, Peter V. Grauman, James J. Hsieh, Scott A. Armstrong, Benjamin L. Ebert

Blood (2017) 130 (24): 2631–2641.

https://doi.org/10.1182/blood-2017-03-775569

Published: 2017

Includes: Supplemental data

Journal Articles

The Role of MMSET E1099K Mutation in Gene Dysregulation, Drug Resistance and Clonogenicity in Acute B-Lymphoblastic Leukemia

Joanna Pierro, DO, Jason Saliba, PhD, Nikki Ann Evensen, PhD BS, Yixiao Gong, Shella Saint Fleur-Lominy, MDPhD, William L. Carroll, MD

Blood (2017) 130 (Supplement 1): 2474.

https://doi.org/10.1182/blood.V130.Suppl_1.2474.2474

Published: 2017

Journal Articles

No Association between Relapse Risk and Thiopurine Methyltransferase Activity By Either Geno- or Phenotype in the NOPHO ALL-2008 Protocol

Stine Nygaard Nielsen, PhD MD, Kathrine Grell, PhD, Jacob Nersting, PhD, Jonas Abrahamsson, MD PhD, Bendik Lund, MD PhD, Jukka A. Kanerva, MD, Ólafur G Jónsson, MD, Goda Vaitkeviciene, MD, Kaie Pruunsild, MD, Malin Lindqvist Appell, Lisa Hjalgrim, PhD, Kjeld Schmiegelow, MD DMSc

Blood (2017) 130 (Supplement 1): 1279.

https://doi.org/10.1182/blood.V130.Suppl_1.1279.1279

Published: 2017

Journal Articles

Evaluation of Nudt15 -Guided Thiopurine Dose Individualization In Vivo Using CRISPR/Cas9-Edited Mouse Model

Takaya Moriyama, MDPhD, Rina Nishii, Laura Janke, DVM, PhD, Lie Li, Chen Ru, Scott A Brown, PhD, Ting-Nien Lin, Chase Suiter, Kentaro Kihira, MD, Hidemi Toyoda, MD PhD, Motohiro Kato, MD PhD, Atushi Manabe, MD PhD, Katsuyoshi Koh, MD, Masatoshi Takagi, MD PhD, Hiroki Hori, MD PhD, Jun J. Yang, PhD

Blood (2017) 130 (Supplement 1): 3879.

https://doi.org/10.1182/blood.V130.Suppl_1.3879.3879

Published: 2017

Journal Articles

PACSIN2 rs2413739 Polymorphism and Thiopurine Pharmacokinetics: Validation Studies in Pediatric Patients

Gabriele Stocco, PhD, Raffaella Franca, Diego Favretto, Nagua Giurici, Alessandro Ventura, Giuliana Decorti, Luciana Vinti, MD, Antonella Colombini, Erica Brivio, Laura Rachele Bettini, Ilaria Bini, Francesca Sismondi, Alessandra Mandese, Noelia Malusà, Stefano Martelossi, Marco Rabusin

Blood (2017) 130 (Supplement 1): 4999.

https://doi.org/10.1182/blood.V130.Suppl_1.4999.4999

Published: 2017

Journal Articles

Magic-TT Mediated Hematopoietic Stem/Progenitor Cells Promote Hematopoietic Recovery after Autologous Bone Marrow Transplantation

Yongjun Zhou, MD, Qiuxia Zhang, MD, Qiusui Mai, MD, Shan Jiang, Hao Huang, Linlin Zhang, MD, Xiaowei Sun, Minchun Zhang, Pengxin Qiao, Chun Zou, Xiaoli Chen, Zhihao Zheng, Jerry Kitbok Majaw, Qifa Liu, MD, Jing Sun, MD, Qianli Jiang, MD PhD

Blood (2017) 130 (Supplement 1): 4952.

https://doi.org/10.1182/blood.V130.Suppl_1.4952.4952

Published: 2017

Journal Articles

Individualized 6-Mercaptopurine Increments in Consolidation Treatment of Childhood Acute Lymphoblastic Leukemia: A NOPHO ALL2008 Randomized Controlled Trial

Morten Tulstrup, MD, Thomas Leth Frandsen, MD PhD, Jonas Abrahamsson, MD PhD, Bendik Lund, MD PhD, Kim Vettenranta, MD PhD, Olafur G. Jonsson, MD PhD, Hanne Vibeke Marquart, MD PhD, Birgitte Klug Albertsen, MD, Mats Heyman, MD PhD, Kjeld Schmiegelow, MD

Blood (2017) 130 (Supplement 1): 142.

https://doi.org/10.1182/blood.V130.Suppl_1.142.142

Published: 2017

Journal Articles

RAS Pathway Mutations As Predictive Biomarker for Treatment Adaptation in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia

Isabel S. Jerchel, MSc, Alex Q. Hoogkamer, BSc, Ingrid M. Ariës, PhD, Elisabeth M.P. Steeghs, MSc, Judith M. Boer, PhD, Nicolle J.M. Besselink, BSc, Aurélie Boeree, BSc, Cesca van de Ven, PhD, Hester A. de Groot-Kruseman, PhD, Valerie De Haas, MD PhD, Martin A. Horstmann, MD, Gabriele Escherich, MD, Ronald W. Stam, PhD, C. Michel Zwaan, MD PhD, Edwin Cuppen, PhD, Marco J. Koudijs, PhD, Rob Pieters, MD PhD, Monique L. Den Boer, MSc, PhD

Blood (2016) 128 (22): 4087.

https://doi.org/10.1182/blood.V128.22.4087.4087

Published: 2016

Journal Articles

Thioguanine Combined with Decitabine Can Overcome Resistance to Hypomethylating Agents: Final Results of a Phase I Trial of a Pharmacodynamically-Conceived Thioguanine/Decitabine Combination in Patients with Advanced Myeloid Malignancies

Daniel J. Lee, MD, Todd L. Rosenblat, MD MS, Mark Lawrence Heaney, MD PhD, Joseph G. Jurcic, MD, Azra Raza, MD, Kristina Gazivoda, Katherine Harwood, Ryan Shelton, Hakim Djaballah, PhD, Joseph M. Scandura, MD PhD, Anthony Letai, MD PhD, Mark G. Frattini, MD PhD

Blood (2016) 128 (22): 2816.

https://doi.org/10.1182/blood.V128.22.2816.2816

Published: 2016

NARROW

High-Dose Cytarabine Is Indispensable for the Survival of Children with Myeloid Leukemia of Down Syndrome Despite Negative Minimal Residual Disease Post-Induction

Combination Thioguanine and Decitabine Is Highly Active in Patients with Advanced Myeloid Malignancies: A Single Institution Experience

Pediatric-Inspired Regimens Are Associated with Better Outcomes When Compared with Hypercvad in Hispanic Adolescents and Young Adults with Acute Lymphoblastic Leukemia

A Retrospective Review of Mercaptopurine Metabolism Reveals High Rate of Patients with Suboptimal Metabolites Successfully Corrected with Allopurinol

Using Pharmacogenomics Testing to Optimize Care in Children with Acute Hematologic Malignancies

A Modified CALGB-10403 in Hispanic Adolescent and Young Adults with Philadelphia -Negative Acute Lymphoblastic Leukemia: Promising Results Despite a High-Rate of Metabolic and Hepatic Toxicities

Loss of KDM6A Confers Drug Resistance in Acute Myeloid Leukemia

Outcome of Infants Younger Than 1 Year with Acute Lymphoblastic Leukemia Treated with the Interfant-06 Protocol; Results from an International Randomised Study

Outcome of Patients with Acute Myeloid Leukemia (AML) Undergoing Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) Beyond First Complete Remission (CR1)

A Network Meta-Analysis of Clinical Trials Assessing Induction Chemotherapy in Newly Diagnosed Acute Myeloid Leukemia Among Young Adults

Treatment of Elderly and Unfit AML Patients with Prolonged Administration of Low Dose Cytarabine and Thioguanine Achieves High Complete Remission Rates in an Outpatient Setting

SETD2 alterations impair DNA damage recognition and lead to resistance to chemotherapy in leukemia

The Role of MMSET E1099K Mutation in Gene Dysregulation, Drug Resistance and Clonogenicity in Acute B-Lymphoblastic Leukemia

No Association between Relapse Risk and Thiopurine Methyltransferase Activity By Either Geno- or Phenotype in the NOPHO ALL-2008 Protocol

Evaluation of Nudt15 -Guided Thiopurine Dose Individualization In Vivo Using CRISPR/Cas9-Edited Mouse Model

PACSIN2 rs2413739 Polymorphism and Thiopurine Pharmacokinetics: Validation Studies in Pediatric Patients

Magic-TT Mediated Hematopoietic Stem/Progenitor Cells Promote Hematopoietic Recovery after Autologous Bone Marrow Transplantation

Individualized 6-Mercaptopurine Increments in Consolidation Treatment of Childhood Acute Lymphoblastic Leukemia: A NOPHO ALL2008 Randomized Controlled Trial

RAS Pathway Mutations As Predictive Biomarker for Treatment Adaptation in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia

Thioguanine Combined with Decitabine Can Overcome Resistance to Hypomethylating Agents: Final Results of a Phase I Trial of a Pharmacodynamically-Conceived Thioguanine/Decitabine Combination in Patients with Advanced Myeloid Malignancies

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American Society of Hematology

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American Society of Hematology

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